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  • Wei-Shou Hu

Model-Driven Engineering of N-Linked Glycosylation in Chinese Hamster Ovary Cells

Stach, C. S., McCann, M. G., O'Brien, C. M., Le, T. S., Somia, N., Chen, X., Lee, K., Fu, H. Y., Daoutidis, P., Zhao, L., Hu, W. S. & Smanski, M., Nov 15 2019, In : ACS Synthetic Biology. 8, 11, p. 2524-2535 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances

Shu, C. C., Chatterjee, A., Hu, W. S. & Ramkrishna, D., Mar 5 2012, In : Chemical Engineering Science. 70, p. 188-199 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Multiplexed clonality verification of cell lines for protein biologic production

O'Brien, S. A., Ojha, J., Wu, P. & Hu, W. S., Jul 1 2020, In : Biotechnology Progress. 36, 4, e2978.

Research output: Contribution to journalArticle

Multiplicity of steady states in glycolysis and shift of metabolic state in cultured mammalian cells

Mulukutla, B. C., Yongky, A., Grimm, S., Daoutidis, P. & Hu, W. S., Mar 25 2015, In : PloS one. 10, 3, e0121561.

Research output: Contribution to journalArticle

27 Scopus citations

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

Le, H., Kabbur, S., Pollastrini, L., Sun, Z., Mills, K., Johnson, K., Karypis, G. & Hu, W. S., Dec 31 2012, In : Journal of Biotechnology. 162, 2-3, p. 210-223 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

Mulukutla, B. C., Gramer, M. & Hu, W. S., Mar 1 2012, In : Metabolic Engineering. 14, 2, p. 138-149 12 p.

Research output: Contribution to journalArticle

74 Scopus citations

PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors

Lo Nigro, A., de Jaime-Soguero, A., Khoueiry, R., Cho, D. S., Ferlazzo, G. M., Perini, I., Abon Escalona, V., Aranguren, X. L., Chuva de Sousa Lopes, S. M., Koh, K. P., Conaldi, P. G., Hu, W. S., Zwijsen, A., Lluis, F. & Verfaillie, C. M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 318-333 16 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Preface

Hu, W. S. & Zeng, A. P., 2012, In : Advances in Biochemical Engineering/Biotechnology. 127

Research output: Contribution to journalArticle

Recurring genomic structural variation leads to clonal instability and loss of productivity

Bandyopadhyay, A. A., O’Brien, S. A., Zhao, L., Fu, H. Y., Vishwanathan, N. & Hu, W-S., Jan 2019, In : Biotechnology and bioengineering. 116, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Regulation of Glucose Metabolism – A Perspective From Cell Bioprocessing

Mulukutla, B. C., Yongky, A., Le, T., Mashek, D. G. & Hu, W. S., Aug 1 2016, In : Trends in biotechnology. 34, 8, p. 638-651 14 p.

Research output: Contribution to journalReview article

26 Scopus citations

Regulation of Metabolic Homeostasis in Cell Culture Bioprocesses

O'Brien, C. M., Mulukutla, B. C., Mashek, D. G. & Hu, W. S., Jan 1 2020, (Accepted/In press) In : Trends in biotechnology. 38, 10, p. 1113-1127 15 p.

Research output: Contribution to journalReview article

RNA-mediated reciprocal regulation between two bacterial operons is RNase III dependent

Johnson, C. M., Haemig, H. H. A., Chatterjee, A., Wei-Shou, H., Weaver, K. E. & Dunny, G. M., 2011, In : mBio. 2, 5, e00189-11.

Research output: Contribution to journalArticle

16 Scopus citations

Role of intracellular stochasticity in biofilm growth. insights from population balance modeling

Shu, C. C., Chatterjee, A., Hu, W. S. & Ramkrishna, D., Nov 13 2013, In : PloS one. 8, 11, e79196.

Research output: Contribution to journalArticle

9 Scopus citations

Scalable expansion of multipotent adult progenitor cells as three-dimensional cell aggregates

Subramanian, K., Park, Y., Verfaillie, C. M. & Hu, W. S., Feb 1 2011, In : Biotechnology and bioengineering. 108, 2, p. 364-375 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Single-cell analysis reveals that the enterococcal sex pheromone response results in expression of full-length conjugation operon transcripts in all induced cells

Erickson, R. J. B., Bandyopadhyay, A. A., Barnes, A. M. T., O'Brien, S. A., Hu, W. S. & Dunny, G. M., Mar 1 2020, In : Journal of bacteriology. 202, 8, e00685-19.

Research output: Contribution to journalArticle

Single Copy Transgene Integration in a Transcriptionally Active Site for Recombinant Protein Synthesis

O'Brien, S. A., Lee, K., Fu, H. Y., Lee, Z., Le, T. S., Stach, C. S., McCann, M. G., Zhang, A. Q., Smanski, M. J., Somia, N. V. & Hu, W. S., Oct 2018, In : Biotechnology Journal. 13, 10, 1800226.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem Cells

García-León, J. A., Kumar, M., Boon, R., Chau, D., One, J., Wolfs, E., Eggermont, K., Berckmans, P., Gunhanlar, N., de Vrij, F., Lendemeijer, B., Pavie, B., Corthout, N., Kushner, S. A., Dávila, J. C., Lambrichts, I., Hu, W. S. & Verfaillie, C. M., Feb 13 2018, In : Stem Cell Reports. 10, 2, p. 655-672 18 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Spheroid culture for enhanced differentiation of human embryonic stem cells to hepatocyte-like cells

Subramanian, K., Owens, D. J., Raju, R., Firpo, M., O'Brien, T. D., Verfaillie, C. M. & Hu, W. S., 2014, In : Stem Cells and Development. 23, 2, p. 124-131 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Stem cell culture engineering - process scale up and beyond

Sharma, S., Raju, R., Sui, S. & Hu, W. S., Nov 1 2011, In : Biotechnology Journal. 6, 11, p. 1317-1329 13 p.

Research output: Contribution to journalReview article

37 Scopus citations

Stem Cell Culture Processes

Raju, R., Sharma, S. & Hu, W. S., Nov 4 2015, Stem Cells in Regenerative Medicine: Science, Regulation and Business Strategies. Wiley-Blackwell, p. 355-374 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stem cell pluripotent state transition: Going from embryonic stem cells to an extraembryonic precursor state and back

Cho, D. S., Sharma, S., Verfaillie, C. & Hu, W-S., Jan 1 2013, Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future. AIChE, 1 p. (Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Stem cell science has made major strides in the last few years. Introduction.

Tzanakakis, E. S. & Hu, W. S., Nov 15 2013, In : Biotechnology Advances. 31, 7, 1 p.

Research output: Contribution to journalEditorial

Stochasticity in the enterococcal sex pheromone response revealed by quantitative analysis of transcription in single cells

Breuer, R. J., Bandyopadhyay, A., O’Brien, S. A., Barnes, A. M. T., Hunter, R. C., Hu, W-S. & Dunny, G. M., Jul 2017, In : PLoS genetics. 13, 7, e1006878.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

The road to regenerative liver therapies: The triumphs, trials and tribulations

Raju, R., Chau, D., Verfaillie, C. M. & Hu, W. S., Nov 15 2013, In : Biotechnology Advances. 31, 7, p. 1085-1093 9 p.

Research output: Contribution to journalReview article

10 Scopus citations

Three-dimensional multipotent progenitor cell aggregates for expansion, osteogenic differentiation and 'in vivo' tracing with AAV vector serotype 6

Ferreira, J. R., Hirsch, M. L., Zhang, L., Park, Y., Samulski, R. J., Hu, W. S. & Ko, C. C., Feb 1 2013, In : Gene therapy. 20, 2, p. 158-168 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Titanium-enriched hydroxyapatite-gelatin scaffolds with osteogenically differentiated progenitor cell aggregates for calvaria bone regeneration

Ferreira, J. R., Padilla, R., Urkasemsin, G., Yoon, K., Goeckner, K., Hu, W. S. & Ko, C. C., Aug 1 2013, In : Tissue Engineering - Part A. 19, 15-16, p. 1803-1816 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Transcriptome data analysis for cell culture processes

Castro-Melchor, M., Le, H. & Hu, W. S., 2012, In : Advances in Biochemical Engineering/Biotechnology. 127, p. 27-70 44 p.

Research output: Contribution to journalArticle

3 Scopus citations

Transcriptome dynamics of transgene amplification in Chinese hamster ovary cells

Vishwanathan, N., Le, H., Jacob, N. M., Tsao, Y. S., Ng, S. W., Loo, B., Liu, Z., Kantardjieff, A. & Hu, W. S., Mar 1 2014, In : Biotechnology and Bioengineering. 111, 3, p. 518-528 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Unveiling gene trait relationship by cross-platform meta-analysis on Chinese hamster ovary cell transcriptome

Zhao, L., Fu, H. Y., Raju, R., Vishwanathan, N. & Hu, W-S., Jul 2017, In : Biotechnology and Bioengineering. 114, 7, p. 1583-1592 10 p.

Research output: Contribution to journalArticle

3 Scopus citations