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  • Horace H Loh
2016

Effect of Opioid on Adult Hippocampal Neurogenesis

Zhang, Y., Loh, H. H. & Law, P-Y., Jan 1 2016, In : Scientific World Journal. 2016, 2601264.

Research output: Contribution to journalReview article

Open Access
13 Scopus citations
2015

Analysis of epigenetic mechanisms regulating opioid receptor gene transcription

Hwang, C. K., Wagley, Y., Law, P. Y., Wei, L. N. & Loh, H. H., Jan 1 2015, In : Methods in Molecular Biology. 1230, p. 39-51 13 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012

MicroRNAs in opioid pharmacology

Hwang, C. K. T., Wagley, Y., Law, P-Y., Wei, L-N. & Loh, H. H., Dec 1 2012, In : Journal of Neuroimmune Pharmacology. 7, 4, p. 808-819 12 p.

Research output: Contribution to journalReview article

28 Scopus citations
2011

Neuron-glial cell communication in the traumatic stress-induced immunomodulation

Zhao, H., Xiao, S., Kong, X., Wang, J., Cao, X., Gencheng, W., Loh, H. H. & Law, P-Y., May 1 2011, In : Synapse. 65, 5, p. 433-440 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Posttranslation modification of G protein-coupled receptor in relationship to biased agonism

Zheng, H., Loh, H. H. & Law, P-Y., 2013, G Protein Coupled ReceptorsModeling, Activation, Interactions and Virtual Screening. Academic Press Inc., p. 391-408 18 p. (Methods in Enzymology; vol. 522).

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Scopus citations
2016

A Mechanistic Approach to the Development of Gene Therapy for Chronic Pain

Kibaly, C., Loh, H. H. & Law, P. Y., Jan 1 2016, International Review of Cell and Molecular Biology. Elsevier Inc., p. 89-161 73 p. (International Review of Cell and Molecular Biology; vol. 327).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2011

Regulation of the transcription of G protein-coupled receptor genes

Hwang, C. K. T., Law, P-Y., Wei, L-N. & Loh, H. H., Aug 4 2011, Methods for the Discovery and Characterization of G Protein-Coupled Receptors. Stevens, C. W. (ed.). p. 49-69 21 p. (Neuromethods; vol. 60).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2018

Morphine regulates adult neurogenesis and contextual memory extinction via the PKCε/Prox1 pathway

Fan, W., Wang, H., Zhang, Y., Loh, H. H., Law, P. Y. & Xu, C., Oct 2018, In : Neuropharmacology. 141, p. 126-138 13 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2012

Cholesterol level influences opioid signaling in cell models and analgesia in mice and humans

Zheng, H., Zou, H., Liu, X., Chu, J., Zhou, Y., Loh, H. H. & Law, P-Y., Jun 1 2012, In : Journal of Lipid Research. 53, 6, p. 1153-1162 10 p.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Role of FK506 binding protein 12 in morphine-induced μ-opioid receptor internalization and desensitization

Yan, Y. H., Wang, Y., Zhao, L. X., Jiang, S., Loh, H. H., Law, P-Y., Chen, H. Z. & Qiu, Y., Apr 30 2014, In : Neuroscience Letters. 566, p. 231-235 5 p.

Research output: Contribution to journalArticle

6 Scopus citations
2011

Cholesterol regulates μ-opioid receptor-induced β-arrestin 2 translocation to membrane lipid rafts

Qiu, Y., Wang, Y., Law, P. Y., Chen, H. Z. & Loh, H. H., Jul 1 2011, In : Molecular Pharmacology. 80, 1, p. 210-218 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

P38 Mitogen-activated protein kinase and PI3-kinase are involved in up-regulation of mu opioid receptor transcription induced by cycloheximide

Kim, D. K., Hwang, C. K., Wagley, Y., Law, P. Y., Wei, L. N. & Loh, H. H., Mar 1 2011, In : Journal of Neurochemistry. 116, 6, p. 1077-1087 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Effects of dextromethorphan and oxycodone on treatment of neuropathic pain in mice

Yang, P. P., Yeh, G. C., Huang, E. Y. K., Law, P. Y., Loh, H. H. & Tao, P. L., Sep 22 2015, In : Journal of biomedical science. 22, 1, 81.

Research output: Contribution to journalArticle

13 Scopus citations
2013
2 Scopus citations
2015

Modulation of mTOR Activity by μ-Opioid Receptor is Dependent upon the Association of Receptor and FK506-Binding Protein 12

Wang, Y., Ge, Y. H., Wang, Y. X., Liu, T., Law, P-Y., Loh, H. H., Chen, H. Z. & Qiu, Y., Jul 1 2015, In : CNS Neuroscience and Therapeutics. 21, 7, p. 591-598 8 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017
Open Access
5 Scopus citations
2011

Differential gene expression activity among species-specific polypyrimidine/polypurine motifs in mu opioid receptor gene promoters

Choe, C. Y., Dong, J., Law, P-Y. & Loh, H. H., Jan 15 2011, In : Gene. 471, 1-2, p. 27-36 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2014

β-arrestin protects neurons by mediating endogenous opioid arrest of inflammatory microglia

Feng, X., Wu, C-Y., Burton, F. H., Loh, H. H. & Wei, L-N., Mar 1 2014, In : Cell Death and Differentiation. 21, 3, p. 397-406 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y. & Yeh, S. H., Mar 1 2017, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1865, 3, p. 336-343 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2012
11 Scopus citations

Non-coding RNAs regulating morphine function: With emphasis on the in vivo and in vitro functions of miR-190

Zheng, H., Law, P. Y. & Loh, H. H., Dec 1 2012, In : Frontiers in Genetics. 3, JUN, Article 113.

Research output: Contribution to journalReview article

18 Scopus citations
2013

MicroRNA 339 down-regulates μ-opioid μeceptor at the post-transcriptional level in response to opioid treatment

Wu, Q., Hwang, C. K. T., Zheng, H., Wagley, Y., Lin, H. Y., Kim, D. K., Law, P-Y., Loh, H. H. & Wei, L-N., Feb 1 2013, In : FASEB Journal. 27, 2, p. 522-535 14 p.

Research output: Contribution to journalArticle

39 Scopus citations
2016

Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice

Yang, P. P., Yeh, G. C., Yeh, T. K., Xi, J., Loh, H. H., Law, P. Y. & Tao, P. L., Sep 1 2016, In : Pharmacological Research. 111, p. 867-876 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2019

The in vivo antinociceptive and μ-opioid receptor activating effects of the combination of N-phenyl-2′,4′-dimethyl-4,5′-bi-1,3-thiazol-2-amines and naloxone

Lin, S. Y., Kuo, Y. H., Tien, Y. W., Ke, Y. Y., Chang, W. T., Chang, H. F., Ou, L. C., Law, P. Y., Xi, J. H., Tao, P. L., Loh, H. H., Chao, Y. S., Shih, C., Chen, C. T., Yeh, S. H. & Ueng, S. H., Apr 1 2019, In : European Journal of Medicinal Chemistry. 167, p. 312-323 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2012

Stress-induced epigenetic regulation of κ-opioid receptor gene involves transcription factor c-Myc

Flaisher-Grinberg, S., Persaud, S. D., Loh, H. H. & Wei, L-N., Jun 5 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 23, p. 9167-9172 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2013

Opioid receptors: Toward separation of analgesic from undesirable effects

Law, P. Y., Reggio, P. H. & Loh, H. H., Jun 1 2013, In : Trends in Biochemical Sciences. 38, 6, p. 275-282 8 p.

Research output: Contribution to journalReview article

36 Scopus citations

NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction

Zheng, H., Zhang, Y., Li, W., Loh, H. H. & Law, P. Y., Apr 1 2013, In : Neuropsychopharmacology. 38, 5, p. 770-777 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

Modulating μ-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCε activation and dendritic spine stability

Zheng, H., Chu, J., Zhang, Y., Loh, H. H. & Law, P. Y., Apr 8 2011, In : Journal of Biological Chemistry. 286, 14, p. 12724-12733 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2012

Naloxone can act as an analgesic agent without measurable chronic side effects in mice with a mutant mu-opioid receptor expressed in different sites of pain pathway

Chou, S. H., Kao, J. H., Tao, P. L., Law, P. Y. & Loh, H. H., Aug 1 2012, In : Synapse. 66, 8, p. 694-704 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015
17 Scopus citations
2012
11 Scopus citations
2016

β-endorphin: Stimulation of DNA-dependent RNA formation

Catlin, D. H., Hui, K. K., Loh, H. H. & Li, C. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 254-259 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2019

Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice

Chao, P. K., Chang, H. F., Ou, L. C., Chuang, J. Y., Lee, P. T., Chang, W. T., Chen, S. C., Ueng, S. H., Hsu, J. T. A., Tao, P. L., Law, P. Y., Loh, H. H. & Yeh, S. H., Dec 1 2019, In : Scientific reports. 9, 1, 2405.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2016

Morphine modulates adult neurogenesis and contextual memory by impeding the maturation of neural progenitors

Zhang, Y., Xu, C., Zheng, H., Loh, H. H. & Law, P. Y., Apr 2016, In : PloS one. 11, 4, e0153628.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
2017

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4 H -indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

Chao, P. K., Ueng, S. H., Ou, L. C., Yeh, T. K., Chang, W. T., Chang, H. F., Chen, S. C., Tao, P. L., Law, P. Y., Loh, H. H., Cheng, M. F., Chuang, J. Y., Chen, C. T., Shih, C. & Yeh, S. H., May 1 2017, In : Anesthesiology. 126, 5, p. 952-966 15 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013
21 Scopus citations
2011

Unidirectional cross-activation of GRPR by MOR1D uncouples itch and analgesia induced by opioids

Liu, X. Y., Liu, Z. C., Sun, Y. G., Ross, M., Kim, S., Tsai, F. F., Li, Q. F., Jeffry, J., Kim, J. Y., Loh, H. H. & Chen, Z. F., Oct 14 2011, In : Cell. 147, 2, p. 447-458 12 p.

Research output: Contribution to journalArticle

163 Scopus citations
2016

Effects of addictive drugs on adult neural stem/progenitor cells

Xu, C., Loh, H. H. & Law, P. Y., Jan 1 2016, In : Cellular and Molecular Life Sciences. 73, 2, p. 327-348 22 p.

Research output: Contribution to journalReview article

Open Access
12 Scopus citations
2014

Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists

Cheng, M. F., Ou, L. C., Chen, S. C., Chang, W. T., Law, P-Y., Loh, H. H., Chao, Y. S., Shih, C., Yeh, S. H. & Ueng, S. H., Sep 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 17, p. 4694-4703 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

μ-Opioid Receptor Attenuates Aβ Oligomers-Induced Neurotoxicity Through mTOR Signaling

Wang, Y., Wang, Y. X., Liu, T., Law, P. Y., Loh, H. H., Qiu, Y. & Chen, H. Z., Jan 1 2015, In : CNS Neuroscience and Therapeutics. 21, 1, p. 8-14 7 p.

Research output: Contribution to journalArticle

22 Scopus citations
2012

Novel dual-binding function of a poly (C)-binding protein 3, transcriptional factor which binds the double-strand and single-stranded DNA sequence

Kang, D. H., Song, K. Y., Choi, H. S., Law, P-Y., Wei, L-N. & Loh, H. H., Jun 10 2012, In : Gene. 501, 1, p. 33-38 6 p.

Research output: Contribution to journalArticle

7 Scopus citations
2015

Effect of naltrexone on neuropathic pain in mice locally transfected with the mutant μ-opioid receptor gene in spinal cord

Kao, J. H., Gao, M. J., Yang, P. P., Law, P. Y., Loh, H. H. & Tao, P. L., Jan 2015, In : British Journal of Pharmacology. 172, 2, p. 630-641 12 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011
44 Scopus citations
2013

A novel noncanonical signaling pathway for the μ-opioid receptor

Zhang, L., Loh, H. H. & Law, P-Y., Dec 1 2013, In : Molecular Pharmacology. 84, 6, p. 844-853 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Opioid doses required for pain management in lung cancer patients with different cholesterol levels: Negative correlation between opioid doses and cholesterol levels

Huang, Z., Liang, L., Li, L., Xu, M., Li, X., Sun, H., He, S., Lin, L., Zhang, Y., Song, Y., Yang, M., Luo, Y., Loh, H. H., Law, P. Y., Zheng, D. & Zheng, H., Jan 1 2016, In : Lipids in Health and Disease. 15, 1, 47.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2013

Opioid Receptors

Law, P. Y. & Loh, H. H., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 354-358 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

FK506-Binding protein 12 modulates m-opioid receptor phosphorylation and protein kinase σ-dependent signaling by its direct interaction with the receptor

Qiu, Y., Zhao, W., Wang, Y., Xu, J. R., Huie, E., Jiang, S., Yan, Y. H., Loh, H. H., Chen, H. Z. & Law, P. Y., Jan 1 2014, In : Molecular Pharmacology. 85, 1, p. 37-49 13 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Possible role of β-endorphin in heat adaptation

Holaday, J. W., Loh, H. H., Wei, E. & Li, C. H., Jan 14 2016, Endorphins in Mental Health Research. Palgrave Macmillan, p. 473-483 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
2013
6 Scopus citations