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  • 2019
  • 2017
  • 2016
  • 2015

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  • Philip S Portoghese
2019

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Bruce, D. J., Peterson, C. D., Kitto, K. F., Akgün, E., Lazzaroni, S., Portoghese, P. S., Fairbanks, C. A. & Wilcox, G. L., Sep 1 2019, In : Anesthesiology. 131, 3, p. 649-663 15 p.

Research output: Contribution to journalArticle

2 Scopus citations

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. R., Portoghese, P. S., Rice, K. C., Watkins, L. R., Hutchinson, M. R. & Wang, X., Aug 1 2019, In : FASEB Journal. 33, 8, p. 9577-9587 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Shueb, S. S., Erb, S. J., Lunzer, M. M., Speltz, R., Harding-Rose, C., Akgün, E., Simone, D. A. & Portoghese, P. S., Dec 1 2019, In : Neuropharmacology. 160, 107690.

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations
2017

Bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

Peterson, C. D., Kitto, K. F., Akgün, E., Lunzer, M. M., Riedl, M. S., Vulchanova, L., Wilcox, G. L., Portoghese, P. S. & Fairbanks, C. A., Jan 1 2017, In : Pain. 158, 12, p. 2431-2441 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese, P. S., Akgün, E. & Lunzer, M. M., Mar 15 2017, In : ACS Chemical Neuroscience. 8, 3, p. 426-428 3 p.

Research output: Contribution to journalArticle

12 Scopus citations
2016

Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice

Angelis, E. M. G. D., Abdelhamid, R. E., Nunez, M. G., Kissel, C. L., Kovács, K. J., Portoghese, P. S. & Larson, A. A., Aug 19 2016, In : Pain. 157, 11, p. 2561-2570 10 p.

Research output: Contribution to journalArticle

2015

Inhibition of inflammatory and neuropathic pain by targeting a Mu opioid receptor/chemokine receptor5 heteromer (MOR-CCR5)

Akgün, E., Javed, M. I., Lunzer, M. M., Powers, M. D., Sham, Y. Y., Watanabe, Y. & Portoghese, P. S., Nov 12 2015, In : Journal of medicinal chemistry. 58, 21, p. 8647-8657 11 p.

Research output: Contribution to journalArticle

27 Scopus citations