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2018
4 Citations

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H. , Bommiasamy, H. , Paz, K. , Wilkinson, A. N. , Owen, M. , Reichenbach, D. K. , Banovic, T. , Wehner, K. , Buchanan, F. , Varelias, A. , Kuns, R. D. , Chang, K. , Fedoriw, Y. , Shea, T. , Coghill, J. , Zaiken, M. , Plank, M. W. , Foster, P. S. , Clouston, A. D. , Blazar, B. R. & 2 others Serody, J. S. & Hill, G. R. Apr 1 2018 In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tissue Donors
Skin
Interleukin-17
Stem Cell Transplantation
2 Citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H. Jan 16 2018 In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming

Acute Graft-versus-Host Disease

Zeiser, R. & Blazar, B. R. Feb 8 2018 In : The New England journal of medicine. 378, 6, 1 p.

Research output: Contribution to journalLetter

Graft vs Host Disease

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T., Curtsinger, J., Davis, Z., Zhang, B., Cooley, S., Cichocki, F., Blazar, B. R. & Miller, J. S. Jul 1 2018 In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Natural Killer Cells
Natural Killer Cell Receptors
Tumor Microenvironment
Programmed Cell Death 1 Receptor

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G. Jan 1 2018 (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
Tumor Necrosis Factor-alpha
T-Lymphocytes
Adoptive Immunotherapy
1 Citations

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L., Goren, E., Mulé, J. J. & Blazar, B. R. Apr 1 2018 In : PLoS ONE. 13, 4, e0193461

Research output: Contribution to journalArticle

Stromal Cells
stromal cells
B-Lymphocytes
T-lymphocytes
Lymph Nodes

Association between recipient TNF rs361525 and acute GVHD: results from analysis of BMT CTN-0201 samples

Rashidi, A., Shanley, R., Yohe, S. L., Thyagarajan, B., Curtsinger, J., Anasetti, C., Waller, E. K., Miller, J. S., Blazar, B. R. & Weisdorf, D. J. Aug 1 2018 In : Bone Marrow Transplantation. 53, 8, p. 1069-1071 3 p.

Research output: Contribution to journalLetter

trans-crotonin
1 Citations

B-cell targeting in chronic graft-versus-host disease

Zeiser, R., Sarantopoulos, S. & Blazar, B. R. Mar 29 2018 In : Blood. 131, 13, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
B-Lymphocytes
Physicians
Therapeutics
1 Citations

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: Randomized phase II results

Koreth, J., Kim, H. T., Lange, P. B., Poryanda, S. J., Reynolds, C. G., Chamling Rai, S., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Yusuf, R., Nikiforow, S., Chen, Y. B., Dey, B., McMasters, M., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P. Feb 28 2018 In : Haematologica. 103, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Tacrolimus
Graft vs Host Disease
Immunosuppression
Methotrexate
2 Citations

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A. , Tkachev, V. , Ponce, R. , Turtle, C. J. , Snyder, J. M. , Liggitt, H. D. , Myerson, D. , Gonzalez-Cuyar, L. , Baldessari, A. , English, C. , Yu, A. , Zheng, H. , Furlan, S. N. , Hunt, D. J. , Hoglund, V. , Finney, O. , Brakke, H. , Blazar, B. R. , Berger, C. , Riddell, S. R. & 3 others Gardner, R., Kean, L. S. & Jensen, M. C. Jun 1 2018 In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Primates
Antigen Receptors
Neurotoxicity Syndromes
Cytokines

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W., Feser, C. J., Tschann, M., McElmury, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J. Apr 1 2018 In : International Journal of Molecular Sciences. 19, 4, 946

Research output: Contribution to journalArticle

Cell Engineering
genes
Genes
engineering
T-cells

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Stefanski, H. E., Xing, Y., Taylor, P. A., Maio, S., Henao-Meija, J., Williams, A., Flavell, R. A., Hollander, G. A. & Blazar, B. R. Jun 1 2018 In : PLoS ONE. 13, 6, e0198871

Research output: Contribution to journalArticle

epithelial cells
Epithelial Cells
thymocytes
Thymocytes
T-lymphocytes
2 Citations
Follistatin
Bone Marrow
Tissue Donors
Clinical Trials
Transplants
1 Citations

