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2017

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R. Nov 30 2017 In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Research - peer-reviewReview article

Transplantation Immunology
Animal Disease Models
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Acute Disease
3 Citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R. Apr 13 2017 In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Research - peer-reviewArticle

Interleukin-17
Microbiota
Graft vs Host Disease
Grafts
Interleukin-17 Receptors
4 Citations

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Kean, L. S., Turka, L. A. & Blazar, B. R. Mar 1 2017 In : Immunological Reviews. 276, 1, p. 192-212 21 p.

Research output: Research - peer-reviewReview article

Yin-Yang
Immunotherapy
Transplantation
T-Lymphocytes
Neoplasms
2 Citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C. Jan 10 2017 In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Research - peer-reviewArticle

Bioluminescence
Imaging techniques
Zebrafish
Ergosterol
Molecules
3 Citations

Alarmins and Their Receptors as Modulators and Indicators of Alloimmune Responses

Matta, B. M., Reichenbach, D. K., Blazar, B. R. & Turnquist, H. R. Feb 1 2017 In : American Journal of Transplantation. 17, 2, p. 320-327 8 p.

Research output: Research - peer-reviewReview article

Alarmins
Biomarkers
Transplants
Cell Transplantation
Homologous Transplantation
1 Citations

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Poe, J. C. , Jia, W. , Su, H. , Anand, S. , Rose, J. J. , Tata, P. V. , Suthers, A. N. , Jones, C. D. , Kuan, P. F. , Vincent, B. G. , Serody, J. S. , Horwitz, M. E. , Ho, V. T. , Pavletic, S. Z. , Hakim, F. T. , Owzar, K. , Zhang, D. , Blazar, B. R. , Siebel, C. W. , Chao, N. J. & 2 others Maillard, I. & Sarantopoulos, S. Nov 9 2017 In : Blood. 130, 19, p. 2131-2145 15 p.

Research output: Research - peer-reviewArticle

Cells
B-Lymphocytes
Grafts
Chemical activation
Graft vs Host Disease

Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology

Osborn, M. J., Webber, B. R., McElmurry, R. T., Rudser, K. D., DeFeo, A. P., Muradian, M., Petryk, A., Hallgrimsson, B., Blazar, B. R., Tolar, J. & Braunlin, E. A. Mar 1 2017 In : Journal of Inherited Metabolic Disease. 40, 2, p. 281-289 9 p.

Research output: Research - peer-reviewArticle

Iduronidase
Mucopolysaccharidosis I
Angiotensin Receptors
Pathology
Renin-Angiotensin System

Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease

Wang, K. S., Kim, H. T., Nikiforow, S., Heubeck, A. T., Ho, V. T., Koreth, J., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Cutler, C. S. & Ritz, J. Dec 28 2017 In : Blood. 130, 26, p. 2889-2899 11 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Surface Antigens
Membranes
Antibodies
Fog dispersal

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S. Dec 1 2017 In : Scientific Reports. 7, 1, 1633

Research output: Research - peer-reviewArticle

Endothelial Cells
In Vitro Techniques
T-Lymphocytes
Chemotactic Factors
Cell Movement

B cells drive autoimmunity in mice with CD28-deficient regulatory T cells

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A. Dec 15 2017 In : Journal of Immunology. 199, 12, p. 3972-3980 9 p.

Research output: Research - peer-reviewArticle

CD28 Antigens
Lymphopoiesis
Lymphocyte Depletion
CD4-Positive T-Lymphocytes
Specific Pathogen-Free Organisms
17 Citations

Chronic graft-versus-host disease: Biological insights from preclinical and clinical studies

MacDonald, K. P. A., Hill, G. R. & Blazar, B. R. Jan 5 2017 In : Blood. 129, 1, p. 13-21 9 p.

Research output: Research - peer-reviewReview article

Graft vs Host Disease
Clinical Studies
Grafts
T-cells
Antigens
1 Citations

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S. Sep 20 2017 In : Science Translational Medicine. 9, 408, eaan3085

Research output: Research - peer-reviewArticle

Sirolimus
T-Lymphocytes
Transplants
Graft vs Host Disease
Th1 Cells
2 Citations

Cytokine mediators of chronic graft-versus-host disease

MacDonald, K. P. A., Blazar, B. R. & Hill, G. R. Jun 30 2017 In : Journal of Clinical Investigation. 127, 7, p. 2452-2463 12 p.

Research output: Research - peer-reviewReview article

Graft vs Host Disease
Cytokines
Germinal Center
Interleukin-17
B-Lymphocytes
1 Citations

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., Blazar, B. R., Borowsky, A. D., Monjazeb, A. M. & Murphy, W. J. Apr 18 2017 In : Journal for ImmunoTherapy of Cancer. 5, 1, 33

Research output: Research - peer-reviewArticle

Spleen
T-Lymphocytes
Phenotype
Therapeutics
Immunotherapy
2 Citations

Erythropoietin receptor-mediated molecular crosstalk promotes T cell immunoregulation and transplant survival

Purroy, C., Fairchild, R. L., Tanaka, T., Baldwin, W. M., Manrique, J., Madsen, J. C., Colvin, R. B., Alessandrini, A., Blazar, B. R., Fribourg, M., Donadei, C., Maggiore, U., Heeger, P. S. & Cravedi, P. Aug 1 2017 In : Journal of the American Society of Nephrology. 28, 8, p. 2377-2392 16 p.

Research output: Research - peer-reviewArticle

Erythropoietin Receptors
T-Lymphocytes
Transplants
Kidney
Antigen-Presenting Cells
4 Citations

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Chung, J. , Ebens, C. L. , Perkey, E. , Radojcic, V. , Koch, U. , Scarpellino, L. , Tong, A. , Allen, F. , Wood, S. , Feng, J. , Friedman, A. , Granadier, D. , Tran, I. T. , Chai, Q. , Onder, L. , Yan, M. , Reddy, P. , Blazar, B. R. , Huang, A. Y. , Brennan, T. V. & 6 others Bishop, D. K., Ludewig, B., Siebel, C. W., Radtke, F., Luther, S. A. & Maillard, I. Apr 3 2017 In : Journal of Clinical Investigation. 127, 4, p. 1574-1588 15 p.

Research output: Research - peer-reviewArticle

Ligands
T-Lymphocytes
Homologous Transplantation
Bone Marrow Transplantation
Graft vs Host Disease
1 Citations

GSK3 inhibition drives maturation of NK cells and enhances their antitumor activity

Cichocki, F. , Valamehr, B. , Bjordahl, R. , Zhang, B. , Rezner, B. , Rogers, P. , Gaidarova, S. , Moreno, S. , Tuininga, K. , Dougherty, P. , McCullar, V. , Howard, P. , Sarhan, D. , Taras, E. , Schlums, H. , Abbot, S. , Shoemaker, D. , Bryceson, Y. T. , Blazar, B. R. , Wolchko, S. & 2 others Cooley, S. & Miller, J. S. Oct 15 2017 In : Cancer Research. 77, 20, p. 5664-5675 12 p.

Research output: Research - peer-reviewArticle

Natural Killer Cells
Neoplasms
Phosphotransferases
Immunologic Monitoring
Interleukin-15
4 Citations

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Bunting, M. D., Varelias, A., Souza-Fonseca-Guimaraes, F., Schuster, I. S., Lineburg, K. E., Kuns, R. D., Fleming, P., Locke, K. R., Huntington, N. D., Blazar, B. R., Lane, S. W., Tey, S. K., MacDonald, K. P. A., Smyth, M. J., Degli-Esposti, M. A. & Hill, G. R. Feb 2 2017 In : Blood. 129, 5, p. 630-642 13 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Innate Immunity
Natural Killer Cells
Leukemia
Viruses
Natural Killer Cells
Non-Hodgkin's Lymphoma
Interleukin-2
Tissue Donors
Therapeutics

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L. Dec 1 2017 In : Scientific Reports. 7, 1, 4258

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Protein Kinase C
In Vitro Techniques
Fetal Blood
Phosphorylation
2 Citations

Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

Miklos, D., Cutler, C. S., Arora, M., Waller, E. K., Jagasia, M., Pusic, I., Flowers, M. E., Logan, A. C., Nakamura, R., Blazar, B. R., Li, Y., Chang, S., Lal, I., Dubovsky, J., James, D. F., Styles, L. & Jaglowski, S. Nov 23 2017 In : Blood. 130, 21, p. 2243-2250 8 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Therapeutics
PCI 32765
Grafts
Adrenal Cortex Hormones
2 Citations

Increased effector memory insulin-specific CD4+ T cells correlate with insulin autoantibodies in patients with recent-onset type 1 diabetes

Spanier, J. A., Sahli, N. L., Wilson, J. C., Martinov, T., Dileepan, T., Burrack, A. L., Finger, E. B., Blazar, B. R., Michels, A. W., Moran, A., Jenkins, M. K. & Fife, B. T. Dec 1 2017 In : Diabetes. 66, 12, p. 3051-3060 10 p.

Research output: Research - peer-reviewArticle

Type 1 Diabetes Mellitus
Autoantibodies
Insulin
T-Lymphocytes
Phenotype
4 Citations

Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells

Du, J., Paz, K., Thangavelu, G., Schneidawind, D., Baker, J., Flynn, R., Duramad, O., Feser, C., Panoskaltsis-Mortari, A., Negrin, R. S. & Blazar, B. R. Jun 8 2017 In : Blood. 129, 23, p. 3121-3125 5 p.

Research output: Research - peer-reviewArticle

Natural Killer T-Cells
Regulatory T-Lymphocytes
Tissue Donors
T-cells
Graft vs Host Disease

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R. Dec 1 2017 In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Research - peer-reviewArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
In Vitro Techniques
Interleukin-2
1 Citations

Low EGF in myeloablative allotransplantation: Association with severe acute GvHD in BMT CTN 0402

Holtan, S. G., Newell, L. F., Cutler, C., Verneris, M. R., Defor, T. E., Wu, J., Howard, A., Macmillan, M. L., Antin, J. H., Blazar, B. R., Weisdorf, D. J. & Panoskaltsis-Mortari, A. Sep 1 2017 In : Bone Marrow Transplantation. 52, 9, p. 1300-1303 4 p.

Research output: Research - peer-reviewArticle

Epidermal Growth Factor
Bone Marrow
Clinical Trials
Transplants
Cell Transplantation

Pathophysiology of chronic graft-versus-host disease and therapeutic targets

Zeiser, R. & Blazar, B. R. Dec 28 2017 In : New England Journal of Medicine. 377, 26, p. 2565-2579 15 p.

Research output: Research - peer-reviewReview article

Animal Disease Models
Hematopoietic Stem Cell Transplantation
Cell Transplantation
Graft vs Host Disease
Immunosuppressive Agents
9 Citations

PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: High response rate but frequent GVHD

Haverkos, B. M. , Abbott, D. , Hamadani, M. , Armand, P. , Flowers, M. E. , Merryman, R. , Kamdar, M. , Kanate, A. S. , Saad, A. , Mehta, A. , Ganguly, S. , Fenske, T. S. , Hari, P. , Lowsky, R. , Andritsos, L. , Jagasia, M. , Bashey, A. , Brown, S. , Bachanova, V. , Stephens, D. & 6 others Mineishi, S., Nakamura, R., Chen, Y. B., Blazar, B. R., Gutman, J. & Devine, S. M. Jul 13 2017 In : Blood. 130, 2, p. 221-228 8 p.

Research output: Research - peer-reviewArticle

Lymphoma
Transplants
Monoclonal Antibodies
Therapeutics
Salvaging
7 Citations

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J. , Paz, K. , Flynn, R. , Vulic, A. , Robinson, T. M. , Lineburg, K. E. , Alexander, K. A. , Meng, J. , Roy, S. , Panoskaltsis-Mortari, A. , Loschi, M. , Hill, G. R. , Serody, J. S. , Maillard, I. , Miklos, D. , Koreth, J. , Cutler, C. S. , Antin, J. H. , Ritz, J. , MacDonald, K. P. & 3 others Schacker, T. W., Luznik, L. & Blazar, B. R. May 4 2017 In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Transforming Growth Factor beta
Macrophages
pirfenidone
Inhibition (Psychology)
Adoptive Transfer
Natural Killer Cells
T-Lymphocytes
Tissue Donors
Drug Therapy
50 Citations

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent

Kamphorst, A. O., Wieland, A., Nasti, T., Yang, S., Zhang, R., Barber, D. L., Konieczny, B. T., Daugherty, C. Z., Koenig, L., Yu, K., Sica, G. L., Sharpe, A. H., Freeman, G. J., Blazar, B. R., Turka, L. A., Owonikoko, T. K., Pillai, R. N., Ramalingam, S. S., Araki, K. & Ahmed, R. Mar 31 2017 In : Science. 355, 6332, p. 1423-1427 5 p.

Research output: Research - peer-reviewArticle

Cell Death
T-Lymphocytes
Therapeutics
Neoplasms
Gene Deletion
1 Citations

Role of myeloid-derived suppressor cells in allogeneic hematopoietic cell transplantation

Koehn, B. H. & Blazar, B. R. Aug 1 2017 In : Journal of Leukocyte Biology. 102, 2, p. 335-341 7 p.

Research output: Research - peer-reviewReview article

Cell Transplantation
Graft vs Host Disease
Myeloid-Derived Suppressor Cells
Hematopoietic Stem Cell Transplantation
Myeloid Cells
2 Citations

Serum miR-29a is upregulated in acute graft-versus-host disease and activates dendritic cells through TLR binding

Ranganathan, P., Ngankeu, A., Zitzer, N. C., Leoncini, P., Yu, X., Casadei, L., Challagundla, K., Reichenbach, D. K., Garman, S., Ruppert, A. S., Volinia, S., Hofstetter, J., Efebera, Y. A., Devine, S. M., Blazar, B. R., Fabbri, M. & Garzon, R. Mar 15 2017 In : Journal of Immunology. 198, 6, p. 2500-2512 13 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Dendritic Cells
Serum
Therapeutics
Hematopoietic Stem Cell Transplantation

T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD

Dant, T. A., Lin, K. L., Bruce, D. W., Montgomery, S. A., Kolupaev, O. V., Bommiasamy, H., Bixby, L. M., Woosley, J. T., McKinnon, K. P., Gonzalez, F. J., Blazar, B. R., Vincent, B. G., Coghill, J. M. & Serody, J. S. Jul 20 2017 In : Blood. 130, 3, p. 348-359 12 p.

Research output: Research - peer-reviewArticle

Aryl Hydrocarbon Receptors
Gastrointestinal Tract
Maintenance
T-Lymphocytes
T-cells
19 Citations

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R. & Blazar, B. R. Feb 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 2, p. 211-234 24 p.

Research output: Research - peer-reviewReview article

National Institutes of Health (U.S.)
Graft vs Host Disease
Advisory Committees
Consensus
Clinical Trials
3 Citations

The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques

Zheng, H. B., Watkins, B., Tkachev, V., Yu, S., Tran, D., Furlan, S., Zeleski, K., Singh, K., Hamby, K., Hotchkiss, C., Lane, J., Gumber, S., Adams, A. B., Cendales, L., Kirk, A. D., Kaur, A., Blazar, B. R., Larsen, C. P. & Kean, L. S. Mar 1 2017 In : American Journal of Transplantation. 17, 3, p. 657-670 14 p.

Research output: Research - peer-reviewArticle

Chimerism
Macaca mulatta
Cytomegalovirus
T-Lymphocytes
Transplants
2 Citations

Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease

Bruce, D. W., Stefanski, H. E., Vincent, B. G., Dant, T. A., Reisdorf, S., Bommiasamy, H., Serody, D. A., Wilson, J. E., McKinnon, K. P., Shlomchik, W. D., Armistead, P. M., Ting, J. P. Y., Woosley, J. T., Blazar, B. R., Zaiss, D. M. W., McKenzie, A. N. J., Coghill, J. M. & Serody, J. S. May 1 2017 In : Journal of Clinical Investigation. 127, 5, p. 1813-1825 13 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Tissue Donors
Lymphocytes
Lower Gastrointestinal Tract
Gastrointestinal Tract
2016
12 Citations

Adaptive NK cells with low TIGIT expression are inherently resistant to myeloid-derived suppressor cells

Sarhan, D., Cichocki, F., Zhang, B., Yingst, A., Spellman, S. R., Cooley, S., Verneris, M. R., Blazar, B. R. & Miller, J. S. Oct 1 2016 In : Cancer Research. 76, 19, p. 5696-5706 11 p.

Research output: Research - peer-reviewArticle

Natural Killer Cells
T-Lymphocytes
Myeloid-Derived Suppressor Cells
Immunoglobulin Domains
Neoplasms
12 Citations

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Schönle, A. , Hartl, F. A. , Mentzel, J. , Nöltner, T. , Rauch, K. S. , Prestipino, A. , Wohlfeil, S. A. , Apostolova, P. , Hechinger, A. K. , Melchinger, W. , Fehrenbach, K. , Guadamillas, M. C. , Follo, M. , Prinz, G. , Ruess, A. K. , Pfeifer, D. , Del Pozo, M. A. , Schmitt-Graeff, A. , Duyster, J. , Hippen, K. I. & 4 others Blazar, B. R., Schachtrup, K., Minguet, S. & Zeiser, R. Apr 14 2016 In : Blood. 127, 15, p. 1930-1939 10 p.

Research output: Research - peer-reviewArticle

Caveolin 1
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Cell Differentiation
T-Lymphocytes
38 Citations

CD56 dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

Cichocki, F., Cooley, S., Davis, Z., DeFor, T. E., Schlums, H., Zhang, B., Brunstein, C. G., Blazar, B. R., Wagner, J., Diamond, D. J., Verneris, M. R., Bryceson, Y. T., Weisdorf, D. J. & Miller, J. S. Feb 1 2016 In : Leukemia. 30, 2, p. 456-463 8 p.

Research output: Research - peer-reviewArticle

Cytomegalovirus
Natural Killer Cells
Leukemia
Transplants
Recurrence
15 Citations

Circulating T follicular helper cells with increased function during chronic graft-versus-host disease

Forcade, E., Kim, H. T., Cutler, C., Wang, K., Alho, A. C., Nikiforow, S., Ho, V. T., Koreth, J., Armand, P., Alyea, E. P., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Ritz, J. May 19 2016 In : Blood. 127, 20, p. 2489-2497 9 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Helper-Inducer T-Lymphocytes
Grafts
B-Lymphocytes
Cells
5 Citations

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

Leveque-El Mouttie, L., Koyama, M., Le Texier, L., Markey, K. A., Cheong, M., Kuns, R. D., Lineburg, K. E., Teal, B. E., Alexander, K. A., Clouston, A. D., Blazar, B. R., Hill, G. R. & MacDonald, K. P. A. Aug 11 2016 In : Blood. 128, 6, p. 794-804 11 p.

Research output: Research - peer-reviewArticle

Antigen Presentation
Graft vs Host Disease
Regulatory T-Lymphocytes
Dendritic Cells
T-cells
5 Citations

CRISPR/Cas9 targeted gene editing and cellular engineering in fanconi anemia

Osborn, M. J., Lonetree, C. L., Webber, B. R., Patel, D., Dunmire, S., Defeo, A. P., McElroy, A. N., Macmillan, M. L., Wagner, J. E., Blazar, B. R. & Tolar, J. Oct 15 2016 In : Stem Cells and Development. 25, 20, p. 1591-1603 13 p.

Research output: Research - peer-reviewArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Cell Engineering
Fanconi Anemia
Genes
Gene Editing
23 Citations

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

Koreth, J., Kim, H. T., Jones, K. T., Lange, P. B., Reynolds, C. G., Chammas, M. J., Dusenbury, K., Whangbo, J., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Chen, Y. B., Avigan, D., Blazar, B. R., Antin, J. H., Ritz, J. & Soiffer, R. J. Jul 7 2016 In : Blood. 128, 1, p. 130-137 8 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Interleukin-2
Therapeutics
Grafts
Durability
Aurora Kinase A
Grafts
Blood
Gene Expression Profiling
Graft vs Host Disease
3 Citations

Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer

D'Alincourt Salazar, M., Manuel, E. R., Tsai, W., D'Apuzzo, M., Goldstein, L., Blazar, B. R. & Diamond, D. J. Jun 2 2016 In : OncoImmunology. 5, 6, e1160184

Research output: Research - peer-reviewArticle

Adaptive Immunity
Pancreatic Neoplasms
Innate Immunity
Neoplasms
Therapeutics
32 Citations

Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

Osborn, M. J. , Webber, B. R. , Knipping, F. , Lonetree, C. L. , Tennis, N. , DeFeo, A. P. , McElroy, A. N. , Starker, C. G. , Lee, C. , Merkel, S. , Lund, T. C. , Kelly-Spratt, K. S. , Jensen, M. C. , Voytas, D. F. , Von Kalle, C. , Schmidt, M. , Gabriel, R. , Hippen, K. L. , Miller, J. S. , Scharenberg, A. M. & 2 others Tolar, J. & Blazar, B. R. Mar 1 2016 In : Molecular Therapy. 24, 3, p. 570-581 12 p.

Research output: Research - peer-reviewArticle

Clustered Regularly Interspaced Short Palindromic Repeats
T-Lymphocytes
Gene Editing
Transcription Activator-Like Effector Nucleases
T-Cell Antigen Receptor

Graft Versus Host Disease after Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management

Murali, A. R., Chandra, S., Stewart, Z., Blazar, B. R., Farooq, U., Ince, M. N. & Dunkelberg, J. Dec 1 2016 In : Transplantation. 100, 12, p. 2661-2670 10 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Liver Transplantation
Mortality
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
32 Citations
Interleukin-15
Natural Killer Cells
Antigens
Survival
Neoplasms
4 Citations

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z. C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G. Jun 2 2016 In : OncoImmunology. 5, 6, e1171445

Research output: Research - peer-reviewArticle

Interleukin-7
T-Lymphocytes
Neoplasms
Aptitude
Immunotherapy