A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

Adam E. Mendrela; Jihyun Cho; Jeffrey A. Fredenburg; Vivek Nagaraj; Tay I Netoff; Michael P. Flynn; Euisik Yoon

doi:10.1109/JSSC.2015.2506651

A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

Adam E. Mendrela, Jihyun Cho, Jeffrey A. Fredenburg, Vivek Nagaraj, Tay I Netoff, Michael P. Flynn, Euisik Yoon

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

This work presents a bidirectional neural interface circuit that enables simultaneous recording and stimulation with a stimulation artifact cancellation circuit. The system employs a common average referencing (CAR) front-end circuit to suppress cross-channel environmental noise to further facilitate use in clinical environment. This paper also introduces a new range-adapting (RA) SAR ADC to lower the system power consumption. A prototype is fabricated in 0.18 μm CMOS and characterized and tested in vivo in an epileptic rat model. The prototype attenuates stimulation artifacts by up to 42 dB and suppresses cross-channel noise by up to 39.8 dB. The measured power consumption per channel is 330 nW, while the area per channel is 0.17 mm².

Original language	English (US)
Article number	7370773
Pages (from-to)	955-965
Number of pages	11
Journal	IEEE Journal of Solid-State Circuits
Volume	51
Issue number	4
DOIs	https://doi.org/10.1109/JSSC.2015.2506651
State	Published - Apr 2016

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Publisher Copyright:
© 2015 IEEE.

Keywords

Closed-loop stimulation
SAR ADC
low power
neural recording
noise cancellation

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10.1109/JSSC.2015.2506651

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abstract = "This work presents a bidirectional neural interface circuit that enables simultaneous recording and stimulation with a stimulation artifact cancellation circuit. The system employs a common average referencing (CAR) front-end circuit to suppress cross-channel environmental noise to further facilitate use in clinical environment. This paper also introduces a new range-adapting (RA) SAR ADC to lower the system power consumption. A prototype is fabricated in 0.18 μm CMOS and characterized and tested in vivo in an epileptic rat model. The prototype attenuates stimulation artifacts by up to 42 dB and suppresses cross-channel noise by up to 39.8 dB. The measured power consumption per channel is 330 nW, while the area per channel is 0.17 mm2.",

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AU - Netoff, Tay I

AU - Flynn, Michael P.

AU - Yoon, Euisik

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A Bidirectional Neural Interface Circuit with Active Stimulation Artifact Cancellation and Cross-Channel Common-Mode Noise Suppression

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