Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2013
  • 2012
  • 2011

Author

  • Kevin H Mayo
2020

Galectin-13/placental protein 13: redox-active disulfides as switches for regulating structure, function and cellular distribution

Yang, T., Yao, Y., Wang, X., Li, Y., Si, Y., Li, X., Ayala, G. J., Wang, Y., Mayo, K. H., Tai, G., Zhou, Y. & Su, J., Jan 28 2020, In : Glycobiology. 30, 2, p. 120-129 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Resetting the ligand binding site of placental protein 13/galectin-13 recovers its ability to bind lactose

Su, J., Cui, L., Si, Y., Song, C., Li, Y., Yang, T., Wang, H., Mayo, K. H., Tai, G. & Zhou, Y., Dec 14 2018, In : Bioscience Reports. 38, 6, BSR20181787.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Preparation of individual galactan oligomers, their prebiotic effects, and use in estimating galactan chain length in pectin-derived polysaccharides

Zheng, Y., Li, L., Feng, Z., Wang, H., Mayo, K. H., Zhou, Y. & Tai, G., Nov 1 2018, In : Carbohydrate Polymers. 199, p. 526-533 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2020

Co-crystal Structure of Thermosynechococcus elongatus Sucrose Phosphate Synthase With UDP and Sucrose-6-Phosphate Provides Insight Into Its Mechanism of Action Involving an Oxocarbenium Ion and the Glycosidic Bond

Li, Y., Yao, Y., Yang, G., Tang, J., Ayala, G. J., Li, X., Zhang, W., Han, Q., Yang, T., Wang, H., Mayo, K. H. & Su, J., May 26 2020, In : Frontiers in Microbiology. 11, 1050.

Research output: Contribution to journalArticle

Open Access
2019

A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1

Wook Park, S., Nhieu, J., Persaud, S. D., Miller, M. C., Xia, Y., Lin, Y. W., Lin, Y. L., Kagechika, H., Mayo, K. H. & Wei, L. N., Dec 1 2019, In : Scientific reports. 9, 1, 10929.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2013

Polycationic calixarene PTX013, a potent cytotoxic agent against tumors and drug resistant cancer

Dings, R. P. M., Levine, J. I., Brown, S. G., Astorgues-Xerri, L., MacDonald, J. R., Hoye, T. R., Raymond, E. & Mayo, K. H., Oct 2013, In : Investigational New Drugs. 31, 5, p. 1142-1150 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain

Miller, M. C., Ippel, H., Suylen, D., Klyosov, A. A., Traber, P. G., Hackeng, T. & Mayo, K. H., May 16 2015, In : Glycobiology. 26, 1, p. 88-99 12 p.

Research output: Contribution to journalArticle

25 Scopus citations
2013

Structure-based optimization of angiostatic agent 6DBF7, an allosteric antagonist of galectin-1

Dings, R. P. M., Kumar, N., Miller, M. C., Loren, M., Rangwala, H., Hoye, T. R. & Mayo, K. H., Mar 2013, In : Journal of Pharmacology and Experimental Therapeutics. 344, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Probing Functional Heteromeric Chemokine Protein–Protein Interactions through Conformation-Assisted Oxime Ligation

Agten, S. M., Koenen, R. R., Ippel, H., Eckardt, V., von Hundelshausen, P., Mayo, K. H., Weber, C. & Hackeng, T. M., 2016, In : Angewandte Chemie - International Edition. 55, 48, p. 14963-14966 4 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2011

Enhancement of T-cell-mediated antitumor response: Angiostatic adjuvant to immunotherapy against cancer

Dings, R. P. M., Vang, K. B., Castermans, K., Popescu, F. E., Zhang, Y., Oude Egbrink, M. G. A., Mescher, M. F., Farrar, M. A., Griffioen, A. W. & Mayo, K. H., May 15 2011, In : Clinical Cancer Research. 17, 10, p. 3134-3145 12 p.

Research output: Contribution to journalArticle

41 Scopus citations
2020

Pro4 prolyl peptide bond isomerization in human galectin-7 modulates the monomer-dimer equilibrum to affect function

Miller, M. C., Nesmelova, I. V., Daragan, V. A., Ippel, H., Michalak, M., Dregni, A., Kaltner, H., Kopitz, J., Gabius, H. J. & Mayo, K. H., Sep 18 2020, In : The Biochemical journal. 477, 17, p. 3147-3165 19 p.

Research output: Contribution to journalArticle

Open Access
2018

Adhesion/growth-regulatory galectins tested in combination: Evidence for formation of hybrids as heterodimers

Miller, M. C., Ludwig, A. K., Wichapong, K., Kaltner, H., Kopitz, J., Gabius, H. J. & Mayo, K. H., Mar 15 2018, In : Biochemical Journal. 475, 5, p. 1003-1018 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature

Huijbers, E. J. M., van Beijnum, J. R., Lê, C. T., Langman, S., Nowak-Sliwinska, P., Mayo, K. H. & Griffioen, A. W., May 17 2018, In : Vaccine. 36, 21, p. 3054-3060 7 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2015

Novel analogs of antitumor agent calixarene 0118: Synthesis, cytotoxicity, click labeling with 2-[18F]fluoroethylazide, and in vivo evaluation

Läppchen, T., Dings, R. P. M., Rossin, R., Simon, J. F., Visser, T. J., Bakker, M., Walhe, P., Van Mourik, T., Donato, K., Van Beijnum, J. R., Griffioen, A. W., Lub, J., Robillard, M. S., Mayo, K. H. & Grüll, H., Jan 7 2015, In : European Journal of Medicinal Chemistry. 89, p. 279-295 17 p.

Research output: Contribution to journalArticle

17 Scopus citations
2018

Galectins as molecular targets for therapeutic intervention

Dings, R. P. M., Miller, M. C., Griffin, R. J. & Mayo, K. H., Mar 19 2018, In : International journal of molecular sciences. 19, 3, 905.

Research output: Contribution to journalReview article

Open Access
23 Scopus citations
2015

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3

Ippel, H., Miller, M. C., Berbís, M. A. L., Suylen, D., André, S., Hackeng, T. M., Cañada, F. J., Weber, C., Gabius, H. J., Jiménez-Barbero, J. & Mayo, K. H., 2015, In : Biomolecular NMR Assignments. 9, 1, p. 59-63 5 p.

Research output: Contribution to journalArticle

12 Scopus citations
2019

Galectin-3 binds selectively to the terminal, non-reducing end of β(1→4)-galactans, with overall affinity increasing with chain length

Miller, M. C., Zheng, Y., Zhou, Y., Tai, G. & Mayo, K. H., Jan 1 2019, In : Glycobiology. 29, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

Tumour thermotolerance, a physiological phenomenon involving vessel normalisation

Dings, R. P. M., Loren, M. L., Zhang, Y., Mikkelson, S., Mayo, K. H., Corry, P. & Griffin, R. J., Feb 1 2011, In : International Journal of Hyperthermia. 27, 1, p. 42-52 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2019

SUMO3 modification by PIAS1 modulates androgen receptor cellular distribution and stability

Yang, N., Liu, S., Qin, T., Liu, X., Watanabe, N., Mayo, K. H., Li, J. & Li, X., Nov 21 2019, In : Cell Communication and Signaling. 17, 1, 153.

Research output: Contribution to journalArticle

Open Access
2013

Protein lysine-Nℓ alkylation and O-phosphorylation mediated by DTT-generated reactive oxygen species

Kumar, N., Ippel, H., Weber, C., Hackeng, T. & Mayo, K. H., Mar 2013, In : Protein Science. 22, 3, p. 327-346 20 p.

Research output: Contribution to journalArticle

2012

From carbohydrate to peptidomimetic inhibitors of galectins

Mayo, K. H., Dec 18 2012, Galectins and Disease Implications for Targeted Therapeutics. American Chemical Society, p. 61-77 17 p. (ACS Symposium Series; vol. 1115).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Dual-targeting of α vβ 3 and galectin-1 improves the specificity of paramagnetic/fluorescent liposomes to tumor endothelium in vivo

Kluza, E., Jacobs, I., Hectors, S. J. C. G., Mayo, K. H., Griffioen, A. W., Strijkers, G. J. & Nicolay, K., Mar 10 2012, In : Journal of Controlled Release. 158, 2, p. 207-214 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
2019

NMR-based insight into galectin-3 binding to endothelial cell adhesion molecule CD146: Evidence for noncanonical interactions with the lectin's CRD β-sandwich F-face

Zhang, Z., Miller, M. C., Xu, X., Song, C., Zhang, F., Zheng, Y., Zhou, Y., Tai, G. & Mayo, K. H., Jul 19 2019, In : Glycobiology. 29, 8, p. 608-618 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018

Treatment of B-cell precursor acute lymphoblastic leukemia with the Galectin-1 inhibitor PTX008

Paz, H., Joo, E. J., Chou, C. H., Fei, F., Mayo, K. H., Abdel-Azim, H., Ghazarian, H., Groffen, J. & Heisterkamp, N., Mar 27 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 67.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2017

Novel polysaccharide binding to the N-terminal tail of galectin-3 is likely modulated by proline isomerization

Miller, M. C., Mayo, K. H. & Tai, G., Nov 1 2017, In : Glycobiology. 27, 11, p. 1038-1051

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2013

Bacterial membrane disrupting dodecapeptide SC4 improves survival of mice challenged with Pseudomonas aeruginosa

Dings, R. P. M., Haseman, J. R., Leslie, D. B., Luong, M., Dunn, D. L. & Mayo, K. H., Jun 2013, In : Biochimica et Biophysica Acta - General Subjects. 1830, 6, p. 3454-3457 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
2011

Structural aspects of binding of-linked digalactosides to human galectin-1

Miller, M. C., Ribeiro, J. P., Roldós, V., Martín-Santamaría, S., Cañada, F. J., Nesmelova, I. A., André, S., Pang, M., Klyosov, A. A., Baum, L. G., Jiménez-Barbero, J., Gabius, H. J. & Mayo, K. H., Dec 2011, In : Glycobiology. 21, 12, p. 1627-1641 15 p.

Research output: Contribution to journalArticle

34 Scopus citations
2015

Defining the potential of aglycone modifications for affinity/selectivity enhancement against medically relevant lectins: Synthesis, activity screening, and HSQC-Based NMR Analysis

Rauthu, S. R., Shiao, T. C., André, S., Miller, M. C., Madej, É., Mayo, K. H., Gabius, H. J. & Roy, R., 2015, In : ChemBioChem. 16, 1, p. 126-139 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2019

Corrigendum to “An improved conjugate vaccine technology; induction of antibody responses to the tumor vasculature” (Vaccine (2018) 36(21) (3054–3060), (S0264410X1830433X), (10.1016/j.vaccine.2018.03.064))

Huijbers, E. J. M., van Beijnum, J. R., Lê, C. T., Langman, S., Nowak-Sliwinska, P., Mayo, K. H. & Griffioen, A. W., Jul 9 2019, In : Vaccine. 37, 30, p. 4231-4232 2 p.

Research output: Contribution to journalComment/debate

Open Access
2020

Structure–function studies of galectin-14, an important effector molecule in embryology

Si, Y., Li, Y., Yang, T., Li, X., Ayala, G. J., Mayo, K. H., Tai, G., Su, J. & Zhou, Y., 2020, (Accepted/In press) In : FEBS Journal.

Research output: Contribution to journalArticle

2015

Structural significance of galectin design: Impairment of homodimer stability by linker insertion and partial reversion by ligand presence

Vértesy, S., Michalak, M., Miller, M. C., Schnölzer, M., André, S., Kopitz, J., Mayo, K. H. & Gabius, H. J., Jan 1 2015, In : Protein Engineering, Design and Selection. 28, 7, p. 199-210 12 p.

Research output: Contribution to journalArticle

21 Scopus citations

Evaluation of 111in-labeled anginex as potential spect tracer for imaging of tumor angiogenesis

Van Mourik, T. R., Läppchen, T., Rossin, R., Van Beijnum, J. R., Macdonald, J. R., Mayo, K. H., Griffioen, A. W., Nicolay, K. & Grüll, H., Nov 2015, In : Anticancer Research. 35, 11, p. 5945-5954 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

Structural features for α-galactomannan binding to galectin-1

Miller, M. C., Klyosov, A. A. & Mayo, K. H., Apr 2012, In : Glycobiology. 22, 4, p. 543-551 9 p.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Identification of the bioactive components from pH-modified citrus pectin and their inhibitory effects on galectin-3 function

Zhang, T., Lan, Y., Zheng, Y., Liu, F., Zhao, D., Mayo, K. H., Zhou, Y. & Tai, G., Jul 1 2016, In : Food Hydrocolloids. 58, p. 113-119 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
2017

Chemokines from a structural perspective

Miller, M. C. & Mayo, K. H., Oct 2017, In : International Journal of Molecular Sciences. 18, 10, 2088.

Research output: Contribution to journalReview article

Open Access
40 Scopus citations

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

Von Hundelshausen, P., Agten, S. M., Eckardt, V., Blanchet, X., Schmitt, M. M., Ippel, H., Neideck, C., Bidzhekov, K., Leberzammer, J., Wichapong, K., Faussner, A., Drechsler, M., Grommes, J., Van Geffen, J. P., Li, H., Ortega-Gomez, A., Megens, R. T. A., Naumann, R., Dijkgraaf, I., Nicolaes, G. A. F. & 8 others, Döring, Y., Soehnlein, O., Lutgens, E., Heemskerk, J. W. M., Koenen, R. R., Mayo, K. H., Hackeng, T. M. & Weber, C., Apr 5 2017, In : Science Translational Medicine. 9, 384, eaah6650.

Research output: Contribution to journalArticle

51 Scopus citations
2020

Chemokines and galectins form heterodimers to modulate inflammation

Eckardt, V., Miller, M. C., Blanchet, X., Duan, R., Leberzammer, J., Duchene, J., Soehnlein, O., Megens, R. T. A., Ludwig, A. K., Dregni, A., Faussner, A., Wichapong, K., Ippel, H., Dijkgraaf, I., Kaltner, H., Döring, Y., Bidzhekov, K., Hackeng, T. M., Weber, C., Gabius, H. J. & 2 others, von Hundelshausen, P. & Mayo, K. H., Apr 3 2020, In : EMBO Reports. 21, 4, e47852.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Injectable hydrogel-loaded nano-hydroxyapatite that improves bone regeneration and alveolar ridge promotion

Pan, Y., Zhao, Y., Kuang, R., Liu, H., Sun, D., Mao, T., Jiang, K., Yang, X., Watanabe, N., Mayo, K. H., Lin, Q. & Li, J., Nov 2020, In : Materials Science and Engineering C. 116, 111158.

Research output: Contribution to journalArticle

1 Scopus citations

Structural insight into the binding of human galectins to corneal keratan sulfate, its desulfated form and related saccharides

Miller, M. C., Cai, C., Wichapong, K., Bhaduri, S., Pohl, N. L. B., Linhardt, R. J., Gabius, H. J. & Mayo, K. H., Dec 1 2020, In : Scientific reports. 10, 1, 15708.

Research output: Contribution to journalArticle

Open Access
2019

Hybrid ligands with calixarene and thiodigalactoside groups: Galectin binding and cytotoxicity

Zhang, H., Ippel, H., Miller, M. C., Wong, T. J., Griffioen, A. W., Mayo, K. H. & Pieters, R. J., Aug 21 2019, In : Organic Chemistry Frontiers. 6, 16, p. 2981-2990 10 p.

Research output: Contribution to journalArticle

Publisher Correction: A new regulatory mechanism for Raf kinase activation, retinoic acid-bound Crabp1 (Scientific Reports, (2019), 9, 1, (10929), 10.1038/s41598-019-47354-7)

Park, S. W., Nhieu, J., Persaud, S. D., Miller, M. C., Xia, Y., Lin, Y. W., Lin, Y. L., Kagechika, H., Mayo, K. H. & Wei, L. N., Dec 1 2019, In : Scientific reports. 9, 1, 17042.

Research output: Contribution to journalComment/debate

Open Access
2011

Synthesis of [ 18F]anginex with high specific activity [ 18F]fluorobenzaldehyde for targeting angiogenic activity in solid tumors

Apana, S. M., Griffin, R. J., Koonce, N. A., Webber, J. S., Dings, R. P. M., Mayo, K. H. & Berridge, M. S., Sep 1 2011, In : Journal of Labelled Compounds and Radiopharmaceuticals. 54, 11, p. 708-713 6 p.

Research output: Contribution to journalArticle

4 Scopus citations
2020

A traditional Chinese medicine, YXQN, reduces amyloid-induced cytotoxicity by inhibiting Aβ42 aggregation and fibril formation

Wang, L., Liu, S., Xu, J., Watanabe, N., Di, J., Wei, W., Mayo, K. H., Li, J. & Li, X., 2020, In : Current pharmaceutical design. 26, 7, p. 780-789 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 31 kDa human galectin-7 (p53-induced gene 1) homodimer, a pro-apoptotic lectin

Nesmelova, I. V., Berbís, M. Á., Miller, M. C., Cañada, F. J., André, S., Jiménez-Barbero, J., Gabius, H. J. & Mayo, K. H., 2012, In : Biomolecular NMR Assignments. 6, 2, p. 127-129 3 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Lactose binding to human galectin-7 (p53-induced gene 1) induces long-range effects through the protein resulting in increased dimer stability and evidence for positive cooperativity

Ermakova, E., Miller, M. C., Nesmelova, I. V., López-Merino, L., Berbís, M. A., Nesmelov, Y., Tkachev, Y. V., Lagartera, L., Daragan, V. A., André, S., Cañada, F. J., Jiménez-Barbero, J., Solís, D., Gabius, H. J. & Mayo, K. H., May 2013, In : Glycobiology. 23, 5, p. 508-523 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Macromolecular assemblies of complex polysaccharides with galectin-3 and their synergistic effects on function

Zhang, T., Miller, M. C., Zheng, Y., Zhang, Z., Xue, H., Zhao, D., Su, J., Mayo, K. H., Zhou, Y. & Tai, G., Nov 15 2017, In : Biochemical Journal. 474, 22, p. 3849-3868 20 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Antitumor agent calixarene 0118 targets human galectin-1 as an allosteric inhibitor of carbohydrate binding

Dings, R. P. M., Miller, M. C., Nesmelova, I., Astorgues-Xerri, L., Kumar, N., Serova, M., Chen, X., Raymond, E., Hoye, T. R. & Mayo, K. H., Jun 14 2012, In : Journal of medicinal chemistry. 55, 11, p. 5121-5129 9 p.

Research output: Contribution to journalArticle

62 Scopus citations