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  • Philip S Portoghese
2011

My farewell to the journal of medicinal chemistry

Portoghese, P. S., Dec 22 2011, In : Journal of Medicinal Chemistry. 54, 24, 1 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2012

Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor

Cawston, E. E., Lam, P. C. H., Harikumar, K. G., Dong, M., Ball, A. M., Augustine, M. L., Akgün, E., Portoghese, P. S., Orry, A., Abagyan, R., Sexton, P. M. & Miller, L. J., May 25 2012, In : Journal of Biological Chemistry. 287, 22, p. 18618-18635 18 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

Inhibition of inflammatory and neuropathic pain by targeting a Mu opioid receptor/chemokine receptor5 heteromer (MOR-CCR5)

Akgün, E., Javed, M. I., Lunzer, M. M., Powers, M. D., Sham, Y. Y., Watanabe, Y. & Portoghese, P. S., Nov 12 2015, In : Journal of medicinal chemistry. 58, 21, p. 8647-8657 11 p.

Research output: Contribution to journalArticle

31 Scopus citations
2018
Open Access
6 Scopus citations
2011

N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers

Yekkirala, A. S., Lunzer, M. M., McCurdy, C. R., Powers, M. D., Kalyuzhny, A. E., Roerig, S. C. & Portoghese, P. S., Mar 22 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 5098-5103 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

A κ opioid pharmacophore becomes a spinally selective κ-δ Agonist when modified with a basic extender arm

Tang, Y., Yang, J., Lunzer, M. M., Powers, M. D. & Portoghese, P. S., Jan 13 2011, In : ACS Medicinal Chemistry Letters. 2, 1, p. 7-10 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling

Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. R., Portoghese, P. S., Rice, K. C., Watkins, L. R., Hutchinson, M. R. & Wang, X., Aug 1 2019, In : FASEB Journal. 33, 8, p. 9577-9587 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands

Yekkirala, A. S., Kalyuzhny, A. E. & Portoghese, P. S., Jul 19 2013, In : ACS Chemical Biology. 8, 7, p. 1412-1416 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2018
Open Access
7 Scopus citations
2012

Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats

Pravetoni, M., Raleigh, M. D., Le Naour, M., Tucker, A. M., Harmon, T. M., Jones, J. M., Birnbaum, A. K., Portoghese, P. S. & Pentel, P. R., Jun 29 2012, In : Vaccine. 30, 31, p. 4617-4624 8 p.

Research output: Contribution to journalArticle

46 Scopus citations
2013

Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens

Pravetoni, M., Le Naour, M., Tucker, A. M., Harmon, T. M., Hawley, T. M., Portoghese, P. S. & Pentel, P. R., Feb 14 2013, In : Journal of medicinal chemistry. 56, 3, p. 915-923 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2019
3 Scopus citations
2012

The δ opioid receptor agonist SNC80 selectively activates heteromeric μ-δ Opioid receptors

Metcalf, M. D., Yekkirala, A. S., Powers, M. D., Kitto, K. F., Fairbanks, C. A., Wilcox, G. L. & Portoghese, P. S., Jul 18 2012, In : ACS Chemical Neuroscience. 3, 7, p. 505-509 5 p.

Research output: Contribution to journalArticle

16 Scopus citations

Clinically employed opioid analgesics produce antinociception via μ-δ Opioid receptor heteromers in rhesus monkeys

Yekkirala, A. S., Banks, M. L., Lunzer, M. M., Negus, S. S., Rice, K. C. & Portoghese, P. S., Sep 19 2012, In : ACS Chemical Neuroscience. 3, 9, p. 720-727 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2014
26 Scopus citations
2011

GRAS flavoring substances 25

Smith, R. L., Waddell, W. J., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Marnett, L. J., Portoghese, P. S., Rietjens, I. M. C. M., Adams, T. B., Gavin, C. L., Mcgowen, M. M. & Taylor, S. V., Jul 2011, In : Food Technology. 65, 7, p. 44-75 32 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice

Angelis, E. M. G. D., Abdelhamid, R. E., Nunez, M. G., Kissel, C. L., Kovács, K. J., Portoghese, P. S. & Larson, A. A., Aug 19 2016, In : Pain. 157, 11, p. 2561-2570 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2017

Heteromer Induction: An Approach to Unique Pharmacology?

Portoghese, P. S., Akgün, E. & Lunzer, M. M., Mar 15 2017, In : ACS Chemical Neuroscience. 8, 3, p. 426-428 3 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations
2019

Combination of a δ-opioid Receptor Agonist and Loperamide Produces Peripherally-mediated Analgesic Synergy in Mice

Bruce, D. J., Peterson, C. D., Kitto, K. F., Akgün, E., Lazzaroni, S., Portoghese, P. S., Fairbanks, C. A. & Wilcox, G. L., Sep 1 2019, In : Anesthesiology. 131, 3, p. 649-663 15 p.

Research output: Contribution to journalArticle

1 Scopus citations
5 Scopus citations
2012

An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia

Pravetoni, M., Le Naour, M., Harmon, T. M., Tucker, A. M., Portoghese, P. S. & Pentel, P. R., Apr 1 2012, In : Journal of Pharmacology and Experimental Therapeutics. 341, 1, p. 225-232 8 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013

Bivalent ligands that target μ opioid (MOP) and cannabinoid1 (CB 1) receptors are potent analgesics devoid of tolerance

Le Naour, M., Akgün, E., Yekkirala, A., Lunzer, M. M., Powers, M. D., Kalyuzhny, A. E. & Portoghese, P. S., Jul 11 2013, In : Journal of medicinal chemistry. 56, 13, p. 5505-5513 9 p.

Research output: Contribution to journalArticle

55 Scopus citations
2012

Opioid activity of spinally selective analogues of N -naphthoyl-β- naltrexamine in HEK-293 cells and mice

Le Naour, M., Lunzer, M. M., Powers, M. D. & Portoghese, P. S., Jan 26 2012, In : Journal of medicinal chemistry. 55, 2, p. 670-677 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013
56 Scopus citations
2011

The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients

Adams, T. B., Gavin, C. L., McGowen, M. M., Waddell, W. J., Cohen, S. M., Feron, V. J., Marnett, L. J., Munro, I. C., Portoghese, P. S., Rietjens, I. M. C. M. & Smith, R. L., Oct 1 2011, In : Food and Chemical Toxicology. 49, 10, p. 2471-2494 24 p.

Research output: Contribution to journalReview article

34 Scopus citations
2019

Targeting MOR-mGluR5 heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Shueb, S. S., Erb, S. J., Lunzer, M. M., Speltz, R., Harding-Rose, C., Akgün, E., Simone, D. A. & Portoghese, P. S., Dec 1 2019, In : Neuropharmacology. 160, 107690.

Research output: Contribution to journalArticle

2 Scopus citations
2017
Open Access
10 Scopus citations
2014

Putative kappa opioid heteromers as targets for developing analgesics free of adverse effects

Le Naour, M., Lunzer, M. M., Powers, M. D., Kalyuzhny, A. E., Benneyworth, M. A., Thomas, M. J. & Portoghese, P. S., Aug 14 2014, In : Journal of medicinal chemistry. 57, 15, p. 6383-6392 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons

Berg, K. A., Rowan, M. P., Gupta, A., Sanchez, T. A., Silva, M., Gomes, I., McGuire, B. A., Portoghese, P. S., Hargreaves, K. M., Devi, L. A. & Clarke, W. P., Feb 2012, In : Molecular Pharmacology. 81, 2, p. 264-272 9 p.

Research output: Contribution to journalArticle

44 Scopus citations