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  • Bruce R Blazar
2019

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vetizou, M., Kuns, R. D., Robb, R. J., Zhang, P., Blazar, B. R., Thomas, R., Begun, J., Waddell, N., Trinchieri, G., Zeiser, R., Clouston, A. D., Degli-Esposti, M. A. & Hill, G. R., Nov 19 2019, In : Immunity. 51, 5, p. 885-898.e7

Research output: Contribution to journalArticle

7 Scopus citations
2015

Inducible T-cell receptor expression in precursor T cells for leukemia control

Hoseini, S. S., Hapke, M., Herbst, J., Wedekind, D., Baumann, R., Heinz, N., Schiedlmeier, B., Vignali, D. A. A., Van Den Brink, M. R. M., Schambach, A., Blazar, B. R. & Sauer, M. G., Jul 13 2015, In : Leukemia. 29, 7, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival

Borges, C. M., Reichenbach, D. K., Kim, B. S., Misra, A., Blazar, B. R. & Turka, L. A., Aug 1 2016, In : Transplant International. 29, 8, p. 930-940 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2011
71 Scopus citations
2017

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2019

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, (2019), 10.1038/s41586-019-1410-1)

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Jan 1 2019, In : Nature. 572, 7770, p. E19

Research output: Contribution to journalComment/debate

Open Access
2020

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Mathew, N. R., Vinnakota, J. M., Apostolova, P., Erny, D., Hamarsheh, S., Andrieux, G., Kim, J. S., Hanke, K., Goldmann, T., Chappell-Maor, L., El-Khawanky, N., Ihorst, G., Schmidt, D., Duyster, J., Finke, J., Blank, T., Boerries, M., Blazar, B. R., Jung, S., Prinz, M. & 1 others, Zeiser, R., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1315-1329 15 p.

Research output: Contribution to journalArticle

Open Access
2019

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2013

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Socie, G. & Blazar, B. R., Jan 1 2013, Elsevier Inc.

Research output: Book/ReportBook

1 Scopus citations
2014

Sdf1 expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish

Lund, T. C., Patrinostro, X., Kramer, A. C., Stadem, P., Ann Higgins, L., Markowski, T. W., Wroblewski, M. S., Lidke, D. S., Tolar, J. & Blazar, B. R., Jan 1 2014, In : STEM CELLS. 32, 10, p. 2767-2779 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

McDonald-Hyman, C., Turka, L. A. & Blazar, B. R., Mar 25 2015, In : Science Translational Medicine. 7, 280, 280rv2.

Research output: Contribution to journalReview article

54 Scopus citations
2011

Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice

Penaloza-MacMaster, P., Rasheed, A. U., Iyer, S. S., Yagita, H., Blazar, B. R. & Ahmed, R., Jul 1 2011, In : Journal of virology. 85, 13, p. 6168-6174 7 p.

Research output: Contribution to journalArticle

40 Scopus citations
2014

Bystander activation and anti-tumor effects of CD8+ T cells following interleukin-2 based immunotherapy is independent of CD4+ T cell help

Monjazeb, A. M., Tietze, J. K., Grossenbacher, S. K., Hsiao, H. H., Zamora, A. E., Mirsoian, A., Koehn, B., Blazar, B. R., Weiss, J. M., Wiltrout, R. H., Sckisel, G. D. & Murphy, W. J., Aug 13 2014, In : PloS one. 9, 8, e102709.

Research output: Contribution to journalArticle

13 Scopus citations
2011

Zinc fingers hit off target.

Cheng, L., Blazar, B., High, K. & Porteus, M., Oct 1 2011, In : Nature Medicine. 17, 10, p. 1192-1193 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

In vitro T-cell generation from adult, embryonic, and induced pluripotent stem cells: Many roads to one destination

Smith, M. J., Webber, B. R., Mohtashami, M., Stefanski, H. E., Zúñiga-Pflücker, J. C. & Blazar, B. R., Nov 2015, In : Stem Cells. 33, 11, p. 3174-3180 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

STAT6 and furin are successive triggers for the production of TGF-β by T cells

Li, Y., Liu, W., Guan, X., Truscott, J., Creemers, J. W., Chen, H. L., Pesu, M., Abiad, R. G. E., Karacay, B., Urban, J. F., Elliott, D. E., Kaplan, M. H., Blazar, B. R. & Nedim Ince, M., Nov 1 2018, In : Journal of Immunology. 201, 9, p. 2612-2623 12 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2016
Open Access
2017

A robust in vitro model for trans-lymphatic endothelial migration

Xiong, Y., Brinkman, C. C., Famulski, K. S., Mongodin, E. F., Lord, C. J., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Dec 1 2017, In : Scientific reports. 7, 1, 1633.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2011

Lipid composition of whole brain and cerebellum in hurler syndrome (MPS IH) mice

Heinecke, K. A., Peacock, B. N., Blazar, B. R., Tolar, J. & Seyfried, T. N., Sep 1 2011, In : Neurochemical Research. 36, 9, p. 1669-1676 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

Hanash, A. M., Dudakov, J. A., Hua, G., O'Connor, M. H., Young, L. F., Singer, N. V., West, M. L., Jenq, R. R., Holland, A. M., Kappel, L. W., Ghosh, A., Tsai, J. J., Rao, U. K., Yim, N. L., Smith, O. M., Velardi, E., Hawryluk, E. B., Murphy, G. F., Liu, C., Fouser, L. A. & 3 others, Kolesnick, R., Blazar, B. R. & van den Brink, M. R. M., Aug 24 2012, In : Immunity. 37, 2, p. 339-350 12 p.

Research output: Contribution to journalArticle

304 Scopus citations
2018

Identification of cellular sources of IL-2 needed for regulatory T cell development and homeostasis

Owen, D. L., Mahmud, S. A., Vang, K. B., Kelly, R. M., Blazar, B. R., Smith, K. A. & Farrar, M. A., Jun 15 2018, In : Journal of Immunology. 200, 12, p. 3926-3933 8 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease

McDonald-Hyman, C. S., Muller, J. T., Loschi, M., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B., Lin, J., Mitchell, J. S., Fife, B. T., Panoskaltsis-Mortari, A., Feser, C. J., Kirchmeier, A. K., Osborn, M. J., Hippen, K. L., Kelekar, A., Serody, J. S. & 6 others, Turka, L. A., Munn, D. H., Chi, H., Neubert, T. A., Dustin, M. L. & Blazar, B. R., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4604-4621 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L., Dec 1 2017, In : Scientific reports. 7, 1, 4258.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Hippen, K. L., Loschi, M., Nicholls, J., MacDonald, K. P. A. & Blazar, B. R., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 57.

Research output: Contribution to journalShort survey

Open Access
12 Scopus citations
2011

Physiologic control of IDO competence in splenic dendritic cells

Baban, B., Chandler, P. R., Johnson, B. A., Huang, L., Li, M., Sharpe, M. L., Francisco, L. M., Sharpe, A. H., Blazar, B. R., Munn, D. H. & Mellor, A. L., Sep 1 2011, In : Journal of Immunology. 187, 5, p. 2329-2335 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

Yang, J., Riella, L. V., Chock, S., Liu, T., Zhao, X., Yuan, X., Paterson, A. M., Watanabe, T., Vanguri, V., Yagita, H., Azuma, M., Blazar, B. R., Freeman, G. J., Rodig, S. J., Sharpe, A. H., Chandraker, A. & Sayegh, M. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

82 Scopus citations
2015

The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment

Sharma, M. D., Shinde, R., McGaha, T. L., Huang, L., Holmgaard, R. B., Wolchok, J. D., Mautino, M. R., Celis, E., Sharpe, A. H., Francisco, L. M., Powell, J. D., Yagita, H., Mellor, A. L., Blazar, B. R. & Munn, D. H., Nov 2015, In : Science Advances. 1, 10, 1500845.

Research output: Contribution to journalArticle

66 Scopus citations

ST2 blockade reduces sST2-producing T cells while maintaining protective mST2-expressing T cells during graft-versus-host disease

Zhang, J., Ramadan, A. M., Griesenauer, B., Li, W., Turner, M. J., Liu, C., Kapur, R., Hanenberg, H., Blazar, B. R., Tawara, I. & Paczesny, S., Oct 7 2015, In : Science Translational Medicine. 7, 308, 308ra160.

Research output: Contribution to journalArticle

70 Scopus citations
2017

Serum miR-29a is upregulated in acute graft-versus-host disease and activates dendritic cells through TLR binding

Ranganathan, P., Ngankeu, A., Zitzer, N. C., Leoncini, P., Yu, X., Casadei, L., Challagundla, K., Reichenbach, D. K., Garman, S., Ruppert, A. S., Volinia, S., Hofstetter, J., Efebera, Y. A., Devine, S. M., Blazar, B. R., Fabbri, M. & Garzon, R., Mar 15 2017, In : Journal of Immunology. 198, 6, p. 2500-2512 13 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R., Nov 30 2017, In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Contribution to journalReview article

Open Access
170 Scopus citations
2013

Minicircle DNA is superior to plasmid DNA in eliciting antigen-specific CD8 + T-cell responses

Dietz, W. M., Skinner, N. E. B., Hamilton, S. E., Jund, M. D., Heitfeld, S. M., Litterman, A. J., Hwu, P., Chen, Z. Y., Salazar, A. M., Ohlfest, J. R., Blazar, B. R., Pennell, C. A. & Osborn, M. J., Aug 2013, In : Molecular Therapy. 21, 8, p. 1526-1535 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
2019

Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy

Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., Vezys, V. & Masopust, D., Dec 1 2019, In : Nature communications. 10, 1, 567.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
2020
Open Access
2012

Control of acute myeloid leukemia relapse - Dance between KIRs and HLA

Miller, J. S. & Blazar, B. R., Aug 30 2012, In : New England Journal of Medicine. 367, 9, p. 866-868 3 p.

Research output: Contribution to journalEditorial

7 Scopus citations
2019

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation

Puleston, D. J., Buck, M. D., Klein Geltink, R. I., Kyle, R. L., Caputa, G., O'Sullivan, D., Cameron, A. M., Castoldi, A., Musa, Y., Kabat, A. M., Zhang, Y., Flachsmann, L. J., Field, C. S., Patterson, A. E., Scherer, S., Alfei, F., Baixauli, F., Austin, S. K., Kelly, B., Matsushita, M. & 17 others, Curtis, J. D., Grzes, K. M., Villa, M., Corrado, M., Sanin, D. E., Qiu, J., Pällman, N., Paz, K., Maccari, M. E., Blazar, B. R., Mittler, G., Buescher, J. M., Zehn, D., Rospert, S., Pearce, E. J., Balabanov, S. & Pearce, E. L., Aug 6 2019, In : Cell Metabolism. 30, 2, p. 352-363.e8

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
2014

Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor cd4 t-cell responses through the PD-1-PD-L1 axis

Ding, Z. C., Lu, X., Yu, M., Lemos, H., Huang, L., Chandler, P., Liu, K., Walters, M., Krasinski, A., Mack, M., Blazar, B. R., Mellor, A. L., Munn, D. H. & Zhou, G., Jul 1 2014, In : Cancer Research. 74, 13, p. 3441-3453 13 p.

Research output: Contribution to journalArticle

68 Scopus citations
2018

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells (vol 24, pg 282, 2018)

Cancer and Leukemia Group B, Apr 2018, In : Nature Medicine. 24, 4, p. 526-526

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2016

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z. C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jun 2 2016, In : OncoImmunology. 5, 6, e1171445.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2011

Sleeping Beauty-mediated correction of Fanconi anemia type C

Hyland, K. A., Olson, E. R., Clark, K. J., Aronovich, E. L., Hackett, P. B., Blazar, B. R., Tolar, J. & Scott Mcivor, R., Sep 1 2011, In : Journal of Gene Medicine. 13, 9, p. 462-469 8 p.

Research output: Contribution to journalArticle

20 Scopus citations
2015

Cutting edge: Identification of autoreactive CD4+ and CD8+ T cell subsets resistant to PD-1 pathway blockade

Pauken, K. E., Nelson, C. E., Martinov, T., Spanier, J. A., Heffernan, J. R., Sahli, N. L., Quarnstrom, C. F., Osum, K. C., Schenkel, J. M., Jenkins, M. K., Blazar, B. R., Vezys, V. & Fife, B. T., Apr 15 2015, In : Journal of Immunology. 194, 8, p. 3551-3555 5 p.

Research output: Contribution to journalArticle

22 Scopus citations
2013

Overview of the Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Socié, G. A. & Blazar, B. R., Aug 27 2013, Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. Elsevier Inc., p. 1-17 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2012

Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function

Zanin-Zhorov, A., Lin, J., Scher, J., Kumari, S., Blair, D., Hippen, K. L., Blazar, B. R., Abramson, S. B., Lafaille, J. J. & Dustin, M. L., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1625-1630 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation

Sun, K., Hsiao, H. H., Li, M., Ames, E., Bouchlaka, M., Welniak, L. A., Hagino, T., Jagdeo, J., Pai, C. C., Chen, M., Blazar, B. R., Abedi, M. & Murphy, W. J., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 2033-2042 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Beyer, M., Thabet, Y., Müller, R. U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K. L. & 15 others, Blazar, B. R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P. A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J. A., Barry, S. C., Sparwasser, T., Riley, J. L. & Schultze, J. L., Sep 1 2011, In : Nature immunology. 12, 9, p. 898-907 10 p.

Research output: Contribution to journalArticle

122 Scopus citations
2019

Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Aug 8 2019, In : Nature. 572, 7768, p. 254-259 6 p.

Research output: Contribution to journalLetter

Open Access
24 Scopus citations
2017

Differential phenotypes of memory CD4 and CD8 T cells in the spleen and peripheral tissues following immunostimulatory therapy

Sckisel, G. D., Mirsoian, A., Minnar, C. M., Crittenden, M., Curti, B., Chen, J. Q., Blazar, B. R., Borowsky, A. D., Monjazeb, A. M. & Murphy, W. J., Apr 18 2017, In : Journal for ImmunoTherapy of Cancer. 5, 1, 33.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2014

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation

Murase, K., Kim, H. T., Gregory Bascug, O. R., Kawano, Y., Ryan, J., Matsuoka, K. I., Davids, M. S., Koreth, J., Ho, V. T., Cutler, C., Armand, P., Alyea, E. P., Blazar, B. R., Antin, J. H., Soiffer, R. J., Letai, A. & Ritz, J., Sep 1 2014, In : Haematologica. 99, 9, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Synthetic zinc finger nuclease design and rapid assembly

Osborn, M. J., Defeo, A. P., Blazar, B. R. & Tolar, J., Sep 1 2011, In : Human gene therapy. 22, 9, p. 1155-1165 11 p.

Research output: Contribution to journalArticle

14 Scopus citations