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  • David D Thomas

Impact of methionine oxidation on calmodulin structural dynamics

McCarthy, M. R., Thompson, A. R., Nitu, F., Moen, R. J., Olenek, M. J., Klein, J. C. & Thomas, D. D., Jan 9 2015, In : Biochemical and Biophysical Research Communications. 456, 2, p. 567-572 6 p.

Research output: Contribution to journalArticle

14 Scopus citations

Impacts of dystrophin and utrophin domains on actin structural dynamics: Implications for therapeutic design

Lin, A. Y., Prochniewicz, E., Henderson, D. M., Li, B., Ervasti, J. M. & Thomas, D. D., Jun 29 2012, In : Journal of Molecular Biology. 420, 1-2, p. 87-98 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

O'Rourke, A. R., Lindsay, A., Tarpey, M. D., Yuen, S., McCourt, P., Nelson, D. M., Perrin, B. J., Thomas, D. D., Spangenburg, E. E., Lowe, D. A. & Ervasti, J. M., Feb 2018, In : FEBS Journal. 285, 3, p. 481-500 20 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

John Gergely (1919-2013): a pillar in the muscle protein field.

Greaser, M. L., Potter, J. D., Thomas, D. D., Strasburg, G. M., Lehrer, S. S., Wang, C. L. A. & Grabarek, Z., Dec 2013, In : Journal of muscle research and cell motility. 34, 5-6, p. 441-446 6 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lipid-mediated folding/unfolding of phospholamban as a regulatory mechanism for the sarcoplasmic reticulum Ca2+-ATPase

Gustavsson, M., Traaseth, N. J., Karim, C. B., Lockamy, E. L., Thomas, D. D. & Veglia, G., May 13 2011, In : Journal of Molecular Biology. 408, 4, p. 755-765 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules that Enhance Ca2+ Transport

Schaaf, T. M., Kleinboehl, E. W., Yuen, S. L., Roelike, L. N., Svensson, B., Thompson, A. R., Cornea, R. L. & Thomas, D. D., May 8 2020, In : Cells. 9, 5

Research output: Contribution to journalArticle

Open Access

Loop L5 assumes three distinct orientations during the ATPase cycle of the mitotic kinesin Eg5: A transient and time-resolved fluorescence study

Muretta, J. M., Behnke-Parks, W. M., Major, J., Petersen, K. J., Goulet, A., Moores, C. A., Thomas, D. D. & Rosenfeld, S. S., Nov 29 2013, In : Journal of Biological Chemistry. 288, 48, p. 34839-34849 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Magnesium impacts myosin v motor activity by altering key conformational changes in the mechanochemical cycle

Trivedi, D. V., Muretta, J. M., Swenson, A. M., Thomas, D. D. & Yengo, C. M., Jul 9 2013, In : Biochemistry. 52, 27, p. 4710-4722 13 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Rohde, J. A., Roopnarine, O., Thomas, D. D. & Muretta, J. M., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7486-E7494

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

Lindsay, A., Baumann, C. W., Rebbeck, R. T., Yuen, S. L., Southern, W. M., Hodges, J. S., Cornea, R. L., Thomas, D. D., Ervasti, J. M. & Lowe, D. A., Feb 1 2020, In : Skeletal muscle. 10, 1, 3.

Research output: Contribution to journalArticle

Open Access

Microsecond molecular dynamics simulations of Mg2+- And K +- Bound E1 intermediate states of the calcium pump

Espinoza-Fonseca, L. M., Autry, J. M. & Thomas, D. D., Apr 23 2014, In : PloS one. 9, 4, e95979.

Research output: Contribution to journalArticle

22 Scopus citations

Molecular modeling of fluorescent SERCA biosensors

Svensson, B., Autry, J. M. & Thomas, D. D., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 503-522 20 p. (Methods in Molecular Biology; vol. 1377).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Olivieri, C., Wang, Y., Li, G. C., Subrahmanian, M. V., Kim, J., Stultz, B. R., Neibergall, M., Porcelli, F., Muretta, J. M., Thomas, D. D., Gao, J., Blumenthal, D. K., Taylor, S. S. & Veglia, G., Apr 2020, In : eLife. 9, e55607.

Research output: Contribution to journalArticle

Open Access

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels

Savich, Y., Binder, B. P., Thompson, A. R. & Thomas, D. D., Aug 5 2019, In : Journal of General Physiology. 151, 8, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C. C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Nucleotide activation of the Ca-ATPase

Autry, J. M., Rubin, J. E., Svensson, B., Li, J. & Thomas, D. D., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 39070-39082 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Oligomeric interactions of sarcolipin and the Ca-ATPase

Autry, J. M., Rubin, J. E., Pietrini, S. D., Winters, D. L., Robia, S. L. & Thomas, D. D., Sep 9 2011, In : Journal of Biological Chemistry. 286, 36, p. 31697-31706 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Open and Closed Conformations of the Isolated Transmembrane Domain of Death Receptor 5 Support a New Model of Activation

Lewis, A. K., James, Z. M., McCaffrey, J. E., Braun, A. R., Karim, C. B., Thomas, D. D. & Sachs, J. N., Mar 18 2014, In : Biophysical journal. 106, 6, p. L21-L24

Research output: Contribution to journalArticle

10 Scopus citations

Optimization of bicelle lipid composition and temperature for EPR spectroscopy of aligned membranes

McCaffrey, J. E., James, Z. M. & Thomas, D. D., Jan 2015, In : Journal of Magnetic Resonance. 250, p. 71-75 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Oxidation increases the strength of the methionine-aromatic interaction

Lewis, A. K., Dunleavy, K. M., Senkow, T. L., Her, C., Horn, B. T., Jersett, M. A., Mahling, R., McCarthy, M. R., Perell, G. T., Valley, C. C., Karim, C. B., Gao, J., Pomerantz, W. C. K., Thomas, D. D., Cembran, A., Hinderliter, A. & Sachs, J. N., Oct 1 2016, In : Nature Chemical Biology. 12, 10, p. 860-866 7 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

Oda, T., Yang, Y., Uchinoumi, H., Thomas, D. D., Chen-Izu, Y., Kato, T., Yamamoto, T., Yano, M., Cornea, R. L. & Bers, D. M., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 240-248 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Phospholamban mutants compete with wild type for SERCA binding in living cells

Gruber, S. J., Haydon, S. & Thomas, D. D., Apr 6 2012, In : Biochemical and Biophysical Research Communications. 420, 2, p. 236-240 5 p.

Research output: Contribution to journalArticle

19 Scopus citations
7 Scopus citations

Phosphomimetic S3D cofilin binds but only weakly severs actin filaments

Austin Elam, W., Cao, W., Kang, H., Huehn, A., Hocky, G. M., Prochniewicz, E., Schramm, A. C., Negrón, K., Garcia, J., Bonello, T. T., Gunning, P. W., Thomas, D. D., Voth, G. A., Sindelar, C. V. & De La Cruz, E. M., Dec 1 2017, In : Journal of Biological Chemistry. 292, 48, p. 19565-19579 15 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Phosphorylated phospholamban stabilizes a compact conformation of the cardiac calcium-ATPase

Pallikkuth, S., Blackwell, D. J., Hu, Z., Hou, Z., Zieman, D. T., Svensson, B., Thomas, D. D. & Robia, S. L., Oct 15 2013, In : Biophysical journal. 105, 8, p. 1812-1821 10 p.

Research output: Contribution to journalArticle

27 Scopus citations
61 Scopus citations

Protein-protein interactions in calcium transport regulation probed by saturation transfer electron paramagnetic resonance

James, Z. M., McCaffrey, J. E., Torgersen, K. D., Karim, C. B. & Thomas, D. D., Sep 19 2012, In : Biophysical journal. 103, 6, p. 1370-1378 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

Lake, E. W., Muretta, J. M., Thompson, A. R., Rasmussen, D. M., Majumdar, A., Faber, E. B., Ruff, E. F., Thomas, D. D. & Levinson, N. M., Dec 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. E11894-E11903

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Redox-sensitive residue in the actin-binding interface of myosin

Moen, R. J., Cornea, S., Oseid, D. E., Binder, B. P., Klein, J. C. & Thomas, D. D., Oct 24 2014, In : Biochemical and Biophysical Research Communications. 453, 3, p. 345-349 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Red-shifted FRET biosensors for high-throughput fluorescence lifetime screening

Schaaf, T. M., Li, A., Grant, B. D., Peterson, K., Yuen, S., Bawaskar, P., Kleinboehl, E., Li, J., Thomas, D. D. & Gillispie, G. D., Oct 24 2018, In : Biosensors. 8, 4, 99.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

McCarthy, M. R., Savich, Y., Cornea, R. L. & Thomas, D. D., Mar 10 2020, In : Biophysical journal. 118, 5, p. 1090-1100 11 p.

Research output: Contribution to journalArticle

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, R. T., Singh, D. P., Janicek, K. A., Bers, D. M., Thomas, D. D., Launikonis, B. S. & Cornea, R. L., Dec 1 2020, In : Scientific reports. 10, 1, 1791.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptoro·calmodulin complex

Rebbeck, R. T., Nitu, F. R., Rohde, D., Most, P., Bers, D. M., Thomas, D. D. & Cornea, R. L., Jul 22 2016, In : Journal of Biological Chemistry. 291, 30, p. 15896-15907 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Sarcolipin and phospholamban inhibit the calcium pump by populating a similar metal ion-free intermediate state

Espinoza-Fonseca, L. M., Autry, J. M. & Thomas, D. D., 2015, In : Biochemical and Biophysical Research Communications. 463, 1-2, p. 37-41 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain

Autry, J. M., Thomas, D. D. & Espinoza-Fonseca, L. M., Nov 8 2016, In : Biochemistry. 55, 44, p. 6083-6086 4 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Sequential myosin phosphorylation activates tarantula thick filament via a disorder-order transition

Espinoza-Fonseca, L. M., Alamo, L., Pinto, A., Thomas, D. D. & Padrón, R., May 18 2015, In : Molecular BioSystems. 11, 8, p. 2167-2179 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
Open Access
20 Scopus citations

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor–Receptor Interactions

Vunnam, N., Lo, C. H., Grant, B. D., Thomas, D. D. & Sachs, J. N., Sep 15 2017, In : Journal of Molecular Biology. 429, 19, p. 2943-2953 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Spectral unmixing plate reader: High-throughput, high-precision FRET Assays in living cells

Schaaf, T. M., Peterson, K. C., Grant, B. D., Thomas, D. D. & Gillispie, G. D., Jan 1 2017, In : SLAS Discovery. 22, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Spectroscopic probes of muscle proteins

Thomas, D. D., Muretta, J. M., Colson, B. A., Mello, R. N. & Kast, D., Dec 1 2012, Comprehensive Biophysics. Elsevier Inc., Vol. 4. p. 226-250 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Scopus citations

Structural and functional dynamics of an integral membrane protein complex modulated by lipid headgroup charge

Li, J., James, Z. M., Dong, X., Karim, C. B. & Thomas, D. D., May 18 2012, In : Journal of Molecular Biology. 418, 5, p. 379-389 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structural and functional impact of site-directed methionine oxidation in myosin

Klein, J. C., Moen, R. J., Smith, E. A., Titus, M. A. & Thomas, D. D., Nov 29 2011, In : Biochemistry. 50, 47, p. 10318-10327 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

Avery, A. W., Fealey, M. E., Wang, F., Orlova, A., Thompson, A. R., Thomas, D. D., Hays, T. S. & Egelman, E. H., Dec 1 2017, In : Nature communications. 8, 1, 1350.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Structural dynamics of calmodulin-ryanodine receptor interactions: Electron paramagnetic resonance using stereospecific spin labels

Her, C., Thompson, A. R., Karim, C. B. & Thomas, D. D., Dec 1 2018, In : Scientific reports. 8, 1, 10681.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Structural dynamics of muscle protein phosphorylation

Colson, B. A., Gruber, S. J. & Thomas, D. D., 2012, In : Journal of muscle research and cell motility. 33, 6, p. 419-429 11 p.

Research output: Contribution to journalReview article

10 Scopus citations

Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin's IDR

Fealey, M. E., Binder, B. P., Uversky, V. N., Hinderliter, A. & Thomas, D. D., Feb 6 2018, In : Biophysical journal. 114, 3, p. 550-561 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Structural kinetics of myosin by transient time-resolved FRET

Nesmelov, Y. E., Agafonov, R. V., Negrashov, I. V., Blakely, S. E., Titus, M. A. & Thomas, D. D., Feb 1 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 5, p. 1891-1896 6 p.

Research output: Contribution to journalArticle

41 Scopus citations