An 8-channel wireless neural signal processing IC, which can perform real-time spike detection, alignment, feature extraction, and wireless data transmission is proposed. A reconfigurable BFSK/QPSK TX at MICS band is incorporated to support different data rate requirement. By using Exponential Component-Polynomial Component (EC-PC) spike processing unit with incremental principal component analysis (IPCA) engine, an overall 625× data reduction is achieved. The EC-PC unit is capable of detecting neural spikes of poor SNR. In TX, dual channels at 401 MHz and 403.8 MHz are supported by applying fixed injection and sequential injection locked techniques while attaining phase noise of -102 dBc/Hz@100 kHz offset. The measured EVM of 4.60%/9.55% with PA output power of -15dBm is achieved for QPSK@8 Mbps and BFSK@12.5 kbps. Fabricated in 65 nm CMOS with an area occupation of 1 mm2, the design consumes a total current of 5~5.6 mA with maximum energy efficiency of 0.7 nJ/b.