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2017
5 Citations

Current Knowledge and Priorities for Future Research in Late Effects after Hematopoietic Cell Transplantation for Inherited Bone Marrow Failure Syndromes: Consensus Statement from the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation

Dietz, A. C., Mehta, P. A., Vlachos, A., Savage, S. A., Bresters, D., Tolar, J., Boulad, F., Dalle, J. H., Bonfim, C., de la Fuente, J., Duncan, C. N., Baker, K. S., Pulsipher, M. A., Lipton, J. M., Wagner, J. E. & Alter, B. P. Jan 14 2017 (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Research - peer-reviewArticle

Cell Transplantation
Bone Marrow
Pediatrics
Transplants
Bone Marrow failure syndromes
5 Citations
Fanconi Anemia
Cell Transplantation
Transplants
Survival
Investigational Therapies
Fetal Blood
Transplantation
Neutrophils
Blood Platelets
Incidence

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R. Dec 1 2017 In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Research - peer-reviewArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
In Vitro Techniques
Interleukin-2
1 Citations

Late Effects Screening Guidelines after Hematopoietic Cell Transplantation for Inherited Bone Marrow Failure Syndromes: Consensus Statement From the Second Pediatric Blood and Marrow Transplant Consortium International Conference on Late Effects After Pediatric HCT

Dietz, A. C., Savage, S. A., Vlachos, A., Mehta, P. A., Bresters, D., Tolar, J., Bonfim, C., Dalle, J. H., de la Fuente, J., Skinner, R., Boulad, F., Duncan, C. N., Baker, K. S., Pulsipher, M. A., Lipton, J. M., Wagner, J. E. & Alter, B. P. 2017 (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Research - peer-reviewArticle

Cell Transplantation
Bone Marrow
Guidelines
Pediatrics
Transplants
Risk Management
Ice
Immunocompromised Host
Mycobacterium
Hematopoietic Stem Cells
2 Citations
HLA-C Antigens
HLA Antigens
Fetal Blood
Transplantation
Transplants
3 Citations

Optimal Practices in Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies

Barker, J. N., Kurtzberg, J., Ballen, K., Boo, M., Brunstein, C., Cutler, C., Horwitz, M., Milano, F., Olson, A., Spellman, S., Wagner, J. E., Delaney, C. & Shpall, E. Jun 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 6, p. 882-896 15 p.

Research output: Research - peer-reviewReview article

Unrelated Donors
Hematologic Neoplasms
Fetal Blood
Transplantation
Graft vs Host Disease
Fanconi Anemia
Mutation
Inborn Genetic Diseases
Bone Marrow
Phenotype
5 Citations

The Second Pediatric Blood and Marrow Transplant Consortium International Consensus Conference on Late Effects after Pediatric Hematopoietic Cell Transplantation: Defining the Unique Late Effects of Children Undergoing Hematopoietic Cell Transplantation for Immune Deficiencies, Inherited Marrow Failure Disorders, and Hemoglobinopathies

Dietz, A. C., Duncan, C. N., Alter, B. P., Bresters, D., Cowan, M. J., Notarangelo, L., Rosenberg, P. S., Shenoy, S., Skinner, R., Walters, M. C., Wagner, J., Baker, K. S. & Pulsipher, M. A. Jan 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 1, p. 24-29 6 p.

Research output: Research - peer-reviewArticle

Hemoglobinopathies
Cell Transplantation
Transplantation
Bone Marrow
Pediatrics

Umbilical Cord Blood Transplantation in Children with Acute Leukemia: Impact of Conditioning on Transplantation Outcomes

Eapen, M., Kurtzberg, J., Zhang, M. J., Hattersely, G., Fei, M., Mendizabal, A., Chan, K. W., De Oliveira, S., Schultz, K. R., Wall, D., Horowitz, M. M. & Wagner, J. E. Oct 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 10, p. 1714-1721 8 p.

Research output: Research - peer-reviewArticle

Transplantation Conditioning
Fetal Blood
Leukemia
Transplantation
Survival
2016
37 Citations

CD56 dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

Cichocki, F., Cooley, S., Davis, Z., DeFor, T. E., Schlums, H., Zhang, B., Brunstein, C. G., Blazar, B. R., Wagner, J., Diamond, D. J., Verneris, M. R., Bryceson, Y. T., Weisdorf, D. J. & Miller, J. S. Feb 1 2016 In : Leukemia. 30, 2, p. 456-463 8 p.

Research output: Research - peer-reviewArticle

Cytomegalovirus
Natural Killer Cells
Leukemia
Transplants
Recurrence
5 Citations

CRISPR/Cas9 targeted gene editing and cellular engineering in fanconi anemia

Osborn, M. J., Lonetree, C. L., Webber, B. R., Patel, D., Dunmire, S., Defeo, A. P., McElroy, A. N., Macmillan, M. L., Wagner, J. E., Blazar, B. R. & Tolar, J. Oct 15 2016 In : Stem Cells and Development. 25, 20, p. 1591-1603 13 p.

Research output: Research - peer-reviewArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Cell Engineering
Fanconi Anemia
Genes
Gene Editing
6 Citations
Fanconi Anemia
Cell Transplantation
Insulin Resistance
Bone and Bones
Health

Establishing the UCB graft potentiality

Wagner, J. E. May 12 2016 In : Blood. 127, 19, p. 2272-2274 3 p.

Research output: Research - peer-reviewArticle

Aldehyde Dehydrogenase
Fetal Blood
Reproducibility of Results
Transplants
Grafts
4 Citations

Fatal myocarditis associated with HHV-6 following immunosuppression in two children

Stefanski, H. E., Thibert, K. A., Pritchett, J., Prusty, B. K., Wagner, J. E. & Lund, T. C. Jan 1 2016 In : Pediatrics. 137, 1, e20151352

Research output: Research - peer-reviewArticle

Human Herpesvirus 6
Myocarditis
Immunosuppression
Herpesviridae Infections
Therapeutics

Hematopoietic Cell Transplantation for Fanconi Anemia

Wagner, J. E., Tolar, J., Auerbach, A. D. & MacMillan, M. L. Jan 1 2016 Thomas' Hematopoietic Cell Transplantation: Fifth Edition. Wiley Blackwell, Vol. 2-2, p. 923-946 24 p.

Research output: ResearchChapter

Fanconi Anemia
Cell Transplantation
Bone Marrow
Radiation
Inborn Genetic Diseases
3 Citations
Graft vs Host Disease
Helper-Inducer T-Lymphocytes
Fetal Blood
Transplantation
B-Lymphocytes
4 Citations

Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials

McKenna, D. H., Sumstad, D., Kadidlo, D. M., Batdorf, B., Lord, C. J., Merkel, S. C., Koellner, C. M., Curtsinger, J. M., June, C. H., Riley, J. L., Levine, B. L., Miller, J. S., Brunstein, C. G., Wagner, J. E., Blazar, B. R. & Hippen, K. L. Aug 16 2016 (Accepted/In press) In : Cytotherapy.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Fetal Blood
Clinical Trials
Graft vs Host Disease
Antigen-Presenting Cells
4 Citations
Cell Transplantation
Gonadotropin-Releasing Hormone
Observation
Transplants
Myeloablative Agonists
1 Citations

Paternal or Maternal Uniparental Disomy of Chromosome 16 Resulting in Homozygosity of a Mutant Allele Causes Fanconi Anemia

Donovan, F. X., Kimble, D. C., Kim, Y., Lach, F. P., Harper, U., Kamat, A., Jones, M., Sanborn, E. M., Tryon, R., Wagner, J. E., Macmillan, M. L., Ostrander, E. A., Auerbach, A. D., Smogorzewska, A. & Chandrasekharappa, S. C. May 1 2016 In : Human Mutation. 37, 5, p. 465-468 4 p.

Research output: Research - peer-reviewArticle

Fanconi Anemia
Alleles
Mothers
Uniparental disomy Chromosome 16
Uniparental Disomy
56 Citations

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

Wagner, J. E., Brunstein, C. G., Boitano, A. E., Defor, T. E., McKenna, D., Sumstad, D., Blazar, B. R., Tolar, J., Le, C., Jones, J., Cooke, M. P. & Bleul, C. C. Jan 7 2016 In : Cell Stem Cell. 18, 1, p. 144-155 12 p.

Research output: Research - peer-reviewArticle

Hematopoietic Stem Cells
Fetal Blood
Transplants
StemRegenin 1
Aryl Hydrocarbon Receptors
10 Citations
Cell Transplantation
Graft vs Host Disease
Fetal Blood
Incidence
Recurrence
1 Citations
Mycophenolic Acid
Graft vs Host Disease
Sirolimus
Fetal Blood
Transplantation
6 Citations
Adoptive Transfer
Cell Transplantation
Natural Killer Cells
Neoplasms
Transplants

Toxic epidermal necrolysis in recessive dystrophic epidermolysis bullosa following bone marrow transplantation

Boull, C. L., Hylwa, S. A., Sajic, D., Wagner, J. E., Tolar, J. & Hook, K. P. Jun 1 2016 In : Journal of Pediatrics. 173, p. 242-244 3 p.

Research output: Research - peer-reviewArticle

Epidermolysis Bullosa Dystrophica
Stevens-Johnson Syndrome
Bone Marrow Transplantation
Biopsy
Skin
57 Citations
Graft vs Host Disease
Regulatory T-Lymphocytes
Fetal Blood
Grafts
Toxicity
1 Citations
Fetal Blood
Acute Myeloid Leukemia
Transplantation
2015
6 Citations

A biologic Velcro patch

Tolar, J. & Wagner, J. E. Jan 22 2015 In : New England Journal of Medicine. 372, 4, p. 382-384 3 p.

Research output: Research - peer-reviewArticle

Collagen Type VII
Epidermolysis Bullosa Dystrophica
Induced Pluripotent Stem Cells
Combined Modality Therapy
Skin Transplantation
18 Citations
KIR Receptors
Cell Transplantation
Cytomegalovirus
Natural Killer Cells
Tissue Donors
67 Citations

A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination

Wang, A. T., Kim, T., Wagner, J. E., Conti, B. A., Lach, F. P., Huang, A. L., Molina, H., Sanborn, E. M., Zierhut, H., Cornes, B. K., Abhyankar, A., Sougnez, C., Gabriel, S. B., Auerbach, A. D., Kowalczykowski, S. C. & Smogorzewska, A. Aug 6 2015 In : Molecular Cell. 59, 3, p. 478-490 13 p.

Research output: Research - peer-reviewArticle

Recombinational DNA Repair
Homologous Recombination
Mutation
DNA
Recombinases
29 Citations

Advances in umbilical cord blood manipulation-from niche to bedside

Lund, T. C., Boitano, A. E., Delaney, C. S., Shpall, E. J. & Wagner, J. E. Mar 28 2015 In : Nature Reviews Clinical Oncology. 12, 3, p. 163-174 12 p.

Research output: Research - peer-reviewArticle

Hematopoietic Stem Cells
Fetal Blood
Bone Marrow
Allografts
Transplantation
35 Citations
Fanconi Anemia
Cell Transplantation
Tissue Donors
fludarabine
Antilymphocyte Serum
2 Citations
Cell Transplantation
Haplotypes
Tissue Donors
Confidence Intervals
Siblings
7 Citations

Bone mineral density in children with fanconi anemia after hematopoietic cell transplantation

Petryk, A., Polgreen, L. E., Barnum, J. L., Zhang, L., Hodges, J. S., Baker, K. S., Wagner, J. E., Steinberger, J. & MacMillan, M. L. May 1 2015 In : Biology of Blood and Marrow Transplantation. 21, 5, p. 894-899 6 p.

Research output: Research - peer-reviewArticle

Fanconi Anemia
Cell Transplantation
Bone Density
Neoplasms
Bone and Bones
1 Citations

Cell therapy product administration and safety: Data capture and analysis from the Production Assistance for Cellular Therapies (PACT) program

Lindblad, R. W., Ibenana, L., Wagner, J. E., McKenna, D. H., Hei, D. J., Hematti, P., Couture, L. A., Silberstein, L. E., Armant, M., Rooney, C. M., Gee, A. P., Welniak, L. A., Heath Mondoro, T., Wood, D. A. & Styers, D. Jan 1 2015 In : Transfusion. 55, 3, p. 674-679 6 p.

Research output: Research - peer-reviewReview article

Factual Databases
Postmarketing Product Surveillance
Forms and Records Control
National Heart, Lung, and Blood Institute (U.S.)
Adoptive Immunotherapy
49 Citations

Fanconi anemia gene editing by the CRISPR/Cas9 system

Osborn, M. J., Gabriel, R., Webber, B. R., Defeo, A. P., McElroy, A. N., Jarjour, J., Starker, C. G., Wagner, J. E., Joung, J. K., Voytas, D. F., Von Kalle, C., Schmidt, M., Blazar, B. R. & Tolar, J. Jan 1 2015 In : Human Gene Therapy. 26, 2, p. 114-126 13 p.

Research output: Research - peer-reviewArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Fanconi Anemia
Genes
Gene Editing
Deoxyribonuclease I
14 Citations
Mycophenolic Acid
Graft vs Host Disease
Fetal Blood
Transplantation
Conditioning (Psychology)
7 Citations
Fetal Blood
Transplantation
Alleles
Treatment Failure
Leukemia
3 Citations
Cryopreservation
Fetal Blood
Transplantation
Blood Cells
Neutrophils
8 Citations

In Vivo T Cell Depletion with Myeloablative Regimens on Outcomes after Cord Blood Transplantation for Acute Lymphoblastic Leukemia in Children

Ponce, D. M., Eapen, M., Sparapani, R., O'Brien, T. A., Chan, K. W., Chen, J., Craddock, J., Schultz, K. R., Wagner, J. E., Perales, M. A. & Barker, J. N. Dec 1 2015 In : Biology of Blood and Marrow Transplantation. 21, 12, p. 2173-2179 7 p.

Research output: Research - peer-reviewArticle

Antilymphocyte Serum
Fetal Blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Transplantation
T-Lymphocytes
4 Citations

One-unit versus two-unit cord-blood transplantation

Wagner, J. E., Eapen, M. & Kurtzberg, J. Jan 15 2015 In : The New England journal of medicine. 372, 3, p. 288 1 p.

Research output: Research - peer-reviewArticle

Cord Blood Stem Cell Transplantation
Hematologic Neoplasms
Fetal Blood
Transplantation
1 Citations

Personalized fludarabine dosing to reduce nonrelapse mortality in hematopoietic stem-cell transplant recipients receiving reduced intensity conditioning

Sanghavi, K., Wiseman, A., Kirstein, M. N., Cao, Q., Brundage, R., Jensen, K., Rogosheske, J., Kurtzweil, A., Long-Boyle, J., Wagner, J., Warlick, E. D., Brunstein, C. G., Weisdorf, D. J. & Jacobson, P. A. Nov 20 2015 (Accepted/In press) In : Translational Research.

Research output: Research - peer-reviewArticle

Hematopoietic Stem Cells
Transplants
Mortality
fludarabine
Transplant Recipients
4 Citations
Cell Transplantation
Transplants
Nerve Growth Factor
Confidence Intervals
Neutrophils
1 Citations

Second Allogeneic Hematopoietic Cell Transplantation for Patients with Fanconi Anemia and Bone Marrow Failure

Ayas, M. , Eapen, M. , Le-Rademacher, J. , Carreras, J. , Abdel-Azim, H. , Alter, B. P. , Anderlini, P. , Battiwalla, M. , Bierings, M. , Buchbinder, D. K. , Bonfim, C. , Camitta, B. M. , Fasth, A. L. , Gale, R. P. , Lee, M. A. , Lund, T. C. , Myers, K. C. , Olsson, R. F. , Page, K. M. , Prestidge, T. D. & 6 others Radhi, M., Shah, A. J., Schultz, K. R., Wirk, B., Wagner, J. E. & Deeg, H. J. Oct 1 2015 In : Biology of Blood and Marrow Transplantation. 21, 10, p. 1790-1795 6 p.

Research output: Research - peer-reviewArticle

Fanconi Anemia
Cell Transplantation
Bone Marrow
Transplants
Graft Survival

The authors reply

Wagner, J. E., Eapen, M. & Kurtzberg, J. Jan 15 2015 In : New England Journal of Medicine. 372, 3, p. 288 1 p.

Research output: Research - peer-reviewArticle

2014
4 Citations

An Update from the United States National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) Program: A Decade of Cell Therapy

Wood, D., Wesselschmidt, R., Hematti, P., Gee, A. P., Rooney, C., Silberstein, L., Armant, M., Couture, L., Wagner, J. E., Mckenna, D. H., Hei, D., Mondoro, T. H., Welniak, L. & Lindblad, R. 2014 In : Clinical and Translational Science. 7, 2, p. 93-99 7 p.

Research output: Research - peer-reviewArticle

National Heart, Lung, and Blood Institute (U.S.)
Program Development
Translational Medical Research
Cell- and Tissue-Based Therapy
Therapeutics
11 Citations
Fetal Blood
Transplantation
Tissue Donors
Recurrence
Confidence Intervals
11 Citations

Comprehensive analysis of pathogenic deletion variants in Fanconi anemia genes

Flynn, E. K., Kamat, A., Lach, F. P., Donovan, F. X., Kimble, D. C., Narisu, N., Sanborn, E., Boulad, F., Davies, S. M., Gillio, A. P., Harris, R. E., Macmillan, M. L., Wagner, J. E., Smogorzewska, A., Auerbach, A. D., Ostrander, E. A. & Chandrasekharappa, S. C. Nov 1 2014 In : Human Mutation. 35, 11, p. 1342-1353 12 p.

Research output: Research - peer-reviewArticle

Fanconi Anemia
Genes
Organism Cloning
Mutation
Comparative Genomic Hybridization
5 Citations
Hematopoietic Stem Cell Transplantation
Myelodysplastic Syndromes
Natural History
Leukemia
Tissue Donors