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2018
6 Citations

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H., Bommiasamy, H., Paz, K., Wilkinson, A. N., Owen, M., Reichenbach, D. K., Banovic, T., Wehner, K., Buchanan, F., Varelias, A., Kuns, R. D., Chang, K., Fedoriw, Y., Shea, T., Coghill, J., Zaiken, M., Plank, M. W., Foster, P. S., Clouston, A. D., Blazar, B. R. & 2 othersSerody, J. S. & Hill, G. R., Apr 1 2018, In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Tissue Donors
Skin
Interleukin-17
Stem Cell Transplantation
3 Citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming

Acute Graft-versus-Host Disease

Zeiser, R. & Blazar, B. R., Feb 8 2018, In : The New England journal of medicine. 378, 6, 1 p.

Research output: Contribution to journalLetter

Graft vs Host Disease
3 Citations

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T., Curtsinger, J., Davis, Z., Zhang, B., Cooley, S. A., Cichocki, F. M., Blazar, B. R. & Miller, J. S., Jul 1 2018, In : Cancer immunology research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Natural Killer Cells
Natural Killer Cell Receptors
Tumor Microenvironment
Programmed Cell Death 1 Receptor

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jan 1 2018, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Oxidative Stress
Cell Death
Tumor Necrosis Factor-alpha
T-Lymphocytes
Adoptive Immunotherapy

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Jan 1 2018, (Accepted/In press) In : Bone Marrow Transplantation.

Research output: Contribution to journalArticle

trans-crotonin
1 Citations

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L. M., Goren, E., Mulé, J. J. & Blazar, B. R., Apr 1 2018, In : PloS one. 13, 4, e0193461.

Research output: Contribution to journalArticle

Transplants
Stromal Cells
Restoration
stromal cells
B-Lymphocytes
1 Citations

Association between recipient TNF rs361525 and acute GVHD: results from analysis of BMT CTN-0201 samples

Rashidi, A., Shanley, R. M., Yohe, S. L., Thyagarajan, B., Curtsinger, J., Anasetti, C., Waller, E. K., Miller, J. S., Blazar, B. R. & Weisdorf, D. J., Aug 1 2018, In : Bone Marrow Transplantation. 53, 8, p. 1069-1071 3 p.

Research output: Contribution to journalLetter

trans-crotonin
2 Citations

B-cell targeting in chronic graft-versus-host disease

Zeiser, R., Sarantopoulos, S. & Blazar, B. R., Mar 29 2018, In : Blood. 131, 13, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
B-Lymphocytes
Cells
Physicians
2 Citations

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: Randomized phase II results

Koreth, J., Kim, H. T., Lange, P. B., Poryanda, S. J., Reynolds, C. G., Chamling Rai, S., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Yusuf, R., Nikiforow, S., Chen, Y. B., Dey, B., McMasters, M., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Feb 28 2018, In : Haematologica. 103, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Tacrolimus
Graft vs Host Disease
Immunosuppression
Methotrexate

CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

Watkins, B. K., Tkachev, V., Furlan, S. N., Hunt, D. J., Betz, K., Yu, A., Brown, M., Poirier, N., Zheng, H. B., Taraseviciute, A., Colonna, L., Mary, C., Blancho, G., Soulillou, J. P., Panoskaltsis-Mortari, A., Sharma, P., Garcia, A., Strobert, E., Hamby, K., Garrett, A. & 4 othersDeane, T., Blazar, B. R., Vanhove, B. & Kean, L. S., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3991-4007 17 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Sirolimus
Primates
T-Lymphocytes
Stem Cell Transplantation
7 Citations

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A., Tkachev, V., Ponce, R., Turtle, C. J., Snyder, J. M., Liggitt, H. D., Myerson, D., Gonzalez-Cuyar, L., Baldessari, A., English, C., Yu, A., Zheng, H., Furlan, S. N., Hunt, D. J., Hoglund, V., Finney, O., Brakke, H., Blazar, B. R., Berger, C., Riddell, S. R. & 3 othersGardner, R., Kean, L. S. & Jensen, M. C., Jun 1 2018, In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

T-Cell Antigen Receptor
Primates
Antigen Receptors
Neurotoxicity Syndromes
Cytokines

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W., Feser, C. J., Tschann, M., Mc Elmurry, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J., Apr 1 2018, In : International journal of molecular sciences. 19, 4, 946.

Research output: Contribution to journalArticle

Cell Engineering
genes
Genes
engineering
T-cells

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Stefanski, H. E., Xing, Y., Taylor, P. A., Maio, S., Henao-Meija, J., Williams, A., Flavell, R. A., Hollander, G. A. & Blazar, B. R., Jun 1 2018, In : PloS one. 13, 6, e0198871.

Research output: Contribution to journalArticle

epithelial cells
Epithelial Cells
thymocytes
T-cells
Thymocytes
2 Citations
Follistatin
Bone Marrow
Tissue Donors
Clinical Trials
Transplants
3 Citations

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Hippen, K. L., Loschi, M., Nicholls, J., MacDonald, K. P. A. & Blazar, B. R., Jan 31 2018, In : Frontiers in Immunology. 9, JAN, 57.

Research output: Contribution to journalShort survey

Graft vs Host Disease
Regulatory T-Lymphocytes
MicroRNAs
Knockout Mice
Long Noncoding RNA
7 Citations

First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation

Romee, R., Cooley, S. A., Berrien-Elliott, M. M., Westervelt, P., Verneris, M. R., Wagner, J. E., Weisdorf, D. J., Blazar, B. R., Ustun, C., De For, T. E., Vivek, S., Peck, L., DiPersio, J. F., Cashen, A. F., Kyllo, R., Musiek, A., Schaffer, A., Anadkat, M. J., Rosman, I., Miller, D. D. & 6 othersEgan, J. O., Jeng, E. K., Rock, A., Wong, H. C., Fehniger, T. A. & Miller, J. S., Jun 7 2018, In : Blood. 131, 23, p. 2515-2527 13 p.

Research output: Contribution to journalArticle

Interleukin-15
T-cells
Transplantation
Recurrence
Cell Transplantation
2 Citations
Natural Killer Cells
Non-Hodgkin's Lymphoma
Tissue Donors
Interleukin-15
Immunosuppressive Agents
3 Citations

Human CD19-Targeted Mouse T Cells Induce B Cell Aplasia and Toxicity in Human CD19 Transgenic Mice

Pennell, C. A., Barnum, J. L., McDonald-Hyman, C. S., Panoskaltsis-Mortari, A., Riddle, M. J., Xiong, Z., Loschi, M., Thangavelu, G., Campbell, H. M., Storlie, M. D., Refaeli, Y., Furlan, S. N., Jensen, M. C., Kean, L. S., Miller, J. S., Tolar, J., Osborn, M. J. & Blazar, B. R., Jun 6 2018, In : Molecular Therapy. 26, 6, p. 1423-1434 12 p.

Research output: Contribution to journalArticle

Transgenic Mice
B-Lymphocytes
T-Lymphocytes
T-Cell Antigen Receptor
Antigen Receptors
1 Citations

Identification of cellular sources of IL-2 needed for regulatory T cell development and homeostasis

Owen, D. L., Mahmud, S. A., Vang, K. B., Kelly, R. M., Blazar, B. R., Smith, K. A. & Farrar, M. A., Jun 15 2018, In : Journal of Immunology. 200, 12, p. 3926-3933 8 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Interleukin-2
Homeostasis
Dendritic Cells
Interleukin-15
2 Citations

Immune regulatory cell infusion for graft-versus-host disease prevention and therapy

Blazar, B. R., MacDonald, K. P. A. & Hill, G. R., Jun 14 2018, In : Blood. 131, 24, p. 2651-2660 10 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Grafts
Transplants
Stem cells
Transplantation (surgical)

Maintenance of CD4 T cell fitness through regulation of Foxo1

Newton, R. H., Shrestha, S., Sullivan, J. M., Yates, K. B., Compeer, E. B., Ron-Harel, N., Blazar, B. R., Bensinger, S. J., Haining, W. N., Dustin, M. L., Campbell, D. J., Chi, H. & Turka, L. A., Aug 1 2018, In : Nature immunology. 19, 8, p. 838-848 11 p.

Research output: Contribution to journalArticle

Maintenance
T-Lymphocytes
Transcription Factors
Cell Division
Immunological Synapses

MicroRNA-155 modulates acute graft-versus-host disease by impacting T cell expansion, migration, and effector function

Zitzer, N. C., Snyder, K., Meng, X., Taylor, P. A., Efebera, Y. A., Devine, S. M., Blazar, B. R., Garzon, R. & Ranganathan, P., Jun 15 2018, In : Journal of Immunology. 200, 12, p. 4170-4179 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
MicroRNAs
Cell Movement
T-Lymphocytes
Acute Disease
1 Citations

MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice

Wu, Y., Schutt, S., Paz, K., Zhang, M., Flynn, R. P., Bastian, D., Hanief Sofi, M., Nguyen, H., Dai, M., Liu, C., Chang, Y. J., Blazar, B. R. & Yu, X. Z., Apr 26 2018, In : Blood. 131, 17, p. 1974-1986 13 p.

Research output: Contribution to journalArticle

T-cells
Graft vs Host Disease
MicroRNAs
Grafts
Virulence
1 Citations

Minimum information about T regulatory cells: A step toward reproducibility and standardization

Fuchs, A., Gliwinski, M., Grageda, N., Spiering, R., Abbas, A. K., Appel, S., Bacchetta, R., Battaglia, M., Berglund, D., Blazar, B., Bluestone, J. A., Bornhäuser, M., Brinke, A. T., Brusko, T. M., Cools, N., Cuturi, M. C., Geissler, E., Giannoukakis, N., Golab, K., Hafler, D. A. & 41 othersvan Ham, S. M., Hester, J., Hippen, K., Di Ianni, M., Ilic, N., Isaacs, J., Issa, F., Iwaszkiewicz-Grzes, D., Jaeckel, E., Joosten, I., Klatzmann, D., Koenen, H., Kooten, C. V., Korsgren, O., Kretschmer, K., Levings, M., Marek-Trzonkowska, N. M., Martinez-Llordella, M., Miljkovic, D., Mills, K. H. G., Miranda, J. P., Piccirillo, C. A., Putnam, A. L., Ritter, T., Roncarolo, M. G., Sakaguchi, S., Sánchez-Ramón, S., Sawitzki, B., Sofronic-Milosavljevic, L., Sykes, M., Tang, Q., Vives-Pi, M., Waldmann, H., Witkowski, P., Wood, K. J., Gregori, S., Hilkens, C. M. U., Lombardi, G., Lord, P., Martinez-Caceres, E. M. & Trzonkowski, P., Jan 15 2018, In : Frontiers in Immunology. 8, JAN, 1844.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Antigen-Presenting Cells
Research Personnel
Autoimmune Diseases
Clinical Trials
1 Citations

MiR-142-3p regulates autophagy by targeting ATG16L1 in thymic-derived regulatory T cell (tTreg) article

Zhang, C., Shen, H., Lu, Y., Gao, J., Zhang, S., Gu, J., Lu, H., Xia, Y., Zhu, Q., Qian, X., Zhang, F., Hippen, K. L., Blazar, B. R., Lu, L. & Wang, X., Mar 1 2018, In : Cell Death and Disease. 9, 3, 290.

Research output: Contribution to journalArticle

Autophagy
Regulatory T-Lymphocytes
Graft vs Host Disease
Autoimmune Diseases
Cell Survival
4 Citations

Murine chronic graft-versus-host disease proteome profiling discovers CCL15 as a novel biomarker in patients

Du, J., Flynn, R., Paz, K., Ren, H. G., Ogata, Y., Zhang, Q., Gafken, P. R., Storer, B. E., Roy, N. H., Burkhardt, J. K., Mathews, W., Tolar, J., Lee, S. J., Blazar, B. R. & Paczesny, S., Apr 12 2018, In : Blood. 131, 15, p. 1743-1754 12 p.

Research output: Contribution to journalArticle

Biomarkers
Graft vs Host Disease
Proteome
Grafts
T-cells
3 Citations

Neutrophils provide cellular communication between ileum and mesenteric lymph nodes at graft-versus-host disease onset

Hülsdünker, J., Ottmüller, K. J., Neeff, H. P., Koyama, M., Gao, Z., Thomas, O. S., Follo, M., Al-Ahmad, A., Prinz, G., Duquesne, S., Dierbach, H., Kirschnek, S., Lämmermann, T., Blaser, M. J., Fife, B. T., Blazar, B. R., Beilhack, A., Hill, G. R., Häcker, G. & Zeiser, R., Apr 19 2018, In : Blood. 131, 16, p. 1858-1869 12 p.

Research output: Contribution to journalArticle

Cellular radio systems
Graft vs Host Disease
Ileum
Grafts
T-cells
7 Citations

Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms

Prestipino, A., Emhardt, A. J., Aumann, K., O'Sullivan, D., Gorantla, S. P., Duquesne, S., Melchinger, W., Braun, L., Vuckovic, S., Boerries, M., Busch, H., Halbach, S., Pennisi, S., Poggio, T., Apostolova, P., Veratti, P., Hettich, M., Niedermann, G., Bartholomä, M., Shoumariyeh, K. & 29 othersJutzi, J. S., Wehrle, J., Dierks, C., Becker, H., Schmitt-Graeff, A., Follo, M., Pfeifer, D., Rohr, J., Fuchs, S., Ehl, S., Hartl, F. A., Minguet, S., Miething, C., Heidel, F. H., Kröger, N., Triviai, I., Brummer, T., Finke, J., Illert, A. L., Ruggiero, E., Bonini, C., Duyster, J., Pahl, H. L., Lane, S. W., Hill, G. R., Blazar, B. R., Von Bubnoff, N., Pearce, E. L. & Zeiser, R., Feb 21 2018, In : Science Translational Medicine. 10, 429, eaam7729.

Research output: Contribution to journalArticle

Cause of Death
Janus Kinase 2
Ligands
Death Domain Receptors
Neoplasms

Pretransplant Serum Citrulline Predicts Acute Graft-versus-Host Disease

Rashidi, A., Shanley, R., Holtan, S. G., MacMillan, M. L., Blazar, B. R., Khoruts, A. & Weisdorf, D. J., Jan 1 2018, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Citrulline
Graft vs Host Disease
Biomarkers
Serum
Fatty Acid-Binding Proteins

Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: Analysis of BMT CTN-0201 and -0901 samples

Rashidi, A., Shanley, R., Yohe, S. L., Thyagarajan, B., Curtsinger, J., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Jan 1 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

Paneth Cells
Graft vs Host Disease
Single Nucleotide Polymorphism
Bone Marrow
Clinical Trials
Hematologic Neoplasms
Allografts
Graft vs Host Disease
Cell Transplantation
Transplants
4 Citations

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells

Mathew, N. R., Baumgartner, F., Braun, L., O'Sullivan, D., Thomas, S., Waterhouse, M., Müller, T. A., Hanke, K., Taromi, S., Apostolova, P., Illert, A. L., Melchinger, W., Duquesne, S., Schmitt-Graeff, A., Osswald, L., Yan, K. L., Weber, A., Tugues, S., Spath, S., Pfeifer, D. & 110 othersFollo, M., Claus, R., Lübbert, M., Rummelt, C., Bertz, H., Wäsch, R., Haag, J., Schmidts, A., Schultheiss, M., Bettinger, D., Thimme, R., Ullrich, E., Tanriver, Y., Vuong, G. L., Arnold, R., Hemmati, P., Wolf, D., Ditschkowski, M., Jilg, C., Wilhelm, K., Leiber, C., Gerull, S., Halter, J., Lengerke, C., Pabst, T., Schroeder, T., Kobbe, G., Rösler, W., Doostkam, S., Meckel, S., Stabla, K., Metzelder, S. K., Halbach, S., Brummer, T., Hu, Z., Dengjel, J., Hackanson, B., Schmid, C., Holtick, U., Scheid, C., Spyridonidis, A., Stölzel, F., Ordemann, R., Müller, L. P., Sicre-De-Fontbrune, F., Ihorst, G., Kuball, J., Ehlert, J. E., Feger, D., Wagner, E. M., Cahn, J. Y., Schnell, J., Kuchenbauer, F., Bunjes, D., Chakraverty, R., Richardson, S., Gill, S., Kröger, N., Ayuk, F., Vago, L., Ciceri, F., Müller, A. M., Kondo, T., Teshima, T., Klaeger, S., Kuster, B., Kim, D. H., Weisdorf, D., Van Der Velden, W., Dörfel, D., Bethge, W., Hilgendorf, I., Hochhaus, A., Andrieux, G., Börries, M., Busch, H., Magenau, J., Reddy, P., Labopin, M., Antin, J. H., Henden, A. S., Hill, G. R., Kennedy, G. A., Bar, M., Sarma, A., McLornan, D., Mufti, G., Oran, B., Rezvani, K., Shah, O., Negrin, R. S., Nagler, A., Prinz, M., Burchert, A., Neubauer, A., Beelen, D., Mackensen, A., Von Bubnoff, N., Herr, W., Becher, B., Socié, G., Caligiuri, M. A., Ruggiero, E., Bonini, C., Häcker, G., Duyster, J., Finke, J., Pearce, E., Blazar, B. R. & Zeiser, R., Mar 1 2018, In : Nature Medicine. 24, 3, p. 282-291 10 p.

Research output: Contribution to journalArticle

Interleukin-15
Grafts
Interferon Regulatory Factor-7
Leukemia
Transplants

STAT6 and Furin Are Successive Triggers for the Production of TGF-β by T Cells

Li, Y., Liu, W., Guan, X., Truscott, J., Creemers, J. W., Chen, H. L., Pesu, M., El Abiad, R. G., Karacay, B., Urban, J. F., Elliott, D. E., Kaplan, M. H., Blazar, B. R. & Ince, M. N., Nov 1 2018, In : Journal of immunology (Baltimore, Md. : 1950). 201, 9, p. 2612-2623 12 p.

Research output: Contribution to journalArticle

Furin
Transforming Growth Factor beta
T-Lymphocytes
Helminths
Th2 Cells
3 Citations

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8+ T cells

Borges Da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., Hippen, K. L., Blazar, B. R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K. A. & Jameson, S. C., Jul 12 2018, In : Nature. 559, 7713, p. 264-268 5 p.

Research output: Contribution to journalArticle

Purinergic Receptors
T-Lymphocytes
Adenosine Triphosphate
Immune System
Immunologic Memory
2017
30 Citations

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R., Nov 30 2017, In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
T-Lymphocytes
Hematologic Diseases
Cell Transplantation
Homologous Transplantation
14 Citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R., Apr 13 2017, In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Interleukin-17
Microbiota
Graft vs Host Disease
Grafts
Interleukin-17 Receptors
10 Citations

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Kean, L. S., Turka, L. A. & Blazar, B. R., Mar 1 2017, In : Immunological Reviews. 276, 1, p. 192-212 21 p.

Research output: Contribution to journalReview article

Yin-Yang
Immunotherapy
Transplantation
T-Lymphocytes
Neoplasms
4 Citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Bioluminescence
Zebrafish
Ergosterol
Imaging techniques
Firefly Luciferases
4 Citations

Alarmins and Their Receptors as Modulators and Indicators of Alloimmune Responses

Matta, B. M., Reichenbach, D. K., Blazar, B. R. & Turnquist, H. R., Feb 1 2017, In : American Journal of Transplantation. 17, 2, p. 320-327 8 p.

Research output: Contribution to journalReview article

Biomarkers
Alarmins
Transplants
Cell Transplantation
Homologous Transplantation
5 Citations

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Poe, J. C., Jia, W., Su, H., Anand, S., Rose, J. J., Tata, P. V., Suthers, A. N., Jones, C. D., Kuan, P. F., Vincent, B. G., Serody, J. S., Horwitz, M. E., Ho, V. T., Pavletic, S. Z., Hakim, F. T., Owzar, K., Zhang, D., Blazar, B. R., Siebel, C. W., Chao, N. J. & 2 othersMaillard, I. & Sarantopoulos, S., Nov 9 2017, In : Blood. 130, 19, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Grafts
Chemical activation
Graft vs Host Disease
3 Citations

Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology

Osborn, M. J., Webber, B. R., Mc Elmurry, R. T., Rudser, K., DeFeo, A. P., Muradian, M., Petryk, A., Hallgrimsson, B., Blazar, B. R., Tolar, J. & Braunlin, E. A., Mar 1 2017, In : Journal of Inherited Metabolic Disease. 40, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Iduronidase
Mucopolysaccharidosis I
Angiotensin Receptors
Renin-Angiotensin System
Pathology
2 Citations

Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease

Wang, K. S., Kim, H. T., Nikiforow, S., Heubeck, A. T., Ho, V. T., Koreth, J., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Cutler, C. S. & Ritz, J., Dec 28 2017, In : Blood. 130, 26, p. 2889-2899 11 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Surface Antigens
Membranes
Antibodies
Tissue Donors
2 Citations

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Dec 1 2017, In : Scientific reports. 7, 1, 1633.

Research output: Contribution to journalArticle

Endothelial Cells
Chemotactic Factors
T-Lymphocytes
Cell Movement
Leukocytes
5 Citations

B cells drive autoimmunity in mice with CD28-deficient regulatory T cells

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A., Dec 15 2017, In : Journal of Immunology. 199, 12, p. 3972-3980 9 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Autoimmunity
B-Lymphocytes
Cell Differentiation
Germinal Center
38 Citations

Chronic graft-versus-host disease: Biological insights from preclinical and clinical studies

MacDonald, K. P. A., Hill, G. R. & Blazar, B. R., Jan 5 2017, In : Blood. 129, 1, p. 13-21 9 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Grafts
T-cells
Isoantibodies
Macrophage Colony-Stimulating Factor
7 Citations

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S., Sep 20 2017, In : Science Translational Medicine. 9, 408, eaan3085.

Research output: Contribution to journalArticle

Sirolimus
Eragrostis
Graft vs Host Disease
T-Lymphocytes
Transplants
4 Citations

Cytokine mediators of chronic graft-versus-host disease

MacDonald, K. P. A., Blazar, B. R. & Hill, G. R., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2452-2463 12 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Germinal Center
Interleukin-17
Cytokines
B-Lymphocytes
2 Citations

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., Blazar, B. R., Borowsky, A. D., Monjazeb, A. M. & Murphy, W. J., Apr 18 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 33.

Research output: Contribution to journalArticle

Spleen
T-Lymphocytes
Phenotype
Therapeutics
Immunotherapy
4 Citations

Erythropoietin receptor-mediated molecular crosstalk promotes T cell immunoregulation and transplant survival

Purroy, C., Fairchild, R. L., Tanaka, T., Baldwin, W. M., Manrique, J., Madsen, J. C., Colvin, R. B., Alessandrini, A., Blazar, B. R., Fribourg, M., Donadei, C., Maggiore, U., Heeger, P. S. & Cravedi, P., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2377-2392 16 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
T-Lymphocytes
Transplants
Kidney
Antigen-Presenting Cells