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  • Stephen S Hecht
2018

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
Open Access
8 Scopus citations

A New Editorial Team for CRT

Hecht, S. S., Jan 16 2018, In : Chemical research in toxicology. 31, 1, 1 p.

Research output: Contribution to journalEditorial

Open Access

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Jan 1 2018, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 228-253 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Goniewicz, M. L., Smith, D. M., Edwards, K. C., Blount, B. C., Caldwell, K. L., Feng, J., Wang, L., Christensen, C., Ambrose, B., Borek, N., van Bemmel, D., Konkel, K., Erives, G., Stanton, C. A., Lambert, E., Kimmel, H. L., Hatsukami, D., Hecht, S. S., Niaura, R. S., Travers, M. & 2 others, Lawrence, C. & Hyland, A. J., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185937

Research output: Contribution to journalArticle

Open Access

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., Al'Absi, M., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J. S., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. G., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations
Open Access
Open Access
9 Scopus citations
Open Access
1 Scopus citations
Open Access
10 Scopus citations

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 1 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview article

6 Scopus citations

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2017

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
2 Scopus citations

A special issue of CRT: Celebrating volume 30

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, 1 p.

Research output: Contribution to journalEditorial

Open Access

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 2017, In : PloS one. 12, 5, e0178435.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions

Hecht, S. S., Jan 1 2017, Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Elsevier Inc., p. 59-73 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Experimental nasal cavity tumors induced by tobacco-specific nitrosamines (TSNA)

Rivenson, A., Furuya, K., Hecht, S. S. & Hoffman, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 79-114 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Open Access
7 Scopus citations
Open Access
7 Scopus citations
Open Access

Nasal cavity carcinogens: Possible routes of metabolic activation

Hecht, S. S., Castonguay, A. & Hoffmann, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, p. 367-375 9 p.

Research output: Contribution to journalReview article

Open Access
18 Scopus citations

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of medicinal chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Polycyclic Aromatic Hydrocarbon Biomarker Levels among Smokers who Switch to Oral Nicotine

Meier, E., Vogel, R. I., Carmella, S., Paiano, V., Hecht, S. & Hatsukami, D., Apr 1 2017, In : Tobacco Regulatory Science. 3, 2, p. 204-209

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V., Jan 1 2017, In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Open Access
14 Scopus citations
Open Access
17 Scopus citations
2015

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L., Jan 1 2015, In : American journal of epidemiology. 182, 11, p. 945-951 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
10 Scopus citations

Combined analysis of the tobacco metabolites cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine

Kotandeniya, D., Carmella, S. G., Ming, X., Murphy, S. E. & Hecht, S. S., Feb 3 2015, In : Analytical chemistry. 87, 3, p. 1514-1517 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
19 Scopus citations

Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home

Hecht, S. S., Koh, W. P., Wang, R., Chen, M., Carmella, S. G., Murphy, S. E. & Yuan, J. M., Mar 25 2015, In : PloS one. 10, 3, e0120023.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers

Hecht, S. S., Carmella, S. G., Kotandeniya, D., Pillsbury, M. E., Chen, M., Ransom, B. W. S., Vogel, R. I., Thompson, E., Murphy, S. E. & Hatsukami, D. K., Jan 1 2015, In : Nicotine and Tobacco Research. 17, 6, p. 704-709 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Evidence supporting product standards for carcinogens in smokeless tobacco products

Hatsukami, D. K., Stepanov, I., Severson, H., Jensen, J. A., Lindgren, B. R., Horn, K., Khariwala, S. S., Martin, J., Carmella, S. G., Murphy, S. E. & Hecht, S. S., Jan 1 2015, In : Cancer Prevention Research. 8, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

GRAS 27 flavoring substances

Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Marnett, L. J., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., McGowen, M. M., Harman, C. L. & Taylor, S. V., Aug 2015, Food Technology, 69, 8.

Research output: Contribution to specialist publicationArticle

6 Scopus citations

Mercapturic acids derived from the toxicants acrolein and crotonaldehyde in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Park, S. L., Carmella, S. G., Chen, M., Patel, Y., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 8 2015, In : PloS one. 10, 6, e0124841.

Research output: Contribution to journalArticle

25 Scopus citations

NIH electronic cigarette workshop: Developing a research agenda

Walton, K. M., Abrams, D. B., Bailey, W. C., Clark, D., Connolly, G. N., Djordjevic, M. V., Eissenberg, T. E., Fiore, M. C., Goniewicz, M. L., Haverkos, L., Hecht, S. S., Henningfield, J. E., Hughes, J. R., Oncken, C. A., Postow, L., Rose, J. E., Wanke, K. L., Yang, L. & Hatsukami, D. K., Feb 1 2015, In : Nicotine and Tobacco Research. 17, 2, p. 259-269 11 p.

Research output: Contribution to journalReview article

68 Scopus citations

Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease

Zabala, V., Tong, M., Yu, R., Ramirez, T., Yalcin, E. B., Balbo, S., Silbermann, E., Deochand, C., Nunez, K., Hecht, S. & de la Monte, S. M., Jan 1 2015, In : Alcohol and Alcoholism. 50, 2, p. 118-131 14 p.

Research output: Contribution to journalArticle

21 Scopus citations

Quantitative analysis of 3'-hydroxynorcotinine in human urine

Upadhyaya, P. & Hecht, S. S., May 1 2015, In : Nicotine and Tobacco Research. 17, 5, p. 524-529 6 p.

Research output: Contribution to journalArticle

Randomized trial of reduced-nicotine standards for cigarettes

Donny, E. C., Denlinger, R. L., Tidey, J. W., Koopmeiners, J. S., Benowitz, N. L., Vandrey, R. G., Al'Absi, M., Carmella, S. G., Cinciripini, P. M., Dermody, S. S., Drobes, D. J., Hecht, S. S., Jensen, J., Lane, T., Le, C. T., McClernon, F. J., Montoya, I. D., Murphy, S. E., Robinson, J. D., Stitzer, M. L. & 3 others, Strasser, A. A., Tindle, H. & Hatsukami, D. K., Oct 1 2015, In : New England Journal of Medicine. 373, 14, p. 1340-1349 10 p.

Research output: Contribution to journalArticle

142 Scopus citations

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS3 Adductomic Approach

Stornetta, A., Villalta, P. W., Hecht, S. S., Sturla, S. J. & Balbo, S., Oct 28 2015, In : Analytical chemistry. 87, 23, p. 11706-11713 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
8 Scopus citations

Variation in levels of the lung carcinogen NNAL and its glucuronides in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Park, S. L., Carmella, S. G., Ming, X., Vielguth, E., Stram, D. O., Le Marchand, L. & Hecht, S. S., Mar 1 2015, In : Cancer Epidemiology Biomarkers and Prevention. 24, 3, p. 561-569 9 p.

Research output: Contribution to journalArticle

22 Scopus citations