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2017
23 Citations

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R., Nov 30 2017, In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Contribution to journalReview article

Transplantation Immunology
Animal Disease Models
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Acute Disease
14 Citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R., Apr 13 2017, In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Interleukin-17
Microbiota
Graft vs Host Disease
Grafts
Interleukin-17 Receptors
8 Citations

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Kean, L. S., Turka, L. A. & Blazar, B. R., Mar 1 2017, In : Immunological Reviews. 276, 1, p. 192-212 21 p.

Research output: Contribution to journalReview article

Yin-Yang
Immunotherapy
Transplantation
T-Lymphocytes
Neoplasms
4 Citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Bioluminescence
Zebrafish
Ergosterol
Imaging techniques
Firefly Luciferases
4 Citations

Alarmins and Their Receptors as Modulators and Indicators of Alloimmune Responses

Matta, B. M., Reichenbach, D. K., Blazar, B. R. & Turnquist, H. R., Feb 1 2017, In : American Journal of Transplantation. 17, 2, p. 320-327 8 p.

Research output: Contribution to journalReview article

Biomarkers
Alarmins
Transplants
Cell Transplantation
Homologous Transplantation
5 Citations

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Poe, J. C. , Jia, W. , Su, H. , Anand, S. , Rose, J. J. , Tata, P. V. , Suthers, A. N. , Jones, C. D. , Kuan, P. F. , Vincent, B. G. , Serody, J. S. , Horwitz, M. E. , Ho, V. T. , Pavletic, S. Z. , Hakim, F. T. , Owzar, K. , Zhang, D. , Blazar, B. R. , Siebel, C. W. , Chao, N. J. & 2 others Maillard, I. & Sarantopoulos, S., Nov 9 2017, In : Blood. 130, 19, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

B-Lymphocytes
Cells
Grafts
Chemical activation
Graft vs Host Disease
3 Citations

Angiotensin receptor blockade mediated amelioration of mucopolysaccharidosis type I cardiac and craniofacial pathology

Osborn, M. J., Webber, B. R., McElmurry, R. T., Rudser, K. D., DeFeo, A. P., Muradian, M., Petryk, A., Hallgrimsson, B., Blazar, B. R., Tolar, J. & Braunlin, E. A., Mar 1 2017, In : Journal of Inherited Metabolic Disease. 40, 2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Iduronidase
Mucopolysaccharidosis I
Angiotensin Receptors
Renin-Angiotensin System
Pathology

Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease

Wang, K. S., Kim, H. T., Nikiforow, S., Heubeck, A. T., Ho, V. T., Koreth, J., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Cutler, C. S. & Ritz, J., Dec 28 2017, In : Blood. 130, 26, p. 2889-2899 11 p.

Research output: Contribution to journalArticle

Fog dispersal
Delta wing aircraft
Hematopoietic Stem Cell Transplantation
Homologous Transplantation
Graft vs Host Disease
2 Citations

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Dec 1 2017, In : Scientific reports. 7, 1, 1633

Research output: Contribution to journalArticle

Endothelial Cells
Chemotactic Factors
T-Lymphocytes
Cell Movement
Leukocytes
4 Citations

B cells drive autoimmunity in mice with CD28-deficient regulatory T cells

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A., Dec 15 2017, In : Journal of Immunology. 199, 12, p. 3972-3980 9 p.

Research output: Contribution to journalArticle

CD28 Antigens
Lymphopoiesis
Lymphocyte Depletion
CD4-Positive T-Lymphocytes
Specific Pathogen-Free Organisms
34 Citations

Chronic graft-versus-host disease: Biological insights from preclinical and clinical studies

MacDonald, K. P. A., Hill, G. R. & Blazar, B. R., Jan 5 2017, In : Blood. 129, 1, p. 13-21 9 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Grafts
T-cells
Isoantibodies
Macrophage Colony-Stimulating Factor
5 Citations

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S., Sep 20 2017, In : Science Translational Medicine. 9, 408, eaan3085

Research output: Contribution to journalArticle

Sirolimus
Graft vs Host Disease
T-Lymphocytes
Transplants
Th1 Cells
4 Citations

Cytokine mediators of chronic graft-versus-host disease

MacDonald, K. P. A., Blazar, B. R. & Hill, G. R., Jun 30 2017, In : Journal of Clinical Investigation. 127, 7, p. 2452-2463 12 p.

Research output: Contribution to journalReview article

Graft vs Host Disease
Germinal Center
Interleukin-17
Cytokines
B-Lymphocytes
1 Citations

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., Blazar, B. R., Borowsky, A. D., Monjazeb, A. M. & Murphy, W. J., Apr 18 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 33

Research output: Contribution to journalArticle

Spleen
T-Lymphocytes
Phenotype
Therapeutics
Immunotherapy
4 Citations

Erythropoietin receptor-mediated molecular crosstalk promotes T cell immunoregulation and transplant survival

Purroy, C., Fairchild, R. L., Tanaka, T., Baldwin, W. M., Manrique, J., Madsen, J. C., Colvin, R. B., Alessandrini, A., Blazar, B. R., Fribourg, M., Donadei, C., Maggiore, U., Heeger, P. S. & Cravedi, P., Aug 1 2017, In : Journal of the American Society of Nephrology. 28, 8, p. 2377-2392 16 p.

Research output: Contribution to journalArticle

Erythropoietin Receptors
T-Lymphocytes
Transplants
Kidney
Antigen-Presenting Cells
10 Citations

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

Chung, J. , Ebens, C. L. , Perkey, E. , Radojcic, V. , Koch, U. , Scarpellino, L. , Tong, A. , Allen, F. , Wood, S. , Feng, J. , Friedman, A. , Granadier, D. , Tran, I. T. , Chai, Q. , Onder, L. , Yan, M. , Reddy, P. , Blazar, B. R. , Huang, A. Y. , Brennan, T. V. & 6 others Bishop, D. K., Ludewig, B., Siebel, C. W., Radtke, F., Luther, S. A. & Maillard, I., Apr 3 2017, In : Journal of Clinical Investigation. 127, 4, p. 1574-1588 15 p.

Research output: Contribution to journalArticle

Homologous Transplantation
Ligands
Bone Marrow Transplantation
T-Lymphocytes
Graft vs Host Disease
8 Citations

GSK3 inhibition drives maturation of NK cells and enhances their antitumor activity

Cichocki, F. , Valamehr, B. , Bjordahl, R. , Zhang, B. , Rezner, B. , Rogers, P. , Gaidarova, S. , Moreno, S. , Tuininga, K. , Dougherty, P. , McCullar, V. , Howard, P. , Sarhan, D. , Taras, E. , Schlums, H. , Abbot, S. , Shoemaker, D. , Bryceson, Y. T. , Blazar, B. R. , Wolchko, S. & 2 others Cooley, S. & Miller, J. S., Oct 15 2017, In : Cancer Research. 77, 20, p. 5664-5675 12 p.

Research output: Contribution to journalArticle

Natural Killer Cells
Neoplasms
Phosphotransferases
Immunologic Monitoring
Interleukin-15
8 Citations

GVHD prevents NK-cell-dependent leukemia and virus-specific innate immunity

Bunting, M. D., Varelias, A., Souza-Fonseca-Guimaraes, F., Schuster, I. S., Lineburg, K. E., Kuns, R. D., Fleming, P., Locke, K. R., Huntington, N. D., Blazar, B. R., Lane, S. W., Tey, S. K., MacDonald, K. P. A., Smyth, M. J., Degli-Esposti, M. A. & Hill, G. R., Feb 2 2017, In : Blood. 129, 5, p. 630-642 13 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Viruses
Innate Immunity
Grafts
Natural Killer Cells

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L., Dec 1 2017, In : Scientific reports. 7, 1, 4258

