Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Bruce R Blazar
Article

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

Sarhan, D., Brandt, L., Felices, M., Guldevall, K., Lenvik, T., Hinderlie, P., Curtsinger, J., Warlick, E., Spellman, S. R., Blazar, B. R., Weisdorf, D. J., Cooley, S., Vallera, D. A., Onfelt, B. & Miller, J. S., Jun 26 2018, In : Blood Advances. 2, 12, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Paul, J., Nakasone, H., Sahaf, B., Wu, F., Wang, K., Ho, V., Wu, J., Kim, H., Blazar, B., Ritz, J., Howard, A., Cutler, C. & Miklos, D., Jun 30 2019, In : Haematologica. 104, 7, p. e314-e317

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H., Bommiasamy, H., Paz, K., Wilkinson, A. N., Owen, M., Reichenbach, D. K., Banovic, T., Wehner, K., Buchanan, F., Varelias, A., Kuns, R. D., Chang, K., Fedoriw, Y., Shea, T., Coghill, J., Zaiken, M., Plank, M. W., Foster, P. S., Clouston, A. D., Blazar, B. R. & 2 others, Serody, J. S. & Hill, G. R., Apr 2018, In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernández, J. A., Xu, X., Griffin, J. H. & Blazar, B. R., Aug 29 2019, In : Blood. 134, 9, p. 776-781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R., Apr 13 2017, In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T., Curtsinger, J., Davis, Z., Zhang, B., Cooley, S., Cichocki, F., Blazar, B. R. & Miller, J. S., Jul 2018, In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Adaptive NK cells with low TIGIT expression are inherently resistant to myeloid-derived suppressor cells

Sarhan, D., Cichocki, F., Zhang, B., Yingst, A., Spellman, S. R., Cooley, S., Verneris, M. R., Blazar, B. R. & Miller, J. S., Oct 1 2016, In : Cancer Research. 76, 19, p. 5696-5706 11 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
1 Scopus citations

Amphiregulin modifies the Minnesota acute graft-versus-host disease risk score: Results from BMT CTN 0302/0802

Holtan, S. G., DeFor, T. E., Panoskaltsis-Mortari, A., Khera, N., Levine, J. E., Flowers, M. E. D., Lee, S. J., Inamoto, Y., Chen, G. L., Mayer, S., Arora, M., Palmer, J., Cutler, C. S., Arai, S., Lazaryan, A., Newell, L. F., Jagasia, M. H., Pusic, I., Wood, W. A., Renteria, A. S. & 17 others, Yanik, G., Hogan, W. J., Hexner, E., Ayuk, F., Holler, E., Bunworasate, U., Efebera, Y. A., Ferrara, J. L. M., Pidala, J., Howard, A., Wu, J., Bolaños-Meade, J., Ho, V., Alousi, A., Blazar, B. R., Weisdorf, D. J. & MacMillan, M. L., Aug 14 2018, In : Blood Advances. 2, 15, p. 1882-1888 7 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Poe, J. C., Jia, W., Su, H., Anand, S., Rose, J. J., Tata, P. V., Suthers, A. N., Jones, C. D., Kuan, P. F., Vincent, B. G., Serody, J. S., Horwitz, M. E., Ho, V. T., Pavletic, S. Z., Hakim, F. T., Owzar, K., Zhang, D., Blazar, B. R., Siebel, C. W., Chao, N. J. & 2 others, Maillard, I. & Sarantopoulos, S., Nov 9 2017, In : Blood. 130, 19, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition

Forcade, E., Paz, K., Flynn, R., Griesenauer, B., Amet, T., Li, W., Liu, L., Bakoyannis, G., Jiang, D., Chu, H. W., Lobera, M., Yang, J., Wilkes, D. S., Du, J., Gartlan, K., Hill, G. R., MacDonald, K. P., Espada, E. L., Blanco, P., Serody, J. S. & 7 others, Koreth, J., Cutler, C. S., Antin, J. H., Soiffer, R. J., Ritz, J., Paczesny, S. & Blazar, B. R., Jun 15 2017, In : JCI Insight. 2, 12

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease

Rashidi, A., Herman, A., Gomes, A. L. C., Peled, J. U., Jenq, R. R., Brereton, D. G., Staley, C., Blazar, B. R. & Weisdorf, D. J., Jun 1 2020, In : British journal of haematology. 189, 5, p. 926-930 5 p.

Research output: Contribution to journalArticle

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Mar 1 2019, In : Bone marrow transplantation. 54, 3, p. 490-493 4 p.

Research output: Contribution to journalArticle

Open Access
Open Access
5 Scopus citations

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L., Goren, E., Mulé, J. J. & Blazar, B. R., Apr 2018, In : PloS one. 13, 4, e0193461.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease

Wang, K. S., Kim, H. T., Nikiforow, S., Heubeck, A. T., Ho, V. T., Koreth, J., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Cutler, C. S. & Ritz, J., Dec 28 2017, In : Blood. 130, 26, p. 2889-2899 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

ARID5B regulates metabolic programming in human adaptive NK cells

Cichocki, F. M., Wu, C-Y., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., Bryceson, Y. T. & Miller, J. S., 2018, In : Journal of Experimental Medicine. 215, 9, p. 2379-2395 17 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Dec 1 2017, In : Scientific reports. 7, 1, 1633.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Le Texier, L., Lineburg, K. E., Cao, B., McDonald-Hyman, C., Leveque-El Mouttie, L., Nicholls, J., Melino, M., Nalkurthi, B. C., Alexander, K. A., Teal, B., Blake, S. J., Souza-Fonseca-Guimaraes, F., Engwerda, C. R., Kuns, R. D., Lane, S. W., Teng, M., Teh, C., Gray, D., Clouston, A. D., Nilsson, S. K. & 3 others, Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Sep 22 2016, In : JCI insight. 1, 15, p. e86850

Research output: Contribution to journalArticle

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Osborn, M. J., Newby, G. A., McElroy, A. N., Knipping, F., Nielsen, S. C., Riddle, M. J., Xia, L., Chen, W., Eide, C. R., Webber, B. R., Wandall, H. H., Dabelsteen, S., Blazar, B. R., Liu, D. R. & Tolar, J., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 338-347.e5

Research output: Contribution to journalArticle

4 Scopus citations

B cells drive autoimmunity in mice with CD28-deficient regulatory T cells

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A., Dec 15 2017, In : Journal of Immunology. 199, 12, p. 3972-3980 9 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

B-cell targeting in chronic graft-versus-host disease

Zeiser, R., Sarantopoulos, S. & Blazar, B. R., Mar 29 2018, In : Blood. 131, 13, p. 1399-1405 7 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

Bortezomib-based immunosuppression after reduced-intensity conditioning hematopoietic stem cell transplantation: Randomized phase II results

Koreth, J., Kim, H. T., Lange, P. B., Poryanda, S. J., Reynolds, C. G., Chamling Rai, S., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Yusuf, R., Nikiforow, S., Chen, Y. B., Dey, B., McMasters, M., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Feb 28 2018, In : Haematologica. 103, 3, p. 522-530 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans

Verghese, D. A., Chun, N., Paz, K., Fribourg, M., Woodruff, T. M., Flynn, R., Hu, Y., Xiong, H., Zhang, W., Yi, Z., Du, J., Blazar, B. R. & Heeger, P. S., Dec 20 2018, In : JCI Insight. 3, 24

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Cadherin 17 mutation associated with leaky severe combined immune deficiency is corrected by HSCT

Smith, A. R., Rota, I. A., Maio, S., Massaad, M. J., Lund, T. C., Notarangelo, L. D., Holländer, G. A. & Blazar, B. R., Oct 24 2017, In : Blood Advances. 1, 23, p. 2083-2087 5 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Schönle, A., Hartl, F. A., Mentzel, J., Nöltner, T., Rauch, K. S., Prestipino, A., Wohlfeil, S. A., Apostolova, P., Hechinger, A. K., Melchinger, W., Fehrenbach, K., Guadamillas, M. C., Follo, M., Prinz, G., Ruess, A. K., Pfeifer, D., Del Pozo, M. A., Schmitt-Graeff, A., Duyster, J., Hippen, K. I. & 4 others, Blazar, B. R., Schachtrup, K., Minguet, S. & Zeiser, R., Apr 14 2016, In : Blood. 127, 15, p. 1930-1939 10 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

Watkins, B. K., Tkachev, V., Furlan, S. N., Hunt, D. J., Betz, K., Yu, A., Brown, M., Poirier, N., Zheng, H. B., Taraseviciute, A., Colonna, L., Mary, C., Blancho, G., Soulillou, J. P., Panoskaltsis-Mortari, A., Sharma, P., Garcia, A., Strobert, E., Hamby, K., Garrett, A. & 4 others, Deane, T., Blazar, B. R., Vanhove, B. & Kean, L. S., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3991-4007 17 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

CD56 dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

Cichocki, F., Cooley, S., Davis, Z., DeFor, T. E., Schlums, H., Zhang, B., Brunstein, C. G., Blazar, B. R., Wagner, J., Diamond, D. J., Verneris, M. R., Bryceson, Y. T., Weisdorf, D. J. & Miller, J. S., Feb 1 2016, In : Leukemia. 30, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Chimeric antigen receptor costimulation domains modulate human regulatory T cell function

Boroughs, A. C., Larson, R. C., Choi, B. D., Bouffard, A. A., Riley, L. S., Schiferle, E., Kulkarni, A. S., Cetrulo, C. L., Ting, D., Blazar, B. R., Demehri, S. & Maus, M. V., 2019, In : JCI Insight. 4, 8, e126194.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A., Tkachev, V., Ponce, R., Turtle, C. J., Snyder, J. M., Liggitt, H. D., Myerson, D., Gonzalez-Cuyar, L., Baldessari, A., English, C., Yu, A., Zheng, H., Furlan, S. N., Hunt, D. J., Hoglund, V., Finney, O., Brakke, H., Blazar, B. R., Berger, C., Riddell, S. R. & 3 others, Gardner, R., Kean, L. S. & Jensen, M. C., Jun 2018, In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations

Chronic stimulation drives human NK cell dysfunction and epigenetic reprograming

Merino, A., Zhang, B., Dougherty, P., Luo, X., Wang, J., Blazar, B. R., Miller, J. S. & Cichocki, F., Sep 3 2019, In : Journal of Clinical Investigation. 129, 9, p. 3770-3785 16 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Circulating T follicular helper cells with increased function during chronic graft-versus-host disease

Forcade, E., Kim, H. T., Cutler, C., Wang, K., Alho, A. C., Nikiforow, S., Ho, V. T., Koreth, J., Armand, P., Alyea, E. P., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Ritz, J., May 19 2016, In : Blood. 127, 20, p. 2489-2497 9 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S., Sep 20 2017, In : Science Translational Medicine. 9, 408, eaan3085.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
Open Access
34 Scopus citations

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

Leveque-El Mouttie, L., Koyama, M., Le Texier, L., Markey, K. A., Cheong, M., Kuns, R. D., Lineburg, K. E., Teal, B. E., Alexander, K. A., Clouston, A. D., Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Aug 11 2016, In : Blood. 128, 6, p. 794-804 11 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations

Crispr/cas9-based cellular engineering for targeted gene overexpression

Osborn, M. J., Lees, C. J., McElroy, A. N., Merkel, S. C., Eide, C. R., Mathews, W., Feser, C. J., Tschann, M., McElmury, R. T., Webber, B. R., Kim, C. J., Blazar, B. R. & Tolar, J., Apr 2018, In : International journal of molecular sciences. 19, 4, 946.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
Open Access
15 Scopus citations

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., Gandhi, S., West, L. J., Piret, J. M., Blazar, B. R. & Levings, M. K., Dec 2019, In : Cytotherapy. 21, 12, p. 1216-1233 18 p.

Research output: Contribution to journalArticle

Cutting Edge: TGF-β and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets

Priyadharshini, B., Loschi, M., Newton, R. H., Zhang, J. W., Finn, K. K., Gerriets, V. A., Huynh, A., Rathmell, J. C., Blazar, B. R. & Turka, L. A., Oct 15 2018, In : Journal of Immunology. 201, 8, p. 2215-2219 5 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD

Koehn, B. H., Saha, A., McDonald-Hyman, C., Loschi, M., Thangavelu, G., Ma, L., Zaiken, M., Dysthe, J., Krepps, W., Panthera, J., Hippen, K., Jameson, S. C., Miller, J. S., Cooper, M. A., Farady, C. J., Iwawaki, T., Ting, J. P. Y., Serody, J. S., Murphy, W. J., Hill, G. R. & 5 others, Murray, P. J., Bronte, V., Munn, D. H., Zeiser, R. & Blazar, B. R., Nov 7 2019, In : Blood. 134, 19, p. 1670-1682 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Delayed immune reconstitution after allogeneic transplantation increases the risks of mortality and chronic GVHD

Bejanyan, N., Brunstein, C. G., Cao, Q., Lazaryan, A., Luo, X., Curtsinger, J. M., Mehta, R. S., Warlick, E. D., Cooley, S. A., Blazar, B. R., Miller, J. S., Weisdorf, D., Wagner, J. E. & Verneris, M. R., Apr 24 2018, In : Blood Advances. 2, 8, p. 909-922 14 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Despite high levels of expression in thymic epithelial cells, miR-181a1 and miR-181b1 are not required for thymic development

Stefanski, H. E., Xing, Y., Taylor, P. A., Maio, S., Henao-Meija, J., Williams, A., Flavell, R. A., Hollander, G. A. & Blazar, B. R., Jun 2018, In : PloS one. 13, 6, e0198871.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations