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  • David A Largaespada
2020

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Law, E. K., Levin-Klein, R., Jarvis, M. C., Kim, H., Argyris, P. P., Carpenter, M. A., Starrett, G. J., Temiz, N. A., Larson, L. K., Durfee, C., Burns, M. B., Vogel, R. I., Stavrou, S., Aguilera, A. N., Wagner, S., Largaespada, D. A., Starr, T. K., Ross, S. R. & Harris, R. S., Dec 7 2020, In : Journal of Experimental Medicine. 217, 12, e20200261.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Epigenomic, genomic, and transcriptomic landscape of schwannomatosis

Mansouri, S., Suppiah, S., Mamatjan, Y., Paganini, I., Liu, J. C., Karimi, S., Patil, V., Nassiri, F., Singh, O., Sundaravadanam, Y., Rath, P., Sestini, R., Gensini, F., Agnihotri, S., Blakeley, J., Ostrow, K., Largaespada, D., Plotkin, S. R., Stemmer-Rachamimov, A., Ferrer, M. M. & 4 others, Pugh, T. J., Aldape, K. D., Papi, L. & Zadeh, G., 2020, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Open Access
Open Access

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Laoharawee, K., Osum, S. H., Larsson, A. T., Williams, K. B., Stratton, N., Yamamoto, K., Peterson, J. J., Rathe, S. K., Mills, L. J., Hudson, W. A., Crosby, M. R., Wang, M., Rahrmann, E. P., Moriarity, B. S. & Largaespada, D. A., Jul 2020, In : Bone. 136, 115353.

Research output: Contribution to journalArticle

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Bomberger, H. E., Shamsan, G. A., Peterson, J. J., Crosby, M. R., Draper, G. M., Becklin, K. L., Rahrmann, E. P., McCarthy, J. B., Odde, D. J., Wood, D. K., Largaespada, D. A. & Moriarity, B. S., Jan 30 2020, In : Oncogene. 39, 5, p. 1049-1062 14 p.

Research output: Contribution to journalArticle

Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia

Sachs, K., Sarver, A. L., Noble-Orcutt, K. E., LaRue, R. S., Antony, M. L., Chang, D., Lee, Y., Navis, C. M., Hillesheim, A. L., Nykaza, I. R., Ha, N. A., Hansen, C. J., Karadag, F. K., Bergerson, R. J., Verneris, M. R., Meredith, M. M., Schomaker, M. L., Linden, M. A., Myers, C. L., Largaespada, D. A. & 1 others, Sachs, Z., Feb 1 2020, In : Cancer Research. 80, 3, p. 458-470 13 p.

Research output: Contribution to journalArticle

Open Access
2019

A comparison of risk factors for metastasis at diagnosis in humans and dogs with osteosarcoma

Diessner, B. J., Marko, T. A., Scott, R. M., Eckert, A. L., Stuebner, K. M., Hohenhaus, A. E., Selting, K. A., Largaespada, D. A., Modiano, J. & Spector, L. G., Jun 2019, In : Cancer medicine. 8, 6, p. 3216-3226 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

CRISPR/Cas9-Based Positive Screens for Cancer-Related Traits

Slipek, N. J., Varshney, J. & Largaespada, D. A., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 137-144 8 p. (Methods in Molecular Biology; vol. 1907).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis

Huang, M., Tailor, J., Zhen, Q., Gillmor, A. H., Miller, M. L., Weishaupt, H., Chen, J., Zheng, T., Nash, E. K., McHenry, L. K., An, Z., Ye, F., Takashima, Y., Clarke, J., Ayetey, H., Cavalli, F. M. G., Luu, B., Moriarity, B. S., Ilkhanizadeh, S., Chavez, L. & 18 others, Yu, C., Kurian, K. M., Magnaldo, T., Sevenet, N., Koch, P., Pollard, S. M., Dirks, P., Snyder, M. P., Largaespada, D. A., Cho, Y. J., Phillips, J. J., Swartling, F. J., Morrissy, A. S., Kool, M., Pfister, S. M., Taylor, M. D., Smith, A. & Weiss, W. A., Sep 5 2019, In : Cell Stem Cell. 25, 3, p. 433-446.e7

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Evaluating the landscape of gene cooperativity with receptor tyrosine kinases in liver tumorigenesis using transposon-mediated mutagenesis

Fan, Y., Bazai, S. K., Daian, F., Arechederra, M., Richelme, S., Temiz, N. A., Yim, A., Habermann, B. H., Dono, R., Largaespada, D. A. & Maina, F., Mar 2019, In : Journal of Hepatology. 70, 3, p. 470-482 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

HBx-K130M/V131I promotes liver cancer in transgenic mice via AKT/FOXO1 signaling pathway and arachidonic acid metabolism

Chiu, A. P., Tschida, B. R., Sham, T. T., Lo, L. H., Moriarity, B. S., Li, X. X., Lo, R. C., Hinton, D. E., Rowlands, D. K., Chan, C. O., Mok, D. K. W., Largaespada, D. A., Warner, N. & Keng, V. W., Jul 1 2019, In : Molecular Cancer Research. 17, 7, p. 1582-1593 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas

Rathe, S. K., Popescu, F. E., Johnson, J. E., Watson, A. L., Marko, T. A., Moriarity, B. S., Ohlfest, J. R. & Largaespada, D. A., Dec 1 2019, In : Scientific reports. 9, 1, 358.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

R-spondin 2 Drives Liver Tumor Development in a Yes-Associated Protein-Dependent Manner

Conboy, C. B., Vélez-Reyes, G. L., Tschida, B. R., Hu, H., Kaufmann, G., Koes, N., Keller, B., Alsinet, C., Cornellà, H., Pinyol, R., Abrahante, J. E., Temiz, N. A., Linden, M. A., Amin, K., Kuka, T. P., Keng, V. W., Llovet, J. M., Starr, T. K. & Largaespada, D. A., Nov 2019, In : Hepatology Communications. 3, 11, p. 1496-1509 14 p.

Research output: Contribution to journalArticle

Open Access

Sleeping beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors

Beckmann, P. J., Larson, J. D., Larsson, A. T., Ostergaard, J. P., Wagner, S., Rahrmann, E. P., Shamsan, G. A., Otto, G. M., Williams, R. L., Wang, J., Lee, C., Tschida, B. R., Das, P., Dubuc, A. M., Moriarity, B. S., Picard, D., Wu, X., Rodriguez, F. J., Rosemarie, Q., Krebs, R. D. & 13 others, Molan, A. M., Demer, A. M., Frees, M. M., Rizzardi, A. E., Schmechel, S. C., Eberhart, C. G., Jenkins, R. B., Wechsler-Reya, R. J., Odde, D. J., Huang, A., Taylor, M. D., Sarver, A. L. & Largaespada, D. A., Mar 1 2019, In : Cancer Research. 79, 5, p. 905-917 13 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Sleeping beauty screen identifies RREB1 and other genetic drivers in human B-cell lymphoma

Rahrmann, E. P., Wolf, N. K., Otto, G. M., Heltemes-Harris, L., Ramsey, L. B., Shu, J., LaRue, R. S., Linden, M. A., Rathe, S. K., Starr, T. K., Farrar, M. A., Moriarity, B. S. & Largaespada, D. A., Feb 2019, In : Molecular Cancer Research. 17, 2, p. 567-582 16 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation

Li, X. X., Lu, X. Y., Zhang, S. J., Chiu, A. P., Lo, L. H., Largaespada, D. A., Chen, Q. B. & Keng, V. W., Mar 2019, In : Biomedicine and Pharmacotherapy. 111, p. 68-75 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Targeted inhibition of the dual specificity phosphatases DUSP1 and DUSP6 suppress MPNST growth via JNK

Ramkissoon, A., Chaney, K. E., Milewski, D., Williams, K. B., Williams, R. L., Choi, K., Miller, A., Kalin, T. V., Pressey, J. G., Szabo, S., Azam, M., Largaespada, D. A. & Ratner, N., 2019, In : Clinical Cancer Research. 25, 13, p. 4117-4127 11 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Riordan, J. D., Feddersen, C. R., Tschida, B. R., Beckmann, P. J., Keng, V. W., Linden, M. A., Amin, K., Stipp, C. S., Largaespada, D. A. & Dupuy, A. J., Mar 2018, In : Hepatology. 67, 3, p. 924-939 16 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
Open Access
34 Scopus citations

CRISPR/Cas9 library screening for drug target discovery

Kurata, M., Yamamoto, K., Moriarity, B. S., Kitagawa, M. & Largaespada, D. A., Feb 1 2018, In : Journal of Human Genetics. 63, 2, p. 179-186 8 p.

Research output: Contribution to journalReview article

22 Scopus citations

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

Isakson, S. H., Rizzardi, A. E., Coutts, A. W., Carlson, D. F., Kirstein, M. N., Fisher, J., Vitte, J., Williams, K. B., Pluhar, G. E., Dahiya, S., Widemann, B. C., Dombi, E., Rizvi, T., Ratner, N., Messiaen, L., Stemmer-Rachamimov, A. O., Fahrenkrug, S. C., Gutmann, D. H., Giovannini, M., Moertel, C. L. & 2 others, Largaespada, D. A. & Watson, A. L., Dec 1 2018, In : Communications biology. 1, 1, 158.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

NRASG12V-Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

ANTONY, MARIE. LUE., Noble, K. E., Sachs, K., Hillesheim, A. L., Chang, D., Mohei, H., Pamukcuoglu, M., Largaespada, D. A. & Sachs, Z., Nov 29 2018, In : Blood.

Research output: Contribution to journalArticle

Social stress shortens lifespan in mice

Razzoli, M., Nyuyki-Dufe, K., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., Touma, C., Palme, R., Largaespada, D. A., Allison, D. B. & Bartolomucci, A., Aug 2018, In : Aging cell. 17, 4, e12778.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2017

Data Descriptor: Transcriptomic analysis of gene signatures associated with sickle pain

Paul, J. A., Aich, A., Abrahante, J. E., Wang, Y., LaRue, R. S., Rathe, S. K., Kalland, K., Mittal, A., Jha, R., Peng, F., Largaespada, D. A., Bagchi, A. & Gupta, K., May 16 2017, In : Scientific Data. 4, 170051.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors

Carlson, M., Watson, A. L., Anderson, L., Largaespada, D. A. & Provenzano, P. P., Nov 1 2017, In : Journal of biomedical optics. 22, 11, 116010.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Sleeping beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumors

Tschida, B. R., Temiz, N. A., Kuka, T. P., Lee, L. A., Riordan, J. D., Tierrablanca, C. A., Hullsiek, R., Wagner, S., Hudson, W. A., Linden, M. A., Amin, K., Beckmann, P. J., Heuer, R. A., Sarver, A. L., Yang, J. D., Roberts, L. R., Nadeau, J. H., Dupuy, A. J., Keng, V. W. & Largaespada, D. A., Dec 1 2017, In : Cancer Research. 77, 23, p. 6576-6588 13 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Transposons As Tools for Functional Genomics in Vertebrate Models

Kawakami, K., Largaespada, D. A. & Ivics, Z., Nov 2017, In : Trends in Genetics. 33, 11, p. 784-801 18 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations