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2018
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Body Fluids
Vegetables
Methanol
2017
Nitrosamines
Metabolism
Proteins
Cytochrome P-450 Enzyme System
Cytochromes
N'-nitrosonornicotine
Enantiomers
Liquid chromatography
Ionization
Mass spectrometry

A special issue of CRT: Celebrating volume 30

Hecht, S. S. Jan 1 2017 In : Chemical Research in Toxicology. 30, 1, 1 p.

Research output: Research - peer-reviewEditorial

Toxicology
1 Citations

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L. May 1 2017 In : PLoS ONE. 12, 5, e0178435

Research output: Research - peer-reviewArticle

nicotine
lung neoplasms
cohort studies
cytochrome P-450
incidence
2 Citations

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F. , Blount, B. C. , Jacob, P. , Saliba, N. A. , Bernert, J. T. , El Hellani, A. , Jatlow, P. , Pappas, R. S. , Wang, L. , Foulds, J. , Ghosh, A. , Hecht, S. S. , Gomez, J. C. , Martin, J. R. , Mesaros, C. , Srivastava, S. , St. Helen, G. , Tarran, R. , Lorkiewicz, P. K. , Blair, I. A. & 4 others Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A. Sep 1 2017 In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Research - peer-reviewArticle

Tobacco Products
Biomarkers
Research Personnel
Research
Tobacco Use
1 Citations

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E. Jan 1 2017 In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Research - peer-reviewArticle

Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
Squamous Cell Neoplasms
Mouth Neoplasms
Head and Neck Neoplasms
Carcinogens
DNA Damage
2 Citations
Deoxycytidine
Tobacco
Carcinogens
DNA
4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Urine
phenanthrene
Epoxy Compounds
2 Citations

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S. Jan 1 2017 In : Chemical Research in Toxicology. 30, 1, p. 367-375 9 p.

Research output: Research - peer-reviewReview article

DNA Adducts
Tobacco Products
Lung Neoplasms
Biomarkers
DNA

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C. Jan 1 2017 In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Research - peer-reviewArticle

Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M. Jan 1 2017 In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Research - peer-reviewArticle

Nicotine
Tobacco Products
Confidence Intervals
Smoking
Biomarkers
1 Citations

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V. Jan 1 2017 In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Research - peer-reviewReview article

thiophenes
flavorings
ingredients
metabolism
Thiophenes
2 Citations

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S. Apr 1 2017 In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Research - peer-reviewReview article

Tobacco
Child Health
Electronic Cigarettes
Smoke
Nicotine
2016
2 Citations
Smoke
Carcinogens
Tobacco
glutathione S-transferase T1
glutathione S-transferase M1
3 Citations
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Tissue
2 Citations

Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles

Farsalinos, K. E., Gillman, I. G., Hecht, S. S., Polosa, R. & Thornburg, J. Nov 14 2016 Elsevier Inc.150 p.

Research output: ResearchBook

Tobacco Products
Aerosols
Industry
Health
Electronic Cigarettes
7 Citations

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A. Jul 1 2016 In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Research - peer-reviewArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
7 Citations

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S. Mar 1 2016 In : PLoS ONE. 11, 3, e0150641

Research output: Research - peer-reviewArticle

cigarettes
benzene
glutathione transferase
uptake mechanisms
acids

Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions

Hecht, S. S. Nov 14 2016 Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Elsevier Inc., p. 59-73 15 p.

Research output: ResearchChapter

Tobacco Products
Biomarkers
Nicotine
Urine
Cotinine
Toxicology
Research
9 Citations
Tobacco Products
Carcinogens
Tobacco
Clinical Trials
Lung
8 Citations

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D. Jan 1 2016 In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Research - peer-reviewArticle

Anthocyanins
Esophageal Neoplasms
Esophagus
Rubus
Cytokines
1 Citations
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
7,8-dihydromethysticin
Lung
Lung Neoplasms
Carcinogenesis
5 Citations
N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens
3 Citations

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S. Dec 19 2016 In : Chemical Research in Toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Research - peer-reviewArticle

Nitrosamines
Tobacco
Metabolism
Cytochrome P-450 Enzyme System
nitrosamides
15 Citations
N'-nitrosonornicotine
Nitrosamines
Tobacco
Biomarkers
Chemical activation

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V. Dec 1 2016 In : Food and Chemical Toxicology. 98, p. 201-209 9 p.

Research output: Research - peer-reviewReview article

Mentha
genotoxicity
flavor
extracts
assays
7 Citations

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study

Yuan, J. M., Nelson, H. H., Butler, L. M., Carmella, S. G., Wang, R., Kuriger-Laber, J. K., Adams-Haduch, J., Hecht, S. S., Gao, Y. T. & Murphy, S. E. May 1 2016 In : International Journal of Cancer. 138, 9, p. 2161-2171 11 p.

Research output: Research - peer-reviewArticle

Nicotine
Smoke
Cytochrome P-450 Enzyme System
Tobacco
Lung Neoplasms
6 Citations
Brassica
Vegetables
Biomarkers
3,3'-diindolylmethane
glucobrassicin
47 Citations

Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis

Smith, M. T., Guyton, K. Z., Gibbons, C. F., Fritz, J. M., Portier, C. J., Rusyn, I., DeMarini, D. M., Caldwell, J. C., Kavlock, R. J., Lambert, P. F., Hecht, S. S., Bucher, J. R., Stewart, B. W., Baan, R. A., Cogliano, V. J. & Straif, K. Jun 1 2016 In : Environmental Health Perspectives. 124, 6, p. 713-721 9 p.

Research output: Research - peer-reviewReview article

International Agencies
Carcinogens
Carcinogenesis
Research
Neoplasms
5 Citations

Metabolites of the polycyclic aromatic hydrocarbon phenanthrene in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Patel, Y. M., Park, S. L., Carmella, S. G., Paiano, V., Olvera, N., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S. Jun 1 2016 In : PLoS ONE. 11, 6, e0156203

Research output: Research - peer-reviewArticle

phenanthrene
cigarettes
polycyclic aromatic hydrocarbons
lung neoplasms
nationalities and ethnic groups
9 Citations

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

Hatsukami, D. K., Severson, H., Anderson, A., Vogel, R. I., Jensen, J., Broadbent, B., Murphy, S. E., Carmella, S. & Hecht, S. S. May 1 2016 In : Tobacco Control. 25, 3, p. 267-274 8 p.

Research output: Research - peer-reviewArticle

Nicotine
Randomized Controlled Trials
nicotine
Tobacco Products
Carbon Monoxide
7 Citations
Vegetables
Research
Neoplasms
indole-3-carbinol
indoles
2 Citations

Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study

Yershova, K., Yuan, J. M., Wang, R., Valentin, L., Watson, C., Gao, Y. T., Hecht, S. S. & Stepanov, I. Sep 15 2016 In : International Journal of Cancer. 139, 6, p. 1261-1269 9 p.

Research output: Research - peer-reviewArticle

Nitrosamines
Polycyclic Aromatic Hydrocarbons
Tobacco Products
Tobacco
Cohort Studies
1 Citations
N'-nitrosonornicotine
Gene Expression Profiling
Esophagus
Mouth
Carcinogenesis
2015
2 Citations

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L. Jan 1 2015 In : American Journal of Epidemiology. 182, 11, p. 945-951 7 p.

Research output: Research - peer-reviewArticle

Cotinine
Nicotine
Cohort Studies
Biomarkers
Oceanic Ancestry Group
3 Citations

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S. Dec 5 2015 In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Research - peer-reviewArticle

Glutathione Transferase
Substrates
benzene oxide
Kinetic parameters
Glutathione
7 Citations
N'-nitrosonornicotine
Tobacco Products
Urine
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
nornicotine
2 Citations
Cotinine
Tobacco
Metabolites
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
Glucuronides
7 Citations
DNA Adducts
Carcinogens
Tobacco
Phosphates
Lung
3 Citations

Elevated levels of mercapturic acids of acrolein and crotonaldehyde in the urine of Chinese women in Singapore who regularly cook at home

Hecht, S. S., Koh, W. P., Wang, R., Chen, M., Carmella, S. G., Murphy, S. E. & Yuan, J. M. Mar 25 2015 In : PLoS ONE. 10, 3, e0120023

Research output: Research - peer-reviewArticle

2-butenal
Acrolein
Singapore
Acetylcysteine
Cooking
58 Citations

Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers

Hecht, S. S., Carmella, S. G., Kotandeniya, D., Pillsbury, M. E., Chen, M., Ransom, B. W. S., Vogel, R. I., Thompson, E., Murphy, S. E. & Hatsukami, D. K. Jan 1 2015 In : Nicotine and Tobacco Research. 17, 6, p. 704-709 6 p.

Research output: Research - peer-reviewArticle

Tobacco Products
Carcinogens
Urine
Electronic Cigarettes
Cotinine
9 Citations

Evidence supporting product standards for carcinogens in smokeless tobacco products

Hatsukami, D. K., Stepanov, I., Severson, H., Jensen, J. A., Lindgren, B. R., Horn, K., Khariwala, S. S., Martin, J., Carmella, S. G., Murphy, S. E. & Hecht, S. S. Jan 1 2015 In : Cancer Prevention Research. 8, 1, p. 20-26 7 p.

Research output: Research - peer-reviewArticle

Smokeless Tobacco
Tobacco Products
Carcinogens
Nitrosamines
Tobacco Use
3 Citations

GRAS 27 flavoring substances

Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Marnett, L. J., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., McGowen, M. M., Harman, C. L. & Taylor, S. V. Aug 1 2015 Food Technology, 69, 8

Research output: ResearchArticle

flavorings
10 Citations

Mercapturic acids derived from the toxicants acrolein and crotonaldehyde in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Park, S. L., Carmella, S. G., Chen, M., Patel, Y., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S. Jun 8 2015 In : PLoS ONE. 10, 6, e0124841

Research output: Research - peer-reviewArticle

2-butenal
Acrolein
Acetylcysteine
Ethnic Groups
Tobacco Products
44 Citations

NIH electronic cigarette workshop: Developing a research agenda

Walton, K. M., Abrams, D. B., Bailey, W. C., Clark, D., Connolly, G. N., Djordjevic, M. V., Eissenberg, T. E., Fiore, M. C., Goniewicz, M. L., Haverkos, L., Hecht, S. S., Henningfield, J. E., Hughes, J. R., Oncken, C. A., Postow, L., Rose, J. E., Wanke, K. L., Yang, L. & Hatsukami, D. K. Feb 1 2015 In : Nicotine and Tobacco Research. 17, 2, p. 259-269 11 p.

Research output: Research - peer-reviewArticle

Education
Research
Electronic Cigarettes
Equipment and Supplies
Nicotine
16 Citations

Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease

Zabala, V., Tong, M., Yu, R., Ramirez, T., Yalcin, E. B., Balbo, S., Silbermann, E., Deochand, C., Nunez, K., Hecht, S. & de la Monte, S. M. Jan 1 2015 In : Alcohol and Alcoholism. 50, 2, p. 118-131 14 p., agu083

Research output: Research - peer-reviewArticle

Nitrosamines
Alcoholic Liver Diseases
Fatty Liver
Ketones
Nicotine

Quantitative analysis of 3'-hydroxynorcotinine in human urine

Upadhyaya, P. & Hecht, S. S. Jan 1 2015 In : Nicotine and Tobacco Research. 17, 5, p. 524-529 6 p.

Research output: Research - peer-reviewArticle

Urine
N'-nitrosonornicotine
Nicotine
Biomarkers
Erythrocebus patas