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  • David A Largaespada
2020

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Law, E. K., Levin-Klein, R., Jarvis, M. C., Kim, H., Argyris, P. P., Carpenter, M. A., Starrett, G. J., Temiz, N. A., Larson, L. K., Durfee, C., Burns, M. B., Vogel, R. I., Stavrou, S., Aguilera, A. N., Wagner, S., Largaespada, D. A., Starr, T. K., Ross, S. R. & Harris, R. S., Dec 7 2020, In : Journal of Experimental Medicine. 217, 12, e20200261.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Epigenomic, genomic, and transcriptomic landscape of schwannomatosis

Mansouri, S., Suppiah, S., Mamatjan, Y., Paganini, I., Liu, J. C., Karimi, S., Patil, V., Nassiri, F., Singh, O., Sundaravadanam, Y., Rath, P., Sestini, R., Gensini, F., Agnihotri, S., Blakeley, J., Ostrow, K., Largaespada, D., Plotkin, S. R., Stemmer-Rachamimov, A., Ferrer, M. M. & 4 others, Pugh, T. J., Aldape, K. D., Papi, L. & Zadeh, G., 2020, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Open Access
Open Access

PLX3397 treatment inhibits constitutive CSF1R-induced oncogenic ERK signaling, reduces tumor growth, and metastatic burden in osteosarcoma

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Laoharawee, K., Osum, S. H., Larsson, A. T., Williams, K. B., Stratton, N., Yamamoto, K., Peterson, J. J., Rathe, S. K., Mills, L. J., Hudson, W. A., Crosby, M. R., Wang, M., Rahrmann, E. P., Moriarity, B. S. & Largaespada, D. A., Jul 2020, In : Bone. 136, 115353.

Research output: Contribution to journalArticle

SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis

Smeester, B. A., Slipek, N. J., Pomeroy, E. J., Bomberger, H. E., Shamsan, G. A., Peterson, J. J., Crosby, M. R., Draper, G. M., Becklin, K. L., Rahrmann, E. P., McCarthy, J. B., Odde, D. J., Wood, D. K., Largaespada, D. A. & Moriarity, B. S., Jan 30 2020, In : Oncogene. 39, 5, p. 1049-1062 14 p.

Research output: Contribution to journalArticle

Single-cell gene expression analyses reveal distinct self-renewing and proliferating subsets in the leukemia stem cell compartment in acute myeloid leukemia

Sachs, K., Sarver, A. L., Noble-Orcutt, K. E., LaRue, R. S., Antony, M. L., Chang, D., Lee, Y., Navis, C. M., Hillesheim, A. L., Nykaza, I. R., Ha, N. A., Hansen, C. J., Karadag, F. K., Bergerson, R. J., Verneris, M. R., Meredith, M. M., Schomaker, M. L., Linden, M. A., Myers, C. L., Largaespada, D. A. & 1 others, Sachs, Z., Feb 1 2020, In : Cancer Research. 80, 3, p. 458-470 13 p.

Research output: Contribution to journalArticle

Open Access
2018

Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice

Riordan, J. D., Feddersen, C. R., Tschida, B. R., Beckmann, P. J., Keng, V. W., Linden, M. A., Amin, K., Stipp, C. S., Largaespada, D. A. & Dupuy, A. J., Mar 2018, In : Hepatology. 67, 3, p. 924-939 16 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
Open Access
34 Scopus citations

CRISPR/Cas9 library screening for drug target discovery

Kurata, M., Yamamoto, K., Moriarity, B. S., Kitagawa, M. & Largaespada, D. A., Feb 1 2018, In : Journal of Human Genetics. 63, 2, p. 179-186 8 p.

Research output: Contribution to journalReview article

22 Scopus citations

Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1

Isakson, S. H., Rizzardi, A. E., Coutts, A. W., Carlson, D. F., Kirstein, M. N., Fisher, J., Vitte, J., Williams, K. B., Pluhar, G. E., Dahiya, S., Widemann, B. C., Dombi, E., Rizvi, T., Ratner, N., Messiaen, L., Stemmer-Rachamimov, A. O., Fahrenkrug, S. C., Gutmann, D. H., Giovannini, M., Moertel, C. L. & 2 others, Largaespada, D. A. & Watson, A. L., Dec 1 2018, In : Communications biology. 1, 1, 158.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

NRASG12V-Mediated Self-Renewal Signaling in Self-Renewing AML Stem Cells.

ANTONY, MARIE. LUE., Noble, K. E., Sachs, K., Hillesheim, A. L., Chang, D., Mohei, H., Pamukcuoglu, M., Largaespada, D. A. & Sachs, Z., Nov 29 2018, In : Blood.

Research output: Contribution to journalArticle

Social stress shortens lifespan in mice

Razzoli, M., Nyuyki-Dufe, K., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., Touma, C., Palme, R., Largaespada, D. A., Allison, D. B. & Bartolomucci, A., Aug 2018, In : Aging cell. 17, 4, e12778.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2017

Data Descriptor: Transcriptomic analysis of gene signatures associated with sickle pain

Paul, J. A., Aich, A., Abrahante, J. E., Wang, Y., LaRue, R. S., Rathe, S. K., Kalland, K., Mittal, A., Jha, R., Peng, F., Largaespada, D. A., Bagchi, A. & Gupta, K., May 16 2017, In : Scientific Data. 4, 170051.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Multiphoton fluorescence lifetime imaging of chemotherapy distribution in solid tumors

Carlson, M., Watson, A. L., Anderson, L., Largaespada, D. A. & Provenzano, P. P., Nov 1 2017, In : Journal of biomedical optics. 22, 11, 116010.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Pomeroy, E. J., Lee, L. A., Lee, R. D. W., Schirm, D. K., Temiz, N. A., Ma, J., Gruber, T. A., Diaz-Flores, E., Moriarity, B. S., Downing, J. R., Shannon, K. M., Largaespada, D. A. & Eckfeldt, C. E., Jun 8 2017, In : Oncogene. 36, 23, p. 3263-3273 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Sleeping beauty insertional mutagenesis in mice identifies drivers of steatosis-associated hepatic tumors

Tschida, B. R., Temiz, N. A., Kuka, T. P., Lee, L. A., Riordan, J. D., Tierrablanca, C. A., Hullsiek, R., Wagner, S., Hudson, W. A., Linden, M. A., Amin, K., Beckmann, P. J., Heuer, R. A., Sarver, A. L., Yang, J. D., Roberts, L. R., Nadeau, J. H., Dupuy, A. J., Keng, V. W. & Largaespada, D. A., Dec 1 2017, In : Cancer Research. 77, 23, p. 6576-6588 13 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Transposons As Tools for Functional Genomics in Vertebrate Models

Kawakami, K., Largaespada, D. A. & Ivics, Z., Nov 2017, In : Trends in Genetics. 33, 11, p. 784-801 18 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations
2016

An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

Patel, A. V., Chaney, K. E., Choi, K., Largaespada, D. A., Kumar, A. R. & Ratner, N., Jan 1 2016, In : EBioMedicine. 9, p. 110-119 10 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
Open Access

CFTR is a tumor suppressor gene in murine and human intestinal cancer

Than, B. L. N., Linnekamp, J. F., Starr, T., Largaespada, D. A., Rod, A., Zhang, Y., Bruner, V., Abrahante - Llorens, J. E., Schumann, A., Luczak, T., Niemczyk, A., O'Sullivan, G., Medema, J. P., Fijneman, R. J. A., Meijer, G. A., Van Den Broek, E., Hodges, C. A., Scott, P. M., Vermeulen, L. & Cormier, R. T., Aug 11 2016, In : Oncogene. 35, 32, p. 4191-4199 9 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

CK2 blockade causes MPNST cell apoptosis and promotes degradation of β-catenin

Kendall, J. J., Chaney, K. E., Patel, A. V., Rizvi, T. A., Largaespada, D. A. & Ratner, N., Aug 1 2016, In : Oncotarget. 7, 33, p. 53191-53203 13 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Divergent clonal selection dominates medulloblastoma at recurrence

