A bidirectional neuromodulation technology for nerve recording and stimulation

Jian Xu; Hongsun Guo; Anh Tuan Nguyen; Hubert Lim; Zhi Yang

doi:10.3390/mi9110538

A bidirectional neuromodulation technology for nerve recording and stimulation

Jian Xu, Hongsun Guo, Anh Tuan Nguyen, Hubert Lim, Zhi Yang

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Electrical nerve recording and stimulation technologies are critically needed to monitor and modulate nerve activity to treat a variety of neurological diseases. However, current neuromodulation technologies presented in the literature or commercially available products cannot support simultaneous recording and stimulation on the same nerve. To solve this problem, a new bidirectional neuromodulation system-on-chip (SoC) is proposed in this paper, which includes a frequency-shaping neural recorder and a fully integrated neural stimulator with charge balancing capability. In addition, auxiliary circuits consisting of power management and data transmission circuits are designed to provide the necessary power supply for the SoC and the bidirectional data communication between the SoC and an external computer via a universal serial bus (USB) interface, respectively. To achieve sufficient low input noise for sensing nerve activity at a sub-10 μ V range, several noise reduction techniques are developed in the neural recorder. The designed SoC was fabricated in a 0.18 μm high-voltage Bipolar CMOS DMOS (BCD) process technology that was described in a previous publication and it has been recently tested in animal experiments that demonstrate the proposed SoC is capable of achieving reliable and simultaneous electrical stimulation and recording on the same nerve.

Original language	English (US)
Article number	538
Journal	Micromachines
Volume	9
Issue number	11
DOIs	https://doi.org/10.3390/mi9110538
State	Published - Oct 23 2018

Bibliographical note

Funding Information:
Funding: This research was funded in part by the DARPA under Grant HR0011-17-2-0060, in part by the NIH under Grant R01-MH111413-01, in part by a startup package provided by the College of Science and Engineering and MnDRIVE Program at the University of Minnesota, in part by the Institute for Engineering in Medicine Fund at the University of Minnesota, and in part by the MnDRIVE Fellowships in Neuromodulation at the University of Minnesota. The APC was funded by the startup package provided by the College of Science and Engineering and MnDRIVE Program at the University of Minnesota.

Publisher Copyright:
© 2018 by the authors.

Keywords

Bidirectional
Closed-loop
Neuromodulation
Precision medicine
Sciatic nerve
System-on-chip
Vagus nerve

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10.3390/mi9110538

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abstract = "Electrical nerve recording and stimulation technologies are critically needed to monitor and modulate nerve activity to treat a variety of neurological diseases. However, current neuromodulation technologies presented in the literature or commercially available products cannot support simultaneous recording and stimulation on the same nerve. To solve this problem, a new bidirectional neuromodulation system-on-chip (SoC) is proposed in this paper, which includes a frequency-shaping neural recorder and a fully integrated neural stimulator with charge balancing capability. In addition, auxiliary circuits consisting of power management and data transmission circuits are designed to provide the necessary power supply for the SoC and the bidirectional data communication between the SoC and an external computer via a universal serial bus (USB) interface, respectively. To achieve sufficient low input noise for sensing nerve activity at a sub-10 μ V range, several noise reduction techniques are developed in the neural recorder. The designed SoC was fabricated in a 0.18 μm high-voltage Bipolar CMOS DMOS (BCD) process technology that was described in a previous publication and it has been recently tested in animal experiments that demonstrate the proposed SoC is capable of achieving reliable and simultaneous electrical stimulation and recording on the same nerve.",

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author = "Jian Xu and Hongsun Guo and Nguyen, {Anh Tuan} and Hubert Lim and Zhi Yang",

note = "Funding Information: Funding: This research was funded in part by the DARPA under Grant HR0011-17-2-0060, in part by the NIH under Grant R01-MH111413-01, in part by a startup package provided by the College of Science and Engineering and MnDRIVE Program at the University of Minnesota, in part by the Institute for Engineering in Medicine Fund at the University of Minnesota, and in part by the MnDRIVE Fellowships in Neuromodulation at the University of Minnesota. The APC was funded by the startup package provided by the College of Science and Engineering and MnDRIVE Program at the University of Minnesota. Publisher Copyright: {\textcopyright} 2018 by the authors.",

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AU - Lim, Hubert

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N1 - Funding Information: Funding: This research was funded in part by the DARPA under Grant HR0011-17-2-0060, in part by the NIH under Grant R01-MH111413-01, in part by a startup package provided by the College of Science and Engineering and MnDRIVE Program at the University of Minnesota, in part by the Institute for Engineering in Medicine Fund at the University of Minnesota, and in part by the MnDRIVE Fellowships in Neuromodulation at the University of Minnesota. The APC was funded by the startup package provided by the College of Science and Engineering and MnDRIVE Program at the University of Minnesota. Publisher Copyright: © 2018 by the authors.

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N2 - Electrical nerve recording and stimulation technologies are critically needed to monitor and modulate nerve activity to treat a variety of neurological diseases. However, current neuromodulation technologies presented in the literature or commercially available products cannot support simultaneous recording and stimulation on the same nerve. To solve this problem, a new bidirectional neuromodulation system-on-chip (SoC) is proposed in this paper, which includes a frequency-shaping neural recorder and a fully integrated neural stimulator with charge balancing capability. In addition, auxiliary circuits consisting of power management and data transmission circuits are designed to provide the necessary power supply for the SoC and the bidirectional data communication between the SoC and an external computer via a universal serial bus (USB) interface, respectively. To achieve sufficient low input noise for sensing nerve activity at a sub-10 μ V range, several noise reduction techniques are developed in the neural recorder. The designed SoC was fabricated in a 0.18 μm high-voltage Bipolar CMOS DMOS (BCD) process technology that was described in a previous publication and it has been recently tested in animal experiments that demonstrate the proposed SoC is capable of achieving reliable and simultaneous electrical stimulation and recording on the same nerve.

AB - Electrical nerve recording and stimulation technologies are critically needed to monitor and modulate nerve activity to treat a variety of neurological diseases. However, current neuromodulation technologies presented in the literature or commercially available products cannot support simultaneous recording and stimulation on the same nerve. To solve this problem, a new bidirectional neuromodulation system-on-chip (SoC) is proposed in this paper, which includes a frequency-shaping neural recorder and a fully integrated neural stimulator with charge balancing capability. In addition, auxiliary circuits consisting of power management and data transmission circuits are designed to provide the necessary power supply for the SoC and the bidirectional data communication between the SoC and an external computer via a universal serial bus (USB) interface, respectively. To achieve sufficient low input noise for sensing nerve activity at a sub-10 μ V range, several noise reduction techniques are developed in the neural recorder. The designed SoC was fabricated in a 0.18 μm high-voltage Bipolar CMOS DMOS (BCD) process technology that was described in a previous publication and it has been recently tested in animal experiments that demonstrate the proposed SoC is capable of achieving reliable and simultaneous electrical stimulation and recording on the same nerve.

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KW - Precision medicine

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A bidirectional neuromodulation technology for nerve recording and stimulation

Abstract

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Keywords

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