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2019

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Bruce, D. J., Peterson, C. D., Kitto, K. F., Akgün, E., Lazzaroni, S., Portoghese, P. S., Fairbanks, C. A. & Wilcox, G. L., Sep 1 2019, In : Anesthesiology. 131, 3, p. 649-663 15 p.

Research output: Contribution to journalArticle

Loperamide
Opioid Receptors
Analgesics
Opioid Analgesics
Analgesia
2 Citations (Scopus)
Opioid Receptors
Neuroglia
Astrocytes
Neurons
Analgesics
1 Citation (Scopus)

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. R., Portoghese, P. S., Rice, K. C., Watkins, L. R., Hutchinson, M. R. & Wang, X., Aug 1 2019, In : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 8, p. 9577-9587 11 p.

Research output: Contribution to journalArticle

Stereochemistry
Toll-Like Receptor 4
Naltrexone
Proteins
Stereoselectivity

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Shueb, S. S., Erb, S. J., Lunzer, M. M., Speltz, R., Harding-Rose, C., Akgün, E., Simone, D. A. & Portoghese, P. S., Dec 1 2019, In : Neuropharmacology. 160, 107690.

Research output: Contribution to journalArticle

Bone Neoplasms
Opioid Analgesics
Calcaneus
Inbred C3H Mouse
Fibrosarcoma
Hyperalgesia
Neuralgia
Peripheral Nervous System Diseases
Reward
Cisplatin
2018
3 Citations (Scopus)
Open Access
mu Opioid Receptor
Arthritis
Opioid Analgesics
Pain
Morphine
5 Citations (Scopus)
Open Access
Nociception
Sickle Cell Anemia
Ligands
Pain
Morphine
2017
10 Citations (Scopus)
Open Access
Metabotropic Glutamate 5 Receptor
Oxymorphone
mu Opioid Receptor
Neuralgia
Ligands
12 Citations (Scopus)

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese, P. S., Akgun, E. & Lunzer, M. M., Mar 15 2017, In : ACS Chemical Neuroscience. 8, 3, p. 426-428 3 p.

Research output: Contribution to journalArticle

Pharmacology
Ligands
Opioid Receptors
Opioid Analgesics
2016

Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice

Angelis, E. M. G. D., Abdelhamid, R. E., Nunez, M. G., Kissel, C. L., Kovács, K. J., Portoghese, P. S. & Larson, A. A., Aug 19 2016, In : Pain. 157, 11, p. 2561-2570 10 p.

Research output: Contribution to journalArticle

Brown Adipose Tissue
Hyperalgesia
Thermogenesis
Rose Bengal
Adrenergic Agonists
2015
27 Citations (Scopus)

Inhibition of inflammatory and neuropathic pain by targeting a Mu opioid receptor/chemokine receptor5 heteromer (MOR-CCR5)

Akgun, E., Javed, M. I., Lunzer, M. M., Powers, M. D., Sham, Y. Y., Watanabe, Y. & Portoghese, P. S., Nov 12 2015, In : Journal of Medicinal Chemistry. 58, 21, p. 8647-8657 11 p.

Research output: Contribution to journalArticle

mu Opioid Receptor
Neuralgia
Chemokines
Chronic Pain
Morphine