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  • Larry Que

1H-ENDOR evidence for a hydrogen-bonding interaction that modulates the reactivity of a nonheme Fe IV=O unit

Shanmugam, M., Xue, G., Que, L. & Hoffman, B. M., Oct 1 2012, In : Inorganic chemistry. 51, 19, p. 10080-10082 3 p.

Research output: Contribution to journalArticle

9 Scopus citations

60 years of dioxygen activation

Que, L., Apr 1 2017, In : Journal of Biological Inorganic Chemistry. 22, 2-3, p. 171-173 3 p.

Research output: Contribution to journalEditorial

Open Access
13 Scopus citations

A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase

Jasniewski, A. J., Knoot, C., Lipscomb, J. D. & Que, L., Oct 18 2016, In : Biochemistry. 55, 41, p. 5818-5831 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A chameleon catalyst for nonheme iron-promoted olefin oxidation

Iyer, S. R., Javadi, M. M., Feng, Y., Hyun, M. Y., Oloo, W. N., Kim, C. & Que, L., Nov 18 2014, In : Chemical Communications. 50, 89, p. 13777-13780 4 p.

Research output: Contribution to journalArticle

19 Scopus citations

Acid p Ka Dependence in O-O Bond Heterolysis of a Nonheme FeIII-OOH Intermediate to Form a Potent FeV=O Oxidant with Heme Compound I-Like Reactivity

Xu, S., Draksharapu, A., Rasheed, W. & Que, L., Oct 9 2019, In : Journal of the American Chemical Society. 141, 40, p. 16093-16107 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Acid-Triggered O−O Bond Heterolysis of a Nonheme FeIII(OOH) Species for the Stereospecific Hydroxylation of Strong C−H Bonds

Serrano-Plana, J., Acuña-Parés, F., Dantignana, V., Oloo, W. N., Castillo, E., Draksharapu, A., Whiteoak, C. J., Martin-Diaconescu, V., Basallote, M. G., Luis, J. M., Que, L., Costas, M. & Company, A., Apr 6 2018, In : Chemistry - A European Journal. 24, 20, p. 5331-5340 10 p.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations
6 Scopus citations

Active-site structure of a β-hydroxylase in antibiotic biosynthesis

Vu, V. V., Makris, T. M., Lipscomb, J. D. & Que, L., May 11 2011, In : Journal of the American Chemical Society. 133, 18, p. 6938-6941 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., Feb 1 2011, In : Journal of Biological Inorganic Chemistry. 16, 2, p. 341-355 15 p.

Research output: Contribution to journalArticle

60 Scopus citations

A Mn II Mn III -Peroxide Complex Capable of Aldehyde Deformylation

Magherusan, A. M., Kal, S., Nelis, D. N., Doyle, L. M., Farquhar, E. R., Que, L. & McDonald, A. R., Apr 16 2019, In : Angewandte Chemie - International Edition. 58, 17, p. 5718-5722 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

A mononuclear carboxylate-rich oxoiron(iv) complex: A structural and functional mimic of TauD intermediate 'J'

McDonald, A. R., Guo, Y., Vu, V. V., Bominaar, E. L., Münck, E. & Que, L., May 1 2012, In : Chemical Science. 3, 5, p. 1680-1693 14 p.

Research output: Contribution to journalArticle

32 Scopus citations

A more reactive trigonal-bipyramidal high-spin oxoiron(IV) complex with a cis-labile site

England, J., Guo, Y., Van Heuvelen, K. M., Cranswick, M. A., Rohde, G. T., Bominaar, E. L., Münck, E. & Que, L., Aug 10 2011, In : Journal of the American Chemical Society. 133, 31, p. 11880-11883 4 p.

Research output: Contribution to journalArticle

78 Scopus citations

An iron(II)[1,3-bis(2'-pyridylimino)isoindoline] complex as a catalyst for substrate oxidation with H2O2 - Evidence for a transient peroxidodiiron(III) species

Pap, J. S., Cranswick, M. A., Balogh-Hergovich, É., Baráth, G., Giorgi, M., Rohde, G. T., Kaizer, J., Speier, G. & Que, L., Oct 31 2013, In : European Journal of Inorganic Chemistry. 22-23, p. 3858-3866 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

An ultra-stable oxoiron(iv) complex and its blue conjugate base

England, J., Bigelow, J. O., Van Heuvelen, K. M., Farquhar, E. R., Martinho, M., Meier, K. K., Frisch, J. R., Münck, E. & Que, L., Mar 2014, In : Chemical Science. 5, 3, p. 1204-1215 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway

Makris, T. M., Vu, V. V., Meier, K. K., Komor, A. J., Rivard, B. S., Münck, E., Que, L. & Lipscomb, J. D., Feb 4 2015, In : Journal of the American Chemical Society. 137, 4, p. 1608-1617 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Assessment of electronic structure methods for the determination of the ground spin states of Fe(II), Fe(III) and Fe(IV) complexes

Verma, P., Varga, Z., Klein, J. E. M. N., Cramer, C., Que, L. & Truhlar, D. G., Jan 1 2017, In : Physical Chemistry Chemical Physics. 19, 20, p. 13049-13069 21 p.

Research output: Contribution to journalArticle

45 Scopus citations
29 Scopus citations

Bioinspired Nonheme Iron Catalysts for C-H and C=C Bond Oxidation: Insights into the Nature of the Metal-Based Oxidants

Oloo, W. N. & Que, L., Aug 17 2015, In : Accounts of Chemical Research. 48, 9, p. 2612-2621 10 p.

Research output: Contribution to journalArticle

192 Scopus citations

Bio-inspired Nonheme Iron Oxidation Catalysis: Involvement of Oxoiron(V) Oxidants in Cleaving Strong C−H Bonds

Kal, S., Xu, S. & Que, L., May 4 2020, In : Angewandte Chemie - International Edition. 59, 19, p. 7332-7349 18 p.

Research output: Contribution to journalReview article

5 Scopus citations

Carboxylate Structural Effects on the Properties and Proton-Coupled Electron Transfer Reactivity of [CuO2CR]2+ Cores

Elwell, C. E., Mandal, M., Bouchey, C. J., Que, L., Cramer, C. J. & Tolman, W. B., Dec 2 2019, In : Inorganic Chemistry. 58, 23, p. 15872-15879 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Caught! Crystal trapping of a side-on peroxo bound to Cr(IV)

De Sousa, D. P., Bigelow, J. O., Sundberg, J., Que, L. & McKenzie, C. J., Feb 18 2015, In : Chemical Communications. 51, 14, p. 2802-2805 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Celebrating Ed Solomon

Karlin, K. & Que, L., Sep 1 2016, In : Journal of Biological Inorganic Chemistry. 21, 5-6, p. 571-574 4 p.

Research output: Contribution to journalEditorial

Characterization of a heterobimetallic nonheme Fe(III)-O-Cr(III) species formed by O2 activation

Zhou, A., Kleespies, S. T., Van Heuvelen, K. M. & Que, L., Aug 5 2015, In : Chemical Communications. 51, 76, p. 14326-14329 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Characterization of a high-spin non-heme FeIII-OOH intermediate and its quantitative conversion to an FeIV=O complex

Li, F., Meier, K. K., Cranswick, M. A., Chakrabarti, M., Van Heuvelen, K. M., Münck, E. & Que, L., May 18 2011, In : Journal of the American Chemical Society. 133, 19, p. 7256-7259 4 p.

Research output: Contribution to journalArticle

80 Scopus citations

Characterization of an O 2 adduct of an active cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Lipscomb, J. D. & Que, L., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 796-799 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Characterization of a paramagnetic mononuclear nonheme iron-superoxo complex

Chiang, C. W., Kleespies, S. T., Stout, H. D., Meier, K. K., Li, P. Y., Bominaar, E. L., Que, L., Münck, E. & Lee, W. Z., Aug 6 2014, In : Journal of the American Chemical Society. 136, 31, p. 10846-10849 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Characterization of a thiolato iron(III) peroxy dianion complex

McDonald, A. R., Van Heuvelen, K. M., Guo, Y., Li, F., Bominaar, E. L., Münck, E. & Que, L., Sep 3 2012, In : Angewandte Chemie - International Edition. 51, 36, p. 9132-9136 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Characterization of a tricationic trigonal bipyramidal iron(IV) cyanide complex, with a very high reduction potential, and its iron(II) and iron(III) congeners

England, J., Farquhar, E. R., Guo, Y., Cranswick, M. A., Ray, K., Münck, E. & Que, L., Apr 4 2011, In : Inorganic Chemistry. 50, 7, p. 2885-2896 12 p.

Research output: Contribution to journalArticle

15 Scopus citations

Characterization of the Fleeting Hydroxoiron(III) Complex of the Pentadentate TMC-py Ligand

Ching, W. M., Zhou, A., Klein, J. E. M. N., Fan, R., Knizia, G., Cramer, C. J., Guo, Y. & Que, L., Jan 1 2017, In : Inorganic chemistry. 56, 18, p. 11129-11140 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

C-H bond cleavage by bioinspired nonheme oxoiron(IV) complexes, including hydroxylation of n-butane

Kleespies, S. T., Oloo, W. N., Mukherjee, A. & Que, L., Jun 1 2015, In : Inorganic Chemistry. 54, 11, p. 5053-5064 12 p.

Research output: Contribution to journalReview article

31 Scopus citations

CmlI N-Oxygenase Catalyzes the Final Three Steps in Chloramphenicol Biosynthesis without Dissociation of Intermediates

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Sep 19 2017, In : Biochemistry. 56, 37, p. 4940-4950 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
17 Scopus citations

Crystallographic Evidence for a Sterically Induced Ferryl Tilt in a Non-Heme Oxoiron(IV) Complex that Makes it a Better Oxidant

Rasheed, W., Draksharapu, A., Banerjee, S., Young, V. G., Fan, R., Guo, Y., Ozerov, M., Nehrkorn, J., Krzystek, J., Telser, J. & Que, L., Jul 20 2018, In : Angewandte Chemie - International Edition. 57, 30, p. 9387-9391 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Cyclohexene as a substrate probe for the nature of the high-valent iron-oxo oxidant in Fe(TPA)-catalyzed oxidations

Oloo, W. N., Feng, Y., Iyer, S., Parmelee, S., Xue, G. & Que, L., Nov 1 2013, In : New Journal of Chemistry. 37, 11, p. 3411-3415 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Detection of a transient FeV(O)(OH) species involved in olefin oxidation by a bio-inspired non-haem iron catalyst

Xu, S., Veach, J. J., Oloo, W. N., Peters, K. C., Wang, J., Perry, R. H. & Que, L., Jan 1 2018, In : Chemical Communications. 54, 63, p. 8701-8704 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Diiron monooxygenases in natural product biosynthesis

Komor, A. J., Jasniewski, A. J., Que, L. & Lipscomb, J. D., Jul 2018, In : Natural Product Reports. 35, 7, p. 646-659 14 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations

Dioxygen activation by biomimetic iron complexes of α-keto acids and α-hydroxy acids

Paine, T. K. & Que, L., 2014, Molecular Design in Inorganic Biochemistry. Springer- Verlag, p. 39-56 18 p. (Structure and Bonding; vol. 160).

Research output: Chapter in Book/Report/Conference proceedingChapter

13 Scopus citations

Dioxygen Activation by Biomimetic Iron Complexes of α-Keto Acids and α-Hydroxy Acids

Paine, T. K. & Que, L., Jan 1 2014, Molecular Design in Inorganic Biochemistry. Springer Verlag, p. 39-56 18 p. (Structure and Bonding; vol. 160).

Research output: Chapter in Book/Report/Conference proceedingChapter

Dioxygen Activation by Nonheme Diiron Enzymes: Diverse Dioxygen Adducts, High-Valent Intermediates, and Related Model Complexes

Jasniewski, A. J. & Que, L., Mar 14 2018, In : Chemical Reviews. 118, 5, p. 2554-2592 39 p.

Research output: Contribution to journalArticle

Open Access
95 Scopus citations
63 Scopus citations

Direct photochemical actIVation of non-heme Fe(IV)O complexes

Chen, J., Draksharapu, A., Harvey, E., Rasheed, W., Que, L. & Browne, W. R., Jan 1 2017, In : Chemical Communications. 53, 91, p. 12357-12360 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

Editorial overview

Armstrong, F. & Que, L., Apr 1 2012, In : Current Opinion in Chemical Biology. 16, 1-2, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Editorial overview

Armstrong, F. & Que, L., Apr 1 2012, In : Current opinion in chemical biology. 16, 1-2, p. 1-2 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
Open Access
23 Scopus citations

Erratum: Evidence for an oxygen evolving iron-oxo-cerium intermediate in iron-catalysed water oxidation (Nature Communications (2015) 6 (5865) DOI: 10.1038/ncomms6865)

Codolà, Z., Gómez, L., Kleespies, S. T., Que, L., Costas, M. & Lloret-Fillol, J., Feb 2015, In : Nature communications. 6, 6405.

Research output: Contribution to journalComment/debate

4 Scopus citations

Evaluating the identity and diiron core transformations of a (μ-Oxo)diiron(III)complex supported by electron-rich tris(pyridyl-2-methyl) amine ligands

Do, L. H., Xue, G., Que, L. & Lippard, S. J., Feb 20 2012, In : Inorganic chemistry. 51, 4, p. 2393-2402 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Evidence for a dual role of an active site histidine in α-Amino-β-carboxymuconate-ε-semialdehyde decarboxylase

Huo, L., Fielding, A. J., Chen, Y., Li, T., Iwaki, H., Hosler, J. P., Chen, L., Hasegawa, Y., Que, L. & Liu, A., Jul 24 2012, In : Biochemistry. 51, 29, p. 5811-5821 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Evidence for an oxygen evolving iron-oxo-cerium intermediate in iron-catalysed water oxidation

Codolà, Z., Gómez, L., Kleespies, S. T., Que, L., Costas, M. & Lloret-Fillol, J., Jan 22 2015, In : Nature communications. 6, 5865.

Research output: Contribution to journalArticle

71 Scopus citations

Facile and Reversible Formation of Iron(III)–Oxo–Cerium(IV) Adducts from Nonheme Oxoiron(IV) Complexes and Cerium(III)

Draksharapu, A., Rasheed, W., Klein, J. E. M. N. & Que, L., Jan 1 2017, In : Angewandte Chemie - International Edition. 56, 31, p. 9091-9095 5 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations