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  • Clark C Chen
2020

Author Correction: Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells (Nature Communications, (2020), 11, 1, (550), 10.1038/s41467-020-14312-1)

Koga, T., Chaim, I. A., Benitez, J. A., Markmiller, S., Parisian, A. D., Hevner, R. F., Turner, K. M., Hessenauer, F. M., D’Antonio, M., Nguyen, N. P. D., Saberi, S., Ma, J., Miki, S., Boyer, A. D., Ravits, J., Frazer, K. A., Bafna, V., Chen, C. C., Mischel, P. S., Yeo, G. W. & 1 others, Furnari, F. B., Dec 1 2020, In : Nature communications. 11, 1, 1958.

Research output: Contribution to journalComment/debate

Open Access

Cost-effectiveness of stereotactic laser ablation (SLA) for brain tumors

Dhawan, S., Bartek, J. & Chen, C. C., Jul 15 2020, In : International Journal of Hyperthermia. 37, 2, p. 61-67 7 p.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

Early versus delayed postoperative radiotherapy for treatment of low-grade gliomas

Dhawan, S., Patil, C. G., Chen, C. & Venteicher, A. S., Jan 20 2020, In : Cochrane Database of Systematic Reviews. 2020, 1, CD009229.

Research output: Contribution to journalArticle

6 Scopus citations

Epidermal Growth Factor Receptor (EGFR) as a molecular determinant of glioblastoma response to dopamine receptor 2 (DRD2) inhibitors.

He, Y., Li, J., Koga, T., Ma, J., Dhawan, S., Suzuki, Y., Furnari, F., Prabhu, V. V., Allen, J. & Chen, C. C., Aug 2020, In : Neuro-Oncology.

Research output: Contribution to journalArticle

Epidermal growth factor receptor expression as a molecular determinant of glioblastoma response to the dopamine receptor D2 antagonist.

He, Y., Ma, J., Dhawan, S., Koga, T., Furnari, F., Prabhu, V. V., Allen, J. & Chen, C. C., 2020.

Research output: Contribution to conferencePoster

Frame-Based Stereotactic Endoscopic Third Ventriculostomy—Toward Improved Precision and Minimizing Morbidities

Chen, C. C., Freeman, D. & Warnke, P. C., Aug 2020, In : World neurosurgery. 140, p. e240-e246

Research output: Contribution to journalArticle

GBP2 enhances glioblastoma invasion through Stat3/fibronectin pathway

Yu, S., Yu, X., Sun, L., Zheng, Y., Chen, L., Xu, H., Jin, J., Lan, Q., Chen, C. C. & Li, M., Jul 2 2020, In : Oncogene. 39, 27, p. 5042-5055 14 p.

Research output: Contribution to journalArticle

Genome engineering evolves brain tumor modeling

Koga, T., Chen, C. C. & Furnari, F. B., 2020, In : Neurologia Medico-Chirurgica. 60, 7, p. 329-336 8 p.

Research output: Contribution to journalArticle

Open Access

Glioblastomas located in proximity to the subventricular zone (SVZ) exhibited enrichment of gene expression profiles associated with the cancer stem cell state

Steed, T. C., Treiber, J. M., Taha, B., Engin, H. B., Carter, H., Patel, K. S., Dale, A. M., Carter, B. S. & Chen, C. C., Jul 1 2020, In : Journal of neuro-oncology. 148, 3, p. 455-462 8 p.

Research output: Contribution to journalArticle

Laser ablation of abnormal neurological tissue using robotic neuroblate system (laantern): Procedural safety and hospitalization

Rennert, R. C., Khan, U., Bartek, J., Tatter, S. B., Field, M., Toyota, B., Fecci, P. E., Judy, K., Mohammadi, A. M., Landazuri, P., Sloan, A. E., Kim, A. H., Leuthardt, E. C. & Chen, C. C., Apr 1 2020, In : Neurosurgery. 86, 4, p. 538-547 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Longitudinal assessment of tumor development using cancer avatars derived from genetically engineered pluripotent stem cells

Koga, T., Chaim, I. A., Benitez, J. A., Markmiller, S., Parisian, A. D., Hevner, R. F., Turner, K. M., Hessenauer, F. M., D’Antonio, M., Nguyen, N. P. D., Saberi, S., Ma, J., Miki, S., Boyer, A. D., Ravits, J., Frazer, K. A., Bafna, V., Chen, C. C., Mischel, P. S., Yeo, G. W. & 1 others, Furnari, F. B., Dec 1 2020, In : Nature communications. 11, 1, 550.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Photodynamic Therapy for the Treatment of Glioblastoma

Cramer, S. W. & Chen, C. C., Jan 21 2020, In : Frontiers in Surgery. 6

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Radiation-induced extracellular vesicle (EV) release of miR-603 promotes IGF1-mediated stem cell state in glioblastomas

Ramakrishnan, V., Xu, B., Akers, J., Nguyen, T., Ma, J., Dhawan, S., Ning, J., Mao, Y., Hua, W., Kokkoli, E., Furnari, F., Carter, B. S. & Chen, C. C., May 2020, In : EBioMedicine. 55, 102736.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Short-term outcome following surgery for rare brain tumor entities in adults: a Swedish nation-wide registry-based study and comparison with SEER database

Bartek, J., Dhawan, S., Thurin, E., Alattar, A., Gulati, S., Rydenhag, B., Henriksson, R., Chen, C. C. & Jakola, A. S., Jun 1 2020, In : Journal of neuro-oncology. 148, 2, p. 281-290 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Surgical management of spontaneous intracerebral hemorrhage: insights from randomized controlled trials

Rennert, R. C., Tringale, K., Steinberg, J. A., Warnke, P., Konety, I., Sand, L. A., Karanjia, N., Tummala, R. & Chen, C. C., Jun 1 2020, In : Neurosurgical Review. 43, 3, p. 999-1006 8 p.

Research output: Contribution to journalReview article

1 Scopus citations

Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

Zhu, Z., Mesci, P., Bernatchez, J. A., Gimple, R. C., Wang, X., Schafer, S. T., Wettersten, H. I., Beck, S., Clark, A. E., Wu, Q., Prager, B. C., Kim, L. J. Y., Dhanwani, R., Sharma, S., Garancher, A., Weis, S. M., Mack, S. C., Negraes, P. D., Trujillo, C. A., Penalva, L. O. & 14 others, Feng, J., Lan, Z., Zhang, R., Wessel, A. W., Dhawan, S., Diamond, M. S., Chen, C. C., Wechsler-Reya, R. J., Gage, F. H., Hu, H., Siqueira-Neto, J. L., Muotri, A. R., Cheresh, D. A. & Rich, J. N., Feb 6 2020, In : Cell Stem Cell. 26, 2, p. 187-204.e10

Research output: Contribution to journalArticle

6 Scopus citations
2019

A Pilot Proof-Of-Principle Analysis Demonstrating Dielectrophoresis (DEP) as a Glioblastoma Biomarker Platform

Lewis, J., Alattar, A. A., Akers, J., Carter, B. S., Heller, M. & Chen, C. C., Dec 1 2019, In : Scientific reports. 9, 1, 10279.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Association between medical academic genealogy and publication outcome: impact of unconscious bias on scientific objectivity

Hirshman, B. R., Alattar, A. A., Dhawan, S., Carley, K. M. & Chen, C. C., Feb 13 2019, In : Acta Neurochirurgica. 161, 2, p. 205-211 7 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma

Zhang, J., Wang, J., Marzese, D. M., Wang, X., Yang, Z., Li, C., Zhang, H., Zhang, J., Chen, C. C., Kelly, D. F., Hua, W., Hoon, D. S. B. & Mao, Y., Jul 1 2019, In : Laboratory Investigation. 99, 8, p. 1117-1129 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Biopsy and Ablation of H3K27 Glioma Using Skull-Mounted Smartframe Device: Technical Case Report

Bartek, J., Alattar, A., Jensdottir, M. & Chen, C. C., Jul 2019, In : World neurosurgery. 127, p. 436-441 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Clinical course in chronic subdural hematoma patients aged 18–49 compared to patients 50 years and above: A multicenter study and meta-analysis

Bartek, J., Sjåvik, K., Dhawan, S., Sagberg, L. M., Kristiansson, H., Ståhl, F., Förander, P., Chen, C. C. & Jakola, A. S., 2019, In : Frontiers in Neurology. 10, APR, 311.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Comparison of Frame-Based Versus Frameless Intracranial Stereotactic Biopsy: Systematic Review and Meta-Analysis

Dhawan, S., He, Y., Bartek, J., Alattar, A. A. & Chen, C. C., Jul 2019, In : World neurosurgery. 127, p. 607-616.e4

Research output: Contribution to journalReview article

10 Scopus citations
Open Access
25 Scopus citations

Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on Treatment Options for Adults with Multiple Metastatic Brain Tumors

Ammirati, M., Nahed, B. V., Andrews, D., Chen, C. C. & Olson, J. J., Mar 1 2019, In : Clinical Neurosurgery. 84, 3, p. E180-E182

Research output: Contribution to journalReview article

Open Access
25 Scopus citations

Development of a Novel Canine Model of Ischemic Stroke: Skull Base Approach with Transient Middle Cerebral Artery Occlusion

Vasquez, C. A., Moen, S. L., Juliano, M. J., Jagadeesan, B. D., Pluhar, G. E., Chen, C. C. & Grande, A. W., Jul 2019, In : World neurosurgery. 127, p. e251-e260

Research output: Contribution to journalArticle

Erratum: Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (Cancer Cell (2019) 35(3) (504–518.e7), (S1535610819300546), (10.1016/j.ccell.2019.01.020))

Ma, J., Benitez, J. A., Li, J., Miki, S., Ponte de Albuquerque, C., Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T., Varki, N. M., Fenton, T. R., Nagahashi Marie, S. K., Lindahl, E., Gahman, T. C., Shiau, A. K., Zhou, H., DeGroot, J., Sulman, E. P. & 4 others, Cavenee, W. K., Kolodner, R. D., Chen, C. C. & Furnari, F. B., Dec 9 2019, In : Cancer Cell. 36, 6, p. 690-691 2 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Erratum: Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair (Cancer Cell (2019)35(3)(504–518.e7), (S1535610819300546), (10.1016/j.ccell.2019.01.020))

Ma, J., Benitez, J. A., Li, J., Miki, S., Ponte de Albuquerque, C., Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T., Varki, N. M., Fenton, T. R., Nagahashi Marie, S. K., Lindahl, E., Gahman, T. C., Shiau, A. K., Zhou, H., DeGroot, J., Sulman, E. P. & 4 others, Cavenee, W. K., Kolodner, R. D., Chen, C. C. & Furnari, F. B., May 13 2019, In : Cancer Cell. 35, 5, 1 p.

Research output: Contribution to journalComment/debate

Open Access
7 Scopus citations

Extracellular vesicles as carriers of suicide mRNA and/or protein in cancer therapy

Erkan, E. P., Saydam, N., Chen, C. C. & Saydam, O., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 87-96 10 p. (Methods in Molecular Biology; vol. 1895).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Infratentorial Glioblastoma Metastasis to Bone

Ricard, J. A., Cramer, S. W., Charles, R., Gil Tommee, C., Le, A., Bell, W. R., Chen, C. C. & Flanagan, M. E., Nov 2019, In : World neurosurgery. 131, p. 90-94 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

Ma, J., Benitez, J. A., Li, J., Miki, S., Ponte de Albuquerque, C., Galatro, T., Orellana, L., Zanca, C., Reed, R., Boyer, A., Koga, T., Varki, N. M., Fenton, T. R., Nagahashi Marie, S. K., Lindahl, E., Gahman, T. C., Shiau, A. K., Zhou, H., DeGroot, J., Sulman, E. P. & 4 others, Cavenee, W. K., Kolodner, R. D., Chen, C. C. & Furnari, F. B., Mar 18 2019, In : Cancer Cell. 35, 3, p. 504-518.e7

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Machine Learning Based Real-Time Image-Guided Cell Sorting and Classification

Gu, Y., Zhang, A. C., Han, Y., Li, J., Chen, C. C. & Lo, Y. H., May 2019, In : Cytometry Part A. 95, 5, p. 499-509 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma

Chahal, K. K., Li, J., Kufareva, I., Parle, M., Durden, D. L., Wechsler-Reya, R. J., Chen, C. C. & Abagyan, R., Sep 1 2019, In : PloS one. 14, 9, e0214901.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Prognostic Importance of Age, Tumor Location, and Tumor Grade in Grade II Astrocytomas: An Integrated Analysis of the Cancer Genome Atlas and the Surveillance, Epidemiology, and End Results Database

Alattar, A. A., Carroll, K. T., Bryant, A. K., Hirshman, B., Joshi, R., Carter, B. S., Harismendy, O. & Chen, C. C., Jan 2019, In : World neurosurgery. 121, p. e411-e418

Research output: Contribution to journalArticle

4 Scopus citations

Prognostic Importance of Cumulative Intracranial Tumor Volume in Patients with Gastrointestinal Brain Metastasis Treated with Stereotactic Radiosurgery

Joshi, R. S., Hirshman, B. R., Ali, M. A., Alattar, A., Carroll, K., Nagano, O., Aiyama, H., Serizawa, T., Yamamoto, M. & Chen, C. C., Jan 2019, In : World neurosurgery. 121, p. e747-e754

Research output: Contribution to journalArticle

3 Scopus citations

Receipt of brachytherapy is an independent predictor of survival in glioblastoma in the Surveillance, Epidemiology, and End Results database

Bartek, J., Alattar, A. A., Dhawan, S., Ma, J., Koga, T., Nakaji, P., Dusenbery, K. E. & Chen, C. C., Oct 2019, In : Journal of neuro-oncology. 145, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Smoking As a Risk Factor for Postcraniotomy 30-Day Mortality

Lochte, B. C., Carroll, K. T., Hirshman, B., Lanman, T., Carter, B. & Chen, C. C., Jul 2019, In : World neurosurgery. 127, p. e400-e406

Research output: Contribution to journalArticle

Stereotactic Laser Ablation as Treatment of Brain Metastases Recurring after Stereotactic Radiosurgery: A Systematic Literature Review

Alattar, A. A., Bartek, J., Chiang, V. L., Mohammadi, A. M., Barnett, G. H., Sloan, A. & Chen, C. C., Aug 2019, In : World neurosurgery. 128, p. 134-142 9 p.

Research output: Contribution to journalReview article

10 Scopus citations

The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

The Extracellular RNA Communication Consortium, Apr 4 2019, In : Cell. 177, 2, p. 231-242 12 p.

Research output: Contribution to journalReview article

Open Access
31 Scopus citations
Open Access
6 Scopus citations

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V. & Masopust, D., Dec 1 2019, In : Nature communications. 10, 1, 567.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

When less is more: Gaining power through gene rearrangement of amplified EGFR

Koga, T., Chen, C. C. & Furnari, F. B., Mar 1 2019, In : Oncotarget. 10, 22, p. 2116-2117 2 p.

Research output: Contribution to journalEditorial

2018

A single-cell translocation and secretion assay (TransSeA)

Cai, W., Chiu, Y. J., Ramakrishnan, V., Tsai, Y., Chen, C. & Lo, Y. H., Oct 21 2018, In : Lab on a chip. 18, 20, p. 3154-3162 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Brachytherapy in glioblastoma: a surveillance, epidemiology, and end results (SEER) analysis.

Alattar, A. A., Bartek Jr., J., Dhawan, S., Ma, J. & Chen, C. C., 2018.

Research output: Contribution to conferencePoster

Cumulative intracranial tumor volume augments the prognostic value of the diagnosis-specific graded prognostic assessment model for survival in patients with melanoma cerebral metastases

Hirshman, B. R., Wilson, B. R., Ali, M. A., Schupper, A. J., Proudfoot, J. A., Goetsch, S. J., Carter, B. S., Sinclair, G., Bartek, J., Chiang, V., Fogarty, G., Hong, A. & Chen, C. C., Aug 2018, In : Clinical Neurosurgery. 83, 2, p. 237-244 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Cystic Formation After Stereotactic Radiosurgery of Brain Metastasis

Alattar, A. A., Carroll, K., Hirshman, B. R., Joshi, R. S., Sanghvi, P. & Chen, C. C., Jun 2018, In : World neurosurgery. 114, p. e719-e728

Research output: Contribution to journalArticle

1 Scopus citations

Diagnostic utility of restriction spectrum imaging (RSI) in glioblastoma patients after concurrent radiation-temozolomide treatment: A pilot study

Khan, U. A., Rennert, R. C., White, N. S., Bartsch, H., Farid, N., Dale, A. M. & Chen, C. C., Dec 2018, In : Journal of Clinical Neuroscience. 58, p. 136-141 6 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

Cloughesy, T. F., Landolfi, J., Vogelbaum, M. A., Ostertag, D., Elder, J. B., Bloomfield, S., Carter, B., Chen, C. C., Kalkanis, S. N., Kesari, S., Lai, A., Lee, I. Y., Liau, L. M., Mikkelsen, T., Nghiemphu, P., Piccioni, D., Accomando, W., Diago, O. R., Hogan, D. J., Gammon, D. & 6 others, Kasahara, N., Kheoh, T., Jolly, D. J., Gruber, H. E., Das, A. & Walbert, T., 2018, In : Neuro-Oncology. 20, 10, p. 1383-1392 10 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Extracellular Vesicles as a Platform for Glioma Therapeutic Development

Santiago-DIeppa, D. R., Gonda, D. D., Cheung, V. J., Steinberg, J. A., Carter, B. S. & Chen, C. C., Jan 1 2018, In : Progress in Neurological Surgery. 32, p. 172-179 8 p.

Research output: Contribution to journalArticle