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  • David R Boulware
2019

Improved detection of group A: Streptococcus during thermal contrast amplification vs. visual reading of clinical rapid diagnostic tests

Wang, Y., Louwagie, E., Larkin, D., Sankey, S., Boulware, D. R. & Bischof, J. C., Apr 21 2019, In : Analytical Methods. 11, 15, p. 2013-2017 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Inadequate diagnostics: The case to move beyond the bacilli for detection of meningitis due to mycobacterium tuberculosis

Bahr, N. C., Meintjes, G. & Boulware, D. R., May 2019, In : Journal of medical microbiology. 68, 5, p. 755-760 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Knowledge gaps and research priorities in tuberculous meningitis

Tuberculous Meningitis International Research Consortium, 2019, In : Wellcome Open Research. 4, 188.

Research output: Contribution to journalLetter

Open Access

Laboratory-reflex cryptococcal antigen screening is associated with a survival benefit in tanzania

Faini, D., Kalinjuma, A. V., Katende, A., Mbwaji, G., Mnzava, D., Nyuri, A., Glass, T. R., Furrer, H., Hatz, C., Boulware, D. R. & Letang, E., Feb 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 2, p. 205-213 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Leave no one behind: response to new evidence and guidelines for the management of cryptococcal meningitis in low-income and middle-income countries

Loyse, A., Burry, J., Cohn, J., Ford, N., Chiller, T., Ribeiro, I., Koulla-Shiro, S., Mghamba, J., Ramadhani, A., Nyirenda, R., Aliyu, S. H., Wilson, D., Le, T., Oladele, R., Lesikari, S., Muzoora, C., Kalata, N., Temfack, E., Mapoure, Y., Sini, V. & 35 others, Chanda, D., Shimwela, M., Lakhi, S., Ngoma, J., Gondwe-Chunda, L., Perfect, C., Shroufi, A., Andrieux-Meyer, I., Chan, A., Schutz, C., Hosseinipour, M., Van der Horst, C., Klausner, J. D., Boulware, D. R., Heyderman, R., Lalloo, D., Day, J., Jarvis, J. N., Rodrigues, M., Jaffar, S., Denning, D., Migone, C., Doherty, M., Lortholary, O., Dromer, F., Stack, M., Molloy, S. F., Bicanic, T., van Oosterhout, J., Mwaba, P., Kanyama, C., Kouanfack, C., Mfinanga, S., Govender, N. & Harrison, T. S., Apr 2019, In : The Lancet Infectious Diseases. 19, 4, p. e143-e147

Research output: Contribution to journalReview article

10 Scopus citations

Longitudinal changes in cd4+, cd8+ t cell phenotype and activation marker expression following antiretroviral therapy initiation among patients with cryptococcal meningitis

Bayiyana, A., Okurut, S., Nabatanzi, R., Zziwa, G., Boulware, D. R., Lutwama, F. & Meya, D., Sep 2019, In : Journal of Fungi. 5, 3, 63.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Management of amphotericin-induced phlebitis among HIV patients with cryptococcal meningitis in a resource-limited setting: A prospective cohort study

Ahimbisibwe, C., Kwizera, R., Ndyetukira, J. F., Kugonza, F., Sadiq, A., Hullsiek, K. H., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., Jun 26 2019, In : BMC infectious diseases. 19, 1, 558.

Research output: Contribution to journalArticle

Open Access

Management of intracranial tuberculous mass lesions: How long should we treat for? [version 2; peer review: 1 approved, 2 approved with reservations]

Tuberculous Meningitis International Research Consortium, 2019, In : Wellcome Open Research. 4, 158.

Research output: Contribution to journalArticle

Open Access
Open Access
2 Scopus citations
1 Scopus citations

Performance of lipoarabinomannan assay using cerebrospinal fluid for the diagnosis of tuberculous meningitis among HIV patients [version 1; peer review: 2 approved]

Kwizera, R., Cresswell, F. V., Mugumya, G., Okirwoth, M., Kagimu, E., Bangdiwala, A. S., Williams, D. A., Rhein, J., Boulware, D. R. & Meya, D. B., 2019, In : Wellcome Open Research. 4, 123.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis

ASTRO-CM Study Team, Dec 1 2019, In : Journal of Pharmacokinetics and Pharmacodynamics. 46, 6, p. 565-576 12 p.

Research output: Contribution to journalArticle

Reflexive laboratory-based cryptococcal antigen screening and preemptive fluconazole therapy for cryptococcal antigenemia in HIV-Infected Individuals with CD4 <100 Cells/μL: A Stepped-Wedge, Cluster-Randomized Trial

Meya, D. B., Kiragga, A. N., Nalintya, E., Morawski, B. M., Rajasingham, R., Park, B. J., Mubiru, A., Kaplan, J. E., Manabe, Y. C. & Boulware, D. R., Feb 1 2019, In : Journal of Acquired Immune Deficiency Syndromes. 80, 2, p. 182-189 8 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Short-course amphotericin B in addition to sertraline and fluconazole for treatment of HIV-associated cryptococcal meningitis in rural Tanzania

the KIULARCO Study Group, Dec 1 2019, In : Mycoses. 62, 12, p. 1127-1132 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Southern African HIV Clinicians Society guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update

Govender, N. P., Meintjes, G., Mangena, P., Nel, J., Potgieter, S., Reddy, D., Rabie, H., Wilson, D., Black, J., Boulware, D., Boyles, T., Chiller, T., Dawood, H., Dlamini, S., Harrison, T. S., Ive, P., Jarvis, J., Karstaedt, A., Madua, M. C., Menezes, C. & 9 others, Moosa, M. Y. S., Motlekar, Z., Shroufi, A., Stacey, S. L., Tsitsi, M., van Cutsem, G., Variava, E., Venter, M. & Wake, R., 2019, In : Southern African Journal of HIV Medicine. 20, 1

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Standardized approaches for clinical sampling and endpoint ascertainment in tuberculous meningitis studies

van Laarhoven, A., Rohlwink, U. K., Chow, F. C., Wasserman, S., Dian, S., Lai, R. P. J., Chaidir, L., Hamers, R. L., Wilkinson, R. J., Boulware, D. R. & Cresswell, F. V., 2019, In : Wellcome Open Research. 4, 204.

Research output: Contribution to journalArticle

Open Access

Symptomatic Cryptococcal Antigenemia Presenting as Early Cryptococcal Meningitis with Negative Cerebral Spinal Fluid Analysis

For the Adjunctive Sertraline for Treatment of HIV-associated Cryptococcal Meningitis Team, Jun 2019, In : Clinical Infectious Diseases. 68, 12, p. 2094-2098 5 p., ciy817.

Research output: Contribution to journalArticle

11 Scopus citations

The conundrum of clinical trials and standard of care in sub-Saharan Africa – the research nurse perspective

Frances Ndyetukira, J., Kwizera, R., Kugonza, F., Ahimbisibwe, C., Namujju, C., Sadiq, A., Namudde, A., Williams, D., Abassi, M., Rhein, J., Boulware, D. R. & Meya, D. B., Dec 1 2019, In : Journal of Research in Nursing. 24, 8, p. 649-660 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

The current global situation for tuberculous meningitis: Epidemiology, diagnostics, treatment and outcomes

Tuberculous Meningitis International Research Consortium, 2019, In : Wellcome Open Research. 4, 167.

Research output: Contribution to journalReview article

Open Access
1 Scopus citations

The mouse inhalation model of Cryptococcus neoformans infection recapitulates strain virulence in humans and shows that closely related strains can possess differential virulence

Mukaremera, L., McDonald, T. R., Nielsen, J. N., Molenaar, C. J., Akampurira, A., Schutz, C., Taseera, K., Muzoora, C., Meintjes, G., Meya, D. B., Boulware, D. R. & Nielsen, K., May 1 2019, In : Infection and immunity. 87, 5, e00046-19.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Tuberculosis at the animal-human interface in the Ugandan cattle corridor using a third-generation sequencing platform: A cross-sectional analysis study

Pullen, M. F., Boulware, D. R., Sreevatsan, S. & Bazira, J., Apr 1 2019, In : BMJ open. 9, 4, e024221.

Research output: Contribution to journalArticle

Open Access

Tuberculous meningitis: New tools and new approaches required [version 1; peer review: Not peer reviewed]

International Tuberculous Meningitis Research Consortium, 2019, In : Wellcome Open Research. 4, 181.

Research output: Contribution to journalEditorial

Open Access
1 Scopus citations

Xpert MTB/RIF ultra for tuberculosis testing in children: A mini-review and commentary

Atherton, R. R., Cresswell, F. V., Ellis, J., Kitaka, S. B. & Boulware, D. R., 2019, In : Frontiers in Pediatrics. 7, FEB, 34.

Research output: Contribution to journalShort survey

Open Access
3 Scopus citations

A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for Covid-19

Boulware, D. R., Pullen, M. F., Bangdiwala, A. S., Pastick, K., Lofgren, S. M., Okafor, E., Skipper, C. P., Nascene, A., Nicol, M. R., Abassi, M., Wyman Engen, N., Cheng, M. P., Lother, S. A., MacKenzie, L. J., Drobot, G., Marten, N., Zarychanski, R., Kelly, L. E., Schwartz, I. S., McDonald, E. G. & 3 others, Rajasingham, R., Lee, T. C. & Huppler Hullsiek, K., Jun 3 2020, In : New England Journal of Medicine.

Research output: Contribution to journalArticle

Open Access

B cell compartmentalization in blood and cerebrospinal fluid of HIV-infected ugandans with cryptococcal meningitis

Okurut, S., Meya, D. B., Bwanga, F., Olobo, J., Eller, M. A., Cham-Jallow, F., Bohjanen, P. R., Pratap, H., Palmer, B. E., Hullsiek, K. H., Manabe, Y. C., Boulware, D. R. & Janoff, E. N., Mar 1 2020, In : Infection and immunity. 88, 3, e00779-19.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Burden of Depression in Outpatient HIV-Infected adults in Sub-Saharan Africa; Systematic Review and Meta-analysis

Lofgren, S. M., Bond, D. J., Nakasujja, N. & Boulware, D. R., Jun 1 2020, In : AIDS and Behavior. 24, 6, p. 1752-1764 13 p.

Research output: Contribution to journalReview article

Change in plasma cryptococcal antigen titer is not associated with survival among human immunodeficiency virus-infected persons receiving preemptive therapy for asymptomatic cryptococcal antigenemia

Pullen, M. F., Kakooza, F., Nalintya, E., Kiragga, A. N., Morawski, B. M., Rajasingham, R., Mubiru, A., Manabe, Y. C., Kaplan, J. E., Meya, D. B. & Boulware, D. R., Jan 15 2020, In : Clinical Infectious Diseases. 70, 2, p. 353-355 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

Cryptococcosis in pregnancy and the postpartum period: Case series and systematic review with recommendations for management

Pastick, K. A., Nalintya, E., Tugume, L., Ssebambulidde, K., Stephens, N., Evans, E. E., Ndyetukira, J. F., Nuwagira, E., Skipper, C., Muzoora, C., Meya, D. B., Rhein, J., Boulware, D. R. & Rajasingham, R., Apr 1 2020, In : Medical mycology. 58, 3, p. 282-292 11 p.

Research output: Contribution to journalArticle

Efficacy of cerebrospinal fluid beta-D-glucan diagnostic testing for fungal meningitis: A systematic review

Davis, C., Joseph Wheat, L., Myint, T., Boulware, D. R. & Bahr, N. C., Jan 1 2020, In : Journal of clinical microbiology. 58, 4, e02094-19.

Research output: Contribution to journalReview article

Evaluation of serum cryptococcal antigen testing using two novel semiquantitative lateral flow assays in persons with cryptococcal antigenemia

Skipper, C., Tadeo, K., Martyn, E., Nalintya, E., Rajasingham, R., Meya, D. B., Kafufu, B., Rhein, J. & Boulware, D. R., Jan 1 2020, In : Journal of clinical microbiology. 58, 4, e02046-19.

Research output: Contribution to journalArticle

1 Scopus citations
Open Access
2 Scopus citations

Landmark clinical observations and immunopathogenesis pathways linked to HIV and Cryptococcus fatal central nervous system co-infection

Okurut, S., Boulware, D. R., Olobo, J. & Meya, D. B., Aug 1 2020, In : Mycoses. 63, 8, p. 840-853 14 p.

Research output: Contribution to journalReview article

Open Access

Methods for rapid diagnosis of meningitis etiology in adults

Poplin, V., Boulware, D. R. & Bahr, N. C., Apr 2020, In : Biomarkers in Medicine. 14, 6, p. 459-479 21 p.

Research output: Contribution to journalReview article

Open Access

Prophylaxie post-exposition ou traitement préventif pour le syndrome respiratoire aigu sévère du coronavirus 2 (SARS-CoV-2) : protocole d’étude pour une étude randomisée contrôlée pragmatique

Translated title of the contribution: Post-exposure prophylaxis or pre-emptive therapy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): study protocol for a pragmatic randomized-controlled trialLother, S. A., Abassi, M., Agostinis, A., Bangdiwala, A. S., Cheng, M. P., Drobot, G., Engen, N., Hullsiek, K. H., Kelly, L. E., Lee, T. C., Lofgren, S. M., MacKenzie, L. J., Marten, N., McDonald, E. G., Okafor, E. C., Pastick, K. A., Pullen, M. F., Rajasingham, R., Schwartz, I., Skipper, C. P. & 3 others, Turgeon, A. F., Zarychanski, R. & Boulware, D. R., 2020, (Accepted/In press) In : Canadian Journal of Anesthesia.

Research output: Contribution to journalArticle

Open Access

Review: Hydroxychloroquine and chloroquine for treatment of SARS-CoV-2 (COVID-19)

Pastick, K. A., Okafor, E. C., Wang, F., Lofgren, S. M., Skipper, C. P., Nicol, M. R., Pullen, M. F., Rajasingham, R., McDonald, E. G., Lee, T. C., Schwartz, I. S., Kelly, L. E., Lother, S. A., Mitjà, O., Letang, E., Abassi, M. & Boulware, D. R., Mar 16 2020, In : Open Forum Infectious Diseases. 7, 4, ofaa130.

Research output: Contribution to journalReview article

Open Access
8 Scopus citations

Shining a light on the evidence for hydroxychloroquine in SARS-CoV-2

Ingraham, N. E., Boulware, D., Sparks, M. A., Schacker, T., Benson, B., Sparks, J. A., Murray, T., Connett, J., Chipman, J. G., Charles, A. & Tignanelli, C. J., Apr 28 2020, In : Critical Care. 24, 1, 182.

Research output: Contribution to journalComment/debate

Open Access

Should we perform the serum cryptococcal antigen test in people living with HIV hospitalized due to a community-acquired pneumonia episode?

Silva, A. P., Zenatti, C. T., Figueiredo-Mello, C., Negra, M. D., Levin, A. S., Boulware, D. R. & Vidal, J. E., Mar 1 2020, In : International Journal of STD and AIDS. 31, 4, p. 345-350 6 p.

Research output: Contribution to journalArticle

Xpert MTB/RIF Ultra for the diagnosis of HIV-associated tuberculous meningitis: a prospective validation study

ASTRO-CM Team, Mar 2020, In : The Lancet Infectious Diseases. 20, 3, p. 308-317 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations