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  • Clark C Chen
2018

Glioblastoma stem cell-derived exosomes induce M2 macrophages and PD-L1 expression on human monocytes

Gabrusiewicz, K., Li, X., Wei, J., Hashimoto, Y., Marisetty, A. L., Ott, M., Wang, F., Hawke, D., Yu, J., Healy, L. M., Hossain, A., Akers, J. C., Maiti, S. N., Yamashita, S., Shimizu, Y., Dunner, K., Zal, M. A., Burks, J. K., Gumin, J., Nwajei, F. & 15 others, Rezavanian, A., Zhou, S., Rao, G., Sawaya, R., Fuller, G. N., Huse, J. T., Antel, J. P., Li, S., Cooper, L., Sulman, E. P., Chen, C., Geula, C., Kalluri, R., Zal, T. & Heimberger, A. B., Apr 3 2018, In : OncoImmunology. 7, 4, e1412909.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

Ricklefs, F. L., Alayo, Q., Krenzlin, H., Mahmoud, A. B., Speranza, M. C., Nakashima, H., Hayes, J. L., Lee, K., Balaj, L., Passaro, C., Rooj, A. K., Krasemann, S., Carter, B. S., Chen, C. C., Steed, T., Treiber, J., Rodig, S., Yang, K., Nakano, I., Lee, H. & 9 others, Weissleder, R., Breakefield, X. O., Godlewski, J., Westphal, M., Lamszus, K., Freeman, G. J., Bronisz, A., Lawler, S. E. & Chiocca, E. A., Mar 7 2018, In : Science Advances. 4, 3, eaar2766.

Research output: Contribution to journalArticle

Open Access
97 Scopus citations

Impact of neurosurgeon specialization on patient outcomes for intracranial and spinal surgery: A retrospective analysis of the Nationwide Inpatient Sample 1998-2009

McCutcheon, B. A., Hirshman, B. R., Gabel, B. C., Heffner, M. W., Marcus, L. P., Cole, T. S., Chen, C. C., Chang, D. C. & Carter, B. S., May 2018, In : Journal of neurosurgery. 128, 5, p. 1578-1588 11 p.

Research output: Contribution to journalReview article

4 Scopus citations

In Reply to “Comments on Results of Carroll et al's Study on Survival Benefits of Gross Total Resection”

Carroll, K. T. & Chen, C. C., Aug 2018, In : World Neurosurgery. 116, p. 479-480 2 p.

Research output: Contribution to journalComment/debate

Interaction Between the Contributions of Tumor Location, Tumor Grade, and Patient Age to the Survival Benefit Associated with Gross Total Resection

Carroll, K. T., Bryant, A. K., Hirshman, B., Alattar, A. A., Joshi, R., Gabel, B., Carter, B. S., Harismendy, O., Vaida, F. & Chen, C. C., Mar 2018, In : World neurosurgery. 111, p. e790-e798

Research output: Contribution to journalArticle

7 Scopus citations

Intraoperative Magnetic Resonance Imaging–Guided Biopsy in the Diagnosis of Suprasellar Langerhans Cell Histiocytosis

Carroll, K. T., Lochte, B. C., Chen, J. Y., Snyder, V. S., Carter, B. S. & Chen, C. C., Apr 2018, In : World neurosurgery. 112, p. 6-13 8 p.

Research output: Contribution to journalArticle

Management of Through-and-Through Penetrating Skull Injury: A Railroad Spike That Transgressed the Anterior Skull Base

Hoshide, R., Steinberg, J., Wali, A., Ko, A., Pannell, J. S. & Chen, C. C., Feb 2018, In : World neurosurgery. 110, p. 65-70 6 p.

Research output: Contribution to journalArticle

Mapping of genomic EGFRvIII deletions in glioblastoma: Insight into rearrangement mechanisms and biomarker development

Koga, T., Li, B., Figueroa, J. M., Ren, B., Chen, C. C., Carter, B. S. & Furnari, F. B., 2018, In : Neuro-Oncology. 20, 10, p. 1310-1320 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Molecular determinant of clinical response to ONC201, an inhibitor of dopamine receptor 2 (DRD2) signaling, in glioblastoma patient.

Li, J., Ma, J., He, Y., Prabhu, V. V., Allen, J. & Chen, C. C., 2018.

Research output: Contribution to conferencePoster

Molecular physiology of contrast enhancement in glioblastomas: An analysis of The Cancer Imaging Archive (TCIA)

Treiber, J. M., Steed, T. C., Brandel, M. G., Patel, K. S., Dale, A. M., Carter, B. S. & Chen, C. C., Sep 2018, In : Journal of Clinical Neuroscience. 55, p. 86-92 7 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Neurosurgical and neurologic emergencies for surgeons

Kasper, E. M., Laviv, Y., Chen, C. C. & Kasper, B. S., Jan 1 2018, Fischer's Mastery of Surgery, Seventh Edition. Wolters Kluwer Health Adis (ESP), Vol. 1. p. 474-488 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Oligodendroglioma resection: A Surveillance, Epidemiology, and End Results (SEER) analysis

Alattar, A. A., Brandel, M. G., Hirshman, B. R., Dong, X., Carroll, K. T., Ali, M. A., Carter, B. S. & Chen, C. C., Apr 2018, In : Journal of neurosurgery. 128, 4, p. 1076-1083 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Patterns of Clinical Use of Stereotactic Laser Ablation: Analysis of a Multicenter Prospective Registry

Rennert, R. C., Khan, U., Tatter, S. B., Field, M., Toyota, B., Fecci, P. E., Judy, K., Mohammadi, A. M., Landazuri, P., Sloan, A., Leuthardt, E. & Chen, C. C., Aug 2018, In : World neurosurgery. 116, p. e566-e570

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Post-operative imaging assessment of non-functioning pituitary adenomas

Patel, K. S., Dhawan, S., Wang, R., Carter, B. S., Chen, J. Y. & Chen, C. C., May 1 2018, In : Acta Neurochirurgica. 160, 5, p. 1029-1039 11 p.

Research output: Contribution to journalReview article

Quantification of glioblastoma mass effect by lateral ventricle displacement

Steed, T. C., Treiber, J. M., Brandel, M. G., Patel, K. S., Dale, A. M., Carter, B. S. & Chen, C. C., Dec 1 2018, In : Scientific reports. 8, 1, 2827.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Racial disparity in the surgical management of skull base chondrosarcomas: A Surveillance, Epidemiology, and End Results (SEER) analysis.

Dhawan, S., Bartek Jr., J., Ma, J., Alattar, A. A. & Chen, C. C., 2018.

Research output: Contribution to conferencePoster

Risk factors for readmission with cerebrospinal fluid leakage within 30 days of vestibular schwannoma surgery

Alattar, A. A., Hirshman, B. R., McCutcheon, B. A., Chen, C. C., Alexander, T., Harris, J. & Carter, B. S., May 1 2018, In : Neurosurgery. 82, 5, p. 630-637 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Superior prognostic value of cumulative intracranial tumor volume relative to largest intracranial tumor volume for stereotactic radiosurgery-treated brain metastasis patients

Hirshman, B. R., Wilson, B., Ali, M. A., Proudfoot, J. A., Koiso, T., Nagano, O., Carter, B. S., Serizawa, T., Yamamot, M. & Chen, C. C., Apr 1 2018, In : Clinical neurosurgery. 82, 4, p. 473-480 8 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Survival patterns of oligoastrocytoma patients: A surveillance, epidemiology and end results (SEER) based analysis

Lanman, T. A., Compton, J. N., Carroll, K. T., Hirshman, B. R., Ali, M. A., Lochte, B., Carter, B. & Chen, C. C., Mar 2018, In : Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. 11, p. 70-75 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

The Utility of Routine Intensive Care Admission for Patients Undergoing Intracranial Neurosurgical Procedures: A Systematic Review

de Almeida, C. C., Boone, M. D., Laviv, Y., Kasper, B. S., Chen, C. C. & Kasper, E. M., Feb 1 2018, In : Neurocritical Care. 28, 1, p. 35-42 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Tumor-related epilepsy: epidemiology, pathogenesis and management

Chen, D. Y., Chen, C. C., Crawford, J. R. & Wang, S. G., Aug 1 2018, In : Journal of neuro-oncology. 139, 1, p. 13-21 9 p.

Research output: Contribution to journalReview article

6 Scopus citations
2017

Association between tumor architecture derived from generalized Q-space MRI and survival in glioblastoma

Taylor, E. N., Ding, Y., Zhu, S., Cheah, E., Alexander, P., Lin, L., Aninwene, G. E., Hoffman, M. P., Mahajan, A., Mohamed, A. S. R., McDannold, N., Fuller, C. D., Chen, C. C. & Gilbert, R. J., 2017, In : Oncotarget. 8, 26, p. 41815-41826 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Clinical efficacy and safety of surface imaging guided radiosurgery (SIG-RS) in the treatment of benign skull base tumors

Lau, S. K. M., Patel, K., Kim, T., Knipprath, E., Kim, G. Y., Cerviño, L. I., Lawson, J. D., Murphy, K. T., Sanghvi, P., Carter, B. S. & Chen, C. C., Apr 1 2017, In : Journal of neuro-oncology. 132, 2, p. 307-312 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Coding and noncoding landscape of extracellular RNA released by human glioma stem cells

Wei, Z., Batagov, A. O., Schinelli, S., Wang, J., Wang, Y., El Fatimy, R., Rabinovsky, R., Balaj, L., Chen, C. C., Hochberg, F., Carter, B., Breakefield, X. O. & Krichevsky, A. M., Dec 1 2017, In : Nature communications. 8, 1, 1145.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

Concurrence of chromosome 6 chromothripsis and glioblastoma metastasis

Rennert, R. C., Hoshide, R. R., Signorelli, J. W., Amaro, D., Sack, J. A., Brennan, C. W. & Chen, C. C., May 2017, In : Journal of neurosurgery. 126, 5, p. 1472-1478 7 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Depression After Spinal Surgery: A Comparative Analysis of the California Outcomes Database

Wilson, B. R., Tringale, K. R., Hirshman, B. R., Zhou, T., Umlauf, A., Taylor, W. R., Ciacci, J. D., Carter, B. S. & Chen, C. C., Jan 1 2017, In : Mayo Clinic Proceedings. 92, 1, p. 88-97 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Detection of wild-Type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

Figueroa, J. M., Skog, J., Akers, J., Li, H., Komotar, R., Jensen, R., Ringel, F., Yang, I., Kalkanis, S., Thompson, R., Loguidice, L., Berghoff, E., Parsa, A., Liau, L., Curry, W., Cahill, D., Bettegowda, C., Lang, F. F., Chiocca, E. A., Henson, J. & 6 others, Kim, R., Breakefield, X., Chen, C., Messer, K., Hochberg, F. & Carter, B. S., Nov 1 2017, In : Neuro-Oncology. 19, 11, p. 1494-1502 9 p.

Research output: Contribution to journalArticle

Open Access
55 Scopus citations

Effect of Gross Total Resection in World Health Organization Grade II Astrocytomas: SEER-Based Survival Analysis

Schupper, A. J., Hirshman, B. R., Carroll, K. T., Ali, M. A., Carter, B. S. & Chen, C. C., Jul 2017, In : World neurosurgery. 103, p. 741-747 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity

Zanca, C., Villa, G. R., Benitez, J. A., Thorne, A. H., Koga, T., D’Antonio, M., Ikegami, S., Ma, J., Boyer, A. D., Banisadr, A., Jameson, N. M., Parisian, A. D., Eliseeva, O. V., Barnabe, G. F., Liu, F., Wu, S., Yang, H., Wykosky, J., Frazer, K. A., Verkhusha, V. V. & 8 others, Isaguliants, M. G., Weiss, W. A., Gahman, T. C., Shiau, A. K., Chen, C. C., Mischel, P. S., Cavenee, W. K. & Furnari, F. B., Jun 15 2017, In : Genes and Development. 31, 12, p. 1212-1227 16 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

ICP management in patients suffering from traumatic brain injury: a systematic review of randomized controlled trials

Abraham, P., Rennert, R. C., Gabel, B. C., Sack, J. A., Karanjia, N., Warnke, P. & Chen, C. C., Dec 1 2017, In : Acta Neurochirurgica. 159, 12, p. 2279-2287 9 p.

Research output: Contribution to journalReview article

4 Scopus citations
Open Access
6 Scopus citations

Improving the Prognostic Value of Disease-Specific Graded Prognostic Assessment Model for Renal Cell Carcinoma by Incorporation of Cumulative Intracranial Tumor Volume

Ali, M. A., Hirshman, B. R., Wilson, B., Schupper, A. J., Joshi, R., Proudfoot, J. A., Goetsch, S. J., Alksne, J. F., Ott, K., Aiyama, H., Nagano, O., Carter, B. S., Chiang, V., Serizawa, T., Yamamoto, M. & Chen, C. C., Dec 2017, In : World neurosurgery. 108, p. 151-156 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis

Carroll, K. T., Hirshman, B., Ali, M. A., Alattar, A. A., Brandel, M. G., Lochte, B., Lanman, T., Carter, B. & Chen, C. C., Jul 1 2017, In : World neurosurgery. 103, p. 186-193 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Prophylactic anticonvulsants in patients with primary glioblastoma

Wali, A. R., Rennert, R. C., Wang, S. G. & Chen, C. C., Nov 1 2017, In : Journal of neuro-oncology. 135, 2, p. 229-235 7 p.

Research output: Contribution to journalReview article

3 Scopus citations

Rapid Isolation and Detection of Exosomes and Associated Biomarkers from Plasma

Ibsen, S. D., Wright, J., Lewis, J. M., Kim, S., Ko, S. Y., Ong, J., Manouchehri, S., Vyas, A., Akers, J., Chen, C. C., Carter, B. S., Esener, S. C. & Heller, M. J., Jul 25 2017, In : ACS nano. 11, 7, p. 6641-6651 11 p.

Research output: Contribution to journalArticle

87 Scopus citations

Real-time magnetic resonance imaging-guided biopsy using smartframe® stereotaxis in the setting of a conventional diagnostic magnetic resonance imaging suite

Scheer, J. K., Hamelin, T., Chang, L., Lemkuil, B., Carter, B. S. & Chen, C. C., Jun 1 2017, In : Operative Neurosurgery. 13, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Role of Biopsies in the Management of Intracranial Gliomas

Patel, K. S., Carter, B. S. & Chen, C. C., 2017, In : Progress in Neurological Surgery. 30, p. 232-243 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Survival Patterns of 5750 Stereotactic Radiosurgery–Treated Patients with Brain Metastasis as a Function of the Number of Lesions

Ali, M. A., Hirshman, B. R., Wilson, B., Carroll, K. T., Proudfoot, J. A., Goetsch, S. J., Alksne, J. F., Ott, K., Aiyama, H., Nagano, O., Carter, B. S., Fogarty, G., Hong, A., Serizawa, T., Yamamoto, M. & Chen, C. C., Nov 2017, In : World neurosurgery. 107, p. 944-951.e1

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Survival trends of oligodendroglial tumor patients and associated clinical practice patterns: a SEER-based analysis

Brandel, M. G., Alattar, A. A., Hirshman, B. R., Dong, X., Carroll, K. T., Ali, M. A., Carter, B. S. & Chen, C. C., May 1 2017, In : Journal of Neuro-Oncology. 133, 1, p. 173-181 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

The Association between Psychiatric Comorbidities and Outcomes for Inpatients with Traumatic Brain Injury

Brandel, M. G., Hirshman, B. R., McCutcheon, B. A., Tringale, K., Carroll, K., Richtand, N. M., Perry, W., Chen, C. C. & Carter, B. S., Mar 1 2017, In : Journal of neurotrauma. 34, 5, p. 1005-1016 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

The use of TMZ embedded hydrogels for the treatment of orthotopic human glioma xenografts

Adhikari, B., Li, J., Brandel, M. G., Futalan, D., Akers, J., Deming, T., Chen, C. C. & Carter, B. S., Nov 2017, In : Journal of Clinical Neuroscience. 45, p. 288-292 5 p.

Research output: Contribution to journalArticle

Vertebroplasty for vertebral compression fractures: Placebo or effective?

Wali, A., Martin, J., Rennert, R., Resnick, D., Taylor, W., Warnke, P. & Chen, C., 2017, In : Surgical Neurology International. 8, 1

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2016

334 A Functional Screen Identifies miRNAs that Induce Radioresistance in Glioblastomas

Chen, C. C., Moskwa, P., Zinn, P. O., Hirshman, B. R., Choi, Y. E., Shukla, S. A., Fendler, W., Lu, J., Golub, T. R., Hjelmeland, A. & Chowdhury, D., Aug 1 2016, In : Neurosurgery. 63, p. 197-198 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

339 Comparative Prognostic Value of the Cumulative Intracranial Tumor Volume and Score Index for Radiosurgery in Brain Metastasis

Hirshman, B. R., Wilson, B., James, P. A., Koiso, T., Nagano, O., Carter, B. S., Serizawa, T., Yamamoto, M. & Chen, C. C., Aug 1 2016, In : Neurosurgery. 63, 1 p.

Research output: Contribution to journalArticle

A pilot study of physician personal preferences for treatment of glioblastoma

Chen, C. C., Depp, C., Wilson, B., Bartek, J. & Carter, B., Oct 1 2016, In : Acta Neurochirurgica. 158, 10, 1 p.

Research output: Contribution to journalLetter

Open Access

Applications of Stereotactic Radiosurgery in Neuro-Oncology

Patel, K. S., Chapman, P. H., Bussiere, M., Loeffler, J. S. & Chen, C. C., Apr 12 2016, Handbook of Neuro-Oncology Neuroimaging: Second Edition. Elsevier Inc., p. 257-271 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

B7-H4(B7x)-mediated cross-talk between glioma-initiating cells and macrophages via the IL6/JAK/STAT3 pathway lead to poor prognosis in glioma patients

Yao, Y., Ye, H., Qi, Z., Mo, L., Yue, Q., Baral, A., Hoon, D. S. B., Vera, J. C., Heiss, J. D., Chen, C. C., Hua, W., Zhang, J., Jin, K., Wang, Y., Mao, Y., Zang, X. & Zhou, L., Jun 1 2016, In : Clinical Cancer Research. 22, 11, p. 2778-2790 13 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations

Characterization and correction of geometric distortions in 814 Diffusion Weighted Images

Treiber, J. M., White, N. S., Steed, T. C., Bartsch, H., Holland, D., Farid, N., McDonald, C. R., Carter, B. S., Dale, A. M. & Chen, C. C., Mar 2016, In : PloS one. 11, 3, e0152472.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Coevolution of Peer-Reviewed Literature and Clinical Practice in High-Grade Glioma Resection

Hirshman, B. R., Jones, L. A., Carroll, K. T., Tang, J. A., Proudfoot, J. A., Carley, K. M., Carter, B. S. & Chen, C. C., Dec 1 2016, In : World neurosurgery. 96, p. 237-241 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Comparative analysis of technologies for quantifying extracellular vesicles (EVs) in clinical cerebrospinal fluids (CSF)

Akers, J. C., Ramakrishnan, V., Nolan, J. P., Duggan, E., Fu, C. C., Hochberg, F. H., Chen, C. C. & Carter, B. S., Feb 2016, In : PloS one. 11, 2, e0149866.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations