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2019
1 Citation (Scopus)

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Aug 8 2019, In : Nature. 572, 7768, p. 254-259 6 p.

Research output: Contribution to journalLetter

Immune Evasion
Acute Myeloid Leukemia
Leukemia
Stem Cells
Ligands

Achievement of tolerance induction to prevent acute graft-vs.-host disease

Thangavelu, G. & Blazar, B. R., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 309.

Research output: Contribution to journalReview article

Open Access
Immune Tolerance
Hematopoietic Stem Cell Transplantation
Immunosuppressive Agents
Transplants
Therapeutics
1 Citation (Scopus)

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Paul, J., Nakasone, H., Sahaf, B., Wu, F., Wang, K., Ho, V., Wu, J., Kim, H., Blazar, B. R., Ritz, J., Howard, A., Cutler, C. & Miklos, D., Jun 30 2019, In : Haematologica. 104, 7, p. e314-e317

Research output: Contribution to journalArticle

Open Access
2 Citations (Scopus)

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F. M., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C. G., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
Natural Killer Cells
Cytomegalovirus
Transplants
Hematologic Neoplasms
Hematopoietic Stem Cells

Amphiregulin in intestinal acute graft-versus-host disease: a possible diagnostic and prognostic aid

Amin, K., Yaqoob, U., Schultz, B., Vaughn, B. P., Khoruts, A., Howard, J. R., De For, T. E., Forster, C., Meyer, C. M., Gandhi, I., Weisdorf, D. J., Rashidi, A., MacMillan, M. L., Blazar, B. R., Panoskaltsis-Mortari, A. & Holtan, S. G., Apr 1 2019, In : Modern Pathology. 32, 4, p. 560-567 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Ulcerative Colitis
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Colitis

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Mar 1 2019, In : Bone marrow transplantation. 54, 3, p. 490-493 4 p.

Research output: Contribution to journalLetter

trans-crotonin

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Brinkman, C. C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33

Research output: Contribution to journalArticle

Open Access
Lysosphingolipid Receptors
Endothelial Cells
T-Lymphocytes
Cell Movement
Vascular Cell Adhesion Molecule-1
2 Citations (Scopus)

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function

Boroughs, A. C., Larson, R. C., Choi, B. D., Bouffard, A. A., Riley, L. S., Schiferle, E., Kulkarni, A. S., Cetrulo, C. L., Ting, D., Blazar, B. R., Demehri, S. & Maus, M. V., Jan 1 2019, In : JCI Insight. 4, 8, e126194.

Research output: Contribution to journalArticle

Open Access
Antigen Receptors
Regulatory T-Lymphocytes
Antigens
Peripheral Tolerance
T-Lymphocytes

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Merino, A. M., Zhang, B., Dougherty, P. R., Luo, X., Wang, J., Blazar, B. R., Miller, J. S. & Cichocki, F., Jun 18 2019, In : The Journal of clinical investigation. 130

Research output: Contribution to journalArticle

Open Access
Epigenomics
Natural Killer Cells
Genome
Natural Killer Cell Receptors
T-Lymphocytes

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

Retinal Dehydrogenase
Aldehyde Dehydrogenase
Graft vs Host Disease
Tretinoin
Dendritic Cells

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K. L., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 1 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
T-cells
Deoxyglucose
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
T-lymphocytes
Cell Transplantation
Graft vs Host Disease
Morbidity
Recurrence
Survival

Early E. Casseliflavus gut colonization and outcomes of allogeneic hematopoietic cell transplantation

Rashidi, A., Ebadi, M., Shields-Cutler, R. R., Kruziki, K., Manias, D. A., Barnes, A. M. T., De For, T. E., Ferrieri, P., Young, J-A. H., Knights, D., Blazar, B. R., Weisdorf, D. J. & Dunny, G. M., Jan 1 2019, In : PloS one. 14, 8, e0220850.

Research output: Contribution to journalArticle

Open Access
cell transplantation
Cell Transplantation
Tryptophan
Agar
Transplants

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Chung, J., Radojcic, V., Perkey, E., Parnell, T. J., Niknafs, Y., Jin, X., Friedman, A., Labrecque, N., Blazar, B. R., Brennan, T. V., Siebel, C. W. & Maillard, I., Jan 1 2019, In : Journal of Immunology. 203, 2, p. 557-568 12 p.

Research output: Contribution to journalArticle

Isoantigens
Graft vs Host Disease
T-Lymphocytes
T-Cell Leukemia
myc Genes

Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease

Belizaire, R., Kim, H. T., Poryanda, S. J., Mirkovic, N. V., Hipolito, E., Savage, W. J., Reynolds, C. G., Fields, M. J., Whangbo, J., Kubo, T., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Blazar, B. R., Antin, J. H., Ritz, J., Soiffer, R. J. & Koreth, J., Apr 9 2019, In : Blood Advances. 3, 7, p. 969-979 11 p.

Research output: Contribution to journalArticle

Open Access
Photopheresis
Graft vs Host Disease
Interleukin-2
Regulatory T-Lymphocytes
Natural Killer Cells

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F. C., Bachanova, V., Vercellotti, G. M., De For, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B. J., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., Jan 1 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-15
Cell- and Tissue-Based Therapy
Acute Myeloid Leukemia
Natural Killer Cells
Cytokines

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Hou, S., Clement, R. L., Diallo, A., Blazar, B. R., Rudensky, A. Y., Sharpe, A. H. & Sage, P. T., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 605-620 16 p.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Antibody Formation
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Chromatin

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Disease

Blazar, B. R., Feb 1 2019, In : Engineering. 5, 1, p. 98-105 8 p.

Research output: Contribution to journalReview article

Cytology
Grafts
T-cells
Bearings (structural)
Cells
Cell Transplantation
Monocytes
Survival
Transplants
Fetal Blood
23 Citations (Scopus)

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., Mirsoian, A., Minnar, C. M., Stoffel, K. M., Sturgill, I. R., Grossenbacher, S. K., Withers, S. S., Rebhun, R. B., Hartigan-O’Connor, D. J., Méndez-Lagares, G., Tarantal, A. F., Isseroff, R. R., Griffith, T. S., Schalper, K. A., Merleev, A. & 13 others, Saha, A., Maverakis, E., Kelly, K., Aljumaily, R., Ibrahimi, S., Mukherjee, S., Machiorlatti, M., Vesely, S. K., Longo, D. L., Blazar, B. R., Canter, R. J., Murphy, W. J. & Monjazeb, A. M., Jan 1 2019, In : Nature Medicine. 25, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

Open Access
T-cells
Tumors
Obesity
T-Lymphocytes
Neoplasms

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Klein Geltink, R. I., Kyle, R. L., Caputa, G., O'Sullivan, D., Cameron, A. M., Castoldi, A., Musa, Y., Kabat, A. M., Zhang, Y., Flachsmann, L. J., Field, C. S., Patterson, A. E., Scherer, S., Alfei, F., Baixauli, F., Austin, S. K., Kelly, B., Matsushita, M. & 17 others, Curtis, J. D., Grzes, K. M., Villa, M., Corrado, M., Sanin, D. E., Qiu, J., Pällman, N., Paz, K., Maccari, M. E., Blazar, B. R., Mittler, G., Buescher, J. M., Zehn, D., Rospert, S., Pearce, E. J., Balabanov, S. & Pearce, E. L., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 352-363.e8

Research output: Contribution to journalArticle

Open Access
Eukaryotic Initiation Factors
Macrophage Activation
Polyamines
Respiration
Oxidative Phosphorylation

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, (2019), 10.1038/s41586-019-1410-1)

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Jan 1 2019, In : Nature.

Research output: Contribution to journalComment/debate

Open Access
Immune Evasion
Leukemia
Stem Cells
Ligands
1 Citation (Scopus)
Open Access
Hematologic Neoplasms
Allografts
Graft vs Host Disease
Cell Transplantation
Transplants

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways

Ni, X., Xia, Y., Zhou, S., Peng, H., Wu, X., Lu, H., Wang, H., Liu, R., Blazar, B. R., Gu, J. & Lu, L., Jan 1 2019, In : Cell Death and Disease. 10, 1, 13.

Research output: Contribution to journalArticle

Graft vs Host Disease
Mesenchymal Stromal Cells
Th17 Cells
Autoimmune Diseases
1 Citation (Scopus)

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease

Yang, J., Ramadan, A., Reichenbach, D. K., Loschi, M., Zhang, J., Griesenauer, B., Liu, H., Hippen, K. L., Blazar, B. R. & Paczesny, S., Mar 7 2019, In : JCI insight. 4, 5

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Regulatory T-Lymphocytes
T-Lymphocytes
Cell Transplantation
Transplantation

Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growth

Phan, T., Nguyen, V. H., D’Alincourt, M. S., Manuel, E. R., Kaltcheva, T., Tsai, W., Blazar, B. R., Diamond, D. J. & Melstrom, L. G., Jan 1 2019, In : Cancer gene therapy.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Innate Immunity
Salmonella
Colorectal Neoplasms
Growth

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

Leung, W. H., Gay, J., Martin, U., Garrett, T. E., Horton, H. M., Certo, M. T., Blazar, B. R., Morgan, R. A., Gregory, P. D., Jarjour, J. & Astrakhan, A., Jun 6 2019, In : JCI insight. 4, 11, e124430.

Research output: Contribution to journalArticle

Open Access
Antigen Receptors
Dimerization
T-Cell Antigen Receptor
Pharmacology
Sirolimus
3 Citations (Scopus)

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, K., Flynn, R. P., Du, J., Qi, J., Luznik, L., Maillard, I., MacDonald, K. P., Hill, G. R., Serody, J. S., Murphy, W. J., Sage, P. T., Sharpe, A. H., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H., Soiffer, R. J., Ritz, J., Bradner, J. E., Melnick, A. M. & 1 others, Blazar, B. R., Jan 3 2019, In : Blood. 133, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

B-Cell Lymphoma
Graft vs Host Disease
Grafts
Germinal Center
Transplants

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C. J., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 1 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Graft vs Host Disease
Germinal Center
Bronchiolitis Obliterans
B-Lymphocytes
2 Citations (Scopus)

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Liu, B., Salgado, O. C., Singh, S., Hippen, K. L., Maynard, J. C., Burlingame, A. L., Ball, L. E., Blazar, B. R., Farrar, M. A., Hogquist, K. A. & Ruan, H-B., Dec 1 2019, In : Nature communications. 10, 1, 354.

Research output: Contribution to journalArticle

T-cells
Regulatory T-Lymphocytes
proteins
effectors
T-Cell Antigen Receptor

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination

Ni, X., Kou, W., Gu, J., Wei, P., Wu, X., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., Park, B. V., Chen, Z., Tian, Y., Fu, J., Newman, S., Wang, X., Shen, H., Li, B., Blazar, B. R., Wang, X. & 3 others, Barbi, J., Pan, F. & Lu, L., May 2 2019, In : EMBO Journal. 38, 9, e99766.

Research output: Contribution to journalArticle

Open Access
TNF Receptor-Associated Factor 6
T-cells
Ubiquitination
Regulatory T-Lymphocytes
Tumors
4 Citations (Scopus)

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S. P., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V. & Masopust, D., Dec 1 2019, In : Nature communications. 10, 1, 567.

Research output: Contribution to journalArticle

T-cells
viruses
Viruses
Immunotherapy
Tumors
2018
6 Citations (Scopus)

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

Sarhan, D. A., Brandt, L., Felices, M., Guldevall, K., Lenvik, T. R., Hinderlie, P., Curtsinger, J. M., Warlick, E. D., Spellman, S. R., Blazar, B. R., Weisdorf, D. J., Cooley, S. A., Vallera, D. A., Önfelt, B. & Miller, J. S., Jun 26 2018, In : Blood Advances. 2, 12, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Myelodysplastic Syndromes
Natural Killer Cells
Interleukin-15
Myeloid-Derived Suppressor Cells
Hematopoiesis
10 Citations (Scopus)

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H., Bommiasamy, H., Paz, K., Wilkinson, A. N., Owen, M., Reichenbach, D. K., Banovic, T., Wehner, K., Buchanan, F., Varelias, A., Kuns, R. D., Chang, K., Fedoriw, Y., Shea, T., Coghill, J., Zaiken, M., Plank, M. W., Foster, P. S., Clouston, A. D., Blazar, B. R. & 2 others, Serody, J. S. & Hill, G. R., Apr 1 2018, In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Tissue Donors
Skin
Interleukin-17
Stem Cell Transplantation
20 Citations (Scopus)

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming

Acute Graft-versus-Host Disease

Zeiser, R. & Blazar, B. R., Feb 8 2018, In : The New England journal of medicine. 378, 6, 1 p.

Research output: Contribution to journalLetter

Graft vs Host Disease
8 Citations (Scopus)

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T. R., Curtsinger, J. M., Davis, Z. B., Zhang, B., Cooley, S. A., Cichocki, F. M., Blazar, B. R. & Miller, J. S., Jul 1 2018, In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Natural Killer Cells
Natural Killer Cell Receptors
Tumor Microenvironment
Programmed Cell Death 1 Receptor
3 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Open Access
Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
1 Citation (Scopus)

Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802

Holtan, S. G., De For, T. E., Panoskaltsis-Mortari, A., Khera, N., Levine, J. E., Flowers, M. E. D., Lee, S. J., Inamoto, Y., Chen, G. L., Mayer, S., Arora, M., Palmer, J., Cutler, C. S., Arai, S., Lazaryan, A., Newell, L. F., Jagasia, M. H., Pusic, I., Wood, W. A., Renteria, A. S. & 17 others, Yanik, G., Hogan, W. J., Hexner, E., Ayuk, F., Holler, E., Bunworasate, U., Efebera, Y. A., Ferrara, J. L. M., Pidala, J., Howard, A., Wu, J., Bolaños-Meade, J., Ho, V., Alousi, A., Blazar, B. R., Weisdorf, D. J. & MacMillan, M. L., Aug 14 2018, In : Blood Advances. 2, 15, p. 1882-1888 7 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Survival
Mortality
Intestinal Mucosa
trans-crotonin
1 Citation (Scopus)

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L. M., Goren, E., Mulé, J. J. & Blazar, B. R., Apr 1 2018, In : PloS one. 13, 4, e0193461.

Research output: Contribution to journalArticle

Transplants
Stromal Cells
Restoration
stromal cells
B-Lymphocytes
11 Citations (Scopus)

ARID5B regulates metabolic programming in human adaptive NK cells

Cichocki, F. M., Wu, C-Y., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., Bryceson, Y. T. & Miller, J. S., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2379-2395 17 p.

Research output: Contribution to journalArticle

Open Access
Natural Killer Cells
Mitochondrial Membrane Potential
Electron Transport
Cytomegalovirus
Chromatin
1 Citation (Scopus)

Association between recipient TNF rs361525 and acute GVHD: results from analysis of BMT CTN-0201 samples

Rashidi, A., Shanley, R. M., Yohe, S. L., Thyagarajan, B., Curtsinger, J. M., Anasetti, C., Waller, E. K., Miller, J. S., Blazar, B. R. & Weisdorf, D. J., Aug 1 2018, In : Bone Marrow Transplantation. 53, 8, p. 1069-1071 3 p.

Research output: Contribution to journalLetter

trans-crotonin
10 Citations (Scopus)

B-cell targeting in chronic graft-versus-host disease

Zeiser, R., Sarantopoulos, S. & Blazar, B. R., Mar 29 2018, In : Blood. 131, 13, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Grafts
B-Lymphocytes
Cells
Physicians
4 Citations (Scopus)

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: Randomized phase II results

Koreth, J., Kim, H. T., Lange, P. B., Poryanda, S. J., Reynolds, C. G., Chamling Rai, S., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Yusuf, R., Nikiforow, S., Chen, Y. B., Dey, B., McMasters, M., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Feb 28 2018, In : Haematologica. 103, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Tacrolimus
Graft vs Host Disease
Immunosuppression
Methotrexate

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans

Verghese, D. A., Chun, N., Paz, K., Fribourg, M., Woodruff, T. M., Flynn, R. P., Hu, Y., Xiong, H., Zhang, W., Yi, Z., Du, J., Blazar, B. R. & Heeger, P. S., Dec 20 2018, In : JCI Insight. 3, 24

Research output: Contribution to journalArticle

Bronchiolitis Obliterans
Graft vs Host Disease
Germinal Center
B-Lymphocytes
T-Lymphocytes
5 Citations (Scopus)

CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

Watkins, B. K., Tkachev, V., Furlan, S. N., Hunt, D. J., Betz, K., Yu, A., Brown, M., Poirier, N., Zheng, H. B., Taraseviciute, A., Colonna, L., Mary, C., Blancho, G., Soulillou, J. P., Panoskaltsis-Mortari, A., Sharma, P., Garcia, A., Strobert, E., Hamby, K., Garrett, A. & 4 others, Deane, T., Blazar, B. R., Vanhove, B. & Kean, L. S., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3991-4007 17 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Sirolimus
Primates
T-Lymphocytes
Stem Cell Transplantation
35 Citations (Scopus)

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A., Tkachev, V., Ponce, R., Turtle, C. J., Snyder, J. M., Liggitt, H. D., Myerson, D., Gonzalez-Cuyar, L., Baldessari, A., English, C., Yu, A., Zheng, H., Furlan, S. N., Hunt, D. J., Hoglund, V., Finney, O., Brakke, H., Blazar, B. R., Berger, C., Riddell, S. R. & 3 others, Gardner, R., Kean, L. S. & Jensen, M. C., Jun 1 2018, In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

Antigen Receptors
Primates
Neurotoxicity Syndromes
T-Cell Antigen Receptor
CD20 Antigens
16 Citations (Scopus)

Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect

Felices, M., Lenvik, A. J., Mc Elmurry, R. T., Chu, S., Hinderlie, P., Bendzick, L., Geller, M. A., Tolar, J., Blazar, B. R. & Miller, J. S., Feb 8 2018, In : JCI Insight. 3, 3

Research output: Contribution to journalArticle

Open Access
Interleukin-15
Natural Killer Cells
Therapeutics
cdc Genes
Fatty Acids

Corrections: B cells drive autoimmunity in mice with CD28-deficient regulatory T cells (Journal of Immunology (2017) 199 (3972-3980) DOI: 10.4049/jimmunol.1700409)

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A., Apr 1 2018, In : Journal of Immunology. 200, 7, p. 2505-2506 2 p.

Research output: Contribution to journalComment/debate

Open Access
Regulatory T-Lymphocytes
Allergy and Immunology
Autoimmunity
B-Lymphocytes
5 Citations (Scopus)

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W. E., Feser, C. J., Tschann, M., Mc Elmurry, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J., Apr 1 2018, In : International journal of molecular sciences. 19, 4, 946.

Research output: Contribution to journalArticle

Cell Engineering
genes
Genes
engineering
T-cells