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  • Wei-Shou Hu

A comparative genomic hybridization approach to study gene copy number variations among chinese hamster cell lines

Vishwanathan, N., Bandyopadhyay, A., Fu, H. Y., Johnson, K. C., Springer, N. M. & Hu, W. S., Aug 2017, In : Biotechnology and bioengineering. 114, 8, p. 1903-1908 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Advancement in bioprocess technology: parallels between microbial natural products and cell culture biologics

Bandyopadhyay, A. A., Khetan, A., Malmberg, L. H., Zhou, W. & Hu, W. S., May 1 2017, In : Journal of Industrial Microbiology and Biotechnology. 44, 4-5, p. 785-797 13 p.

Research output: Contribution to journalReview article

7 Scopus citations

Advances in process monitoring tools for cell culture bioprocesses

Zhao, L., Fu, H. Y., Zhou, W. & Hu, W. S., Jan 1 2015, In : Engineering in Life Sciences. 15, 5, p. 459-468 10 p.

Research output: Contribution to journalReview article

33 Scopus citations

Advancing biopharmaceutical process science through transcriptome analysis

Vishwanathan, N., Le, H., Le, T. & Hu, W. S., Dec 2014, In : Current Opinion in Biotechnology. 30, p. 113-119 7 p.

Research output: Contribution to journalReview article

18 Scopus citations

Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Boon, R., Kumar, M., Tricot, T., Elia, I., Ordovas, L., Jacobs, F., One, J., De Smedt, J., Eelen, G., Bird, M., Roelandt, P., Doglioni, G., Vriens, K., Rossi, M., Vazquez, M. A., Vanwelden, T., Chesnais, F., El Taghdouini, A., Najimi, M., Sokal, E. & 8 others, Cassiman, D., Snoeys, J., Monshouwer, M., Hu, W. S., Lange, C., Carmeliet, P., Fendt, S. M. & Verfaillie, C. M., Dec 1 2020, In : Nature communications. 11, 1, 1393.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

An integrated platform for mucin-type O-glycosylation network generation and visualization

Le, T., O’Brien, C., Gupta, U., Sousa, G., Daoutidis, P. & Hu, W-S., Jun 2019, In : Biotechnology and bioengineering. 116, 6, p. 1341-1354 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

An LDHa single allele CHO cell mutant exhibits altered metabolic state and enhanced culture performance

Wilkens, C. A., Vishwanathan, N., Baltes, N. J., Lucero, A. T., Hu, W. S. & Gerdtzen, Z. P., May 2019, In : Journal of Chemical Technology and Biotechnology. 94, 5, p. 1488-1498 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Antagonistic donor density effect conserved in multiple enterococcal conjugative plasmids

Bandyopadhyay, A., O'Brien, S., Frank, K. L., Dunny, G. M. & Hu, W. S., Jan 1 2016, In : Applied and environmental microbiology. 82, 15, p. 4537-4545 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer

Chatterjee, A., Cook, L. C. C., Shu, C. C., Chen, Y., Manias, D. A., Ramkrishna, D., Dunny, G. M. & Hu, W. S., Apr 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 17, p. 7086-7090 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

A special preface: Laudatio for Professor Wei-Shou Hu

Hu, W. S. & Zeng, A. P., 2012, In : Advances in Biochemical Engineering/Biotechnology. 127

Research output: Contribution to journalArticle

1 Scopus citations

Augmenting Chinese hamster genome assembly by identifying regions of high confidence

Vishwanathan, N., Bandyopadhyay, A. A., Fu, H. Y., Sharma, M., Johnson, K. C., Mudge, J., Ramaraj, T., Onsongo, G., Silverstein, K. A. T., Jacob, N. M., Le, H., Karypis, G. & Hu, W. S., Sep 1 2016, In : Biotechnology Journal. 11, 9, p. 1151-1157 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Automated network generation and analysis of biochemical reaction pathways using RING

Gupta, U., Le, T., Hu, W-S., Bhan, A. & Daoutidis, P., Sep 2018, In : Metabolic Engineering. 49, p. 84-93 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Bio-based chemical engineering: Editorial overview

Liao, J. C. & Hu, W. S., Nov 2012, In : Current Opinion in Chemical Engineering. 1, 4, p. 353-354 2 p.

Research output: Contribution to journalEditorial

Biological assessment of a calcium silicate incorporated hydroxyapatite-gelatin nanocomposite: A comparison to decellularized bone matrix

Lee, D. J., Padilla, R., Zhang, H., Hu, W. S. & Ko, C. C., 2014, In : BioMed Research International. 2014, 837524.

Research output: Contribution to journalArticle

14 Scopus citations

Biotechnology Advances

Tzanakakis, E. S. & Hu, W. S., Nov 15 2013, In : Biotechnology Advances. 31, 7, 1 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Biotechnology and bioprocess engineering: Editorial overview

Hu, W. S. & Liao, J. C., Nov 2013, In : Current Opinion in Chemical Engineering. 2, 4, p. 363-364 2 p.

Research output: Contribution to journalEditorial

Bistability in glycolysis pathway as a physiological switch in energy metabolism

Mulukutla, B. C., Yongky, A., Daoutidis, P. & Hu, W. S., Jun 9 2014, In : PloS one. 9, 6, e98756.

Research output: Contribution to journalArticle

34 Scopus citations

Cell-based liver support systems: Status and prospect

Raju, R., Verfaillie, C. M. & Hu, W. S., Feb 2013, In : Current Opinion in Chemical Engineering. 2, 1, p. 26-31 6 p.

Research output: Contribution to journalReview article

1 Scopus citations

Cell Expansion during Directed Differentiation of Stem Cells Toward the Hepatic Lineage

Raju, R., Chau, D., Cho, D. S., Park, Y., Verfaillie, C. M. & Hu, W. S., Feb 15 2017, In : Stem Cells and Development. 26, 4, p. 274-284 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Cell line development for biomanufacturing processes: recent advances and an outlook

Le, H., Vishwanathan, N., Jacob, N. M., Gadgil, M. & Hu, W. S., Aug 1 2015, In : Biotechnology Letters. 37, 8, p. 1553-1564 12 p.

Research output: Contribution to journalReview article

20 Scopus citations

Dynamic gene expression for metabolic engineering of mammalian cells in culture

Le, H., Vishwanathan, N., Kantardjieff, A., Doo, I., Srienc, M., Zheng, X., Somia, N. & Hu, W. S., Nov 2013, In : Metabolic Engineering. 20, p. 212-220 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Dynamics of cell induction in enterococcus faecalis

Tran, V., Bandyopadhyaya, A., Dunny, G., Hu, W. S. & Ramkrishna, D., Jan 1 2015, Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting. AIChE, p. 456-465 10 p. (Computing and Systems Technology Division 2015 - Core Programming Area at the 2015 AIChE Annual Meeting; vol. 1).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Effects of endogenous levels of master regulator PrgX and peptide pheromones on inducibility of conjugation in the enterococcal pCF10 system

Erickson, R. J. B., Manias, D. A., Hu, W. S. & Dunny, G. M., Sep 1 2019, In : Molecular Microbiology. 112, 3, p. 1010-1023 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Elmer L. Gaden, Jr. Tribute

Clark, D. S., Blanch, H. W., Wang, D. I. C., Demain, A. L., Wandrey, C., Hu, W. S., Schultz, J. S., Shuler, M. L., Hoare, M., Lightfoot, E. N., Humphrey, A. E., Dordick, J. S. & Asenjo, J. A., Oct 2012, In : Biotechnology and bioengineering. 109, 10, p. 2417-2421 5 p.

Research output: Contribution to journalEditorial

Enhancing CHO by Systems Biotechnology

Borth, N. & Hu, W. S., Mar 2018, In : Biotechnology Journal. 13, 3, 1800077.

Research output: Contribution to journalEditorial

Open Access

Enhancing CHO by Systems Biotechnology

Borth, N. & Hu, W. S., Oct 2018, In : Biotechnology Journal. 13, 10, 1800488.

Research output: Contribution to journalEditorial

Open Access

Exploring the transcriptome space of a recombinant BHK cell line through next generation sequencing

Johnson, K. C., Yongky, A., Vishwanathan, N., Jacob, N. M., Jayapal, K. P., Goudar, C. T., Karypis, G. & Hu, W. S., Apr 2014, In : Biotechnology and bioengineering. 111, 4, p. 770-781 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Generation of induced pluripotent stem cells from Chinese hamster embryonic fibroblasts

Pei, H., Fu, H. Y., Cho, D. S., Cho, D. S., Dutton, J., Hu, W. S., Hirai, H., Verfaillie, C. M. & O'Brien, T. D., May 1 2017, In : Stem Cell Research. 21, p. 132-136 5 p.

Research output: Contribution to journalArticle

Open Access

Genomics and systems biology of mammalian cell culture

Hu, W. S. & Zeng, A. P., Dec 1 2012, Genomics and Systems Biology of Mammalian Cell Culture. Hu, W-S. & Zeng, A-P. (eds.). (Advances in Biochemical Engineering/Biotechnology; vol. 127).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Genomics and systems biotechnology in biopharmaceutical processing

Bandyopadhyay, A., Fu, H. Y., Vishwanathan, N. & Hu, W. S., Nov 2014, In : Chemical Engineering Progress. 110, 11, p. 45-50 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Global insights into the Chinese hamster and CHO cell transcriptomes

Vishwanathan, N., Yongky, A., Johnson, K. C., Fu, H. Y., Jacob, N. M., Le, H., Yusufi, F. N. K., Lee, D. Y. & Hu, W. S., May 1 2015, In : Biotechnology and bioengineering. 112, 5, p. 965-976 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Increased titer and reduced lactate accumulation in recombinant retrovirus production through the down-regulation of HIF1 and PDK

Rodrigues, A. F., Guerreiro, M. R., Formas-Oliveira, A. S., Fernandes, P., Blechert, A. K., Genzel, Y., Alves, P. M., Hu, W. S. & Coroadinha, A. S., Jan 1 2016, In : Biotechnology and bioengineering. 113, 1, p. 150-162 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Interspecies Organogenesis for Human Transplantation

Crane, A. T., Aravalli, R. N., Asakura, A., Grande, A. W., Krishna, V. D., Carlson, D. F., Cheeran, M. C. J., Danczyk, G., Dutton, J. R., Hackett, P. B., Hu, W. S., Li, L., Lu, W. C., Miller, Z. D., O’Brien, T. D., Panoskaltsis-Mortari, A., Parr, A. M., Pearce, C., Ruiz-Estevez, M., Shiao, M. & 6 others, Sipe, C. J., Toman, N. G., Voth, J., Xie, H., Steer, C. J. & Low, W. C., Sep 1 2019, In : Cell transplantation. 28, 9-10, p. 1091-1105 15 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations

In vitro pluripotent stem cell differentiation to hepatocyte ceases further maturation at an equivalent stage of e15 in mouse embryonic liver development

Raju, R., Chau, D., Notelaers, T., Myers, C. L., Verfaillie, C. M. & Hu, W. S., Jul 1 2018, In : Stem Cells and Development. 27, 13, p. 910-921 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Kinetic model optimization and its application to mitigating the Warburg effect through multiple enzyme alterations

O'Brien, C., Allman, A., Daoutidis, P. & Hu, W-S., Dec 2019, In : Metabolic Engineering. 56, p. 154-164 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line

Yusufi, F. N. K., Lakshmanan, M., Ho, Y. S., Loo, B. L. W., Ariyaratne, P., Yang, Y., Ng, S. K., Tan, T. R. M., Yeo, H. C., Lim, H. L., Ng, S. W., Hiu, A. P., Chow, C. P., Wan, C., Chen, S., Teo, G., Song, G., Chin, J. X., Ruan, X., Sung, K. W. K. & 5 others, Hu, W. S., Yap, M. G. S., Bardor, M., Nagarajan, N. & Lee, D. Y., May 24 2017, In : Cell Systems. 4, 5, p. 530-542.e6

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

MAPC culture conditions support the derivation of cells with nascent hypoblast features from bone marrow and blastocysts

Lo Nigro, A., Geraerts, M., Notelaers, T., Roobrouck, V. D., Muijtjens, M., Eggermont, K., Subramanian, K., Ulloa-Montoya, F., Park, Y., Owens, J., Burns, T. C., Low, W., Sharma, S., Sohni, A., Crabbe, A., Pauwelyn, K., Roelandt, P., Agirre, X., Prosper, F., O'Brien, T. D. & 4 others, Zwijsen, A., Hu, W. S., Binas, B. & Verfaillie, C. M., Dec 2012, In : Journal of Molecular Cell Biology. 4, 6, p. 423-426 4 p.

Research output: Contribution to journalLetter

15 Scopus citations

Mechanism for multiplicity of steady states with distinct cell concentration in continuous culture of mammalian cells

Yongky, A., Lee, J., Le, T., Mulukutla, B. C., Daoutidis, P. & Hu, W. S., Jul 1 2015, In : Biotechnology and bioengineering. 112, 7, p. 1437-1445 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mechanism of antibiotic resistant transfer in Enterococcus faecalis in planktonic cells via competing sensing/antisensing system

Tran, V., Shu, C. C., Dunny, G., Hu, W. S. & Ramkrishna, D., Jan 1 2014, Food, Pharmaceutical and Bioengineering Division 2014 - Core Programming Area at the 2014 AIChE Annual Meeting. AIChE, Vol. 2. 1 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mechanisms of peptide sex pheromone regulation of conjugation in Enterococcus faecalis

Chen, Y., Bandyopadhyay, A., Kozlowicz, B. K., Haemig, H. A. H., Tai, A., Hu, W. S. & Dunny, G. M., Aug 2017, In : MicrobiologyOpen. 6, 4, e00492.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

Metabolic pathways recruited in the production of a recombinant enveloped virus: Mining targets for process and cell engineering

Rodrigues, A. F., Formas-Oliveira, A. S., Bandeira, V. S., Alves, P. M., Hu, W. S. & Coroadinha, A. S., Nov 2013, In : Metabolic Engineering. 20, p. 131-145 15 p.

Research output: Contribution to journalArticle

16 Scopus citations

Model-Driven Engineering of N-Linked Glycosylation in Chinese Hamster Ovary Cells

Stach, C. S., McCann, M. G., O'Brien, C. M., Le, T. S., Somia, N., Chen, X., Lee, K., Fu, H. Y., Daoutidis, P., Zhao, L., Hu, W. S. & Smanski, M., Nov 15 2019, In : ACS Synthetic Biology. 8, 11, p. 2524-2535 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Modeling of gene regulatory processes by population-mediated signaling: New applications of population balances

Shu, C. C., Chatterjee, A., Hu, W. S. & Ramkrishna, D., Mar 5 2012, In : Chemical Engineering Science. 70, p. 188-199 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Multiplexed clonality verification of cell lines for protein biologic production

O'Brien, S. A., Ojha, J., Wu, P. & Hu, W. S., Jul 1 2020, In : Biotechnology Progress. 36, 4, e2978.

Research output: Contribution to journalArticle

Multiplicity of steady states in glycolysis and shift of metabolic state in cultured mammalian cells

Mulukutla, B. C., Yongky, A., Grimm, S., Daoutidis, P. & Hu, W. S., Mar 25 2015, In : PloS one. 10, 3, e0121561.

Research output: Contribution to journalArticle

27 Scopus citations

Multivariate analysis of cell culture bioprocess data—Lactate consumption as process indicator

Le, H., Kabbur, S., Pollastrini, L., Sun, Z., Mills, K., Johnson, K., Karypis, G. & Hu, W. S., Dec 31 2012, In : Journal of Biotechnology. 162, 2-3, p. 210-223 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

On metabolic shift to lactate consumption in fed-batch culture of mammalian cells

Mulukutla, B. C., Gramer, M. & Hu, W. S., Mar 1 2012, In : Metabolic Engineering. 14, 2, p. 138-149 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

PDGFRα+ Cells in Embryonic Stem Cell Cultures Represent the In Vitro Equivalent of the Pre-implantation Primitive Endoderm Precursors

Lo Nigro, A., de Jaime-Soguero, A., Khoueiry, R., Cho, D. S., Ferlazzo, G. M., Perini, I., Abon Escalona, V., Aranguren, X. L., Chuva de Sousa Lopes, S. M., Koh, K. P., Conaldi, P. G., Hu, W. S., Zwijsen, A., Lluis, F. & Verfaillie, C. M., Feb 14 2017, In : Stem Cell Reports. 8, 2, p. 318-333 16 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Preface

Hu, W. S. & Zeng, A. P., 2012, In : Advances in Biochemical Engineering/Biotechnology. 127

Research output: Contribution to journalArticle

Recurring genomic structural variation leads to clonal instability and loss of productivity

Bandyopadhyay, A. A., O’Brien, S. A., Zhao, L., Fu, H. Y., Vishwanathan, N. & Hu, W-S., Jan 2019, In : Biotechnology and bioengineering. 116, 1, p. 41-53 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations