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  • Paul D Robbins
2019

Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis–like symptoms in NOD mice

Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J. & Robbins, P. D., Aug 1 2019, In : FASEB Journal. 33, 8, p. 9505-9515 11 p.

Research output: Contribution to journalArticle

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A. B., Narita, M., Niedernhofer, L., Passos, J. F., Robbins, P. D., Schmitt, C. A. & 6 others, Sedivy, J., Vougas, K., von Zglinicki, T., Zhou, D., Serrano, M. & Demaria, M., Oct 31 2019, In : Cell. 179, 4, p. 813-827 15 p.

Research output: Contribution to journalReview article

13 Scopus citations

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Nogueira-Recalde, U., Lorenzo-Gómez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Domínguez, E. & Caramés, B., Jul 2019, In : EBioMedicine. 45, p. 588-605 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Measuring biological age in mice using differential mass spectrometry

Bell-Temin, H., Yousefzadeh, M. J., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J. & Yates, N. A., Jan 1 2019, In : Aging. 11, 3, p. 1045-1061 17 p.

Research output: Contribution to journalArticle

Open Access

Methods to quantify the NF-κB pathway during senescence

Zhang, L., Zhao, J., Gurkar, A., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 231-250 20 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Mouse models of accelerated cellular senescence

Yousefzadeh, M., Melos, K. I., Angelini, L., Burd, C. E., Robbins, P. D. & Niedernhofer, L. J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 203-230 28 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Murine models of accelerated aging and musculoskeletal disease

Hambright, W. S., Niedernhofer, L. J., Huard, J. & Robbins, P. D., Aug 2019, In : Bone. 125, p. 122-127 6 p.

Research output: Contribution to journalArticle

Oxidative stress-induced senescence markedly increases disc cell bioenergetics

Patil, P., Falabella, M., Saeed, A., Lee, D., Kaufman, B., Shiva, S., Croix, C. S., Van Houten, B., Niedernhofer, L. J., Robbins, P. D., Lee, J., Gwendolyn, S. & Vo, N. V., Jun 2019, In : Mechanisms of Ageing and Development. 180, p. 97-106 10 p.

Research output: Contribution to journalArticle

Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice

Kawakami, Y., Hambright, W. S., Takayama, K., Mu, X., Lu, A., Cummins, J. H., Matsumoto, T., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 64-76 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Sa-β-galactosidase-based screening assay for the identification of senotherapeutic drugs

Fuhrmann-Stroissnigg, H., Santiago, F. E., Grassi, D., Ling, Y. Y., Niedernhofer, L. J. & Robbins, P. D., Jun 2019, In : Journal of Visualized Experiments. 2019, 148, e58133.

Research output: Contribution to journalArticle

Signal transduction, ageing and disease

Zhang, L., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Subcellular Biochemistry. Springer New York, p. 227-247 21 p. (Subcellular Biochemistry; vol. 91).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Systemic clearance of p16INK4a-positive senescent cells mitigates age-associated intervertebral disc degeneration

Patil, P., Dong, Q., Wang, D., Chang, J., Wiley, C., Demaria, M., Lee, J., Kang, J., Niedernhofer, L. J., Robbins, P. D., Sowa, G., Campisi, J., Zhou, D. & Vo, N., Jun 2019, In : Aging cell. 18, 3, e12927.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
6 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

Open Access
245 Scopus citations

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R. W., Boccuzzi, L., Robbins, P. D. & Ricordi, C., Jun 1 2017, In : European review for medical and pharmacological sciences. 21, 12, p. 2940-2956 17 p.

Research output: Contribution to journalReview article

22 Scopus citations

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Extracellular vesicles and aging

Robbins, P. D., Dec 1 2017, In : Stem Cell Investigation. 4, 12, 98.

Research output: Contribution to journalReview article

Open Access
14 Scopus citations

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature communications. 8, 1, 422.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

Proto, J. D., Lu, A., Dorronsoro, A., Scibetta, A., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jun 2017, In : PloS one. 12, 6, e0179270.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jul 2017, In : Journal of Orthopaedic Research. 35, 7, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., Jan 1 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Garcia-Contreras, M., Shah, S. H., Tamayo, A., Robbins, P. D., Golberg, R. B., Mendez, A. J. & Ricordi, C., Dec 1 2017, In : Scientific reports. 7, 1, 5998.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Quantitative analysis of cellular senescence in culture and in Vivo

Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D. B., St. Croix, C. M., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2017, In : Current protocols in cytometry. 2017, p. 9.51.1-9.51.25

Research output: Contribution to journalArticle

5 Scopus citations

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

Ngo, K., Patil, P., McGowan, S. J., Niedernhofer, L. J., Robbins, P. D., Kang, J., Sowa, G. & Vo, N., Sep 2017, In : Mechanisms of Ageing and Development. 166, p. 16-23 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Systems biology guided by XCMS Online metabolomics

Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., Aisporna, A., Hilmers, B., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Robbins, P. D., Niedernhofer, L. J., Ideker, T., Majumder, E. L., Wall, J. D., Rattray, N. J. W. & 3 others, Goodacre, R., Lairson, L. L. & Siuzdak, G., Apr 27 2017, In : Nature Methods. 14, 5, p. 461-462 2 p.

Research output: Contribution to journalLetter

Open Access
58 Scopus citations

The Clinical Potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. & Robbins, P. D., Oct 2017, In : Journal of the American Geriatrics Society. 65, 10, p. 2297-2301 5 p.

Research output: Contribution to journalArticle

Open Access
110 Scopus citations
2016

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : STEM CELLS. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., Jun 1 2016, In : Aging cell. 15, 3, p. 428-435 8 p.

Research output: Contribution to journalArticle

185 Scopus citations

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins, P. D., Dorronsoro, A. & Booker, C. N., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1173-1180 8 p.

Research output: Contribution to journalReview article

84 Scopus citations

Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Northen, T. R., Robbins, P. D., Niedernhofer, L. J., Lairson, L., Benton, H. P. & Siuzdak, G., Oct 4 2016, In : Analytical chemistry. 88, 19, p. 9753-9758 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Arthritis Gene Therapy: A Brief History and Perspective

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 2015, Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., p. 85-98 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Cell-type specific penetrating peptides: Therapeutic promises and challenges

Zahid, M. & Robbins, P. D., Jul 1 2015, In : Molecules. 20, 7, p. 13055-13070 16 p.

Research output: Contribution to journalReview article

32 Scopus citations

D-amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity

Reay, D. P., Bastacky, S. I., Wack, K. E., Stolz, D. B., Robbins, P. D. & Clemens, P. R., Jan 1 2015, In : Molecular Medicine. 21, p. 442-452 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

Flores, R. R., Kim, E., Zhou, L., Yang, C., Zhao, J., Gambotto, A. & Robbins, P. D., Nov 1 2015, In : European Journal of Immunology. 45, 11, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

NF-κB activation with aging: Characterization and therapeutic inhibition

Zhao, J., Li, X., McGowan, S., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 543-557 15 p.

Research output: Contribution to journalArticle

8 Scopus citations

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Proto, J. D., Tang, Y., Lu, A., Chen, W. C. W., Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. & Huard, J., Apr 23 2015, In : Cell Death and Disease. 6, 4, e1730.

Research output: Contribution to journalArticle

20 Scopus citations

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., LaRusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B. & 13 others, McGowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., Aug 1 2015, In : Aging cell. 14, 4, p. 644-658 15 p.

Research output: Contribution to journalArticle

438 Scopus citations