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  • Bruce R Blazar
2020

Base Editor Correction of COL7A1 in Recessive Dystrophic Epidermolysis Bullosa Patient-Derived Fibroblasts and iPSCs

Osborn, M. J., Newby, G. A., McElroy, A. N., Knipping, F., Nielsen, S. C., Riddle, M. J., Xia, L., Chen, W., Eide, C. R., Webber, B. R., Wandall, H. H., Dabelsteen, S., Blazar, B. R., Liu, D. R. & Tolar, J., Feb 2020, In : Journal of Investigative Dermatology. 140, 2, p. 338-347.e5

Research output: Contribution to journalArticle

4 Scopus citations

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

Field, C. S., Baixauli, F., Kyle, R. L., Puleston, D. J., Cameron, A. M., Sanin, D. E., Hippen, K. L., Loschi, M., Thangavelu, G., Corrado, M., Edwards-Hicks, J., Grzes, K. M., Pearce, E. J., Blazar, B. R. & Pearce, E. L., Feb 4 2020, In : Cell Metabolism. 31, 2, p. 422-437.e5

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2011

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Beyer, M., Thabet, Y., Müller, R. U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K. L. & 15 others, Blazar, B. R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P. A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J. A., Barry, S. C., Sparwasser, T., Riley, J. L. & Schultze, J. L., Sep 1 2011, In : Nature immunology. 12, 9, p. 898-907 10 p.

Research output: Contribution to journalArticle

122 Scopus citations
2019

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

MacDonald, K. N., Ivison, S., Hippen, K. L., Hoeppli, R. E., Hall, M., Zheng, G., Dijke, I. E., Aklabi, M. A., Freed, D. H., Rebeyka, I., Gandhi, S., West, L. J., Piret, J. M., Blazar, B. R. & Levings, M. K., Dec 2019, In : Cytotherapy. 21, 12, p. 1216-1233 18 p.

Research output: Contribution to journalArticle

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2017

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L., Dec 1 2017, In : Scientific reports. 7, 1, 4258.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2011

Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice

Li, J., Semple, K., Suh, W. K., Liu, C., Chen, F., Blazar, B. R. & Yu, X. Z., Jul 1 2011, In : Biology of Blood and Marrow Transplantation. 17, 7, p. 962-969 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2018

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A., Tkachev, V., Ponce, R., Turtle, C. J., Snyder, J. M., Liggitt, H. D., Myerson, D., Gonzalez-Cuyar, L., Baldessari, A., English, C., Yu, A., Zheng, H., Furlan, S. N., Hunt, D. J., Hoglund, V., Finney, O., Brakke, H., Blazar, B. R., Berger, C., Riddell, S. R. & 3 others, Gardner, R., Kean, L. S. & Jensen, M. C., Jun 2018, In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations
2011

Peritransplant palifermin use and lymphocyte recovery after T-cell replete, matched related allogeneic hematopoietic cell transplantation

Rizwan, R., Levine, J. E., Defor, T., Ferarra, J. L. M., Weisdorf, D. J., Blazar, B. R. & Verneris, M. R., Oct 1 2011, In : American Journal of Hematology. 86, 10, p. 879-882 4 p.

Research output: Contribution to journalLetter

12 Scopus citations
2017

The Knife’s Edge of Tolerance: Inducing Stable Multilineage Mixed Chimerism but With a Significant Risk of CMV Reactivation and Disease in Rhesus Macaques

Zheng, H. B., Watkins, B., Tkachev, V., Yu, S., Tran, D., Furlan, S., Zeleski, K., Singh, K., Hamby, K., Hotchkiss, C., Lane, J., Gumber, S., Adams, A. B., Cendales, L., Kirk, A. D., Kaur, A., Blazar, B. R., Larsen, C. P. & Kean, L. S., Mar 1 2017, In : American Journal of Transplantation. 17, 3, p. 657-670 14 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2018

CD28 blockade controls T cell activation to prevent graft-versus-host disease in primates

Watkins, B. K., Tkachev, V., Furlan, S. N., Hunt, D. J., Betz, K., Yu, A., Brown, M., Poirier, N., Zheng, H. B., Taraseviciute, A., Colonna, L., Mary, C., Blancho, G., Soulillou, J. P., Panoskaltsis-Mortari, A., Sharma, P., Garcia, A., Strobert, E., Hamby, K., Garrett, A. & 4 others, Deane, T., Blazar, B. R., Vanhove, B. & Kean, L. S., Aug 31 2018, In : Journal of Clinical Investigation. 128, 9, p. 3991-4007 17 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2015

CMV reactivation drives posttransplant T-cell reconstitution and results in defects in the underlying TCRβ repertoire

Suessmuth, Y., Mukherjee, R., Watkins, B., Koura, D. T., Finstermeier, K., Desmarais, C., Stempora, L., Horan, J. T., Langston, A., Qayed, M., Khoury, H. J., Grizzle, A., Cheeseman, J. A., Conger, J. A., Robertson, J., Garrett, A., Kirk, A. D., Waller, E. K., Blazar, B. R., Mehta, A. K. & 2 others, Robins, H. S. & Kean, L. S., Jun 18 2015, In : Blood. 125, 25, p. 3835-3850 16 p.

Research output: Contribution to journalArticle

76 Scopus citations
2019

Reduction in murine acute GVHD severity by human gingival tissue-derived mesenchymal stem cells via the CD39 pathways

Ni, X., Xia, Y., Zhou, S., Peng, H., Wu, X., Lu, H., Wang, H., Liu, R., Blazar, B. R., Gu, J. & Lu, L., Jan 1 2019, In : Cell Death and Disease. 10, 1, 13.

Research output: Contribution to journalArticle

Open Access
2013

Pharmacologic inhibition of PKCa & PKCu prevents GVHD while preserving GVL activity in mice

Haarberg, K. M. K., Li, J., Heinrichs, J., Wang, D., Liu, C., Bronk, C. C., Kaosaard, K., Owyang, A. M., Holland, S., Masuda, E., Tso, K., Blazar, B. R., Anasetti, C., Beg, A. A. & Yu, X. Z., 2013, In : Blood. 122, 14, p. 2500-2511 12 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Le Texier, L., Lineburg, K. E., Cao, B., McDonald-Hyman, C., Leveque-El Mouttie, L., Nicholls, J., Melino, M., Nalkurthi, B. C., Alexander, K. A., Teal, B., Blake, S. J., Souza-Fonseca-Guimaraes, F., Engwerda, C. R., Kuns, R. D., Lane, S. W., Teng, M., Teh, C., Gray, D., Clouston, A. D., Nilsson, S. K. & 3 others, Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Sep 22 2016, In : JCI insight. 1, 15, p. e86850

Research output: Contribution to journalArticle

2020

IL-2 enhances ex vivo-expanded regulatory T-cell persistence after adoptive transfer

Furlan, S. N., Singh, K., Lopez, C., Tkachev, V., Hunt, D. J., Hibbard, J., Betz, K. M., Blazar, B. R., Trapnell, C. & Kean, L. S., Apr 28 2020, In : Blood Advances. 4, 8, p. 1594-1605 12 p.

Research output: Contribution to journalArticle

Open Access
2012

Understanding Chronic GVHD from Different Angles

Blazar, B., White, E. S. & Couriel, D., Jan 1 2012, In : Biology of Blood and Marrow Transplantation. 18, 1 SUPPL., p. S184-S188

Research output: Contribution to journalArticle

8 Scopus citations
2018

C5aR1 regulates T follicular helper differentiation and chronic graft-versus-host disease bronchiolitis obliterans

Verghese, D. A., Chun, N., Paz, K., Fribourg, M., Woodruff, T. M., Flynn, R., Hu, Y., Xiong, H., Zhang, W., Yi, Z., Du, J., Blazar, B. R. & Heeger, P. S., Dec 20 2018, In : JCI Insight. 3, 24

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2013

Bone Marrow Stromal and Vascular Smooth Muscle Cells Have Chemosensory Capacity via Bitter Taste Receptor Expression

Lund, T. C., Kobs, A. J., Kramer, A., Nyquist, M., Kuroki, M. T., Osborn, J., Lidke, D. S., Low-Nam, S. T., Blazar, B. R. & Tolar, J., Mar 8 2013, In : PloS one. 8, 3, e58945.

Research output: Contribution to journalArticle

33 Scopus citations
2016

Isoform-specific targeting of ROCK proteins in immune cells

Zanin-Zhorov, A., Flynn, R., Waksal, S. D. & Blazar, B. R., Jul 2 2016, In : Small GTPases. 7, 3, p. 173-177 5 p.

Research output: Contribution to journalComment/debate

Open Access
9 Scopus citations
2017

Alarmins and Their Receptors as Modulators and Indicators of Alloimmune Responses

Matta, B. M., Reichenbach, D. K., Blazar, B. R. & Turnquist, H. R., Feb 1 2017, In : American Journal of Transplantation. 17, 2, p. 320-327 8 p.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations
2018

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journalArticle

Open Access
32 Scopus citations
2016
Open Access
2011

Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation

Glass, T. J., Lund, T. C., Patrinostro, X., Tolar, J., Bowman, T. V., Zon, L. I. & Blazar, B. R., Jul 21 2011, In : Blood. 118, 3, p. 766-774 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
2019

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C. J., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

A Randomized Trial of One versus Two Doses of Influenza Vaccine after Allogeneic Transplantation

Karras, N. A., Weeres, M., Sessions, W., Xu, X., DeFor, T., Young, J. A. H., Stefanski, H., Brunstein, C., Cooley, S., Miller, J. S., Blazar, B. R., Wagner, J. E. & Verneris, M. R., Jan 1 2013, In : Biology of Blood and Marrow Transplantation. 19, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R., Aug 18 2016, In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations
2014

Bystander activation and anti-tumor effects of CD8+ T cells following interleukin-2 based immunotherapy is independent of CD4+ T cell help

Monjazeb, A. M., Tietze, J. K., Grossenbacher, S. K., Hsiao, H. H., Zamora, A. E., Mirsoian, A., Koehn, B., Blazar, B. R., Weiss, J. M., Wiltrout, R. H., Sckisel, G. D. & Murphy, W. J., Aug 13 2014, In : PloS one. 9, 8, e102709.

Research output: Contribution to journalArticle

13 Scopus citations
2011
112 Scopus citations
2014

Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Flynn, R., Du, J., Veenstra, R. G., Reichenbach, D. K., Panoskaltsis-Mortari, A., Taylor, P. A., Freeman, G. J., Serody, J. S., Murphy, W. J., Munn, D. H., Sarantopoulos, S., Luznik, L., Maillard, I., Koreth, J., Cutler, C., Soiffer, R. J., Antin, J. H., Ritz, J., Dubovsky, J. A., Byrd, J. C. & 3 others, MacDonald, K. P., Hill, G. R. & Blazar, B. R., Jun 19 2014, In : Blood. 123, 25, p. 3988-3998 11 p.

Research output: Contribution to journalArticle

100 Scopus citations
2015

A Bortezomib-Based Regimen Offers Promising Survival and Graft-versus-Host Disease Prophylaxis in Myeloablative HLA-Mismatched and Unrelated Donor Transplantation: A Phase II Trial

Koreth, J., Kim, H. T., Lange, P. B., Bindra, B., Reynolds, C. G., Chammas, M. J., Armand, P., Cutler, C. S., Ho, V. T., Glotzbecker, B., Nikiforow, S., Ritz, J., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Alyea, E. P., Nov 2015, In : Biology of Blood and Marrow Transplantation. 21, 11, p. 1907-1913 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2011

Synthetic zinc finger nuclease design and rapid assembly

Osborn, M. J., Defeo, A. P., Blazar, B. R. & Tolar, J., Sep 1 2011, In : Human gene therapy. 22, 9, p. 1155-1165 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Socie, G. & Blazar, B. R., Jan 1 2013, Elsevier Inc.

Research output: Book/ReportBook

1 Scopus citations
2015

Role of transgene regulation in ex vivo lentiviral correction of artemis deficiency

Multhaup, M. M., Podetz-Pedersen, K. M., Karlen, A. D., Olson, E. R., Gunther, R., Somia, N. V., Blazar, B. R., Cowan, M. J. & McIvor, R. S., Apr 1 2015, In : Human gene therapy. 26, 4, p. 232-243 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2019

Achievement of tolerance induction to prevent acute graft-vs.-host disease

Thangavelu, G. & Blazar, B. R., Jan 1 2019, In : Frontiers in immunology. 10, MAR, 309.

Research output: Contribution to journalReview article

Open Access
6 Scopus citations
2012

IFN-γ receptor-deficient donor T cells mediate protection from graft-versus-host disease and preserve graft-versus-tumor responses after allogeneic bone marrow transplantation

Sun, K., Hsiao, H. H., Li, M., Ames, E., Bouchlaka, M., Welniak, L. A., Hagino, T., Jagdeo, J., Pai, C. C., Chen, M., Blazar, B. R., Abedi, M. & Murphy, W. J., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 2033-2042 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2020

Tissue mast cell counts may be associated with decreased severity of gastrointestinal acute GVHD and nonrelapse mortality

Ustun, C., DeFor, T. E., Karadag, F. K., Yun, H. D., Nathan, S., Brunstein, C. G., Blazar, B. R., Weisdorf, D. J., Holtan, S. G. & Amin, K., May 26 2020, In : Blood Advances. 4, 10, p. 2317-2324 8 p.

Research output: Contribution to journalArticle

Open Access

β2-Adrenergic receptor activation on donor cells ameliorates acute GvHD

Mohammadpour, H., Sarow, J. L., MacDonald, C. R., Chen, G. L., Qiu, J., Sharma, U. C., Cao, X., Herr, M. M., Hahn, T. E., Blazar, B. R., Repasky, E. A. & McCarthy, P. L., Jun 18 2020, In : JCI Insight. 5, 12

Research output: Contribution to journalArticle

Open Access
2012

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer

Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R. K., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A. K., Oct 17 2012, In : Science Translational Medicine. 4, 156, 156ra139.

Research output: Contribution to journalArticle

162 Scopus citations
2019

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Disease

Blazar, B. R., Feb 2019, In : Engineering. 5, 1, p. 98-105 8 p.

Research output: Contribution to journalReview article

Open Access
2011

Oxygen is a master regulator of the immunogenicity of primary human glioma cells

Olin, M. R., Andersen, B. M., Litterman, A. J., Grogan, P. T., Sarver, A. L., Robertson, P. T., Liang, X., Chen, W., Parney, I. F., Hunt, M. A., Blazar, B. R. & Ohlfest, J. R., Nov 1 2011, In : Cancer Research. 71, 21, p. 6583-6589 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2016

MiR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

Lu, Y., Hippen, K. L., Lemire, A. L., Gu, J., Wang, W., Ni, X., Ranganathan, P., Levine, B. L., Riley, J. L., June, C. H., Turka, L. A., Munn, D. H., Garzon, R., Lu, L. & Blazar, B. R., Sep 8 2016, In : Blood. 128, 10, p. 1424-1435 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
Open Access
6 Scopus citations
2018

A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression

Stefanski, H. E., Jonart, L., Goren, E., Mulé, J. J. & Blazar, B. R., Apr 2018, In : PloS one. 13, 4, e0193461.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2013

Phase i study of alemtuzumab for therapy of steroid-refractory chronic graft-versus-host disease

Nikiforow, S., Kim, H. T., Bindra, B., McDonough, S., Glotzbecker, B., Armand, P., Koreth, J., Ho, V. T., Alyea, E. P., Blazar, B. R., Ritz, J., Soiffer, R. J., Antin, J. H. & Cutler, C. S., May 1 2013, In : Biology of Blood and Marrow Transplantation. 19, 5, p. 804-811 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2020

STING differentially regulates experimental GVHD mediated by CD8 versus CD4 T cell subsets

Bader, C. S., Barreras, H., Lightbourn, C. O., Copsel, S. N., Wolf, D., Meng, J., Ahn, J., Komanduri, K. V., Blazar, B. R., Jin, L., Barber, G. N., Roy, S. & Levy, R. B., Jul 15 2020, In : Science Translational Medicine. 12, 552

Research output: Contribution to journalArticle

2011

Natural killer-cell differentiation by myeloid progenitors

Grzywacz, B., Kataria, N., Kataria, N., Blazar, B. R., Miller, J. S. & Verneris, M. R., Mar 31 2011, In : Blood. 117, 13, p. 3548-3558 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

The programmed Death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A., Sayegh, M. H., Blazar, B. R., Freeman, G. J. & Sharpe, A. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

95 Scopus citations