Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011

Author

  • Bruce R Blazar

161533 TriKE stimulates NK-cell function to overcome myeloid-derived suppressor cells in MDS

Sarhan, D., Brandt, L., Felices, M., Guldevall, K., Lenvik, T., Hinderlie, P., Curtsinger, J., Warlick, E., Spellman, S. R., Blazar, B. R., Weisdorf, D. J., Cooley, S., Vallera, D. A., Onfelt, B. & Miller, J. S., Jun 26 2018, In : Blood Advances. 2, 12, p. 1459-1469 11 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial

Koreth, J., Kim, H. T., Lange, P. B., Bindra, B., Reynolds, C. G., Chammas, M. J., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Nikiforow, S., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Nov 2015, In : Biology of Blood and Marrow Transplantation. 21, 11, p. 1907-1913 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Aug 8 2019, In : Nature. 572, 7768, p. 254-259 6 p.

Research output: Contribution to journalLetter

Open Access
24 Scopus citations

Achievement of tolerance induction to prevent acute graft-vs.-host disease

Thangavelu, G. & Blazar, B. R., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 309.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations

A confirmation of chronic graft-versus-host disease prediction using allogeneic HY antibodies following sex-mismatched hematopoietic cell transplantation

Paul, J., Nakasone, H., Sahaf, B., Wu, F., Wang, K., Ho, V., Wu, J., Kim, H., Blazar, B., Ritz, J., Howard, A., Cutler, C. & Miklos, D., Jun 30 2019, In : Haematologica. 104, 7, p. e314-e317

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

A critical role for donor-derived IL-22 in cutaneous chronic GVHD

Gartlan, K. H., Bommiasamy, H., Paz, K., Wilkinson, A. N., Owen, M., Reichenbach, D. K., Banovic, T., Wehner, K., Buchanan, F., Varelias, A., Kuns, R. D., Chang, K., Fedoriw, Y., Shea, T., Coghill, J., Zaiken, M., Plank, M. W., Foster, P. S., Clouston, A. D., Blazar, B. R. & 2 others, Serody, J. S. & Hill, G. R., Apr 2018, In : American Journal of Transplantation. 18, 4, p. 810-820 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Activated protein C ameliorates chronic graft-versus-host disease by PAR1-dependent biased cell signaling on T cells

Sinha, R. K., Flynn, R., Zaiken, M., Paz, K., Gavin, A. L., Nemazee, D., Fernández, J. A., Xu, X., Griffin, J. H. & Blazar, B. R., Aug 29 2019, In : Blood. 134, 9, p. 776-781 6 p.

Research output: Contribution to journalArticle

2 Scopus citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

Acute Graft-versus-Host Disease

Zeiser, R. & Blazar, B. R., Feb 8 2018, In : The New England journal of medicine. 378, 6, 1 p.

Research output: Contribution to journalLetter

4 Scopus citations

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R., Nov 30 2017, In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Contribution to journalReview article

Open Access
170 Scopus citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R., Apr 13 2017, In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
32 Scopus citations

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Adaptive NK cells resist regulatory T-cell suppression driven by IL37

Sarhan, D., Hippen, K. L., Lemire, A., Hying, S., Luo, X., Lenvik, T., Curtsinger, J., Davis, Z., Zhang, B., Cooley, S., Cichocki, F., Blazar, B. R. & Miller, J. S., Jul 2018, In : Cancer Immunology Research. 6, 7, p. 766-775 10 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Adaptive NK cells with low TIGIT expression are inherently resistant to myeloid-derived suppressor cells

Sarhan, D., Cichocki, F., Zhang, B., Yingst, A., Spellman, S. R., Cooley, S., Verneris, M. R., Blazar, B. R. & Miller, J. S., Oct 1 2016, In : Cancer Research. 76, 19, p. 5696-5706 11 p.

Research output: Contribution to journalArticle

Open Access
52 Scopus citations

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Mirsoian, A., Bouchlaka, M. N., Sckisel, G. D., Chen, M., Pai, C. C. S., Maverakis, E., Spencer, R. G., Fishbein, K. W., Siddiqui, S., Monjazeb, A. M., Martin, B., Maudsley, S., Hesdorffer, C., Ferrucci, L., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Taub, D. D. & Murphy, W. J., 2014, In : Journal of Experimental Medicine. 211, 12, p. 2373-2383 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
55 Scopus citations

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

McDonald-Hyman, C., Turka, L. A. & Blazar, B. R., Mar 25 2015, In : Science Translational Medicine. 7, 280, 280rv2.

Research output: Contribution to journalReview article

54 Scopus citations

Advances in graft-versus-host disease biology and therapy

Blazar, B. R., Murphy, W. J. & Abedi, M., Jun 1 2012, In : Nature Reviews Immunology. 12, 6, p. 443-458 16 p.

Research output: Contribution to journalReview article

489 Scopus citations

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Kean, L. S., Turka, L. A. & Blazar, B. R., Mar 1 2017, In : Immunological Reviews. 276, 1, p. 192-212 21 p.

Research output: Contribution to journalReview article

Open Access
22 Scopus citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy

Bouchlaka, M. N., Sckisel, G. D., Chen, M., Mirsoian, A., Zamora, A. E., Maverakis, E., Wilkins, D. E. C., Alderson, K. L., Hsiao, H. H., Weiss, J. M., Monjazeb, A. M., Hesdorffer, C., Ferrucci, L., Longo, D. L., Blazar, B. R., Wiltrout, R. H., Redelman, D., Taub, D. D. & Murphy, W. J., Oct 2013, In : Journal of Experimental Medicine. 210, 11, p. 2223-2237 15 p.

Research output: Contribution to journalArticle

68 Scopus citations

Alarmins and Their Receptors as Modulators and Indicators of Alloimmune Responses

Matta, B. M., Reichenbach, D. K., Blazar, B. R. & Turnquist, H. R., Feb 1 2017, In : American Journal of Transplantation. 17, 2, p. 320-327 8 p.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

A low frequency of pancreatic islet insulin-expressing cells derived from cord blood stem cell allografts in humans

Huang, C. J., Butler, A. E., Moran, A., Rao, P. N., Wagner, J. E., Blazar, B. R., Rizza, R. A., Manivel, J. C. & Butler, P. C., May 2011, In : Diabetologia. 54, 5, p. 1066-1074 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z. C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
55 Scopus citations
1 Scopus citations

Amphiregulin modifies the Minnesota acute graft-versus-host disease risk score: Results from BMT CTN 0302/0802

Holtan, S. G., DeFor, T. E., Panoskaltsis-Mortari, A., Khera, N., Levine, J. E., Flowers, M. E. D., Lee, S. J., Inamoto, Y., Chen, G. L., Mayer, S., Arora, M., Palmer, J., Cutler, C. S., Arai, S., Lazaryan, A., Newell, L. F., Jagasia, M. H., Pusic, I., Wood, W. A., Renteria, A. S. & 17 others, Yanik, G., Hogan, W. J., Hexner, E., Ayuk, F., Holler, E., Bunworasate, U., Efebera, Y. A., Ferrara, J. L. M., Pidala, J., Howard, A., Wu, J., Bolaños-Meade, J., Ho, V., Alousi, A., Blazar, B. R., Weisdorf, D. J. & MacMillan, M. L., Aug 14 2018, In : Blood Advances. 2, 15, p. 1882-1888 7 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD

Poe, J. C., Jia, W., Su, H., Anand, S., Rose, J. J., Tata, P. V., Suthers, A. N., Jones, C. D., Kuan, P. F., Vincent, B. G., Serody, J. S., Horwitz, M. E., Ho, V. T., Pavletic, S. Z., Hakim, F. T., Owzar, K., Zhang, D., Blazar, B. R., Siebel, C. W., Chao, N. J. & 2 others, Maillard, I. & Sarantopoulos, S., Nov 9 2017, In : Blood. 130, 19, p. 2131-2145 15 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

An activated Th17-prone T cell subset involved in chronic graft-versus-host disease sensitive to pharmacological inhibition

Forcade, E., Paz, K., Flynn, R., Griesenauer, B., Amet, T., Li, W., Liu, L., Bakoyannis, G., Jiang, D., Chu, H. W., Lobera, M., Yang, J., Wilkes, D. S., Du, J., Gartlan, K., Hill, G. R., MacDonald, K. P., Espada, E. L., Blanco, P., Serody, J. S. & 7 others, Koreth, J., Cutler, C. S., Antin, J. H., Soiffer, R. J., Ritz, J., Paczesny, S. & Blazar, B. R., Jun 15 2017, In : JCI Insight. 2, 12

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

An alpha-defensin gene single nucleotide polymorphism modulates the gut microbiota and may alter the risk of acute graft-versus-host disease

Rashidi, A., Herman, A., Gomes, A. L. C., Peled, J. U., Jenq, R. R., Brereton, D. G., Staley, C., Blazar, B. R. & Weisdorf, D. J., Jun 1 2020, In : British journal of haematology. 189, 5, p. 926-930 5 p.

Research output: Contribution to journalArticle

Analysis of BMT CTN-0201 and -0901 samples did not reproduce the reported association between recipient REG3A rs7588571 and chronic GVHD

Rashidi, A., Shanley, R., Anasetti, C., Waller, E. K., Scott, B. L., Blazar, B. R. & Weisdorf, D. J., Mar 1 2019, In : Bone marrow transplantation. 54, 3, p. 490-493 4 p.

Research output: Contribution to journalArticle

Open Access
Open Access
5 Scopus citations

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B. R., Pardoll, D., Mellor, A., Shi, H. & Munn, D., May 23 2013, In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

106 Scopus citations

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L., Goren, E., Mulé, J. J. & Blazar, B. R., Apr 2018, In : PloS one. 13, 4, e0193461.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Antibodies targeting surface membrane antigens in patients with chronic graft-versus-host disease

Wang, K. S., Kim, H. T., Nikiforow, S., Heubeck, A. T., Ho, V. T., Koreth, J., Alyea, E. P., Armand, P., Blazar, B. R., Soiffer, R. J., Antin, J. H., Cutler, C. S. & Ritz, J., Dec 28 2017, In : Blood. 130, 26, p. 2889-2899 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A Phase II Study of Bortezomib Plus Prednisone for Initial Therapy of Chronic Graft-versus-Host Disease

Herrera, A. F., Kim, H. T., Bindra, B., Jones, K. T., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Nikiforow, S., Blazar, B. R., Ritz, J., Antin, J. H., Soiffer, R. J. & Koreth, J., Nov 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 11, p. 1737-1743 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer

Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R. K., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A. K., Oct 17 2012, In : Science Translational Medicine. 4, 156, 156ra139.

Research output: Contribution to journalArticle

162 Scopus citations

A Randomized Trial of One versus Two Doses of Influenza Vaccine after Allogeneic Transplantation

Karras, N. A., Weeres, M., Sessions, W., Xu, X., DeFor, T., Young, J. A. H., Stefanski, H., Brunstein, C., Cooley, S., Miller, J. S., Blazar, B. R., Wagner, J. E. & Verneris, M. R., Jan 1 2013, In : Biology of Blood and Marrow Transplantation. 19, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

A refined risk score for acute graft-versus-host disease that predicts response to initial therapy, survival, and transplant-related mortality

MacMillan, M. L., Robin, M., Harris, A. C., DeFor, T. E., Martin, P. J., Alousi, A., Ho, V. T., Bolaños-Meade, J., Ferrara, J. L. M., Jones, R., Arora, M., Blazar, B. R., Holtan, S. G., Jacobsohn, D., Pasquini, M., Socie, G., Antin, J. H., Levine, J. E. & Weisdorf, D. J., Apr 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 4, p. 761-767 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

ARID5B regulates metabolic programming in human adaptive NK cells

Cichocki, F. M., Wu, C-Y., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., Bryceson, Y. T. & Miller, J. S., 2018, In : Journal of Experimental Medicine. 215, 9, p. 2379-2395 17 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Dec 1 2017, In : Scientific reports. 7, 1, 1633.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Association between recipient TNF rs361525 and acute GVHD: results from analysis of BMT CTN-0201 samples

Rashidi, A., Shanley, R., Yohe, S. L., Thyagarajan, B., Curtsinger, J., Anasetti, C., Waller, E. K., Miller, J. S., Blazar, B. R. & Weisdorf, D. J., Aug 1 2018, In : Bone marrow transplantation. 53, 8, p. 1069-1071 3 p.

Research output: Contribution to journalLetter

Open Access
1 Scopus citations

Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt

Fulton, L. M., Carlson, M. J., Coghill, J. M., Ott, L. E., West, M. L., Panoskaltsis-Mortari, A., Littman, D. R., Blazar, B. R. & Serody, J. S., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
Open Access

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Le Texier, L., Lineburg, K. E., Cao, B., McDonald-Hyman, C., Leveque-El Mouttie, L., Nicholls, J., Melino, M., Nalkurthi, B. C., Alexander, K. A., Teal, B., Blake, S. J., Souza-Fonseca-Guimaraes, F., Engwerda, C. R., Kuns, R. D., Lane, S. W., Teng, M., Teh, C., Gray, D., Clouston, A. D., Nilsson, S. K. & 3 others, Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Sep 22 2016, In : JCI insight. 1, 15, p. e86850

Research output: Contribution to journalArticle

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Veenstra, R. G., Flynn, R., Kreymborg, K., McDonald-Hyman, C., Saha, A., Taylor, P. A., Osborn, M. J., Panoskaltsis-Mortari, A., Schmitt-Graeff, A., Lieberknect, E., Murphy, W. J., Serody, J. S., Munn, D. H., Freeman, G. J., Allison, J. P., Mak, T. W., van den Brink, M., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Blood. 125, 21, p. 3335-3346 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Osborn, M. J., Newby, G. A., McElroy, A. N., Knipping, F., Nielsen, S. C., Riddle, M. J., Xia, L., Chen, W., Eide, C. R., Webber, B. R., Wandall, H. H., Dabelsteen, S., Blazar, B. R., Liu, D. R. & Tolar, J., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 338-347.e5

Research output: Contribution to journalArticle

4 Scopus citations

B cells drive autoimmunity in mice with CD28-deficient regulatory T cells

Zhang, R., Sage, P. T., Finn, K., Huynh, A., Blazar, B. R., Marangoni, F., Mempel, T. R., Sharpe, A. H. & Turka, L. A., Dec 15 2017, In : Journal of Immunology. 199, 12, p. 3972-3980 9 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

B Cells in Chronic Graft-versus-Host Disease

Sarantopoulos, S., Blazar, B. R., Cutler, C. & Ritz, J., Jan 1 2015, In : Biology of Blood and Marrow Transplantation. 21, 1, p. 16-23 8 p.

Research output: Contribution to journalReview article

50 Scopus citations