Find Research Outputs

Search concepts
Selected Filters
2019
11 Citations (Scopus)

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Aug 8 2019, In : Nature. 572, 7768, p. 254-259 6 p.

Research output: Contribution to journalLetter

Immune Evasion
Acute Myeloid Leukemia
Leukemia
Stem Cells
Ligands
1 Citation (Scopus)

Achievement of tolerance induction to prevent acute graft-vs.-host disease

Thangavelu, G. & Blazar, B. R., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 309.

Research output: Contribution to journalReview article

Open Access
Immune Tolerance
Hematopoietic Stem Cell Transplantation
Immunosuppressive Agents
Transplants
Therapeutics
1 Citation (Scopus)

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Paul, J., Nakasone, H., Sahaf, B., Wu, F., Wang, K., Ho, V., Wu, J., Kim, H., Blazar, B., Ritz, J., Howard, A., Cutler, C. & Miklos, D., Jun 30 2019, In : Haematologica. 104, 7, p. e314-e317

Research output: Contribution to journalArticle

Open Access
Cell Transplantation
Graft vs Host Disease
H-Y antibody
2 Citations (Scopus)

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernández, J. A., Xu, X., Griffin, J. H. & Blazar, B. R., Aug 29 2019, In : Blood. 134, 9, p. 776-781 6 p.

Research output: Contribution to journalArticle

PAR-1 Receptor
Cell signaling
T-cells
Graft vs Host Disease
Protein C
6 Citations (Scopus)

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
Natural Killer Cells
Cytomegalovirus
Transplants
Hematologic Neoplasms
Hematopoietic Stem Cells
1 Citation (Scopus)
Graft vs Host Disease
Ulcerative Colitis
Epidermal Growth Factor Receptor
Epidermal Growth Factor
Colitis

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Mar 1 2019, In : Bone marrow transplantation. 54, 3, p. 490-493 4 p.

Research output: Contribution to journalLetter

trans-crotonin
1 Citation (Scopus)

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
Lysosphingolipid Receptors
Endothelial Cells
T-Lymphocytes
Cell Movement
Vascular Cell Adhesion Molecule-1
6 Citations (Scopus)

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function

Boroughs, A. C., Larson, R. C., Choi, B. D., Bouffard, A. A., Riley, L. S., Schiferle, E., Kulkarni, A. S., Cetrulo, C. L., Ting, D., Blazar, B. R., Demehri, S. & Maus, M. V., Jan 1 2019, In : JCI Insight. 4, 8, e126194.

Research output: Contribution to journalArticle

Open Access
Antigen Receptors
Regulatory T-Lymphocytes
Antigens
Peripheral Tolerance
T-Lymphocytes
1 Citation (Scopus)

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Merino, A., Zhang, B., Dougherty, P., Luo, X., Wang, J., Blazar, B. R., Miller, J. S. & Cichocki, F., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3770-3785 16 p.

Research output: Contribution to journalArticle

Open Access
Epigenomics
Natural Killer Cells
NK Cell Lectin-Like Receptor Subfamily C
Genome
T-Lymphocytes

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., Gandhi, S., West, L. J., Piret, J. M., Blazar, B. R. & Levings, M. K., Dec 2019, In : Cytotherapy. 21, 12, p. 1216-1233 18 p.

Research output: Contribution to journalArticle

Cryopreservation
Regulatory T-Lymphocytes
Cell- and Tissue-Based Therapy
Antigen-Presenting Cells
Antibodies
1 Citation (Scopus)

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C., Loschi, M., Thangavelu, G., Ma, L., Zaiken, M., Dysthe, J., Krepps, W., Panthera, J., Hippen, K., Jameson, S. C., Miller, J. S., Cooper, M. A., Farady, C. J., Iwawaki, T., Ting, J. P. Y., Serody, J. S., Murphy, W. J., Hill, G. R. & 5 others, Murray, P. J., Bronte, V., Munn, D. H., Zeiser, R. & Blazar, B. R., Nov 7 2019, In : Blood. 134, 19, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

Inflammasomes
Graft vs Host Disease
Interleukin-1
Grafts
Adenosine Triphosphate
1 Citation (Scopus)

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

Retinal Dehydrogenase
Aldehyde Dehydrogenase
Graft vs Host Disease
Tretinoin
Dendritic Cells

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
T-cells
Deoxyglucose
T-Lymphocyte Subsets
Regulatory T-Lymphocytes
T-lymphocytes
1 Citation (Scopus)

Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node

Simon, T., Li, L., Wagner, C., Zhang, T., Saxena, V., Brinkman, C. C., Tostanoski, L. H., Ostrand-Rosenberg, S., Jewell, C., Shea-Donohue, T., Hippen, K. L., Blazar, B. R., Abdi, R. & Bromberg, J. S., Oct 1 2019, In : Transplantation. 103, 10, p. 2075-2089 15 p.

Research output: Contribution to journalArticle

Laminin
Immunity
Lymph Nodes
T-Lymphocytes
Dystroglycans

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., Jan 1 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
T-Lymphocytes
Mortality
Metabolic Networks and Pathways
Oxygen Consumption

Dose-escalated interleukin-2 therapy for refractory chronic graft-versus-host disease in adults and children

Whangbo, J. S., Kim, H. T., Mirkovic, N., Leonard, L., Poryanda, S., Silverstein, S., Kim, S., Reynolds, C. G., Rai, S. C., Verrill, K., Lee, M. A., Margossian, S., Duncan, C., Lehmann, L., Huang, J., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T. & 5 others, Blazar, B. R., Antin, J. H., Soiffer, R. J., Ritz, J. & Koreth, J., Sep 10 2019, In : Blood Advances. 3, 17, p. 2550-2561 12 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Interleukin-2
Maximum Tolerated Dose
Therapeutics
Pediatrics
Cell Transplantation
Graft vs Host Disease
Morbidity
Recurrence
Survival

Early E. Casseliflavus gut colonization and outcomes of allogeneic hematopoietic cell transplantation

Rashidi, A., Ebadi, M., Shields-Cutler, R. R., Kruziki, K., Manias, D. A., Barnes, A. M. T., DeFor, T. E., Ferrieri, P., Young, J. A. H., Knights, D., Blazar, B. R., Weisdorf, D. J. & Dunny, G. M., Jan 1 2019, In : PloS one. 14, 8, e0220850.

Research output: Contribution to journalArticle

Open Access
cell transplantation
Cell Transplantation
Tryptophan
Agar
Transplants
1 Citation (Scopus)

Early notch signals induce a pathogenic molecular signature during priming of alloantigen-specific conventional CD4+ T cells in graft-versus-host disease

Chung, J., Radojcic, V., Perkey, E., Parnell, T. J., Niknafs, Y., Jin, X., Friedman, A., Labrecque, N., Blazar, B. R., Brennan, T. V., Siebel, C. W. & Maillard, I., Jan 1 2019, In : Journal of Immunology. 203, 2, p. 557-568 12 p.

Research output: Contribution to journalArticle

Isoantigens
Graft vs Host Disease
T-Lymphocytes
T-Cell Leukemia
myc Genes
3 Citations (Scopus)

Efficacy and immunologic effects of extracorporeal photopheresis plus interleukin-2 in chronic graft-versus-host disease

Belizaire, R., Kim, H. T., Poryanda, S. J., Mirkovic, N. V., Hipolito, E., Savage, W. J., Reynolds, C. G., Fields, M. J., Whangbo, J., Kubo, T., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Blazar, B. R., Antin, J. H., Ritz, J., Soiffer, R. J. & Koreth, J., Apr 9 2019, In : Blood Advances. 3, 7, p. 969-979 11 p.

Research output: Contribution to journalArticle

Open Access
Photopheresis
Graft vs Host Disease
Interleukin-2
Regulatory T-Lymphocytes
Natural Killer Cells
2 Citations (Scopus)

First-in-human trial of rhIL-15 and haploidentical natural killer cell therapy for advanced acute myeloid leukemia

Cooley, S., He, F., Bachanova, V., Vercellotti, G. M., DeFor, T. E., Curtsinger, J. M., Robertson, P., Grzywacz, B., Conlon, K. C., Waldmann, T. A., McKenna, D. H., Blazar, B. R., Weisdorf, D. J. & Miller, J. S., Jan 1 2019, In : Blood Advances. 3, 13, p. 1970-1980 11 p.

Research output: Contribution to journalArticle

Open Access
Interleukin-15
Cell- and Tissue-Based Therapy
Acute Myeloid Leukemia
Natural Killer Cells
Cytokines
5 Citations (Scopus)

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Clement, R. L., Daccache, J., Mohammed, M. T., Diallo, A., Blazar, B. R., Kuchroo, V. K., Lovitch, S. B., Sharpe, A. H. & Sage, P. T., Oct 1 2019, In : Nature immunology. 20, 10, p. 1360-1371 12 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Humoral Immunity
B-Lymphocytes
Immunoglobulin E
Pyroglyphidae
4 Citations (Scopus)

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Hou, S., Clement, R. L., Diallo, A., Blazar, B. R., Rudensky, A. Y., Sharpe, A. H. & Sage, P. T., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 605-620 16 p.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Antibody Formation
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Chromatin

Generation and function of progenitor t cells from stemregenin-1-expanded CD34+ human hematopoietic progenitor cells

Singh, J., Chen, E. L. Y., Xing, Y., Stefanski, H. E., Blazar, B. R. & Zúñiga-Pflücker, J. C., Jan 1 2019, In : Blood Advances. 3, 20, p. 2934-2948 15 p.

Research output: Contribution to journalArticle

Open Access
Hematopoietic Stem Cells
Stem Cells
T-Lymphocytes
Fetal Blood
Hematopoietic Stem Cell Transplantation

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Disease

Blazar, B. R., Feb 1 2019, In : Engineering. 5, 1, p. 98-105 8 p.

Research output: Contribution to journalReview article

Cytology
Grafts
T-cells
Bearings (structural)
Cells
3 Citations (Scopus)

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vetizou, M., Kuns, R. D., Robb, R. J., Zhang, P., Blazar, B. R., Thomas, R., Begun, J., Waddell, N., Trinchieri, G., Zeiser, R., Clouston, A. D., Degli-Esposti, M. A. & Hill, G. R., Nov 19 2019, In : Immunity. 51, 5, p. 885-898.e7

Research output: Contribution to journalArticle

Microbiota
Histocompatibility Antigens Class II
Antigen Presentation
Graft vs Host Disease
Intestinal Mucosa
Cell Transplantation
Monocytes
Survival
Transplants
Fetal Blood
1 Citation (Scopus)
Graft vs Host Disease
Steroids
Mycophenolic Acid
Survival
Mortality
36 Citations (Scopus)

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Wang, Z., Aguilar, E. G., Luna, J. I., Dunai, C., Khuat, L. T., Le, C. T., Mirsoian, A., Minnar, C. M., Stoffel, K. M., Sturgill, I. R., Grossenbacher, S. K., Withers, S. S., Rebhun, R. B., Hartigan-O’Connor, D. J., Méndez-Lagares, G., Tarantal, A. F., Isseroff, R. R., Griffith, T. S., Schalper, K. A., Merleev, A. & 13 others, Saha, A., Maverakis, E., Kelly, K., Aljumaily, R., Ibrahimi, S., Mukherjee, S., Machiorlatti, M., Vesely, S. K., Longo, D. L., Blazar, B. R., Canter, R. J., Murphy, W. J. & Monjazeb, A. M., Jan 1 2019, In : Nature Medicine. 25, 1, p. 141-151 11 p.

Research output: Contribution to journalArticle

Open Access
T-cells
Tumors
Obesity
T-Lymphocytes
Neoplasms
2 Citations (Scopus)

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Klein Geltink, R. I., Kyle, R. L., Caputa, G., O'Sullivan, D., Cameron, A. M., Castoldi, A., Musa, Y., Kabat, A. M., Zhang, Y., Flachsmann, L. J., Field, C. S., Patterson, A. E., Scherer, S., Alfei, F., Baixauli, F., Austin, S. K., Kelly, B., Matsushita, M. & 17 others, Curtis, J. D., Grzes, K. M., Villa, M., Corrado, M., Sanin, D. E., Qiu, J., Pällman, N., Paz, K., Maccari, M. E., Blazar, B. R., Mittler, G., Buescher, J. M., Zehn, D., Rospert, S., Pearce, E. J., Balabanov, S. & Pearce, E. L., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 352-363.e8

Research output: Contribution to journalArticle

Open Access
Eukaryotic Initiation Factors
Macrophage Activation
Polyamines
Respiration
Oxidative Phosphorylation

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, (2019), 10.1038/s41586-019-1410-1)

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Jan 1 2019, In : Nature. 572, 7770, p. E19

Research output: Contribution to journalComment/debate

Open Access
Immune Evasion
Leukemia
Stem Cells
Ligands
1 Citation (Scopus)
Open Access
Hematologic Neoplasms
Allografts
Graft vs Host Disease
Cell Transplantation
Transplants

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways

Ni, X., Xia, Y., Zhou, S., Peng, H., Wu, X., Lu, H., Wang, H., Liu, R., Blazar, B. R., Gu, J. & Lu, L., Jan 1 2019, In : Cell Death and Disease. 10, 1, 13.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Mesenchymal Stromal Cells
Th17 Cells
Autoimmune Diseases
1 Citation (Scopus)

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease

Yang, J., Ramadan, A., Reichenbach, D. K., Loschi, M., Zhang, J., Griesenauer, B., Liu, H., Hippen, K. L., Blazar, B. R. & Paczesny, S., Mar 7 2019, In : JCI Insight. 4, 5

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Regulatory T-Lymphocytes
T-Lymphocytes
Cell Transplantation
Transplantation
1 Citation (Scopus)

Salmonella-mediated therapy targeting indoleamine 2, 3-dioxygenase 1 (IDO) activates innate immunity and mitigates colorectal cancer growth

Phan, T., Nguyen, V. H., D’Alincourt, M. S., Manuel, E. R., Kaltcheva, T., Tsai, W., Blazar, B. R., Diamond, D. J. & Melstrom, L. G., Jan 1 2019, In : Cancer gene therapy.

Research output: Contribution to journalArticle

Indoleamine-Pyrrole 2,3,-Dioxygenase
Innate Immunity
Salmonella
Colorectal Neoplasms
Growth
1 Citation (Scopus)

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

Leung, W. H., Gay, J., Martin, U., Garrett, T. E., Horton, H. M., Certo, M. T., Blazar, B. R., Morgan, R. A., Gregory, P. D., Jarjour, J. & Astrakhan, A., Jun 6 2019, In : JCI insight. 4, 11, e124430.

Research output: Contribution to journalArticle

Open Access
Antigen Receptors
Dimerization
T-Cell Antigen Receptor
Pharmacology
Sirolimus
4 Citations (Scopus)

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Qi, J., Luznik, L., Maillard, I., MacDonald, K. P., Hill, G. R., Serody, J. S., Murphy, W. J., Sage, P. T., Sharpe, A. H., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H., Soiffer, R. J., Ritz, J., Bradner, J. E., Melnick, A. M. & 1 others, Blazar, B. R., Jan 3 2019, In : Blood. 133, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

Open Access
B-Cell Lymphoma
Graft vs Host Disease
Grafts
Germinal Center
Transplants
Open Access
Graft vs Host Disease
Macrophages
Steroids
Aryl Hydrocarbon Receptors
Ligands

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C. J., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

1-Phosphatidylinositol 4-Kinase
Graft vs Host Disease
Germinal Center
Bronchiolitis Obliterans
B-Lymphocytes
7 Citations (Scopus)

The lineage stability and suppressive program of regulatory T cells require protein O-GlcNAcylation

Liu, B., Salgado, O. C., Singh, S., Hippen, K. L., Maynard, J. C., Burlingame, A. L., Ball, L. E., Blazar, B. R., Farrar, M. A., Hogquist, K. A. & Ruan, H. B., Dec 1 2019, In : Nature communications. 10, 1, 354.

Research output: Contribution to journalArticle

T-cells
Regulatory T-Lymphocytes
proteins
effectors
T-Cell Antigen Receptor
5 Citations (Scopus)

TRAF6 directs FOXP3 localization and facilitates regulatory T-cell function through K63-linked ubiquitination

Ni, X., Kou, W., Gu, J., Wei, P., Wu, X., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., Park, B. V., Chen, Z., Tian, Y., Fu, J., Newman, S., Wang, X., Shen, H., Li, B., Blazar, B. R., Wang, X. & 3 others, Barbi, J., Pan, F. & Lu, L., May 2 2019, In : EMBO Journal. 38, 9, e99766.

Research output: Contribution to journalArticle

Open Access
TNF Receptor-Associated Factor 6
T-cells
Ubiquitination
Regulatory T-Lymphocytes
Tumors
10 Citations (Scopus)

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S. P., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V. & Masopust, D., Dec 1 2019, In : Nature communications. 10, 1, 567.

Research output: Contribution to journalArticle

T-cells
viruses
Viruses
Immunotherapy
Tumors
2018
10 Citations (Scopus)

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

Sarhan, D. A., Brandt, L., Felices, M., Guldevall, K., Lenvik, T. R., Hinderlie, P., Curtsinger, J. M., Warlick, E. D., Spellman, S. R., Blazar, B. R., Weisdorf, D. J., Cooley, S. A., Vallera, D. A., Onfelt, B. & Miller, J. S., Jun 26 2018, In : Blood Advances. 2, 12, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Open Access
Myelodysplastic Syndromes
Natural Killer Cells
Interleukin-15
Myeloid-Derived Suppressor Cells
Hematopoiesis
12 Citations (Scopus)

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H., Bommiasamy, H., Paz, K., Wilkinson, A. N., Owen, M., Reichenbach, D. K., Banovic, T., Wehner, K., Buchanan, F., Varelias, A., Kuns, R. D., Chang, K., Fedoriw, Y., Shea, T., Coghill, J., Zaiken, M., Plank, M. W., Foster, P. S., Clouston, A. D., Blazar, B. R. & 2 others, Serody, J. S. & Hill, G. R., Apr 2018, In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Tissue Donors
Skin
Interleukin-17
Stem Cell Transplantation
25 Citations (Scopus)

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming
3 Citations (Scopus)

Acute Graft-versus-Host Disease

Zeiser, R. & Blazar, B. R., Feb 8 2018, In : The New England journal of medicine. 378, 6, 1 p.

Research output: Contribution to journalLetter

Graft vs Host Disease
12 Citations (Scopus)

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T., Curtsinger, J., Davis, Z., Zhang, B., Cooley, S., Cichocki, F., Blazar, B. R. & Miller, J. S., Jul 2018, In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Open Access
Regulatory T-Lymphocytes
Natural Killer Cells
Natural Killer Cell Receptors
Tumor Microenvironment
Programmed Cell Death 1 Receptor
5 Citations (Scopus)

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Open Access
Oxidative Stress
Cell Death
T-Lymphocytes
Adoptive Immunotherapy
Neoplasms
3 Citations (Scopus)

Amphiregulin modifies the Minnesota acute graft-versus-host disease risk score: Results from BMT CTN 0302/0802

Holtan, S. G., DeFor, T. E., Panoskaltsis-Mortari, A., Khera, N., Levine, J. E., Flowers, M. E. D., Lee, S. J., Inamoto, Y., Chen, G. L., Mayer, S., Arora, M., Palmer, J., Cutler, C. S., Arai, S., Lazaryan, A., Newell, L. F., Jagasia, M. H., Pusic, I., Wood, W. A., Renteria, A. S. & 17 others, Yanik, G., Hogan, W. J., Hexner, E., Ayuk, F., Holler, E., Bunworasate, U., Efebera, Y. A., Ferrara, J. L. M., Pidala, J., Howard, A., Wu, J., Bolaños-Meade, J., Ho, V., Alousi, A., Blazar, B. R., Weisdorf, D. J. & MacMillan, M. L., Aug 14 2018, In : Blood Advances. 2, 15, p. 1882-1888 7 p.

Research output: Contribution to journalArticle

Open Access
Graft vs Host Disease
Survival
Mortality
Intestinal Mucosa
trans-crotonin