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Hippen, K. L., Loschi, M., Nicholls, J., MacDonald, K. P. A. & Blazar, B. R. Jan 31 2018 In : Frontiers in Immunology. 9, JAN, 57

Research output: Contribution to journalShort survey

Graft vs Host Disease
Regulatory T-Lymphocytes
MicroRNAs
Knockout Mice
Long Noncoding RNA
3 Citations

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

Romee, R. , Cooley, S. , Berrien-Elliott, M. M. , Westervelt, P. , Verneris, M. R. , Wagner, J. E. , Weisdorf, D. J. , Blazar, B. R. , Ustun, C. , DeFor, T. E. , Vivek, S. , Peck, L. , DiPersio, J. F. , Cashen, A. F. , Kyllo, R. , Musiek, A. , Schaffer, A. , Anadkat, M. J. , Rosman, I. , Miller, D. & 6 others Egan, J. O., Jeng, E. K., Rock, A., Wong, H. C., Fehniger, T. A. & Miller, J. S. Jun 7 2018 In : Blood. 131, 23, p. 2515-2527 13 p.

Research output: Contribution to journalArticle

Interleukin-15
Transplantation
Recurrence
Natural Killer Cells
Cell Transplantation
Natural Killer Cells
Non-Hodgkin's Lymphoma
Tissue Donors
Interleukin-15
Immunosuppressive Agents
2 Citations

Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice

Pennell, C. A., Barnum, J. L., McDonald-Hyman, C. S., Panoskaltsis-Mortari, A., Riddle, M. J., Xiong, Z., Loschi, M., Thangavelu, G., Campbell, H. M., Storlie, M. D., Refaeli, Y., Furlan, S. N., Jensen, M. C., Kean, L. S., Miller, J. S., Tolar, J., Osborn, M. J. & Blazar, B. R. Jun 6 2018 In : Molecular Therapy. 26, 6, p. 1423-1434 12 p.

Research output: Contribution to journalArticle

Transgenic Mice
B-Lymphocytes
T-Lymphocytes
T-Cell Antigen Receptor
Cell- and Tissue-Based Therapy

Identification of cellular sources of IL-2 needed for regulatory T cell development and homeostasis

Owen, D. L., Mahmud, S. A., Vang, K. B., Kelly, R. M., Blazar, B. R., Smith, K. A. & Farrar, M. A. Jun 15 2018 In : Journal of Immunology. 200, 12, p. 3926-3933 8 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Interleukin-2
Homeostasis
Dendritic Cells
Interleukin-15

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

Blazar, B. R., MacDonald, K. P. A. & Hill, G. R. Jun 14 2018 In : Blood. 131, 24, p. 2651-2660 10 p.

Research output: Contribution to journalReview article

Slip forming
Graft vs Host Disease
Transplants
Therapeutics
Natural Killer T-Cells

Maintenance of CD4 T cell fitness through regulation of Foxo1

Newton, R. H., Shrestha, S., Sullivan, J. M., Yates, K. B., Compeer, E. B., Ron-Harel, N., Blazar, B. R., Bensinger, S. J., Haining, W. N., Dustin, M. L., Campbell, D. J., Chi, H. & Turka, L. A. Jul 9 2018 (Accepted/In press) In : Nature immunology. p. 1-11 11 p.

Research output: Contribution to journalArticle

Maintenance
T-Lymphocytes
Transcription Factors
Cell Division
Immunological Synapses

MicroRNA-155 modulates acute graft-versus-host disease by impacting T cell expansion, migration, and effector function

Zitzer, N. C., Snyder, K., Meng, X., Taylor, P. A., Efebera, Y. A., Devine, S. M., Blazar, B. R., Garzon, R. & Ranganathan, P. Jun 15 2018 In : Journal of Immunology. 200, 12, p. 4170-4179 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
MicroRNAs
Cell Movement
T-Lymphocytes
Acute Disease

MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice

Wu, Y., Schutt, S., Paz, K., Zhang, M., Flynn, R. P., Bastian, D., Hanief Sofi, M., Nguyen, H., Dai, M., Liu, C., Chang, Y. J., Blazar, B. R. & Yu, X. Z. Apr 26 2018 In : Blood. 131, 17, p. 1974-1986 13 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
MicroRNAs
Virulence
B-Lymphocytes
T-Lymphocytes

Minimum information about T regulatory cells: A step toward reproducibility and standardization

Fuchs, A. , Gliwinski, M. , Grageda, N. , Spiering, R. , Abbas, A. K. , Appel, S. , Bacchetta, R. , Battaglia, M. , Berglund, D. , Blazar, B. , Bluestone, J. A. , Bornhäuser, M. , Brinke, A. T. , Brusko, T. M. , Cools, N. , Cuturi, M. C. , Geissler, E. , Giannoukakis, N. , Golab, K. , Hafler, D. A. & 41 others van Ham, S. M., Hester, J., Hippen, K., Di Ianni, M., Ilic, N., Isaacs, J., Issa, F., Iwaszkiewicz-Grzes, D., Jaeckel, E., Joosten, I., Klatzmann, D., Koenen, H., Kooten, C. V., Korsgren, O., Kretschmer, K., Levings, M., Marek-Trzonkowska, N. M., Martinez-Llordella, M., Miljkovic, D., Mills, K. H. G., Miranda, J. P., Piccirillo, C. A., Putnam, A. L., Ritter, T., Roncarolo, M. G., Sakaguchi, S., Sánchez-Ramón, S., Sawitzki, B., Sofronic-Milosavljevic, L., Sykes, M., Tang, Q., Vives-Pi, M., Waldmann, H., Witkowski, P., Wood, K. J., Gregori, S., Hilkens, C. M. U., Lombardi, G., Lord, P., Martinez-Caceres, E. M. & Trzonkowski, P. Jan 15 2018 In : Frontiers in Immunology. 8, JAN, 1844

Research output: Contribution to journalArticle

Immune Tolerance
Regulatory T-Lymphocytes
Cell- and Tissue-Based Therapy
Immunotherapy
Antigen-Presenting Cells

MiR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg) article

Zhang, C., Shen, H., Lu, Y., Gao, J., Zhang, S., Gu, J., Lu, H., Xia, Y., Zhu, Q., Qian, X., Zhang, F., Hippen, K. L., Blazar, B. R., Lu, L. & Wang, X. Mar 1 2018 In : Cell Death and Disease. 9, 3, 290

Research output: Contribution to journalArticle

Autophagy
Regulatory T-Lymphocytes
Graft vs Host Disease
Autoimmune Diseases
Cell Survival
3 Citations

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients

Du, J., Flynn, R., Paz, K., Ren, H. G., Ogata, Y., Zhang, Q., Gafken, P. R., Storer, B. E., Roy, N. H., Burkhardt, J. K., Mathews, W., Tolar, J., Lee, S. J., Blazar, B. R. & Paczesny, S. Apr 12 2018 In : Blood. 131, 15, p. 1743-1754 12 p.

Research output: Contribution to journalArticle

Delta wing aircraft
Graft vs Host Disease
Proteome
Biomarkers
Proteomics
1 Citations

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset

Hülsdünker, J., Ottmüller, K. J., Neeff, H. P., Koyama, M., Gao, Z., Thomas, O. S., Follo, M., Al-Ahmad, A., Prinz, G., Duquesne, S., Dierbach, H., Kirschnek, S., Lämmermann, T., Blaser, M. J., Fife, B. T., Blazar, B. R., Beilhack, A., Hill, G. R., Häcker, G. & Zeiser, R. Apr 19 2018 In : Blood. 131, 16, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

Slip forming
Pinch effect
Ring lasers
Graft vs Host Disease
Ileum
1 Citations

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Prestipino, A. , Emhardt, A. J. , Aumann, K. , O'Sullivan, D. , Gorantla, S. P. , Duquesne, S. , Melchinger, W. , Braun, L. , Vuckovic, S. , Boerries, M. , Busch, H. , Halbach, S. , Pennisi, S. , Poggio, T. , Apostolova, P. , Veratti, P. , Hettich, M. , Niedermann, G. , Bartholomä, M. , Shoumariyeh, K. & 29 others Jutzi, J. S., Wehrle, J., Dierks, C., Becker, H., Schmitt-Graeff, A., Follo, M., Pfeifer, D., Rohr, J., Fuchs, S., Ehl, S., Hartl, F. A., Minguet, S., Miething, C., Heidel, F. H., Kröger, N., Triviai, I., Brummer, T., Finke, J., Illert, A. L., Ruggiero, E., Bonini, C., Duyster, J., Pahl, H. L., Lane, S. W., Hill, G. R., Blazar, B. R., Von Bubnoff, N., Pearce, E. L. & Zeiser, R. Feb 21 2018 In : Science Translational Medicine. 10, 429, eaam7729

Research output: Contribution to journalArticle

Janus Kinase 2
Ligands
Death Domain Receptors
Neoplasms
STAT3 Transcription Factor

Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: Analysis of BMT CTN-0201 and -0901 samples

Rashidi, A., Shanley, R., Yohe, S. L., Thyagarajan, B., Curtsinger, J., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J. Jan 1 2018 (Accepted/In press) In : British journal of haematology.

Research output: Contribution to journalArticle

Paneth Cells
Graft vs Host Disease
Single Nucleotide Polymorphism
Bone Marrow
Clinical Trials
2 Citations

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Mathew, N. R. , Baumgartner, F. , Braun, L. , O'Sullivan, D. , Thomas, S. , Waterhouse, M. , Müller, T. A. , Hanke, K. , Taromi, S. , Apostolova, P. , Illert, A. L. , Melchinger, W. , Duquesne, S. , Schmitt-Graeff, A. , Osswald, L. , Yan, K. L. , Weber, A. , Tugues, S. , Spath, S. , Pfeifer, D. & 110 others Follo, M., Claus, R., Lübbert, M., Rummelt, C., Bertz, H., Wäsch, R., Haag, J., Schmidts, A., Schultheiss, M., Bettinger, D., Thimme, R., Ullrich, E., Tanriver, Y., Vuong, G. L., Arnold, R., Hemmati, P., Wolf, D., Ditschkowski, M., Jilg, C., Wilhelm, K., Leiber, C., Gerull, S., Halter, J., Lengerke, C., Pabst, T., Schroeder, T., Kobbe, G., Rösler, W., Doostkam, S., Meckel, S., Stabla, K., Metzelder, S. K., Halbach, S., Brummer, T., Hu, Z., Dengjel, J., Hackanson, B., Schmid, C., Holtick, U., Scheid, C., Spyridonidis, A., Stölzel, F., Ordemann, R., Müller, L. P., Sicre-De-Fontbrune, F., Ihorst, G., Kuball, J., Ehlert, J. E., Feger, D., Wagner, E. M., Cahn, J. Y., Schnell, J., Kuchenbauer, F., Bunjes, D., Chakraverty, R., Richardson, S., Gill, S., Kröger, N., Ayuk, F., Vago, L., Ciceri, F., Müller, A. M., Kondo, T., Teshima, T., Klaeger, S., Kuster, B., Kim, D. H., Weisdorf, D., Van Der Velden, W., Dörfel, D., Bethge, W., Hilgendorf, I., Hochhaus, A., Andrieux, G., Börries, M., Busch, H., Magenau, J., Reddy, P., Labopin, M., Antin, J. H., Henden, A. S., Hill, G. R., Kennedy, G. A., Bar, M., Sarma, A., McLornan, D., Mufti, G., Oran, B., Rezvani, K., Shah, O., Negrin, R. S., Nagler, A., Prinz, M., Burchert, A., Neubauer, A., Beelen, D., Mackensen, A., Von Bubnoff, N., Herr, W., Becher, B., Socié, G., Caligiuri, M. A., Ruggiero, E., Bonini, C., Häcker, G., Duyster, J., Finke, J., Pearce, E., Blazar, B. R. & Zeiser, R. Mar 1 2018 In : Nature medicine. 24, 3, p. 282-291 10 p.

Research output: Contribution to journalArticle

Interleukin-15
Interferon Regulatory Factor-7
Leukemia
Transplants
Acute Myeloid Leukemia
1 Citations

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

Borges Da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., Hippen, K. L., Blazar, B. R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K. A. & Jameson, S. C. Jul 12 2018 In : Nature. 559, 7713, p. 264-268 5 p.

Research output: Contribution to journalArticle

Purinergic Receptors
T-Lymphocytes
Adenosine Triphosphate
Immune System
Immunologic Memory
2017
18 Citations

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R. Nov 30 2017 In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Contribution to journalReview article

Transplantation Immunology
Animal Disease Models
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Acute Disease
14 Citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R. Apr 13 2017 In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Interleukin-17
Microbiota
Graft vs Host Disease
Grafts
Interleukin-17 Receptors
8 Citations

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Kean, L. S., Turka, L. A. & Blazar, B. R. Mar 1 2017 In : Immunological Reviews. 276, 1, p. 192-212 21 p.

Research output: Contribution to journalReview article

Yin-Yang
Immunotherapy
Transplantation
T-Lymphocytes
Neoplasms
4 Citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C. Jan 10 2017 In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Bioluminescence
Zebrafish
Ergosterol
Imaging techniques
Firefly Luciferases
4 Citations

Alarmins and Their Receptors as Modulators and Indicators of Alloimmune Responses

Matta, B. M., Reichenbach, D. K., Blazar, B. R. & Turnquist, H. R. Feb 1 2017 In : American Journal of Transplantation. 17, 2, p. 320-327 8 p.

Research output: Contribution to journalReview article

Biomarkers
Alarmins
Transplants
Cell Transplantation
Homologous Transplantation
4 Citations

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Poe, J. C. , Jia, W. , Su, H. , Anand, S. , Rose, J. J. , Tata, P. V. , Suthers, A. N. , Jones, C. D. , Kuan, P. F. , Vincent, B. G. , Serody, J. S. , Horwitz, M. E. , Ho, V. T. , Pavletic, S. Z. , Hakim, F. T. , Owzar, K. , Zhang, D. , Blazar, B. R. , Siebel, C. W. , Chao, N. J. & 2 others Maillard, I. & Sarantopoulos, S. Nov 9 2017 In : Blood. 130, 19, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Grafts
Chemical activation
Graft vs Host Disease
2 Citations

Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology

Osborn, M. J., Webber, B. R., McElmurry, R. T., Rudser, K. D., DeFeo, A. P., Muradian, M., Petryk, A., Hallgrimsson, B., Blazar, B. R., Tolar, J. & Braunlin, E. A. Mar 1 2017 In : Journal of Inherited Metabolic Disease. 40, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Iduronidase
Mucopolysaccharidosis I
Angiotensin Receptors
Renin-Angiotensin System
Pathology

Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease

Wang, K. S., Kim, H. T., Nikiforow, S., Heubeck, A. T., Ho, V. T., Koreth, J., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Cutler, C. S. & Ritz, J. Dec 28 2017 In : Blood. 130, 26, p. 2889-2899 11 p.

Research output: Contribution to journalArticle

Fog dispersal
Delta wing aircraft
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Graft vs Host Disease
1 Citations

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S. Dec 1 2017 In : Scientific Reports. 7, 1, 1633

Research output: Contribution to journalArticle

Endothelial Cells
Chemotactic Factors
T-Lymphocytes
Cell Movement
Leukocytes
4 Citations

B cells drive autoimmunity in mice with CD28-deficient regulatory T cells

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A. Dec 15 2017 In : Journal of Immunology. 199, 12, p. 3972-3980 9 p.

Research output: Contribution to journalArticle

CD28 Antigens
Lymphopoiesis
Lymphocyte Depletion
CD4-Positive T-Lymphocytes
Specific Pathogen-Free Organisms
31 Citations

Chronic graft-versus-host disease: Biological insights from preclinical and clinical studies

MacDonald, K. P. A., Hill, G. R. & Blazar, B. R. Jan 5 2017 In : Blood. 129, 1, p. 13-21 9 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Grafts
T-cells
Isoantibodies
Macrophage Colony-Stimulating Factor
4 Citations

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S. Sep 20 2017 In : Science Translational Medicine. 9, 408, eaan3085

Research output: Contribution to journalArticle

Sirolimus
Graft vs Host Disease
T-Lymphocytes
Transplants
Th1 Cells
4 Citations

Cytokine mediators of chronic graft-versus-host disease

MacDonald, K. P. A., Blazar, B. R. & Hill, G. R. Jun 30 2017 In : Journal of Clinical Investigation. 127, 7, p. 2452-2463 12 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Germinal Center
Interleukin-17
Cytokines
B-Lymphocytes
1 Citations

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., Blazar, B. R., Borowsky, A. D., Monjazeb, A. M. & Murphy, W. J. Apr 18 2017 In : Journal for ImmunoTherapy of Cancer. 5, 1, 33

Research output: Contribution to journalArticle

Spleen
T-Lymphocytes
Phenotype
Therapeutics
Immunotherapy
4 Citations

Erythropoietin receptor-mediated molecular crosstalk promotes T cell immunoregulation and transplant survival

Purroy, C., Fairchild, R. L., Tanaka, T., Baldwin, W. M., Manrique, J., Madsen, J. C., Colvin, R. B., Alessandrini, A., Blazar, B. R., Fribourg, M., Donadei, C., Maggiore, U., Heeger, P. S. & Cravedi, P. Aug 1 2017 In : Journal of the American Society of Nephrology. 28, 8, p. 2377-2392 16 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
T-Lymphocytes
Transplants
Kidney
Antigen-Presenting Cells
8 Citations

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Chung, J. , Ebens, C. L. , Perkey, E. , Radojcic, V. , Koch, U. , Scarpellino, L. , Tong, A. , Allen, F. , Wood, S. , Feng, J. , Friedman, A. , Granadier, D. , Tran, I. T. , Chai, Q. , Onder, L. , Yan, M. , Reddy, P. , Blazar, B. R. , Huang, A. Y. , Brennan, T. V. & 6 others Bishop, D. K., Ludewig, B., Siebel, C. W., Radtke, F., Luther, S. A. & Maillard, I. Apr 3 2017 In : Journal of Clinical Investigation. 127, 4, p. 1574-1588 15 p.

Research output: Contribution to journalArticle

Homologous Transplantation
Ligands
Bone Marrow Transplantation
T-Lymphocytes
Graft vs Host Disease
7 Citations

GSK3 inhibition drives maturation of NK cells and enhances their antitumor activity

Cichocki, F. , Valamehr, B. , Bjordahl, R. , Zhang, B. , Rezner, B. , Rogers, P. , Gaidarova, S. , Moreno, S. , Tuininga, K. , Dougherty, P. , McCullar, V. , Howard, P. , Sarhan, D. , Taras, E. , Schlums, H. , Abbot, S. , Shoemaker, D. , Bryceson, Y. T. , Blazar, B. R. , Wolchko, S. & 2 others Cooley, S. & Miller, J. S. Oct 15 2017 In : Cancer Research. 77, 20, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Neoplasms
Phosphotransferases
Immunologic Monitoring
Interleukin-15
7 Citations

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Bunting, M. D., Varelias, A., Souza-Fonseca-Guimaraes, F., Schuster, I. S., Lineburg, K. E., Kuns, R. D., Fleming, P., Locke, K. R., Huntington, N. D., Blazar, B. R., Lane, S. W., Tey, S. K., MacDonald, K. P. A., Smyth, M. J., Degli-Esposti, M. A. & Hill, G. R. Feb 2 2017 In : Blood. 129, 5, p. 630-642 13 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Viruses
Innate Immunity
Grafts
Natural Killer Cells

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L. Dec 1 2017 In : Scientific Reports. 7, 1, 4258

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Protein Kinase C
Fetal Blood
Eragrostis
Immunological Synapses
13 Citations

Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

Miklos, D., Cutler, C. S., Arora, M., Waller, E. K., Jagasia, M., Pusic, I., Flowers, M. E., Logan, A. C., Nakamura, R., Blazar, B. R., Li, Y., Chang, S., Lal, I., Dubovsky, J., James, D. F., Styles, L. & Jaglowski, S. Nov 23 2017 In : Blood. 130, 21, p. 2243-2250 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Adrenal Cortex Hormones
Therapeutics
T-cells