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Protein Kinase C
Fetal Blood
Eragrostis
Immunological Synapses
19 Citations

Ibrutinib for chronic graft-versus-host disease after failure of prior therapy

Miklos, D., Cutler, C. S., Arora, M., Waller, E. K., Jagasia, M., Pusic, I., Flowers, M. E., Logan, A. C., Nakamura, R., Blazar, B. R., Li, Y., Chang, S., Lal, I., Dubovsky, J., James, D. F., Styles, L. & Jaglowski, S., Nov 23 2017, In : Blood. 130, 21, p. 2243-2250 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Adrenal Cortex Hormones
Therapeutics
T-cells
3 Citations

Increased effector memory insulin-specific CD4+ T cells correlate with insulin autoantibodies in patients with recent-onset type 1 diabetes

Spanier, J. A., Sahli, N. L., Wilson, J. C., Martinov, T., Dileepan, T., Burrack, A. L., Finger, E. B., Blazar, B. R., Michels, A. W., Moran, A., Jenkins, M. K. & Fife, B. T., Dec 1 2017, In : Diabetes. 66, 12, p. 3051-3060 10 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Autoantibodies
Insulin
T-Lymphocytes
Phenotype
10 Citations

Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells

Du, J., Paz, K., Thangavelu, G., Schneidawind, D., Baker, J., Flynn, R., Duramad, O., Feser, C., Panoskaltsis-Mortari, A., Negrin, R. S. & Blazar, B. R., Jun 8 2017, In : Blood. 129, 23, p. 3121-3125 5 p.

Research output: Contribution to journalArticle

Natural Killer T-Cells
T-cells
Regulatory T-Lymphocytes
Graft vs Host Disease
Grafts
2 Citations

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R., Dec 1 2017, In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Contribution to journalArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
Interleukin-2
Graft vs Host Disease
2 Citations
1 Citations

Low EGF in myeloablative allotransplantation: Association with severe acute GvHD in BMT CTN 0402

Holtan, S. G., Newell, L. F., Cutler, C., Verneris, M. R., Defor, T. E., Wu, J., Howard, A., Macmillan, M. L., Antin, J. H., Blazar, B. R., Weisdorf, D. J. & Panoskaltsis-Mortari, A., Sep 1 2017, In : Bone Marrow Transplantation. 52, 9, p. 1300-1303 4 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor
Cell Transplantation
Bone Marrow
Clinical Trials
Transplants
8 Citations

Optimization of cGMP purification and expansion of umbilical cord blood–derived T-regulatory cells in support of first-in-human clinical trials

McKenna, D. H., Sumstad, D., Kadidlo, D. M., Batdorf, B., Lord, C. J., Merkel, S. C., Koellner, C. M., Curtsinger, J. M., June, C. H., Riley, J. L., Levine, B. L., Miller, J. S., Brunstein, C. G., Wagner, J. E., Blazar, B. R. & Hippen, K. L., Feb 1 2017, In : Cytotherapy. 19, 2, p. 250-262 13 p.

Research output: Contribution to journalArticle

Regulatory T-Lymphocytes
Fetal Blood
Clinical Trials
Graft vs Host Disease
Antigen-Presenting Cells
13 Citations

Pathophysiology of chronic graft-versus-host disease and therapeutic targets

Zeiser, R. & Blazar, B. R., Dec 28 2017, In : New England Journal of Medicine. 377, 26, p. 2565-2579 15 p.

Research output: Contribution to journalReview article

Animal Disease Models
Hematopoietic Stem Cell Transplantation
Cell Transplantation
Graft vs Host Disease
Immunosuppressive Agents
37 Citations

PD-1 blockade for relapsed lymphoma post-allogeneic hematopoietic cell transplant: High response rate but frequent GVHD

Haverkos, B. M. , Abbott, D. , Hamadani, M. , Armand, P. , Flowers, M. E. , Merryman, R. , Kamdar, M. , Kanate, A. S. , Saad, A. , Mehta, A. , Ganguly, S. , Fenske, T. S. , Hari, P. , Lowsky, R. , Andritsos, L. , Jagasia, M. , Bashey, A. , Brown, S. , Bachanova, V. , Stephens, D. & 6 others Mineishi, S., Nakamura, R., Chen, Y. B., Blazar, B. R., Gutman, J. & Devine, S. M., Jul 13 2017, In : Blood. 130, 2, p. 221-228 8 p.

Research output: Contribution to journalArticle

Transplants
Lymphoma
Monoclonal Antibodies
Salvaging
Refractory materials
17 Citations

Pirfenidone ameliorates murine chronic GVHD through inhibition of macrophage infiltration and TGF-β production

Du, J. , Paz, K. , Flynn, R. , Vulic, A. , Robinson, T. M. , Lineburg, K. E. , Alexander, K. A. , Meng, J. , Roy, S. , Panoskaltsis-Mortari, A. , Loschi, M. , Hill, G. R. , Serody, J. S. , Maillard, I. , Miklos, D. , Koreth, J. , Cutler, C. S. , Antin, J. H. , Ritz, J. , MacDonald, K. P. & 3 others Schacker, T. W., Luznik, L. & Blazar, B. R., May 4 2017, In : Blood. 129, 18, p. 2570-2580 11 p.

Research output: Contribution to journalArticle

Macrophages
Graft vs Host Disease
Infiltration
Grafts
Transforming Growth Factor beta
Adoptive Transfer
Natural Killer Cells
T-Lymphocytes
Tissue Donors
Remission Induction
113 Citations

Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent

Kamphorst, A. O., Wieland, A., Nasti, T., Yang, S., Zhang, R., Barber, D. L., Konieczny, B. T., Daugherty, C. Z., Koenig, L., Yu, K., Sica, G. L., Sharpe, A. H., Freeman, G. J., Blazar, B. R., Turka, L. A., Owonikoko, T. K., Pillai, R. N., Ramalingam, S. S., Araki, K. & Ahmed, R., Mar 31 2017, In : Science. 355, 6332, p. 1423-1427 5 p.

Research output: Contribution to journalArticle

Cell Death
T-Lymphocytes
Therapeutics
Neoplasms
Gene Deletion
5 Citations

Role of myeloid-derived suppressor cells in allogeneic hematopoietic cell transplantation

Koehn, B. H. & Blazar, B. R., Aug 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 335-341 7 p.

Research output: Contribution to journalReview article

Cell Transplantation
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Myeloid Cells
Inflammation
8 Citations

Serum miR-29a is upregulated in acute graft-versus-host disease and activates dendritic cells through TLR binding

Ranganathan, P., Ngankeu, A., Zitzer, N. C., Leoncini, P., Yu, X., Casadei, L., Challagundla, K., Reichenbach, D. K., Garman, S., Ruppert, A. S., Volinia, S., Hofstetter, J., Efebera, Y. A., Devine, S. M., Blazar, B. R., Fabbri, M. & Garzon, R., Mar 15 2017, In : Journal of Immunology. 198, 6, p. 2500-2512 13 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Dendritic Cells
Serum
Hematopoietic Stem Cell Transplantation
MicroRNAs
1 Citations

T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD

Dant, T. A., Lin, K. L., Bruce, D. W., Montgomery, S. A., Kolupaev, O. V., Bommiasamy, H., Bixby, L. M., Woosley, J. T., McKinnon, K. P., Gonzalez, F. J., Blazar, B. R., Vincent, B. G., Coghill, J. M. & Serody, J. S., Jul 20 2017, In : Blood. 130, 3, p. 348-359 12 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
T-cells
Gastrointestinal Tract
Maintenance
T-Lymphocytes
35 Citations

The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease

Cooke, K. R., Luznik, L., Sarantopoulos, S., Hakim, F. T., Jagasia, M., Fowler, D. H., van den Brink, M. R. M., Hansen, J. A., Parkman, R., Miklos, D. B., Martin, P. J., Paczesny, S., Vogelsang, G., Pavletic, S., Ritz, J., Schultz, K. R. & Blazar, B. R., Feb 1 2017, In : Biology of Blood and Marrow Transplantation. 23, 2, p. 211-234 24 p.

Research output: Contribution to journalReview article

National Institutes of Health (U.S.)
Graft vs Host Disease
Advisory Committees
Consensus
Clinical Trials
5 Citations

The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques

Zheng, H. B., Watkins, B., Tkachev, V., Yu, S., Tran, D., Furlan, S., Zeleski, K., Singh, K., Hamby, K., Hotchkiss, C., Lane, J., Gumber, S., Adams, A. B., Cendales, L., Kirk, A. D., Kaur, A., Blazar, B. R., Larsen, C. P. & Kean, L. S., Mar 1 2017, In : American Journal of Transplantation. 17, 3, p. 657-670 14 p.

Research output: Contribution to journalArticle

Chimerism
Macaca mulatta
Cytomegalovirus
T-Lymphocytes
Transplants
7 Citations

Type 2 innate lymphoid cells treat and prevent acute gastrointestinal graft-versus-host disease

Bruce, D. W., Stefanski, H. E., Vincent, B. G., Dant, T. A., Reisdorf, S., Bommiasamy, H., Serody, D. A., Wilson, J. E., McKinnon, K. P., Shlomchik, W. D., Armistead, P. M., Ting, J. P. Y., Woosley, J. T., Blazar, B. R., Zaiss, D. M. W., McKenzie, A. N. J., Coghill, J. M. & Serody, J. S., May 1 2017, In : Journal of Clinical Investigation. 127, 5, p. 1813-1825 13 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Lower Gastrointestinal Tract
Tissue Donors
Lymphocytes
Gastrointestinal Tract
2016
19 Citations

Adaptive NK cells with low TIGIT expression are inherently resistant to myeloid-derived suppressor cells

Sarhan, D., Cichocki, F., Zhang, B., Yingst, A., Spellman, S. R., Cooley, S., Verneris, M. R., Blazar, B. R. & Miller, J. S., Oct 1 2016, In : Cancer Research. 76, 19, p. 5696-5706 11 p.

Research output: Contribution to journalArticle

Natural Killer Cells
T-Lymphocytes
Reactive Oxygen Species
Costimulatory and Inhibitory T-Cell Receptors
Neoplasms
14 Citations

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Schönle, A. , Hartl, F. A. , Mentzel, J. , Nöltner, T. , Rauch, K. S. , Prestipino, A. , Wohlfeil, S. A. , Apostolova, P. , Hechinger, A. K. , Melchinger, W. , Fehrenbach, K. , Guadamillas, M. C. , Follo, M. , Prinz, G. , Ruess, A. K. , Pfeifer, D. , Del Pozo, M. A. , Schmitt-Graeff, A. , Duyster, J. , Hippen, K. I. & 4 others Blazar, B. R., Schachtrup, K., Minguet, S. & Zeiser, R., Apr 14 2016, In : Blood. 127, 15, p. 1930-1939 10 p.

Research output: Contribution to journalArticle

Caveolin 1
T-cells
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Cell Differentiation
56 Citations

CD56 dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

Cichocki, F., Cooley, S., Davis, Z., DeFor, T. E., Schlums, H., Zhang, B., Brunstein, C. G., Blazar, B. R., Wagner, J., Diamond, D. J., Verneris, M. R., Bryceson, Y. T., Weisdorf, D. J. & Miller, J. S., Feb 1 2016, In : Leukemia. 30, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle

Cytomegalovirus
Natural Killer Cells
Leukemia
Transplants
Recurrence
21 Citations

Circulating T follicular helper cells with increased function during chronic graft-versus-host disease

Forcade, E., Kim, H. T., Cutler, C., Wang, K., Alho, A. C., Nikiforow, S., Ho, V. T., Koreth, J., Armand, P., Alyea, E. P., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Ritz, J., May 19 2016, In : Blood. 127, 20, p. 2489-2497 9 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Helper-Inducer T-Lymphocytes
Grafts
B-Lymphocytes
Cells
9 Citations

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

Leveque-El Mouttie, L., Koyama, M., Le Texier, L., Markey, K. A., Cheong, M., Kuns, R. D., Lineburg, K. E., Teal, B. E., Alexander, K. A., Clouston, A. D., Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Aug 11 2016, In : Blood. 128, 6, p. 794-804 11 p.

Research output: Contribution to journalArticle

T-cells
Antigen Presentation
Graft vs Host Disease
Regulatory T-Lymphocytes
Grafts
7 Citations

CRISPR/Cas9 targeted gene editing and cellular engineering in fanconi anemia

Osborn, M. J., Lonetree, C. L., Webber, B. R., Patel, D., Dunmire, S., Defeo, A. P., McElroy, A. N., Macmillan, M. L., Wagner, J. E., Blazar, B. R. & Tolar, J., Oct 15 2016, In : Stem Cells and Development. 25, 20, p. 1591-1603 13 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
Cell Engineering
Fanconi Anemia
Induced Pluripotent Stem Cells
Genes
35 Citations

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

Koreth, J., Kim, H. T., Jones, K. T., Lange, P. B., Reynolds, C. G., Chammas, M. J., Dusenbury, K., Whangbo, J., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Chen, Y. B., Avigan, D., Blazar, B. R., Antin, J. H., Ritz, J. & Soiffer, R. J., Jul 7 2016, In : Blood. 128, 1, p. 130-137 8 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Grafts
Interleukin-2
Durability
T-cells
Aurora Kinase A
Gene Expression Profiling
Graft vs Host Disease
Grafts
Blood
5 Citations

Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer

D'Alincourt Salazar, M., Manuel, E. R., Tsai, W., D'Apuzzo, M., Goldstein, L., Blazar, B. R. & Diamond, D. J., Jun 2 2016, In : OncoImmunology. 5, 6, e1160184

Research output: Contribution to journalArticle

Adaptive Immunity
Pancreatic Neoplasms
Innate Immunity
Granulocytes
Natural Killer Cells
43 Citations

Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

Osborn, M. J. , Webber, B. R. , Knipping, F. , Lonetree, C. L. , Tennis, N. , DeFeo, A. P. , McElroy, A. N. , Starker, C. G. , Lee, C. , Merkel, S. , Lund, T. C. , Kelly-Spratt, K. S. , Jensen, M. C. , Voytas, D. F. , Von Kalle, C. , Schmidt, M. , Gabriel, R. , Hippen, K. L. , Miller, J. S. , Scharenberg, A. M. & 2 others Tolar, J. & Blazar, B. R., Mar 1 2016, In : Molecular Therapy. 24, 3, p. 570-581 12 p.

Research output: Contribution to journalArticle

Clustered Regularly Interspaced Short Palindromic Repeats
T-Lymphocytes
T-Cell Antigen Receptor
Adoptive Immunotherapy
Neoplasm Antigens
4 Citations

Graft Versus Host Disease after Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management

Murali, A. R., Chandra, S., Stewart, Z., Blazar, B. R., Farooq, U., Ince, M. N. & Dunkelberg, J., Dec 1 2016, In : Transplantation. 100, 12, p. 2661-2670 10 p.

Research output: Contribution to journalArticle

Graft vs Host Disease
Liver Transplantation
Mortality
Hepatocellular Carcinoma
Tumor Necrosis Factor-alpha
46 Citations
Interleukin-15
Natural Killer Cells
Antigens
Cell Degranulation
Survival
5 Citations

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z. C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jun 2 2016, In : OncoImmunology. 5, 6, e1171445

Research output: Contribution to journalArticle

Interleukin-7
T-Lymphocytes
Aptitude
Immunotherapy
Neoplasms