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  • Paul D Robbins

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis–like symptoms in NOD mice

Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J. & Robbins, P. D., Aug 1 2019, In : FASEB Journal. 33, 8, p. 9505-9515 11 p.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
6 Scopus citations

Age-dependent changes i n i ntervertebral di sc cell mi tochondri a and bi oenergeti cs

Hartman, R., Patil, P., Tisherman, R., St. Croix, C., Niedernhofer, L. J., Robbins, P. D., Ambrosio, F., Van Houten, B., Sowa, G. & Vo, N., Jan 1 2018, In : European Cells and Materials. 36, p. 171-183 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : STEM CELLS. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Arthritis Gene Therapy: A Brief History and Perspective

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 2015, Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., p. 85-98 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Arthritis Gene Therapy Approved in Korea

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 15 2018, In : Journal of the American Academy of Orthopaedic Surgeons. 26, 2, p. e36-e38

Research output: Contribution to journalArticle

6 Scopus citations

Arthritis gene therapy is becoming a reality

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jul 1 2018, In : Nature Reviews Rheumatology. 14, 7, p. 381-382 2 p.

Research output: Contribution to journalComment/debate

7 Scopus citations

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Cell-type specific penetrating peptides: Therapeutic promises and challenges

Zahid, M. & Robbins, P. D., Jul 1 2015, In : Molecules. 20, 7, p. 13055-13070 16 p.

Research output: Contribution to journalReview article

34 Scopus citations

Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., Gil, J., Hara, E., Krizhanovsky, V., Jurk, D., Maier, A. B., Narita, M., Niedernhofer, L., Passos, J. F., Robbins, P. D., Schmitt, C. A. & 6 others, Sedivy, J., Vougas, K., von Zglinicki, T., Zhou, D., Serrano, M. & Demaria, M., Oct 31 2019, In : Cell. 179, 4, p. 813-827 15 p.

Research output: Contribution to journalReview article

53 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

Open Access
288 Scopus citations

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans

Yousefzadeh, M. J., Schafer, M. J., Noren Hooten, N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K. & Niedernhofer, L. J., Apr 2018, In : Aging cell. 17, 2, e12706.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

D-amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity

Reay, D. P., Bastacky, S. I., Wack, K. E., Stolz, D. B., Robbins, P. D. & Clemens, P. R., Jan 1 2015, In : Molecular Medicine. 21, p. 442-452 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L. J., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A. & Barzilai, N., Dec 1 2018, In : Cardiovascular Endocrinology and Metabolism. 7, 4, p. 80-83 4 p.

Research output: Contribution to journalReview article

13 Scopus citations

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D. P., McGowan, S. J., Corbo, L., Clemens, P. R., Wilson, G. M., Watkins, S. C., Solt, L. A., Cameron, M. D., Huard, J., Niedernhofer, L. J., Kamenecka, T. M. & Robbins, P. D., Jun 2018, In : PLoS biology. 16, 6, e2004663.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., Croix, C. M. S., Niedernhofer, L. J. & Gill, M. S., Sep 2018, In : Redox Biology. 18, p. 191-199 9 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R. W., Boccuzzi, L., Robbins, P. D. & Ricordi, C., Jun 1 2017, In : European review for medical and pharmacological sciences. 21, 12, p. 2940-2956 17 p.

Research output: Contribution to journalReview article

27 Scopus citations

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Extracellular vesicles and aging

Robbins, P. D., Dec 1 2017, In : Stem Cell Investigation. 4, 12, 98.

Research output: Contribution to journalReview article

Open Access
17 Scopus citations

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Nogueira-Recalde, U., Lorenzo-Gómez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Domínguez, E. & Caramés, B., Jul 2019, In : EBioMedicine. 45, p. 588-605 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

Open Access
71 Scopus citations

Gene Delivery to Joints by Intra-Articular Injection

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 2018, In : Human gene therapy. 29, 1, p. 2-14 13 p.

Research output: Contribution to journalReview article

Open Access
23 Scopus citations

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, H., Niedernhofer, L. J. & Robbins, P. D., May 3 2018, In : Cell Cycle. 17, 9, p. 1048-1055 8 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., Jun 1 2016, In : Aging cell. 15, 3, p. 428-435 8 p.

Research output: Contribution to journalArticle

Open Access
219 Scopus citations

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature communications. 8, 1, 422.

Research output: Contribution to journalArticle

Open Access
126 Scopus citations

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

Flores, R. R., Kim, E., Zhou, L., Yang, C., Zhao, J., Gambotto, A. & Robbins, P. D., Nov 1 2015, In : European Journal of Immunology. 45, 11, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

Proto, J. D., Lu, A., Dorronsoro, A., Scibetta, A., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jun 2017, In : PloS one. 12, 6, e0179270.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Measuring biological age in mice using differential mass spectrometry

Bell-Temin, H., Yousefzadeh, M. J., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J. & Yates, N. A., Jan 1 2019, In : Aging. 11, 3, p. 1045-1061 17 p.

Research output: Contribution to journalArticle

Open Access

Methods to quantify the NF-κB pathway during senescence

Zhang, L., Zhao, J., Gurkar, A., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 231-250 20 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., Jan 1 2018, In : Journal of Extracellular Vesicles. 7, 1, 1535750.

Research output: Contribution to journalArticle

Open Access
648 Scopus citations

Mouse models of accelerated cellular senescence

Yousefzadeh, M., Melos, K. I., Angelini, L., Burd, C. E., Robbins, P. D. & Niedernhofer, L. J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 203-230 28 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jul 2017, In : Journal of Orthopaedic Research. 35, 7, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Murine models of accelerated aging and musculoskeletal disease

Hambright, W. S., Niedernhofer, L. J., Huard, J. & Robbins, P. D., Aug 2019, In : Bone. 125, p. 122-127 6 p.

Research output: Contribution to journalArticle

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., Jan 1 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
118 Scopus citations

NF-κB activation with aging: Characterization and therapeutic inhibition

Zhao, J., Li, X., McGowan, S., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 543-557 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Proto, J. D., Tang, Y., Lu, A., Chen, W. C. W., Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. & Huard, J., Apr 23 2015, In : Cell Death and Disease. 6, 4, e1730.

Research output: Contribution to journalArticle

20 Scopus citations

Nuclear Genomic Instability and Aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J. & Robbins, P. D., Jun 20 2018, In : Annual Review of Biochemistry. 87, p. 295-322 28 p.

Research output: Contribution to journalReview article

19 Scopus citations

Oxidative stress-induced senescence markedly increases disc cell bioenergetics

Patil, P., Falabella, M., Saeed, A., Lee, D., Kaufman, B., Shiva, S., Croix, C. S., Van Houten, B., Niedernhofer, L. J., Robbins, P. D., Lee, J., Gwendolyn, S. & Vo, N. V., Jun 2019, In : Mechanisms of Ageing and Development. 180, p. 97-106 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Garcia-Contreras, M., Shah, S. H., Tamayo, A., Robbins, P. D., Golberg, R. B., Mendez, A. J. & Ricordi, C., Dec 1 2017, In : Scientific reports. 7, 1, 5998.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Quantitative analysis of cellular senescence in culture and in Vivo

Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D. B., St. Croix, C. M., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2017, In : Current protocols in cytometry. 2017, p. 9.51.1-9.51.25

Research output: Contribution to journalArticle

6 Scopus citations

Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem/Progenitor Cells from Progeroid Mice

Kawakami, Y., Hambright, W. S., Takayama, K., Mu, X., Lu, A., Cummins, J. H., Matsumoto, T., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Sep 13 2019, In : Molecular Therapy - Methods and Clinical Development. 14, p. 64-76 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins, P. D., Dorronsoro, A. & Booker, C. N., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1173-1180 8 p.

Research output: Contribution to journalReview article

Open Access
93 Scopus citations

Sa-β-galactosidase-based screening assay for the identification of senotherapeutic drugs

Fuhrmann-Stroissnigg, H., Santiago, F. E., Grassi, D., Ling, Y. Y., Niedernhofer, L. J. & Robbins, P. D., Jun 2019, In : Journal of Visualized Experiments. 2019, 148, e58133.

Research output: Contribution to journalArticle

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

Ngo, K., Patil, P., McGowan, S. J., Niedernhofer, L. J., Robbins, P. D., Kang, J., Sowa, G. & Vo, N., Sep 2017, In : Mechanisms of Ageing and Development. 166, p. 16-23 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Open Access
260 Scopus citations

Senotherapeutics for healthy ageing

Niedernhofer, L. J. & Robbins, P. D., Apr 27 2018, In : Nature Reviews Drug Discovery. 17, 5, 1 p.

Research output: Contribution to journalLetter

Open Access
19 Scopus citations

Signal transduction, ageing and disease

Zhang, L., Yousefzadeh, M. J., Suh, Y., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Subcellular Biochemistry. Springer New York, p. 227-247 21 p. (Subcellular Biochemistry; vol. 91).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Northen, T. R., Robbins, P. D., Niedernhofer, L. J., Lairson, L., Benton, H. P. & Siuzdak, G., Oct 4 2016, In : Analytical chemistry. 88, 19, p. 9753-9758 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations