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  • Stephen S Hecht

(S)-N'-Nitrosonornicotine, a constituent of smokeless tobacco, is a powerful oral cavity carcinogen in rats

Balbo, S., James-Yi, S., Johnson, C. S., O'Sullivan, M. G., Stepanov, I., Wang, M., Bandyopadhyay, D., Kassie, F., Carmella, S., Upadhyaya, P. & Hecht, S. S., Sep 2013, In : Carcinogenesis. 34, 9, p. 2178-2183 6 p.

Research output: Contribution to journalArticle

37 Scopus citations
Open Access
13 Scopus citations

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
8 Scopus citations
26 Scopus citations

Analysis of acrolein-derived 1, N 2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers

Zhang, S., Balbo, S., Wang, M. & Hecht, S. S., Jan 14 2011, In : Chemical research in toxicology. 24, 1, p. 119-124 6 p.

Research output: Contribution to journalArticle

34 Scopus citations
Open Access
8 Scopus citations
Open Access
2 Scopus citations
Open Access
10 Scopus citations
22 Scopus citations
6 Scopus citations

Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles

Farsalinos, K. E., Gillman, I. G., Hecht, S. S., Polosa, R. & Thornburg, J., Nov 14 2016, Elsevier Inc. 150 p.

Research output: Book/ReportBook

5 Scopus citations

An approach to the evaluation of berries for cancer prevention with emphasis on esophageal cancer

Stoner, G. D., Wang, L. S., Kresty, L. A., Peiffer, D., Kuo, C. T., Huang, Y. W., Wang, D., Ransom, B., Carmella, S. & Hecht, S. S., 2014, Cancer Prevention: Dietary Factors and Pharmacology. Bode, A. M. & Dong, Z. (eds.). p. 107-133 27 p. (Methods in Pharmacology and Toxicology).

Research output: Chapter in Book/Report/Conference proceedingChapter

A New Editorial Team for CRT

Hecht, S. S., Jan 16 2018, In : Chemical research in toxicology. 31, 1, 1 p.

Research output: Contribution to journalEditorial

Open Access

Anthocyanins, anthocyanin derivatives, and colorectal cancer

Wang, L. S., Kuo, C. T., Peiffer, D., Seguin, C., Stoner, K., Huang, Y. W., Huang, T. H. M., Salzman, N., Liu, Z., Rosenberg, D., Yang, G. Y., Yang, W., Bi, X., Carmella, S., Hecht, S. & Stoner, G., Jan 1 2013, Anthocyanins in Health and Disease. CRC Press, p. 225-243 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Anthocyanins and cancer prevention

Wang, L. S., Carmella, S., Keyes, R., Kuo, C. T., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Dec 1 2012, Nutraceuticals and Cancer. Springer Netherlands, Vol. 9789400726307. p. 201-229 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
43 Scopus citations

A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure

Meier, E., Lindgren, B. R., Anderson, A., Reisinger, S. A., Norton, K. J., Jensen, J., Strayer, L., Dick, L., Tang, M. K., Chen, M., Carmella, S. G., Hecht, S. S., Murphy, S. E., Yang, J., Stepanov, I., O'Connor, R. J., Shields, P. G. & Hatsukami, D. K., Apr 17 2020, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22, 4, p. 473-481 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

A special issue of CRT: Celebrating volume 30

Hecht, S. S., Jan 1 2017, In : Chemical research in toxicology. 30, 1, 1 p.

Research output: Contribution to journalEditorial

Open Access

Assessing secondhand smoke using biological markers

Avila-Tang, E., Al-Delaimy, W. K., Ashley, D. L., Benowitz, N., Bernert, J. T., Kim, S., Samet, J. M. & Hecht, S. S., May 1 2013, In : Tobacco control. 22, 3, p. 164-171 8 p.

Research output: Contribution to journalReview article

123 Scopus citations

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 2017, In : PloS one. 12, 5, e0178435.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Associations between genetic ancestries and nicotine metabolism biomarkers in the multiethnic cohort study

Wang, H., Park, S. L., Stram, D. O., Haiman, C. A., Wilkens, L. R., Hecht, S. S., Kolonel, L. N., Murphy, S. E. & Marchand, L. L., Jan 1 2015, In : American journal of epidemiology. 182, 11, p. 945-951 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Benzene oxide is a substrate for glutathione S-transferases

Zarth, A. T., Murphy, S. E. & Hecht, S. S., Dec 5 2015, In : Chemico-Biological Interactions. 242, p. 390-395 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Benzene uptake in hookah smokers and non-smokers attending hookah social events: Regulatory implications

Kassem, N. O. F., Kassem, N. O., Jackson, S. R., Liles, S., Daffa, R. M., Zarth, A. T., Younis, M. A., Carmella, S. G., Hofstetter, C. R., Chatfield, D. A., Matt, G. E., Hecht, S. S. & Hovell, M. F., Dec 1 2014, In : Cancer Epidemiology Biomarkers and Prevention. 23, 12, p. 2793-2809 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Biochemical Verification of Tobacco Use and Abstinence: 2019 Update

Benowitz, N. L., Bernert, J. T., Foulds, J., Hecht, S. S., Jacob, P., Jarvis, M. J., Joseph, A., Oncken, C. & Piper, M. E., Jun 12 2020, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22, 7, p. 1086-1097 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Biomarkers for Assessment of Chemical Exposures From e-Cigarette Emissions

Hecht, S. S., Jan 1 2017, Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles. Elsevier Inc., p. 59-73 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers of exposure among adult smokeless tobacco users in the population assessment of Tobacco and health study (WAVE 1, 2013-2014)

Cheng, Y. C., Reyes-Guzman, C. M., Christensen, C. H., Rostron, B. L., Edwards, K. C., Wang, L., Feng, J., Jarrett, J. M., Ward, C. D., Xia, B., Kimmel, H. L., Conway, K., Leggett, C., Taylor, K., Lawrence, C., Niaura, R., Travers, M. J., Hyland, A., Hecht, S. S., Hatsukami, D. K. & 4 others, Goniewicz, M. L., Borek, N., Blount, B. C. & van Bemmel, D. M., 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 3, p. 659-667 9 p.

Research output: Contribution to journalReview article

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

Peterson, L. A., Urban, A. M. & Hecht, S. S., Jan 1 2018, Respiratory Toxicology. Elsevier Inc., Vol. 15-15. p. 228-253 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Carcinogenicity and DNA adduct formation of 4-(methylnitrosamino)-1-(3-pyridyl)- 1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanol in F-344 rats

Balbo, S., Johnson, C. S., Kovi, R. C., James-Yi, S. A., Gerard O'Sullivan, M., Wang, M., Le, C. T., Khariwala, S. S., Upadhyaya, P. & Hecht, S. S., Dec 1 2014, In : Carcinogenesis. 35, 12, p. 2798-2806 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Carcinogenic tobacco-specific N-nitrosamines in US cigarettes: Three decades of remarkable neglect by the tobacco industry

Stepanov, I., Knezevich, A., Zhang, L., Watson, C. H., Hatsukami, D. K. & Hecht, S. S., May 20 2011, In : Tobacco control. 21, 1, p. 44-48 5 p.

Research output: Contribution to journalArticle

39 Scopus citations
Open Access

Chemoprevention of esophageal cancer with black raspberries, their component anthocyanins, and a major anthocyanin metabolite, protocatechuic acid

Peiffer, D. S., Zimmerman, N. P., Wang, L. S., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Siddiqui, J., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jun 2014, In : Cancer Prevention Research. 7, 6, p. 574-584 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Children's exposure to secondhand and thirdhand smoke carcinogens and toxicants in homes of hookah smokers

Kassem, N. O. F., Daffa, R. M., Liles, S., Jackson, S. R., Kassem, N. O., Younis, M. A., Mehta, S., Chen, M., Jacob, P., Carmella, S. G., Chatfield, D. A., Benowitz, N. L., Matt, G. E., Hecht, S. S. & Hovell, M. F., Jul 2014, In : Nicotine and Tobacco Research. 16, 7, p. 961-975 15 p., ntu016.

Research output: Contribution to journalArticle

40 Scopus citations

Cigarette Smokers Versus Cousers of Cannabis and Cigarettes: Exposure to Toxicants

Meier, E., Vandrey, R., Rubin, N., Pacek, L. R., Jensen, J. A., Donny, E. C., Hecht, S. S., Carmella, S. G., Murphy, S. E., Luo, X., Stepanov, I., Ikuemonisan, J., Severson, H., al'Absi, M. N. & Hatsukami, D. K., Jul 16 2020, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22, 8, p. 1383-1389 7 p.

Research output: Contribution to journalArticle

Clinical and biochemical studies support smokeless tobacco's carcinogenic potential in thehumanoral cavity

Mallery, S. R., Tong, M., Michaels, G. C., Kiyani, A. R. & Hecht, S. S., Jan 2014, In : Cancer Prevention Research. 7, 1, p. 23-32 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers

Yuan, J. M., Stepanov, I., Murphy, S. E., Wang, R., Allen, S., Jensen, J., Strayer, L., Adams-Haduch, J., Upadhyaya, P., Le, C., Kurzer, M. S., Nelson, H. H., Yu, M. C., Hatsukami, D. & Hecht, S. S., May 2016, In : Cancer Prevention Research. 9, 5, p. 396-405 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
11 Scopus citations

Combined analysis of the tobacco metabolites cotinine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol in human urine

Kotandeniya, D., Carmella, S. G., Ming, X., Murphy, S. E. & Hecht, S. S., Feb 3 2015, In : Analytical chemistry. 87, 3, p. 1514-1517 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Goniewicz, M. L., Smith, D. M., Edwards, K. C., Blount, B. C., Caldwell, K. L., Feng, J., Wang, L., Christensen, C., Ambrose, B., Borek, N., van Bemmel, D., Konkel, K., Erives, G., Stanton, C. A., Lambert, E., Kimmel, H. L., Hatsukami, D., Hecht, S. S., Niaura, R. S., Travers, M. & 2 others, Lawrence, C. & Hyland, A. J., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185937

Research output: Contribution to journalArticle

Open Access
62 Scopus citations
20 Scopus citations

Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen

Ainslie-Waldman, C. E., Simpkins, S. W., Upadhyaya, P., Carmella, S. G., Hecht, S. S. & Trudo, S. P., Sep 20 2013, In : Food and Chemical Toxicology. 62, p. 188-193 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Continuing excellence for chemical research in toxicology

Hecht, S. S., Jan 18 2013, In : Chemical research in toxicology. 26, 1, 1 p.

Research output: Contribution to journalEditorial

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Narayanapillai, S. C., Von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations