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2019

Measuring biological age in mice using differential mass spectrometry

Bell-Temin, H., Yousefzadeh, M., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J. & Yates, N. A., Jan 1 2019, In : Aging. 11, 3, p. 1045-1061 17 p.

Research output: Contribution to journalArticle

Open Access
Mass Spectrometry
Sirolimus
Inbred C57BL Mouse
Proteomics
Mammals

Methods to quantify the NF-κB pathway during senescence

Zhang, L., Zhao, J., Gurkar, A., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 231-250 20 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

RNA
In Situ Hybridization
Cell Aging
Adaptive Immunity
Innate Immunity

Mouse models of accelerated cellular senescence

Yousefzadeh, M., Melos, K. I., Angelini, L., Burd, C. E., Robbins, P. D. & Niedernhofer, L. J., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 203-230 28 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cell Aging
Age of Onset
Vertebrates
Regeneration
Phenotype

Murine models of accelerated aging and musculoskeletal disease

Hambright, W. S., Niedernhofer, L. J., Huard, J. & Robbins, P. D., Aug 1 2019, In : Bone. 125, p. 122-127 6 p.

Research output: Contribution to journalArticle

Musculoskeletal Diseases
Pathology
Sarcopenia
Age of Onset
Osteoarthritis

Oxidative stress-induced senescence markedly increases disc cell bioenergetics

Patil, P., Falabella, M., Saeed, A., Lee, D., Kaufman, B., Shiva, S., Croix, C. S., Van Houten, B., Niedernhofer, L. J., Robbins, P. D., Lee, J., Gwendolyn, S. & Vo, N. V., Jun 1 2019, In : Mechanisms of Ageing and Development. 180, p. 97-106 10 p.

Research output: Contribution to journalArticle

Energy Metabolism
Cell Aging
Oxidative Stress
Phenotype
Intervertebral Disc Degeneration

Signal transduction, ageing and disease

Zhang, L., Yousefzadeh, M., Suh, Y., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Subcellular Biochemistry. Springer New York, p. 227-247 21 p. (Subcellular Biochemistry; vol. 91).

Research output: Chapter in Book/Report/Conference proceedingChapter

Signal transduction
Signal Transduction
Aging of materials
Tissue homeostasis
Sirtuins

Systemic clearance of p16INK4a-positive senescent cells mitigates age-associated intervertebral disc degeneration

Patil, P., Dong, Q., Wang, D., Chang, J., Wiley, C., Demaria, M., Lee, J., Kang, J., Niedernhofer, L. J., Robbins, P. D., Sowa, G., Campisi, J., Zhou, D. & Vo, N., Jun 1 2019, In : Aging cell. 18, 3, e12927.

Research output: Contribution to journalArticle

Open Access
Intervertebral Disc Degeneration
Cell Aging
Aggrecans
Peptide Hydrolases
Ganciclovir
2018

Age-dependent changes i n i ntervertebral di sc cell mi tochondri a and bi oenergeti cs

Hartman, R., Patil, P., Tisherman, R., St. Croix, C., Niedernhofer, L. J., Robbins, P. D., Ambrosio, F., Van Houten, B., Sowa, G. & Vo, N., Jan 1 2018, In : European Cells and Materials. 36, p. 171-183 13 p.

Research output: Contribution to journalArticle

Open Access
Energy Metabolism
Intervertebral Disc Degeneration
Aging of materials
Respiration
Tissue
5 Citations (Scopus)

Arthritis Gene Therapy Approved in Korea

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 15 2018, In : Journal of the American Academy of Orthopaedic Surgeons. 26, 2, p. e36-e38

Research output: Contribution to journalArticle

Korea
Genetic Therapy
Arthritis
Cartilage
6 Citations (Scopus)

Arthritis gene therapy is becoming a reality

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jul 1 2018, In : Nature Reviews Rheumatology. 14, 7, p. 381-382 2 p.

Research output: Contribution to journalComment/debate

Genetic Therapy
Arthritis
11 Citations (Scopus)

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans

Yousefzadeh, M., Schafer, M. J., Noren Hooten, N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K. & Niedernhofer, L. J., Apr 1 2018, In : Aging cell. 17, 2, e12706.

Research output: Contribution to journalArticle

Open Access
Chemokine CCL2
Biomarkers
Progeria
Genetic Engineering
Aortic Valve Stenosis

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L. J., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A. & Barzilai, N., Dec 1 2018, In : Cardiovascular Endocrinology and Metabolism. 7, 4, p. 80-83 4 p.

Research output: Contribution to journalReview article

Clinical Trials
Metformin
Age of Onset
Animal Models
Biomarkers
5 Citations (Scopus)

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D. P., McGowan, S. J., Corbo, L., Clemens, P. R., Wilson, G. M., Watkins, S. C., Solt, L. A., Cameron, M. D., Huard, J., Niedernhofer, L. J., Kamenecka, T. M. & Robbins, P. D., Jun 1 2018, In : PLoS biology. 16, 6, e2004663.

Research output: Contribution to journalArticle

Open Access
IKappaB kinase
Modulators
Lipopolysaccharides
Chemical activation
Duchenne Muscular Dystrophy
2 Citations (Scopus)

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., Croix, C. M. S., Niedernhofer, L. J. & Gill, M. S., Sep 1 2018, In : Redox Biology. 18, p. 191-199 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Damage
Aging of materials
Chemical activation
DNA
Oxidative stress
27 Citations (Scopus)

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 1 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

Open Access
Flavonoids
Health
Tissue
Aging of materials
Adipose Tissue
15 Citations (Scopus)

Gene Delivery to Joints by Intra-Articular Injection

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 2018, In : Human gene therapy. 29, 1, p. 2-14 13 p.

Research output: Contribution to journalReview article

Open Access
Intra-Articular Injections
Joints
Osteoarthritis
Dependovirus
Chondrocytes
4 Citations (Scopus)

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, H., Niedernhofer, L. J. & Robbins, P. D., May 3 2018, In : Cell Cycle. 17, 9, p. 1048-1055 8 p.

Research output: Contribution to journalReview article

Open Access
Pharmaceutical Preparations
Cell Aging
Chronic Disease
Inflammation
Phenotype
167 Citations (Scopus)

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., Jan 1 2018, In : Journal of Extracellular Vesicles. 7, 1, 1535750.

Research output: Contribution to journalArticle

Open Access
Guidelines
Exosomes
Cell-Derived Microparticles
Extracellular Vesicles
Checklist
4 Citations (Scopus)

Nuclear Genomic Instability and Aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J. & Robbins, P. D., Jun 20 2018, In : Annual Review of Biochemistry. 87, p. 295-322 28 p.

Research output: Contribution to journalReview article

Genomic Instability
DNA Damage
Aging of materials
DNA
Mammals
132 Citations (Scopus)

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Open Access
Health
Tissue
Cell Aging
Quercetin
Pathology
14 Citations (Scopus)

Senotherapeutics for healthy ageing

Niedernhofer, L. J. & Robbins, P. D., Apr 27 2018, In : Nature Reviews Drug Discovery. 17, 5, 1 p.

Research output: Contribution to journalLetter

11 Citations (Scopus)

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 1 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

DNA Damage
Oxidation-Reduction
Genes
Aging of materials
Genome

Treating age-related diseases with somatic stem cells

Brooks, R. W. & Robbins, P. D., Jan 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 29-45 17 p. (Advances in Experimental Medicine and Biology; vol. 1056).

Research output: Chapter in Book/Report/Conference proceedingChapter

Adult Stem Cells
Stem cells
Stem Cells
Aging of materials
Tissue homeostasis
2017
2 Citations (Scopus)

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Intervertebral Disc Degeneration
Aggrecans
Smoke
Tobacco
Smoking
3 Citations (Scopus)
Free Radical Scavengers
Stem Cell Factor
Metformin
Drug Delivery Systems
NAD
187 Citations (Scopus)

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

fibrosis
Pulmonary diseases
Cell Aging
Idiopathic Pulmonary Fibrosis
Lung Diseases
15 Citations (Scopus)

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R. W., Boccuzzi, L., Robbins, P. D. & Ricordi, C., Jun 1 2017, In : European review for medical and pharmacological sciences. 21, 12, p. 2940-2956 17 p.

Research output: Contribution to journalReview article

Exosomes
Type 1 Diabetes Mellitus
Biomarkers
Disease Progression
Early Diagnosis
16 Citations (Scopus)

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 1 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
Cell Aging
Bone Marrow
Intervertebral Disc Degeneration
Myeloid-Derived Suppressor Cells
Inbred C57BL Mouse
10 Citations (Scopus)

Extracellular vesicles and aging

Robbins, P. D., Dec 1 2017, In : Stem Cell Investigation. 4, 12, 98.

Research output: Contribution to journalReview article

Regeneration
Homeostasis
Stem Cells
Parabiosis
Extracellular Vesicles
78 Citations (Scopus)

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature communications. 8, 1, 422.

Research output: Contribution to journalArticle

Open Access
inhibitors
drugs
Aging of materials
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
mice
1 Citation (Scopus)

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

Proto, J. D., Lu, A., Dorronsoro, A., Scibetta, A., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jun 1 2017, In : PloS one. 12, 6, e0179270.

Research output: Contribution to journalArticle

Stem cells
stress tolerance
Muscle
stem cells
Stem Cells
8 Citations (Scopus)

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jul 1 2017, In : Journal of Orthopaedic Research. 35, 7, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
Sirolimus
Stem Cells
Muscles
DNA Damage
Autophagy
76 Citations (Scopus)

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., Jan 1 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
flavone
Human Umbilical Vein Endothelial Cells
Apoptosis
Quercetin
fisetin
23 Citations (Scopus)

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Garcia-Contreras, M., Shah, S. H., Tamayo, A., Robbins, P. D., Golberg, R. B., Mendez, A. J. & Ricordi, C., Dec 1 2017, In : Scientific Reports. 7, 1, 5998.

Research output: Contribution to journalArticle

Open Access
Exosomes
MicroRNAs
Type 1 Diabetes Mellitus
Multivesicular Bodies
Transmission Electron Microscopy
5 Citations (Scopus)

Quantitative analysis of cellular senescence in culture and in Vivo

Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D. B., St. Croix, C. M., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2017, In : Current Protocols in Cytometry. 2017, p. 9.51.1-9.51.25

Research output: Contribution to journalArticle

Cell Aging
Cells
Galactosidases
Biomarkers
Matrix Metalloproteinases
5 Citations (Scopus)

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

Ngo, K., Patil, P., McGowan, S. J., Niedernhofer, L. J., Robbins, P. D., Kang, J., Sowa, G. & Vo, N., Sep 1 2017, In : Mechanisms of Ageing and Development. 166, p. 16-23 8 p.

Research output: Contribution to journalArticle

Intervertebral Disc
Proteoglycans
Homeostasis
Phenotype
Cell Aging
44 Citations (Scopus)

Systems biology guided by XCMS Online metabolomics

Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., Aisporna, A., Hilmers, B., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Robbins, P. D., Niedernhofer, L. J., Ideker, T., Majumder, E. L., Wall, J. D., Rattray, N. J. W. & 3 others, Goodacre, R., Lairson, L. L. & Siuzdak, G., Apr 27 2017, In : Nature Methods. 14, 5, p. 461-462 2 p.

Research output: Contribution to journalLetter

Open Access
79 Citations (Scopus)

The Clinical Potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. & Robbins, P. D., Oct 1 2017, In : Journal of the American Geriatrics Society. 65, 10, p. 2297-2301 5 p.

Research output: Contribution to journalArticle

Open Access
Pharmaceutical Preparations
Clinical Trials
Geriatrics
Vascular Calcification
Intervertebral Disc Degeneration
2016
4 Citations (Scopus)

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : Stem Cells. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Arsenic
Muscle Cells
Stem Cells
Fibroblasts
Muscles
9 Citations (Scopus)

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Research
Research Personnel
Pharmaceutical Preparations
Drug Discovery
Therapeutics
162 Citations (Scopus)

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., Jun 1 2016, In : Aging cell. 15, 3, p. 428-435 8 p.

Research output: Contribution to journalArticle

Umbilical Veins
Epithelial Cells
Quercetin
Computational Biology
Fibroblasts
72 Citations (Scopus)

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins, P. D., Dorronsoro, A. & Booker, C. N., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1173-1180 8 p.

Research output: Contribution to journalReview article

Multivesicular Bodies
MicroRNAs
Autoimmunity
Cell Communication
Nucleic Acids
8 Citations (Scopus)

Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Northen, T. R., Robbins, P. D., Niedernhofer, L. J., Lairson, L., Benton, H. P. & Siuzdak, G., Oct 4 2016, In : Analytical chemistry. 88, 19, p. 9753-9758 6 p.

Research output: Contribution to journalArticle

Smartphones
Mobile devices
Screening
Visualization
Cluster analysis
2015
30 Citations (Scopus)

Cell-type specific penetrating peptides: Therapeutic promises and challenges

Zahid, M. & Robbins, P. D., Jul 1 2015, In : Molecules. 20, 7, p. 13055-13070 16 p.

Research output: Contribution to journalReview article

Cell-Penetrating Peptides
peptides
Peptides
cells
Therapeutics
1 Citation (Scopus)

D-amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity

Reay, D. P., Bastacky, S. I., Wack, K. E., Stolz, D. B., Robbins, P. D. & Clemens, P. R., Jan 1 2015, In : Molecular Medicine. 21, p. 442-452 11 p.

Research output: Contribution to journalArticle

Inbred mdx Mouse
Amino Acid Substitution
Skeletal Muscle
Protein Isoforms
Kidney
9 Citations (Scopus)

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

Flores, R. R., Kim, E., Zhou, L., Yang, C., Zhao, J., Gambotto, A. & Robbins, P. D., Nov 1 2015, In : European Journal of Immunology. 45, 11, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

Inbred NOD Mouse
Interleukin-12
Type 1 Diabetes Mellitus
Cytokines
Interleukin-27
7 Citations (Scopus)

NF-κB activation with aging: Characterization and therapeutic inhibition

Zhao, J., Li, X., McGowan, S., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 543-557 15 p.

Research output: Contribution to journalArticle

Therapeutics
DNA Damage
Carrier Proteins
Oxidative Stress
Homeostasis
18 Citations (Scopus)

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Proto, J. D., Tang, Y., Lu, A., Chen, W. C. W., Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. & Huard, J., Apr 23 2015, In : Cell Death and Disease. 6, 4, e1730.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Skeletal Muscle
Duchenne Muscular Dystrophy
Stem Cells
Muscles
375 Citations (Scopus)

The Achilles' heel of senescent cells: from transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., LaRusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B. & 13 others, McGowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., Aug 1 2015, In : Aging cell. 14, 4, p. 644-658 15 p.

Research output: Contribution to journalArticle

Transcriptome
Pharmaceutical Preparations
Quercetin
Transgenic Suicide Genes
Ephrins