This paper presents a 5-300MHz multi-nuclei NMR transceiver designed with spectroscopy for drug discovery in mind. The overall transceiver (transmitter and receiver), is implemented in 130nm CMOS, occupies an active area of 2mm 2 and consumes 12mA from a 1.5V supply. The measured phase noise for the on-chip frequency synthesizer is -110dBc at 10KHz offset when the LO frequency is 212.966MHz (∼1 H Larmor frequency at 5T). The measured input referred noise floor for the overall receiver is 3.5nV/√Hz. The receiver NMR functionality was validated using a variety of chemical samples, including adenosine triphosphaste(ATP), benzene(C6H 6) and ethanol(CH3CH2OH) in a 5T magnet. Full transceiver NMR functionality, including that of of the internal power amplifier, was validated with the help of a 0.3mL H2O sample.