Morrissy, A. S., Garzia, L., Shih, D. J. H., Zuyderduyn, S., Huang, X., Skowron, P., Remke, M., Cavalli, F. M. G., Ramaswamy, V., Lindsay, P. E., Jelveh, S., Donovan, L. K., Wang, X., Luu, B., Zayne, K., Li, Y., Mayoh, C., Thiessen, N., Mercier, E., Mungall, K. L. & 118 others, Ma, Y., Tse, K., Zeng, T., Shumansky, K., Roth, A. J. L., Shah, S., Farooq, H., Kijima, N., Holgado, B. L., Lee, J. J. Y., Matan-Lithwick, S., Liu, J., Mack, S. C., Manno, A., Michealraj, K. A., Nor, C., Peacock, J., Qin, L., Reimand, J., Rolider, A., Thompson, Y. Y., Wu, X., Pugh, T., Ally, A., Bilenky, M., Butterfield, Y. S. N., Carlsen, R., Cheng, Y., Chuah, E., Corbett, R. D., Dhalla, N., He, A., Lee, D., Li, H. I., Long, W., Mayo, M., Plettner, P., Qian, J. Q., Schein, J. E., Tam, A., Wong, T., Birol, I., Zhao, Y., Faria, C. C., Pimentel, J., Nunes, S., Shalaby, T., Grotzer, M., Pollack, I. F., Hamilton, R. L., Li, X. N., Bendel, A. E., Fults, D. W., Walter, A. W., Kumabe, T., Tominaga, T., Collins, V. P., Cho, Y. J., Hoffman, C., Lyden, D., Wisoff, J. H., Garvin, J. H., Stearns, D. S., Massimi, L., Schüller, U., Sterba, J., Zitterbart, K., Puget, S., Ayrault, O., Dunn, S. E., Tirapelli, D. P. C., Carlotti, C. G., Wheeler, H., Hallahan, A. R., Ingram, W., MacDonald, T. J., Olson, J. J., Van Meir, E. G., Lee, J. Y., Wang, K. C., Kim, S. K., Cho, B. K., Pietsch, T., Fleischhack, G., Tippelt, S., Ra, Y. S., Bailey, S., Lindsey, J. C., Clifford, S. C., Eberhart, C. G., Cooper, M. K., Packer, R. J., Massimino, M., Garre, M. L., Bartels, U., Tabori, U., Hawkins, C. E., Dirks, P., Bouffet, E., Rutka, J. T., Wechsler-Reya, R. J., Weiss, W. A., Collier, L. S., Dupuy, A. J., Korshunov, A., Jones, D. T. W., Kool, M., Northcott, P. A., Pfister, S. M., Largaespada, D. A., Mungall, A. J., Moore, R. A., Jabado, N., Bader, G. D., Jones, S. J. M., Malkin, D., Marra, M. A. & Taylor, M. D., Jan 21 2016, In : Nature. 529, 7586, p. 351-357 7 p.

Research output: Contribution to journalArticle

Open Access
150 Scopus citations

Engineered swine models of cancer

Watson, A. L., Carlson, D. F., Largaespada, D. A., Hackett, P. B. & Fahrenkrug, S. C., May 9 2016, In : Frontiers in Genetics. 7, MAY, 78.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

Imprinting defects at human 14q32 locus alters gene expression and is associated with the pathobiology of osteosarcoma

Shu, J., Li, L., Sarver, A. E., Pope, E. A., Varshney, J., Thayanithy, V., Spector, L., Largaespada, D. A., Steer, C. J. & Subramanian, S., Apr 19 2016, In : Oncotarget. 7, 16, p. 21298-21314 17 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation

Wu, J., Keng, V. W., Patmore, D. M., Kendall, J. J., Patel, A. V., Jousma, E., Jessen, W. J., Choi, K., Tschida, B. R., Silverstein, K. A. T., Fan, D., Schwartz, E. B., Fuchs, J. R., Zou, Y., Kim, M. O., Dombi, E., Levy, D. E., Huang, G., Cancelas, J. A., Stemmer-Rachamimov, A. O. & 3 others, Spinner, R. J., Largaespada, D. A. & Ratner, N., Mar 1 2016, In : Cell reports. 14, 8, p. 1979-1990 12 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

Yun, Y. S., Kim, K. H., Tschida, B., Sachs, Z., Noble-Orcutt, K. E., Moriarity, B. S., Ai, T., Ding, R., Williams, J., Chen, L., Largaespada, D. & Kim, D. H., Feb 18 2016, In : Molecular Cell. 61, 4, p. 625-639 15 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Phase i trials using sleeping beauty to generate CD19-specific CAR T cells

Kebriaei, P., Singh, H., Huls, M. H., Figliola, M. J., Bassett, R., Olivares, S., Jena, B., Dawson, M. J., Kumaresan, P. R., Su, S., Maiti, S., Dai, J., Moriarity, B., Forget, M. A., Senyukov, V., Orozco, A., Liu, T., McCarty, J., Jackson, R. N., Moyes, J. S. & 19 others, Rondon, G., Qazilbash, M., Ciurea, S., Alousi, A., Nieto, Y., Rezvani, K., Marin, D., Popat, U., Hosing, C., Shpall, E. J., Kantarjian, H., Keating, M., Wierda, W., Do, K. A., Largaespada, D. A., Lee, D. A., Hackett, P. B., Champlin, R. E. & Cooper, L. J. N., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3363-3376 14 p.

Research output: Contribution to journalArticle

Open Access
202 Scopus citations

RALB provides critical survival signals downstream of Ras in acute myeloid leukemia

Eckfeldt, C. E., Pomeroy, E. J., Lee, R. D. W., Hazen, K. S., Lee, L. A., Moriarity, B. S. & Largaespada, D. A., Jan 1 2016, In : Oncotarget. 7, 40, p. 65147-65156 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the wnt pathway, as potential targets in del(5q) myeloid neoplasms

Stoddart, A., Qian, Z., Fernald, A. A., Bergerson, R. J., Wang, J., Karrison, T., Anastasi, J., Bartom, E. T., Sarver, A. L., McNerney, M. E., Largaespada, D. A. & Le Beau, M. M., May 31 2016, In : Haematologica. 101, 6, p. e232-e236

Research output: Contribution to journalLetter

Open Access
8 Scopus citations

RNA sequencing of Sleeping Beauty transposon-induced tumors detects transposon-RNA fusions in forward genetic cancer screens

Temiz, N. A., Moriarity, B. S., Wolf, N. K., Riordan, J. D., Dupuy, A. J., Largaespada, D. A. & Sarver, A. L., Jan 2016, In : Genome research. 26, 1, p. 119-129 11 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Sleeping Beauty transposon screen identifies signaling modules that cooperate with STAT5 activation to induce B-cell acute lymphoblastic leukemia

Heltemes-Harris, L. M., Larson, J. D., Starr, T. K., Hubbard, G. K., Sarver, A. L., Largaespada, D. A. & Farrar, M. A., Jun 30 2016, In : Oncogene. 35, 26, p. 3454-3464 11 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Slit-Robo GTPase-Activating Protein 2 as a metastasis suppressor in osteosarcoma

Marko, T. A., Shamsan, G. A., Edwards, E. N., Hazelton, P. E., Rathe, S., Cornax, I., Overn, P. R., Varshney, J., Diessner, B. J., Moriarity, B. S., O'Sullivan, G., Odde, D. J. & Largaespada, D. A., Dec 14 2016, In : Scientific reports. 6, 39059.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency

Sachs, Z., Been, R. A., Decoursin, K. J., Nguyen, H. T., Mohd Hassan, N. A., Noble-Orcutt, K. E., Eckfeldt, C. E., Pomeroy, E. J., Diaz-Flores, E., Geurts, J. L., Diers, M. D., Hasz, D. E., Morgan, K. J., Macmillan, M. L., Shannon, K. M., Largaespada, D. A. & Wiesner, S. M., Sep 30 2016, In : Haematologica. 101, 10, p. 1190-1199 10 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Understanding the osteosarcoma pathobiology: A comparative oncology approach

Varshney, J., Scott, M. C., Largaespada, D. A. & Subramanian, S., Mar 1 2016, In : Veterinary Sciences. 3, 1, 3.

Research output: Contribution to journalReview article

Open Access
16 Scopus citations

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML

Kurata, M., Rathe, S. K., Bailey, N. J., Aumann, N. K., Jones, J. M., Veldhuijzen, G. W., Moriarity, B. S. & Largaespada, D. A., Nov 3 2016, In : Scientific reports. 6, 36199.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations