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  • Stephen S Hecht
Article
Open Access
13 Scopus citations

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
8 Scopus citations
Open Access
2 Scopus citations
10 Scopus citations

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 2017, In : PloS one. 12, 5, e0178435.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L., Jan 1 2015, In : American journal of epidemiology. 182, 11, p. 945-951 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers

Yuan, J. M., Stepanov, I., Murphy, S. E., Wang, R., Allen, S., Jensen, J., Strayer, L., Adams-Haduch, J., Upadhyaya, P., Le, C., Kurzer, M. S., Nelson, H. H., Yu, M. C., Hatsukami, D. & Hecht, S. S., May 2016, In : Cancer Prevention Research. 9, 5, p. 396-405 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
10 Scopus citations

Combined analysis of the tobacco metabolites cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine

Kotandeniya, D., Carmella, S. G., Ming, X., Murphy, S. E. & Hecht, S. S., Feb 3 2015, In : Analytical chemistry. 87, 3, p. 1514-1517 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Goniewicz, M. L., Smith, D. M., Edwards, K. C., Blount, B. C., Caldwell, K. L., Feng, J., Wang, L., Christensen, C., Ambrose, B., Borek, N., van Bemmel, D., Konkel, K., Erives, G., Stanton, C. A., Lambert, E., Kimmel, H. L., Hatsukami, D., Hecht, S. S., Niaura, R. S., Travers, M. & 2 others, Lawrence, C. & Hyland, A. J., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185937

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Narayanapillai, S. C., Von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

Zarth, A. T., Upadhyaya, P., Yang, J. & Hecht, S. S., Mar 21 2016, In : Chemical research in toxicology. 29, 3, p. 380-389 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., Al'Absi, M., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J. S., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. G., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home

Hecht, S. S., Koh, W. P., Wang, R., Chen, M., Carmella, S. G., Murphy, S. E. & Yuan, J. M., Mar 25 2015, In : PloS one. 10, 3, e0120023.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Dec 19 2016, In : Chemical research in toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers

Hecht, S. S., Carmella, S. G., Kotandeniya, D., Pillsbury, M. E., Chen, M., Ransom, B. W. S., Vogel, R. I., Thompson, E., Murphy, S. E. & Hatsukami, D. K., Jan 1 2015, In : Nicotine and Tobacco Research. 17, 6, p. 704-709 6 p.

Research output: Contribution to journalArticle

118 Scopus citations

Evidence supporting product standards for carcinogens in smokeless tobacco products

Hatsukami, D. K., Stepanov, I., Severson, H., Jensen, J. A., Lindgren, B. R., Horn, K., Khariwala, S. S., Martin, J., Carmella, S. G., Murphy, S. E. & Hecht, S. S., Jan 1 2015, In : Cancer Prevention Research. 8, 1, p. 20-26 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
47 Scopus citations
19 Scopus citations

GRAS 27 flavoring substances

Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Marnett, L. J., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., McGowen, M. M., Harman, C. L. & Taylor, S. V., Aug 2015, Food Technology, 69, 8.

Research output: Contribution to specialist publicationArticle

6 Scopus citations

Harnessing the power of cruciferous vegetables: Developing a biomarker for brassica vegetable consumption using urinary 3,3'-diindolylmethane

Fujioka, N., Ransom, B. W., Carmella, S. G., Upadhyaya, P., Lindgren, B. R., Roper-Batker, A., Hatsukami, D. K., Fritz, V. A., Rohwer, C. & Hecht, S. S., Oct 2016, In : Cancer Prevention Research. 9, 10, p. 788-793 6 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
Open Access
7 Scopus citations
Open Access
Open Access
7 Scopus citations
Open Access
9 Scopus citations
Open Access

Mercapturic acids derived from the toxicants acrolein and crotonaldehyde in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Park, S. L., Carmella, S. G., Chen, M., Patel, Y., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 8 2015, In : PloS one. 10, 6, e0124841.

Research output: Contribution to journalArticle

25 Scopus citations

Metabolites of the polycyclic aromatic hydrocarbon phenanthrene in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Patel, Y. M., Park, S. L., Carmella, S. G., Paiano, V., Olvera, N., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 1 2016, In : PloS one. 11, 6, e0156203.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
Open Access
1 Scopus citations
Open Access
10 Scopus citations

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of medicinal chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Polycyclic Aromatic Hydrocarbon Biomarker Levels among Smokers who Switch to Oral Nicotine

Meier, E., Vogel, R. I., Carmella, S., Paiano, V., Hecht, S. & Hatsukami, D., Apr 1 2017, In : Tobacco Regulatory Science. 3, 2, p. 204-209

Research output: Contribution to journalArticle

Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease

Zabala, V., Tong, M., Yu, R., Ramirez, T., Yalcin, E. B., Balbo, S., Silbermann, E., Deochand, C., Nunez, K., Hecht, S. & de la Monte, S. M., Jan 1 2015, In : Alcohol and Alcoholism. 50, 2, p. 118-131 14 p.

Research output: Contribution to journalArticle

21 Scopus citations
Open Access
8 Scopus citations

Quantitative analysis of 3'-hydroxynorcotinine in human urine

Upadhyaya, P. & Hecht, S. S., May 1 2015, In : Nicotine and Tobacco Research. 17, 5, p. 524-529 6 p.

Research output: Contribution to journalArticle

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

Hatsukami, D. K., Severson, H., Anderson, A., Vogel, R. I., Jensen, J., Broadbent, B., Murphy, S. E., Carmella, S. G. & Hecht, S. S., May 2016, In : Tobacco control. 25, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Randomized trial of reduced-nicotine standards for cigarettes

Donny, E. C., Denlinger, R. L., Tidey, J. W., Koopmeiners, J. S., Benowitz, N. L., Vandrey, R. G., Al'Absi, M., Carmella, S. G., Cinciripini, P. M., Dermody, S. S., Drobes, D. J., Hecht, S. S., Jensen, J., Lane, T., Le, C. T., McClernon, F. J., Montoya, I. D., Murphy, S. E., Robinson, J. D., Stitzer, M. L. & 3 others, Strasser, A. A., Tindle, H. & Hatsukami, D. K., Oct 1 2015, In : New England Journal of Medicine. 373, 14, p. 1340-1349 10 p.

Research output: Contribution to journalArticle

142 Scopus citations

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS3 Adductomic Approach

Stornetta, A., Villalta, P. W., Hecht, S. S., Sturla, S. J. & Balbo, S., Oct 28 2015, In : Analytical chemistry. 87, 23, p. 11706-11713 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
8 Scopus citations