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  • Reuben Harris
2018

Apobec3H subcellular localization determinants define zipcode for targeting HIV-1 for restriction

Salamango, D. J., Becker, J. T., McCann, J. L., Cheng, A. Z., Demir, Ö., Amaro, R. E., Brown, W. L., Shaban, N. M. & Harrisa, R. S., Dec 1 2018, In : Molecular and cellular biology. 38, 23, e00356.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017

APOBEC3B lysine residues are dispensable for DNA cytosine deamination, HIV-1 restriction, and nuclear localization

Molan, A. M., Hanson, H. M., Chweya, C. M., Anderson, B. D., Starrett, G. J., Richards, C. M. & Harris, R. S., Nov 2017, In : Virology. 511, p. 74-81 8 p.

Research output: Contribution to journalArticle

Open Access
2015

Pillars article: AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature. 2002. 418: 99-103

Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S., Mar 1 2015, In : Journal of Immunology. 194, 5, p. 2043-2047 5 p.

Research output: Contribution to journalArticle

2014

Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis

Matsui, Y., Shindo, K., Nagata, K., Io, K., Tada, K., Iwai, F., Kobayashi, M., Kadowaki, N., Harris, R. S. & Takaori-Kondo, A., Jan 20 2014, In : Virology. 449, p. 82-87 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
2019

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

Kvach, M. V., Barzak, F. M., Harjes, S., Schares, H. A. M., Jameson, G. B., Ayoub, A. M., Moorthy, R., Aihara, H., Harris, R. S., Filichev, V. V., Harki, D. A. & Harjes, E., Feb 5 2019, In : Biochemistry. 58, 5, p. 391-400 10 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2012

Endogenous origins of HIV-1 G-to-A hypermutation and restriction in the nonpermissive T cell line CEM2n

Refsland, E. W., Hultquist, J. F. & Harris, R. S., Jul 2012, In : PLoS pathogens. 8, 7, p. 39 1 p., e1002800.

Research output: Contribution to journalArticle

73 Scopus citations
2020

MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets

McCann, J. L., Salamango, D., Law, E. K., Brown, W. L. & Harris, R. S., Feb 24 2020, In : Life science alliance. 3, 4, LSA.201900606.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment

Evgin, L., Huff, A. L., Kottke, T., Thompson, J., Molan, A. M., Driscoll, C. B., Schuelke, M., Shim, K. G., Wongthida, P., Ilett, E. J., Smith, K. K., Harris, R. S., Coffey, M., Pulido, J. S., Pandha, H., Selby, P. J., Harrington, K. J., Melcher, A. & Vile, R. G., May 2019, In : Cancer Immunology Research. 7, 5, p. 828-840 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

The SAMHD1 dNTP Triphosphohydrolase Is Controlled by a Redox Switch

Mauney, C. H., Rogers, L. C., Harris, R. S., Daniel, L. W., Devarie-Baez, N. O., Wu, H., Furdui, C. M., Poole, L. B., Perrino, F. W. & Hollis, T., Dec 1 2017, In : Antioxidants and Redox Signaling. 27, 16, p. 1317-1331 15 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
2014

Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity

Refsland, E. W., Hultquist, J. F., Luengas, E. M., Ikeda, T., Shaban, N. M., Law, E. K., Brown, W. L., Reilly, C., Emerman, M. & Harris, R. S., Nov 1 2014, In : PLoS genetics. 10, 11

Research output: Contribution to journalArticle

55 Scopus citations
2020

Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers

Argyris, P., Wilkinson, P. E., Jarvis, M. C., Magliocca, K. R., Patel, M. R., Vogel, R. I., Gopalakrishnan, R., Koutlas, I. G. & Harris, R. S., 2020, (Accepted/In press) In : Modern Pathology.

Research output: Contribution to journalArticle

2015

Vif determines the requirement for CBF-β in APOBEC3 degradation

Yoshikawa, R., Takeuchi, J. S., Yamada, E., Nakano, Y., Ren, F., Tanaka, H., Münk, C., Harris, R. S., Miyazawa, T., Koyanag, Y. & Sato, K., Apr 1 2015, In : Journal of General Virology. 96, 4, p. 887-892 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

APOBECs and virus restriction

Harris, R. S. & Dudley, J. P., May 1 2015, In : Virology. 479-480, p. 131-145 15 p.

Research output: Contribution to journalReview article

187 Scopus citations
2017

Opossum APOBEC1 is a DNA mutator with retrovirus and retroelement restriction activity

Ikeda, T., Shimoda, M., Ebrahimi, D., VandeBerg, J. L., Harris, R. S., Koito, A. & Maeda, K., 2017, In : Scientific reports. 7, 46719.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2020

APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy

Driscoll, C. B., Schuelke, M. R., Kottke, T., Thompson, J. M., Wongthida, P., Tonne, J. M., Huff, A. L., Miller, A., Shim, K. G., Molan, A., Wetmore, C., Selby, P., Samson, A., Harrington, K., Pandha, H., Melcher, A., Pulido, J. S., Harris, R., Evgin, L. & Vile, R. G., Dec 1 2020, In : Nature communications. 11, 1, 790.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2013

Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic

Land, A. M., Law, E. K., Carpenter, M. A., Lackey, L., Brown, W. L. & Harris, R. S., Jun 14 2013, In : Journal of Biological Chemistry. 288, 24, p. 17253-17260 8 p.

Research output: Contribution to journalArticle

44 Scopus citations
2017

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

Shi, K., Carpenter, M. A., Banerjee, S., Shaban, N. M., Kurahashi, K., Salamango, D. J., McCann, J. L., Starrett, G. J., Duffy, J. V., Demir, Ö., Amaro, R. E., Harki, D. A., Harris, R. S. & Aihara, H., Feb 1 2017, In : Nature Structural and Molecular Biology. 24, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

Open Access
86 Scopus citations
2012

Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

Stanley, D. J., Bartholomeeusen, K., Crosby, D. C., Kim, D. Y., Kwon, E., Yen, L., Cartozo, N. C., Li, M., Jäger, S., Mason-Herr, J., Hayashi, F., Yokoyama, S., Krogan, N. J., Harris, R. S., Peterlin, B. M. & Gross, J. D., Dec 2012, In : PLoS pathogens. 8, 12, e1003085.

Research output: Contribution to journalArticle

44 Scopus citations
2018

Mutation signatures including APOBEC in cancer cell lines

Jarvis, M. C., Ebrahimi, D., Temiz, N. A. & Harris, R. S., Jan 1 2018, In : JNCI Cancer Spectrum. 2, 1, pky002.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2013

Evidence for APOBEC3B mutagenesis in multiple human cancers

Burns, M. B., Temiz, N. A. & Harris, R. S., Sep 1 2013, In : Nature Genetics. 45, 9, p. 977-983 7 p.

Research output: Contribution to journalArticle

399 Scopus citations
2014

APOBEC3 multimerization correlates with HIV-1 packaging and restriction activity in living cells

Li, J., Chen, Y., Li, M., Carpenter, M. A., McDougle, R. M., Luengas, E. M., Macdonald, P. J., Harris, R. S. & Mueller, J. D., Mar 20 2014, In : Journal of Molecular Biology. 426, 6, p. 1296-1307 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2013

APOBEC3B is an enzymatic source of mutation in breast cancer

Burns, M. B., Lackey, L., Carpenter, M. A., Rathore, A., Land, A. M., Leonard, B., Refsland, E. W., Kotandeniya, D., Tretyakova, N., Nikas, J. B., Yee, D., Temiz, N. A., Donohue, D. E., Mcdougle, R. M., Brown, W. L., Law, E. K. & Harris, R. S., Feb 21 2013, In : Nature. 494, 7437, p. 366-370 5 p.

Research output: Contribution to journalArticle

449 Scopus citations
2019

HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators

Salamango, D. J., Ikeda, T., Moghadasi, S. A., Wang, J., McCann, J. L., Serebrenik, A. A., Ebrahimi, D., Jarvis, M. C., Brown, W. L. & Harris, R. S., Oct 29 2019, In : Cell reports. 29, 5, p. 1057-1065.e4

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2020

Characterization of the mechanism by which the rb/e2f pathway controls expression of the cancer genomic dna deaminase apobec3b

Roelofs, P. A., Goh, C. Y., Chua, B. H., Jarvis, M. C., Stewart, T. A., McCann, J. L., McDougle, R. M., Carpenter, M. A., Martens, J. W. M., Span, P. N., Kappei, D. & Harris, R. S., Sep 2020, In : eLife. 9, p. 1-64 64 p.

Research output: Contribution to journalArticle

Open Access
2012

APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair

Nowarski, R., Wilner, O. I., Cheshin, O., Shahar, O. D., Kenig, E., Baraz, L., Britan-Rosich, E., Nagler, A., Harris, R. S., Goldberg, M., Willner, I. & Kotler, M., Jul 12 2012, In : Blood. 120, 2, p. 366-375 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2019

The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H

Wang, J., Becker, J. T., Shi, K., Lauer, K. V., Salamango, D. J., Aihara, H., Shaban, N. M. & Harris, R. S., Dec 6 2019, In : Journal of Molecular Biology. 431, 24, p. 5019-5031 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Degradation of the cancer genomic DNA deaminase APOBEC3B by SIV Vif

Land, A. M., Wang, J., Law, E. K., Aberle, R., Kirmaier, A., Krupp, A., Johnson, W. E. & Harris, R. S., 2015, In : Oncotarget. 6, 37, p. 39969-39979 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Computational Model and Dynamics of Monomeric Full-Length APOBEC3G

Gorle, S., Pan, Y., Sun, Z., Shlyakhtenko, L. S., Harris, R. S., Lyubchenko, Y. L. & Vuković, L., Nov 22 2017, In : ACS Central Science. 3, 11, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2018

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity

Anderson, B. D., Ikeda, T., Moghadasi, S. A., Martin, A. S., Brown, W. L. & Harris, R. S., Dec 17 2018, In : Retrovirology. 15, 1, 78.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2015

Transcriptional regulation of APOBEC3 antiviral immunity through the CBF-b/RUNX axis

Anderson, B. D. & Harris, R. S., Jan 1 2015, In : Science Advances. 1, 8, 1500296.

Research output: Contribution to journalArticle

25 Scopus citations
2017

Reassessing APOBEC3G Inhibition by HIV-1 Vif-Derived Peptides

Richards, C. M., Li, M., Perkins, A. L., Rathore, A., Harki, D. A. & Harris, R. S., Jan 6 2017, In : Journal of Molecular Biology. 429, 1, p. 88-96 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2014

Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus

Albin, J. S., Brown, W. L. & Harris, R. S., Feb 1 2014, In : Virology. 450-451, p. 49-54 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
2019

A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes

Martin, A. S., Salamango, D. J., Serebrenik, A. A., Shaban, N. M., Brown, W. L. & Harris, R. S., Dec 1 2019, In : Scientific reports. 9, 1, 497.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2017

Nanoscale Characterization of Interaction of APOBEC3G with RNA

Pan, Y., Sun, Z., Maiti, A., Kanai, T., Matsuo, H., Li, M., Harris, R. S., Shlyakhtenko, L. S. & Lyubchenko, Y. L., Mar 14 2017, In : Biochemistry. 56, 10, p. 1473-1481 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2018

Simian immunodeficiency virus Vif and human APOBEC3B interactions resemble those between HIV-1 Vif and human APOBEC3G

Wang, J., Shaban, N. M., Land, A. M., Brown, W. L. & Harris, R. S., Jun 1 2018, In : Journal of virology. 92, 12, e00447-18.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Evaluation of sequence variability in HIV-1 gp41 C-peptide helix-grafted proteins

Tennyson, R. L., Walker, S. N., Ikeda, T., Harris, R. S. & McNaughton, B. R., Mar 15 2018, In : Bioorganic and Medicinal Chemistry. 26, 6, p. 1220-1224 5 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces

Salamango, D. J., McCann, J. L., Demir, Ö., Brown, W. L., Amaro, R. E. & Harris, R. S., Aug 17 2018, In : Journal of Molecular Biology. 430, 17, p. 2695-2708 14 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2011

Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein

Demorest, Z. L., Li, M. & Harris, R. S., Jul 29 2011, In : Journal of Biological Chemistry. 286, 30, p. 26568-26575 8 p.

Research output: Contribution to journalArticle

26 Scopus citations
2018

HIV-1 adaptation studies reveal a novel Env-mediated homeostasis mechanism for evading lethal hypermutation by APOBEC3G

Ikeda, T., Symeonides, M., Albin, J. S., Li, M., Thali, M. & Harris, R. S., Apr 2018, In : PLoS pathogens. 14, 4, e1007010.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2012

Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

Hultquist, J. F., Binka, M., LaRue, R. S., Simon, V. & Harris, R., Mar 1 2012, In : Journal of virology. 86, 5, p. 2874-2877 4 p.

Research output: Contribution to journalArticle

58 Scopus citations

First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G

Li, M., Shandilya, S. M. D., Carpenter, M. A., Rathore, A., Brown, W. L., Perkins, A. L., Harki, D. A., Solberg, J., Hook, D. J., Pandey, K. K., Parniak, M. A., Johnson, J. R., Krogan, N. J., Somasundaran, M., Ali, A., Schiffer, C. A. & Harris, R. S., Mar 16 2012, In : ACS Chemical Biology. 7, 3, p. 506-517 12 p.

Research output: Contribution to journalArticle

77 Scopus citations
2018

APOBEC3 Mediates Resistance to Oncolytic Viral Therapy

Huff, A. L., Wongthida, P., Kottke, T., Thompson, J. M., Driscoll, C. B., Schuelke, M., Shim, K. G., Harris, R. S., Molan, A., Pulido, J. S., Selby, P. J., Harrington, K. J., Melcher, A., Evgin, L. & Vile, R. G., Dec 21 2018, In : Molecular Therapy - Oncolytics. 11, p. 1-13 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2013

Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold

Olson, M. E., Li, M., Harris, R. S. & Harki, D. A., Jan 2013, In : ChemMedChem. 8, 1, p. 112-117 6 p.

Research output: Contribution to journalArticle

21 Scopus citations

Atomic force microscopy studies of APOBEC3G oligomerization and dynamics

Shlyakhtenko, L. S., Lushnikov, A. Y., Miyagi, A., Li, M., Harris, R. S. & Lyubchenko, Y. L., Nov 2013, In : Journal of Structural Biology. 184, 2, p. 217-225 9 p.

Research output: Contribution to journalArticle

30 Scopus citations
2018

Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease

Ebrahimi, D., Richards, C. M., Carpenter, M. A., Wang, J., Ikeda, T., Becker, J. T., Cheng, A. Z., McCann, J. L., Shaban, N. M., Salamango, D. J., Starrett, G. J., Lingappa, J. R., Yong, J., Brown, W. L. & Harris, R. S., Dec 1 2018, In : Nature communications. 9, 1, 4137.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2017

Erratum: Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation (PLoS pathogens (2017) 13 5 (e1006348))

Nakano, Y., Misawa, N., Juarez-Fernandez, G., Moriwaki, M., Nakaoka, S., Funo, T., Yamada, E., Soper, A., Yoshikawa, R., Ebrahimi, D., Tachiki, Y., Iwami, S., Harris, R. S., Koyanagi, Y. & Sato, K., Sep 1 2017, In : PLoS pathogens. 13, 9, p. e1006606

Research output: Contribution to journalComment/debate

Open Access
2020

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

Law, E. K., Levin-Klein, R., Jarvis, M. C., Kim, H., Argyris, P. P., Carpenter, M. A., Starrett, G. J., Temiz, N. A., Larson, L. K., Durfee, C., Burns, M. B., Vogel, R. I., Stavrou, S., Aguilera, A. N., Wagner, S., Largaespada, D. A., Starr, T. K., Ross, S. R. & Harris, R. S., Dec 7 2020, In : Journal of Experimental Medicine. 217, 12, e20200261.

Research output: Contribution to journalArticle

2011

Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-Deficient HIV-1

Hultquist, J. F., Lengyel, J. A., Refsland, E. W., LaRue, R. S., Lackey, L., Brown, W. L. & Harris, R., Nov 2011, In : Journal of virology. 85, 21, p. 11220-11234 15 p.

Research output: Contribution to journalArticle

216 Scopus citations
2012

Extensive somatic L1 retrotransposition in colorectal tumors

Solyom, S., Ewing, A. D., Rahrmann, E. P., Doucet, T., Nelson, H. H., Burns, M. B., Harris, R. S., Sigmon, D. F., Casella, A., Erlanger, B., Wheelan, S., Upton, K. R., Shukla, R., Faulkner, G. J., Largaespada, D. A. & Kazazian, H. H., Dec 2012, In : Genome research. 22, 12, p. 2328-2338 11 p.

Research output: Contribution to journalArticle

162 Scopus citations
2018

Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

Venkatesan, S., Rosenthal, R., Kanu, N., McGranahan, N., Bartek, J., Quezada, S. A., Hare, J., Harris, R. S. & Swanton, C., Mar 1 2018, In : Annals of Oncology. 29, 3, p. 563-572 10 p.

Research output: Contribution to journalReview article

Open Access
36 Scopus citations