Find Research Outputs

Search concepts
Selected Filters
2018
2 Citations

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Acrolein
Tobacco Smoke Pollution
Tobacco Products
Tobacco
Smoking

A New Editorial Team for CRT

Hecht, S. S., Jan 16 2018, In : Chemical research in toxicology. 31, 1, 1 p.

Research output: Contribution to journalEditorial

3 Citations

Identification of more than 100 structurally unique DNA-phosphate adducts formed during rat lung carcinogenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

Ma, B., Zarth, A. T., Carlson, E. S., Villalta, P. W., Upadhyaya, P., Stepanov, I. & Hecht, S. S., Feb 1 2018, In : Carcinogenesis. 39, 2, p. 232-241 10 p.

Research output: Contribution to journalArticle

Nitrosamines
DNA Adducts
Tobacco
Carcinogenesis
Phosphates
Bronchiolo-Alveolar Adenocarcinoma
Enantiomers
Inbred F344 Rats
Metabolites
Pancreatic Neoplasms
1 Citations
Enantiomers
DNA Adducts
Metabolites
Rats
Phosphates

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 1 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview article

Food Safety
Safety
Glucuronic Acid
Food Chain
Biotransformation

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 1 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Flavors
ingredients
flavor
Safety
Food
2017
Nitrosamines
Cytochromes
Metabolism
Proteins
Cytochrome P-450 Enzyme System
1 Citations
N'-nitrosonornicotine
Enantiomers
Liquid chromatography
Tandem Mass Spectrometry
Liquid Chromatography

A special issue of CRT: Celebrating volume 30

Hecht, S. S., Jan 1 2017, In : Chemical Research in Toxicology. 30, 1, 1 p.

Research output: Contribution to journalEditorial

Toxicology
4 Citations

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 1 2017, In : PLoS One. 12, 5, e0178435.

Research output: Contribution to journalArticle

nicotine
lung neoplasms
cohort studies
Nicotine
cytochrome P-450
9 Citations

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 othersKimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 1 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Tobacco Products
Biomarkers
Research Personnel
Tobacco Use
Research

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Dec 15 2017, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 228-253 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Smoke
Tobacco Products
Respiratory System
Lung Neoplasms
Carcinogens
8 Citations

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Singapore
Genetic Polymorphisms
Nicotine
Smoke
Cytochrome P-450 Enzyme System
2 Citations
Squamous Cell Neoplasms
Mouth Neoplasms
Head and Neck Neoplasms
Carcinogens
DNA Damage
3 Citations
Deoxycytidine
Carcinogens
Tobacco
DNA
Nitrosamines
Polycyclic Aromatic Hydrocarbons
Acetylcysteine
Epoxy Compounds
Urine
Creosote
8 Citations

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, p. 367-375 9 p.

Research output: Contribution to journalReview article

DNA Adducts
Biomarkers
Tobacco Products
Lung Neoplasms
DNA
1 Citations

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of Medicinal Chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Lactones
Structure-Activity Relationship
Adenoma
Lung Neoplasms
Lung
2 Citations
Nitrosamines
Tobacco
Enantiomers
DNA Adducts
Metabolites
9 Citations

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Nicotine
Tobacco Products
Confidence Intervals
Smoking
Biomarkers
4 Citations

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V., Jan 1 2017, In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Contribution to journalReview article

thiophenes
Thiophenes
flavorings
Metabolism
ingredients
6 Citations

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Tobacco
Smoke
Nicotine
National Institute of Environmental Health Sciences (U.S.)
Biomarkers
1 Citations
DNA Adducts
Benzo(a)pyrene
Carcinogens
Liquid chromatography
DNA
2016
8 Citations
2-butenal
Smoke
Acrolein
Carcinogens
Tobacco
3 Citations
N'-nitrosonornicotine
Deoxyguanosine
DNA Adducts
Rats
Inbred F344 Rats
2 Citations

Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles

Farsalinos, K. E., Gillman, I. G., Hecht, S. S., Polosa, R. & Thornburg, J., Nov 14 2016, Elsevier Inc. 150 p.

Research output: Book/ReportBook

Tobacco Products
Aerosols
Industry
Medical Marijuana
Information Science
11 Citations

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 1 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Nicotine
Randomized Controlled Trials
Biomarkers
Smoking
Tobacco Products
7 Citations

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 1 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

cigarettes
benzene
Benzene
glutathione transferase
Tobacco Products

Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions

Hecht, S. S., Nov 14 2016, Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Elsevier Inc., p. 59-73 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tobacco Products
Biomarkers
Nicotine
Urine
Cotinine
18 Citations
Tobacco Products
Carcinogens
Tobacco
Clinical Trials
Lung
12 Citations

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 1 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Anthocyanins
Esophageal Neoplasms
Esophagus
Cytokines
Diet
2 Citations
Lung
Lung Neoplasms
Carcinogenesis
DNA Adducts
4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol
7 Citations
N'-nitrosonornicotine
Hydroxylation
Tobacco
DNA Adducts
Carcinogens
7 Citations

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Dec 19 2016, In : Chemical Research in Toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Contribution to journalArticle

N'-nitrosonornicotine
Nitrosamines
Tobacco
Metabolism
Cytochrome P-450 Enzyme System
28 Citations
N'-nitrosonornicotine
Nitrosamines
Tobacco
Biomarkers
Chemical activation
1 Citations

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Dec 1 2016, In : Food and Chemical Toxicology. 98, p. 201-209 9 p.

Research output: Contribution to journalReview article

Mentha
Flavors
genotoxicity
Assays
Micronucleus Tests
13 Citations

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study

Yuan, J. M., Nelson, H. H., Butler, L. M., Carmella, S. G., Wang, R., Kuriger-Laber, J. K., Adams-Haduch, J., Hecht, S. S., Gao, Y. T. & Murphy, S. E., May 1 2016, In : International Journal of Cancer. 138, 9, p. 2161-2171 11 p.

Research output: Contribution to journalArticle

Nicotine
Smoke
Cytochrome P-450 Enzyme System
Tobacco
Lung Neoplasms
9 Citations
Brassica
Vegetables
Biomarkers
3,3'-diindolylmethane
glucobrassicin
90 Citations

Key characteristics of carcinogens as a basis for organizing data on mechanisms of carcinogenesis

Smith, M. T., Guyton, K. Z., Gibbons, C. F., Fritz, J. M., Portier, C. J., Rusyn, I., DeMarini, D. M., Caldwell, J. C., Kavlock, R. J., Lambert, P. F., Hecht, S. S., Bucher, J. R., Stewart, B. W., Baan, R. A., Cogliano, V. J. & Straif, K., Jun 1 2016, In : Environmental health perspectives. 124, 6, p. 713-721 9 p.

Research output: Contribution to journalReview article

International Agencies
Carcinogens
Carcinogenesis
Research
Neoplasms
6 Citations

Metabolites of the polycyclic aromatic hydrocarbon phenanthrene in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Patel, Y. M., Park, S. L., Carmella, S. G., Paiano, V., Olvera, N., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 1 2016, In : PloS one. 11, 6, e0156203.

Research output: Contribution to journalArticle

phenanthrene
cigarettes
Polycyclic Aromatic Hydrocarbons
polycyclic aromatic hydrocarbons
lung neoplasms
14 Citations

Randomised clinical trial of snus versus medicinal nicotine among smokers interested in product switching

Hatsukami, D. K., Severson, H., Anderson, A., Vogel, R. I., Jensen, J., Broadbent, B., Murphy, S. E., Carmella, S. & Hecht, S. S., May 1 2016, In : Tobacco Control. 25, 3, p. 267-274 8 p.

Research output: Contribution to journalArticle

Nicotine
nicotine
Tobacco Products
Randomized Controlled Trials
N'-nitrosonornicotine
13 Citations
indoles
Vegetables
vegetables
Glucosinolates
neoplasms
5 Citations

Tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study

Yershova, K., Yuan, J. M., Wang, R., Valentin, L., Watson, C., Gao, Y. T., Hecht, S. S. & Stepanov, I., Sep 15 2016, In : International Journal of Cancer. 139, 6, p. 1261-1269 9 p.

Research output: Contribution to journalArticle

Nitrosamines
Polycyclic Aromatic Hydrocarbons
Tobacco Products
Tobacco
Cohort Studies
2 Citations
N'-nitrosonornicotine
Gene Expression Profiling
Esophagus
Mouth
Carcinogenesis
2015
5 Citations

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L., Jan 1 2015, In : American Journal of Epidemiology. 182, 11, p. 945-951 7 p.

Research output: Contribution to journalArticle

Cotinine
Nicotine
Cohort Studies
Biomarkers
Oceanic Ancestry Group
3 Citations

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Contribution to journalArticle

Glutathione Transferase
Substrates
Kinetic parameters
Glutathione
Detoxification