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2017

Allogeneic hematopoietic cell transplantation in morphologic leukemia-free aplastic state

Rashidi, A., Ali, A. M., Vij, K. R., Shanley, R., Romee, R., Cooley, S. A., Westervelt, P., DiPersio, J. F., Miller, J. S., Weisdorf, D. J. & Ustun, C. Sep 1 2017 In : American Journal of Hematology. 92, 9, p. E549-E552

Research output: Research - peer-reviewLetter

Cell Transplantation
Leukemia
1 Citations
1 Citations

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S. Sep 20 2017 In : Science Translational Medicine. 9, 408, eaan3085

Research output: Research - peer-reviewArticle

Sirolimus
T-Lymphocytes
Transplants
Graft vs Host Disease
Th1 Cells
Hematologic Neoplasms
Blood Donors
Fetal Blood
Dendritic Cells
Siblings
3 Citations
Antibody-Dependent Cell Cytotoxicity
Natural Killer Cells
Interleukin-15
Pharmaceutical Preparations
Neoplasms
1 Citations

GSK3 inhibition drives maturation of NK cells and enhances their antitumor activity

Cichocki, F. , Valamehr, B. , Bjordahl, R. , Zhang, B. , Rezner, B. , Rogers, P. , Gaidarova, S. , Moreno, S. , Tuininga, K. , Dougherty, P. , McCullar, V. , Howard, P. , Sarhan, D. , Taras, E. , Schlums, H. , Abbot, S. , Shoemaker, D. , Bryceson, Y. T. , Blazar, B. R. , Wolchko, S. & 2 others Cooley, S. & Miller, J. S. Oct 15 2017 In : Cancer Research. 77, 20, p. 5664-5675 12 p.

Research output: Research - peer-reviewArticle

Natural Killer Cells
Neoplasms
Phosphotransferases
Immunologic Monitoring
Interleukin-15
Natural Killer Cells
Non-Hodgkin's Lymphoma
Interleukin-2
Tissue Donors
Therapeutics
2 Citations

HLA-Bw4-I-80 isoform differentially influences clinical outcome as compared to HLA-Bw4-T-80 and HLA-A-Bw4 isoforms in rituximab or dinutuximab-based cancer immunotherapy

Erbe, A. K., Wang, W., Reville, P. K., Carmichael, L., Kim, K. M., Mendonca, E. A., Song, Y., Hank, J. A., London, W. B., Naranjo, A., Hong, F., Hogarty, M. D., Maris, J. M., Park, J. R., Ozkaynak, M. F., Miller, J. S., Gilman, A. L., Kahl, B., Yu, A. L. & Sondel, P. M. Jun 12 2017 In : Frontiers in Immunology. 8, JUN, 675

Research output: Research - peer-reviewArticle

HLA-A Antigens
Immunotherapy
Epitopes
Protein Isoforms
Neoplasms
7 Citations

IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer

Felices, M., Chu, S., Kodal, B., Bendzick, L., Ryan, C., Lenvik, A. J., Boylan, K. L. M., Wong, H. C., Skubitz, A. P. N., Miller, J. S. & Geller, M. A. Jun 1 2017 In : Gynecologic Oncology. 145, 3, p. 453-461 9 p.

Research output: Research - peer-reviewArticle

Interleukin-15
Natural Killer Cells
Ovarian Neoplasms
ALT-803
Ascites

In Vitro Induction of Human Regulatory T Cells Using Conditions of Low Tryptophan Plus Kynurenines

Hippen, K. L., O'Connor, R. S., Lemire, A. M., Saha, A., Hanse, E. A., Tennis, N. C., Merkel, S. C., Kelekar, A., Riley, J. L., Levine, B. L., June, C. H., Turka, L. A., Kean, L. S., MacMillan, M. L., Miller, J. S., Wagner, J. E., Munn, D. H. & Blazar, B. R. Dec 1 2017 In : American Journal of Transplantation. 17, 12, p. 3098-3113 16 p.

Research output: Research - peer-reviewArticle

Kynurenine
Regulatory T-Lymphocytes
Tryptophan
In Vitro Techniques
Interleukin-2
2 Citations
HLA-C Antigens
HLA Antigens
Fetal Blood
Transplantation
Transplants
2 Citations
Natural Killer Cells
Immunotherapy
Neoplasms
Neoplasm Antigens
Therapeutics
3 Citations

Recipient HLA-C Haplotypes and microRNA 148a/b Binding Sites Have No Impact on Allogeneic Hematopoietic Cell Transplantation Outcomes

Hoff, G. A., Fischer, J. C., Hsu, K., Cooley, S., Miller, J. S., Wang, T., Haagenson, M., Spellman, S., Lee, S. J., Uhrberg, M., Venstrom, J. M. & Verneris, M. R. Jan 1 2017 In : Biology of Blood and Marrow Transplantation. 23, 1, p. 153-160 8 p.

Research output: Research - peer-reviewArticle

HLA-C Antigens
Cell Transplantation
MicroRNAs
Haplotypes
Binding Sites
Adoptive Transfer
Natural Killer Cells
T-Lymphocytes
Tissue Donors
Drug Therapy
2016
12 Citations

Adaptive NK cells with low TIGIT expression are inherently resistant to myeloid-derived suppressor cells

Sarhan, D., Cichocki, F., Zhang, B., Yingst, A., Spellman, S. R., Cooley, S., Verneris, M. R., Blazar, B. R. & Miller, J. S. Oct 1 2016 In : Cancer Research. 76, 19, p. 5696-5706 11 p.

Research output: Research - peer-reviewArticle

Natural Killer Cells
T-Lymphocytes
Myeloid-Derived Suppressor Cells
Immunoglobulin Domains
Neoplasms
21 Citations

Advances in clinical NK cell studies: Donor selection, manufacturing and quality control

Koehl, U., Kalberer, C., Spanholtz, J., Lee, D. A., Miller, J. S., Cooley, S., Lowdell, M., Uharek, L., Klingemann, H., Curti, A., Leung, W. & Alici, E. Apr 2 2016 In : OncoImmunology. 5, 4

Research output: Research - peer-reviewReview article

Donor Selection
Natural Killer Cells
Quality Control
Neoplasms
Antigen Receptors
38 Citations

CD56 dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

Cichocki, F., Cooley, S., Davis, Z., DeFor, T. E., Schlums, H., Zhang, B., Brunstein, C. G., Blazar, B. R., Wagner, J., Diamond, D. J., Verneris, M. R., Bryceson, Y. T., Weisdorf, D. J. & Miller, J. S. Feb 1 2016 In : Leukemia. 30, 2, p. 456-463 8 p.

Research output: Research - peer-reviewArticle

Cytomegalovirus
Natural Killer Cells
Leukemia
Transplants
Recurrence
11 Citations

Diversification and functional specialization of human NK cell subsets

Cichocki, F., Schlums, H., Theorell, J., Tesi, B., Miller, J. S., Ljunggren, H. G. & Bryceson, Y. T. Feb 1 2016 In : Current Topics in Microbiology and Immunology. 395, p. 63-93 31 p.

Research output: Research - peer-reviewArticle

Natural Killer Cells
Immunologic Monitoring
Immunity
Cytokines
Recognition (Psychology)
4 Citations

Donor KIR B Genotype Improves Progression-Free Survival of Non-Hodgkin Lymphoma Patients Receiving Unrelated Donor Transplantation

Bachanova, V., Weisdorf, D. J., Wang, T., Marsh, S. G. E., Trachtenberg, E., Haagenson, M. D., Spellman, S. R., Ladner, M., Guethlein, L. A., Parham, P., Miller, J. S. & Cooley, S. A. Sep 1 2016 In : Biology of Blood and Marrow Transplantation. 22, 9, p. 1602-1607 6 p.

Research output: Research - peer-reviewArticle

KIR Receptors
Unrelated Donors
Non-Hodgkin's Lymphoma
Disease-Free Survival
Transplantation
13 Citations

Enhanced ADCC and NK cell activation of an anticarcinoma bispecific antibody by genetic insertion of a modified IL-15 cross-linker

Schmohl, J. U., Felices, M., Taras, E., Miller, J. S. & Vallera, D. A. Aug 1 2016 In : Molecular Therapy. 24, 7, p. 1312-1322 11 p.

Research output: Research - peer-reviewArticle

Bispecific Antibodies
Antibody-Dependent Cell Cytotoxicity
Interleukin-15
Natural Killer Cells
Cytokines
32 Citations

Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

Osborn, M. J. , Webber, B. R. , Knipping, F. , Lonetree, C. L. , Tennis, N. , DeFeo, A. P. , McElroy, A. N. , Starker, C. G. , Lee, C. , Merkel, S. , Lund, T. C. , Kelly-Spratt, K. S. , Jensen, M. C. , Voytas, D. F. , Von Kalle, C. , Schmidt, M. , Gabriel, R. , Hippen, K. L. , Miller, J. S. , Scharenberg, A. M. & 2 others Tolar, J. & Blazar, B. R. Mar 1 2016 In : Molecular Therapy. 24, 3, p. 570-581 12 p.

Research output: Research - peer-reviewArticle

Clustered Regularly Interspaced Short Palindromic Repeats
T-Lymphocytes
Gene Editing
Transcription Activator-Like Effector Nucleases
T-Cell Antigen Receptor
5 Citations

Generation of BiKEs and TriKEs to improve NK cell-mediated targeting of tumor cells

Felices, M., Lenvik, T. R., Davis, Z. B., Miller, J. S. & Vallera, D. A. Jan 1 2016 Methods in Molecular Biology. Humana Press Inc., Vol. 1441, p. 333-346 14 p. (Methods in Molecular Biology; vol. 1441)

Research output: ResearchChapter

Natural Killer Cells
Antibodies
Neoplasms
Immunotherapy
Natural Killer Cell Receptors
12 Citations

Heterodimeric Bispecific Single Chain Variable Fragments (scFv) Killer Engagers (BiKEs) Enhance NK-cell Activity Against CD133+ Colorectal Cancer Cells

Schmohl, J. U., Gleason, M. K., Dougherty, P. R., Miller, J. S. & Vallera, D. A. Jun 1 2016 In : Targeted Oncology. 11, 3, p. 353-361 9 p.

Research output: Research - peer-reviewArticle

Single-Chain Antibodies
Natural Killer Cells
Colorectal Neoplasms
Pharmaceutical Preparations
Neoplastic Stem Cells
32 Citations
Interleukin-15
Natural Killer Cells
Antigens
Survival
Neoplasms
21 Citations

Immunodynamics: A cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

Kohrt, H. E. , Tumeh, P. C. , Benson, D. , Bhardwaj, N. , Brody, J. , Formenti, S. , Fox, B. A. , Galon, J. , June, C. H. , Kalos, M. , Kirsch, I. , Kleen, T. , Kroemer, G. , Lanier, L. , Levy, R. , Lyerly, H. K. , Maecker, H. , Marabelle, A. , Melenhorst, J. , Miller, J. & 15 others Melero, I., Odunsi, K., Palucka, K., Peoples, G., Ribas, A., Robins, H., Robinson, W., Serafini, T., Sondel, P., Vivier, E., Weber, J., Wolchok, J., Zitvogel, L., Disis, M. L. & Cheever, M. A. Mar 15 2016 In : Journal for ImmunoTherapy of Cancer. 4, 1, 15

Research output: Research - peer-reviewReview article

Immunologic Monitoring
Immunotherapy
Clinical Trials
Neoplasms
Pharmacokinetics
15 Citations

Induced Pluripotent Stem Cell-Derived Natural Killer Cells for Treatment of Ovarian Cancer

Hermanson, D. L., Bendzick, L., Pribyl, L., McCullar, V., Vogel, R. I., Miller, J. S., Geller, M. A. & Kaufman, D. S. Jan 1 2016 In : Stem Cells. 34, 1, p. 93-101 9 p.

Research output: Research - peer-reviewArticle

Induced Pluripotent Stem Cells
Natural Killer Cells
Ovarian Neoplasms
Therapeutics
Neoplasms
3 Citations
Graft vs Host Disease
Helper-Inducer T-Lymphocytes
Fetal Blood
Transplantation
B-Lymphocytes
6 Citations
Cell Transplantation
Hematologic Neoplasms
Tissue Donors
Lymphocytes
Drug Therapy

Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation

Verneris, M. R. & Miller, J. S. Jan 1 2016 Thomas' Hematopoietic Cell Transplantation: Fifth Edition. Wiley Blackwell, Vol. 1-2, p. 126-138 13 p.

Research output: ResearchChapter

Cell Transplantation
Natural Killer Cells
Immune System
Therapeutics
KIR Receptors

NK cells pave the road for alloengraftment

Felices, M. & Miller, J. S. Mar 3 2016 In : Blood. 127, 9, p. 1083-1084 2 p.

Research output: Research - peer-reviewArticle

Grafts
Blood
Natural Killer Cells
Transplants
6 Citations

Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials

McKenna, D. H., Sumstad, D., Kadidlo, D. M., Batdorf, B., Lord, C. J., Merkel, S. C., Koellner, C. M., Curtsinger, J. M., June, C. H., Riley, J. L., Levine, B. L., Miller, J. S., Brunstein, C. G., Wagner, J. E., Blazar, B. R. & Hippen, K. L. Aug 16 2016 (Accepted/In press) In : Cytotherapy.

Research output: Research - peer-reviewArticle

Regulatory T-Lymphocytes
Fetal Blood
Clinical Trials
Graft vs Host Disease
Antigen-Presenting Cells
5 Citations

Proceedings from the Second Haploidentical Stem Cell Transplantation Symposium-Haplo2014, San Francisco, California, December 4, 2014

Al Malki, M. M., Horowitz, M., Handgretinger, R., Leung, W., Roy, D. C., Huang, X. J., Fuchs, E., Locatelli, F., Blaise, D., Mineishi, S., Martelli, M., Miller, J., June, C., Ai, H. S., Luznik, L., Mavilio, D., Lugli, E., van den Brink, M. R. M., Champlin, R. E. & Ciurea, S. O. Apr 1 2016 In : Biology of Blood and Marrow Transplantation. 22, 4, p. 594-604 11 p.

Research output: Research - peer-reviewArticle

San Francisco
Stem Cell Transplantation
Transplantation
Recurrence
Therapeutics
17 Citations

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Saha, A. , O'Connor, R. S. , Thangavelu, G. , Lovitch, S. B. , Dandamudi, D. B. , Wilson, C. B. , Vincent, B. G. , Tkachev, V. , Pawlicki, J. M. , Furlan, S. N. , Kean, L. S. , Aoyama, K. , Taylor, P. A. , Panoskaltsis-Mortari, A. , Foncea, R. , Ranganathan, P. , Devine, S. M. , Burrill, J. S. , Guo, L. , Sacristan, C. & 15 others Snyder, N. W., Blair, I. A., Milone, M. C., Dustin, M. L., Riley, J. L., Bernlohr, D. A., Murphy, W. J., Fife, B. T., Munn, D. H., Miller, J. S., Serody, J. S., Freeman, G. J., Sharpe, A. H., Turka, L. A. & Blazar, B. R. Jul 1 2016 In : Journal of Clinical Investigation. 126, 7, p. 2642-2660 19 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Tissue Donors
Ligands
T-Lymphocytes
Transplants
5 Citations

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Furlan, S. N., Watkins, B., Tkachev, V., Cooley, S., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Hunt, D. J., Schell, J. B., Zeleski, K., Yu, A., Giver, C. R., Waller, E. K., Miller, J. S., Blazar, B. R. & Kean, L. S. Nov 24 2016 In : Blood. 128, 21, p. 2568-2579 12 p.

Research output: Research - peer-reviewArticle

Graft vs Host Disease
Systems Analysis
Haplorhini
T-Lymphocytes
T-cells
3 Citations

Targeting KIR blockade in multiple myeloma: Trouble in checkpoint paradise?

Felices, M. & Miller, J. S. Nov 1 2016 In : Clinical Cancer Research. 22, 21, p. 5161-5163 3 p.

Research output: Research - peer-reviewArticle

Multiple Myeloma
Natural Killer Cells
Monocytes
IPH 2101
3 Citations

Tetraspecific scFv construct provides NK cell mediated ADCC and self-sustaining stimuli via insertion of IL-15 as a cross-linker

Schmohl, J. U., Felices, M., Todhunter, D., Taras, E., Miller, J. S. & Vallera, D. A. Jan 1 2016 In : Oncotarget. 7, 45, p. 73830-73844 15 p.

Research output: Research - peer-reviewArticle

Antibody-Dependent Cell Cytotoxicity
Interleukin-15
Natural Killer Cells
Cytokines
Carcinoma
7 Citations
Adoptive Transfer
Cell Transplantation
Natural Killer Cells
Neoplasms
Transplants

The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: Multiple myeloma, lymphoma, and acute leukemia

Boyiadzis, M. , Bishop, M. R. , Abonour, R. , Anderson, K. C. , Ansell, S. M. , Avigan, D. , Barbarotta, L. , Barrett, A. J. , Besien, K. , Bergsagel, P. L. , Borrello, I. , Brody, J. , Brufsky, J. , Cairo, M. , Chari, A. , Cohen, A. , Cortes, J. , Forman, S. J. , Friedberg, J. W. , Fuchs, E. J. & 28 others Gore, S. D., Jagannath, S., Kahl, B. S., Kline, J., Kochenderfer, J. N., Kwak, L. W., Levy, R., Lima, M., Litzow, M. R., Mahindra, A., Miller, J., Munshi, N. C., Orlowski, R. Z., Pagel, J. M., Porter, D. L., Russell, S. J., Schwartz, K., Shipp, M. A., Siegel, D., Stone, R. M., Tallman, M. S., Timmerman, J. M., Rhee, F., Waller, E. K., Welsh, A., Werner, M., Wiernik, P. H. & Dhodapkar, M. V. Dec 20 2016 In : Journal for ImmunoTherapy of Cancer. 4, 1, 90

Research output: Research - peer-reviewArticle

Hematologic Neoplasms
Multiple Myeloma
Immunotherapy
Lymphoma
Leukemia
60 Citations
Graft vs Host Disease
Regulatory T-Lymphocytes
Fetal Blood
Grafts
Toxicity
15 Citations

Viraemia, immunogenicity, and survival outcomes of cytomegalovirus chimeric epitope vaccine supplemented with PF03512676 (CMVPepVax) in allogeneic haemopoietic stem-cell transplantation: Randomised phase 1b trial

Nakamura, R., Rosa, C. L., Longmate, J., Drake, J., Slape, C., Zhou, Q., Lampa, M. G., O'Donnell, M., Cai, J. L., Farol, L., Salhotra, A., Snyder, D. S., Aldoss, I., Forman, S. J., Miller, J. S., Zaia, J. A. & Diamond, D. J. Feb 1 2016 In : The Lancet Haematology. 3, 2, p. e87-e98

Research output: Research - peer-reviewArticle

Viremia
Stem Cell Transplantation
Cytomegalovirus
Epitopes
Vaccines
2015

ADAM17 and CD56lowCD16low NK cells

Romee, R. & Miller, J. S. Jan 1 2015 In : Haematologica. 100, 8

Research output: Research - peer-reviewLetter

CD56 Antigens
IgG Receptors
Immunophenotyping
Lymphocyte Subsets
Natural Killer Cells
18 Citations
KIR Receptors
Cell Transplantation
Cytomegalovirus
Natural Killer Cells
Tissue Donors
133 Citations

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function

Schlums, H., Cichocki, F., Tesi, B., Theorell, J., Beziat, V., Holmes, T. D., Han, H., Chiang, S. C. C., Foley, B., Mattsson, K., Larsson, S., Schaffer, M., Malmberg, K. J., Ljunggren, H. G., Miller, J. S. & Bryceson, Y. T. Jan 1 2015 In : Immunity. 42, 3, p. 443-456 14 p.

Research output: Research - peer-reviewArticle

Cytomegalovirus Infections
Epigenomics
Natural Killer Cells
Proteins
Virus Diseases
22 Citations

GVHD-associated, inflammasome-mediated loss of function in adoptively transferred myeloid-derived suppressor cells

Koehn, B. H., Apostolova, P., Haverkamp, J. M., Miller, J. S., McCullar, V., Tolar, J., Munn, D. H., Murphy, W. J., Brickey, W. J., Serody, J. S., Gabrilovich, D. I., Bronte, V., Murray, P. J., Ting, J. P. Y., Zeiser, R. & Blazar, B. R. Sep 24 2015 In : Blood. 126, 13, p. 1621-1628 8 p.

Research output: Research - peer-reviewArticle

Inflammasomes
Graft vs Host Disease
Myeloid-Derived Suppressor Cells
Grafts
Survival
7 Citations

Human group 3 innate lymphoid cells express DR3 and respond to TL1A with enhanced IL-22 production and IL-2-dependent proliferation

Ahn, Y. O., Weeres, M. A., Neulen, M. L., Choi, J., Kang, S. H., Heo, D. S., Bergerson, R., Blazar, B. R., Miller, J. S. & Verneris, M. R. Jan 1 2015 In : European Journal of Immunology. 45, 8, p. 2335-2342 8 p.

Research output: Research - peer-reviewArticle

Interleukin-23
Interleukin-2
Lymphocytes
interleukin-22
Cytokines
6 Citations

Human natural killer cell microRNA: Differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs

Presnell, S. R., Al-Attar, A., Cichocki, F., Miller, J. S. & Lutz, C. T. Jan 24 2015 In : Genes and Immunity. 16, 1, p. 89-98 10 p.

Research output: Research - peer-reviewArticle

MicroRNAs
Natural Killer Cells
Genes
Transforming Growth Factor beta
Cell Differentiation
7 Citations
Fetal Blood
Transplantation
Alleles
Treatment Failure
Leukemia
19 Citations

Natural killer cell adoptive transfer therapy: Exploiting the first line of defense against cancer

Davis, Z. B., Felices, M., Verneris, M. R. & Miller, J. S. Jan 1 2015 In : Cancer Journal (United States). 21, 6, p. 486-491 6 p.

Research output: Research - peer-reviewReview article

Adoptive Transfer
Natural Killer Cells
Neoplasms
Therapeutics
Tumor Microenvironment
11 Citations
B-Lymphocytes
Ligands
Neoplasms
Single-Chain Antibodies
Safety