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  • Paul D Robbins
2017

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

Proto, J. D., Lu, A., Dorronsoro, A., Scibetta, A., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jun 2017, In : PloS one. 12, 6, e0179270.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2013

Arthritis gene therapy and its tortuous path into the clinic

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Apr 2013, In : Translational Research. 161, 4, p. 205-216 12 p.

Research output: Contribution to journalReview article

58 Scopus citations
2011

Dedifferentiation rescues senescence of progeria cells but only while pluripotent

Niedernhofer, L. J., Glorioso, J. C. & Robbins, P. D., Sep 9 2011, In : Stem Cell Research and Therapy. 2, 3, 28.

Research output: Contribution to journalReview article

10 Scopus citations
2017

Systems biology guided by XCMS Online metabolomics

Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., Aisporna, A., Hilmers, B., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Robbins, P. D., Niedernhofer, L. J., Ideker, T., Majumder, E. L., Wall, J. D., Rattray, N. J. W. & 3 others, Goodacre, R., Lairson, L. L. & Siuzdak, G., Apr 27 2017, In : Nature Methods. 14, 5, p. 461-462 2 p.

Research output: Contribution to journalLetter

Open Access
63 Scopus citations
2018

Arthritis Gene Therapy Approved in Korea

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 15 2018, In : Journal of the American Academy of Orthopaedic Surgeons. 26, 2, p. e36-e38

Research output: Contribution to journalArticle

7 Scopus citations
2017

Extracellular vesicles and aging

Robbins, P. D., Dec 1 2017, In : Stem Cell Investigation. 4, 12, 98.

Research output: Contribution to journalReview article

Open Access
18 Scopus citations
2018

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations
2012

NF-κB inhibition delays DNA damage - Induced senescence and aging in mice

Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., Huard, J., Clemens, P. R., Stolz, D. B., Guttridge, D. C., Watkins, S. C., Garinis, G. A., Wang, Y., Niedernhofer, L. J. & Robbins, P. D., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

214 Scopus citations
2018

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., Croix, C. M. S., Niedernhofer, L. J. & Gill, M. S., Sep 2018, In : Redox Biology. 18, p. 191-199 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2012

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells

Lu, A., Proto, J. D., Guo, L., Tang, Y., Lavasani, M., Tilstra, J. S., Niedernhofer, L. J., Wang, B., Guttridge, D. C., Robbins, P. D. & Huard, J., Mar 2012, In : Molecular Therapy. 20, 3, p. 661-668 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2017

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature communications. 8, 1, 422.

Research output: Contribution to journalArticle

Open Access
135 Scopus citations
2014

Pharmacologic IKK/NF-kappa;B inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death

Tilstra, J. S., Gaddy, D. F., Zhao, J., Davé, S. H., Niedernhofer, L. J., Plevy, S. E. & Robbins, P. D., Jan 10 2014, In : Scientific reports. 4, 3631.

Research output: Contribution to journalArticle

15 Scopus citations
2011

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

Reay, D. P., Yang, M., Watchko, J. F., Daood, M., O'Day, T. L., Rehman, K. K., Guttridge, D. C., Robbins, P. D. & Clemens, P. R., Sep 1 2011, In : Neurobiology of Disease. 43, 3, p. 598-608 11 p.

Research output: Contribution to journalArticle

34 Scopus citations
2016

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : STEM CELLS. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2019

Methods to quantify the NF-κB pathway during senescence

Zhang, L., Zhao, J., Gurkar, A., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 231-250 20 p. (Methods in Molecular Biology; vol. 1896).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
2013

DNA damage drives accelerated bone aging via an NF- κ B-dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J. & Ouyang, H., May 1 2013, In : Journal of Bone and Mineral Research. 28, 5, p. 1214-1228 15 p.

Research output: Contribution to journalArticle

50 Scopus citations
2018

Arthritis gene therapy is becoming a reality

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jul 1 2018, In : Nature Reviews Rheumatology. 14, 7, p. 381-382 2 p.

Research output: Contribution to journalComment/debate

7 Scopus citations
2011
9 Scopus citations
2013

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J. & Evans, C. H., Jun 1 2013, In : Journal of Orthopaedic Research. 31, 6, p. 831-837 7 p.

Research output: Contribution to journalReview article

57 Scopus citations
2017

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

Open Access
300 Scopus citations

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
2020

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., McGowan, S. J., Angelini, L., O'Kelly, R., Li, H., Corbo, L., Sano, T., Nick, H., Pola, E., Pilla, S. P. S., Ladiges, W. C. & 4 others, Vo, N., Huard, J., Niedernhofer, L. J. & Robbins, P. D., Mar 31 2020, In : Aging. 12, 6, p. 4688-4710 23 p.

Research output: Contribution to journalArticle

1 Scopus citations

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M. & Robbins, P. D., Jun 1 2020, In : GeroScience. 42, 3, p. 951-961 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2012

DsAAV8-mediated gene transfer and Β-cell expression of IL-4 and Β-cell growth factors are capable of reversing early-onset diabetes in NOD mice

Gaddy, D. F., Riedel, M. J., Bertera, S., Kieffer, T. J. & Robbins, P. D., Aug 1 2012, In : Gene therapy. 19, 8, p. 791-799 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Lim Mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through kruppel-like factor-4 downregulation and further bone-specific gene expression

Barba, M., Pirozzi, F., Saulnier, N., Vitali, T., Natale, M. T., Logroscino, G., Robbins, P. D., Gambotto, A., Neri, G., Michetti, F., Pola, E. & Lattanzi, W., 2012, In : Journal of Biomedicine and Biotechnology. 2012, 813894.

Research output: Contribution to journalArticle

17 Scopus citations
2017

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
123 Scopus citations
2016

Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Northen, T. R., Robbins, P. D., Niedernhofer, L. J., Lairson, L., Benton, H. P. & Siuzdak, G., Oct 4 2016, In : Analytical chemistry. 88, 19, p. 9753-9758 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2018

Development of clinical trials to extend healthy lifespan

Justice, J. N., Niedernhofer, L. J., Robbins, P. D., Aroda, V. R., Espeland, M. A., Kritchevsky, S. B., Kuchel, G. A. & Barzilai, N., Dec 1 2018, In : Cardiovascular Endocrinology and Metabolism. 7, 4, p. 80-83 4 p.

Research output: Contribution to journalReview article

14 Scopus citations

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans

Yousefzadeh, M. J., Schafer, M. J., Noren Hooten, N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K. & Niedernhofer, L. J., Apr 2018, In : Aging cell. 17, 2, e12706.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations
2019

Measuring biological age in mice using differential mass spectrometry

Bell-Temin, H., Yousefzadeh, M. J., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J. & Yates, N. A., Jan 1 2019, In : Aging. 11, 3, p. 1045-1061 17 p.

Research output: Contribution to journalArticle

Open Access
2013

LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells

Lin, Z., Rios, H. F., Park, C. H., Taut, A. D., Jin, Q., Sugai, J. V., Robbins, P. D. & Giannobile, W. V., Jan 1 2013, In : Gene therapy. 20, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
2019

Murine models of accelerated aging and musculoskeletal disease

Hambright, W. S., Niedernhofer, L. J., Huard, J. & Robbins, P. D., Aug 2019, In : Bone. 125, p. 122-127 6 p.

Research output: Contribution to journalArticle

2018

Age-dependent changes i n i ntervertebral di sc cell mi tochondri a and bi oenergeti cs

Hartman, R., Patil, P., Tisherman, R., St. Croix, C., Niedernhofer, L. J., Robbins, P. D., Ambrosio, F., Van Houten, B., Sowa, G. & Vo, N., Jan 1 2018, In : European Cells and Materials. 36, p. 171-183 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Hsp90 inhibitors as senolytic drugs to extend healthy aging

Fuhrmann-Stroissnigg, H., Niedernhofer, L. J. & Robbins, P. D., May 3 2018, In : Cell Cycle. 17, 9, p. 1048-1055 8 p.

Research output: Contribution to journalReview article

Open Access
12 Scopus citations
2015

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Proto, J. D., Tang, Y., Lu, A., Chen, W. C. W., Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. & Huard, J., Apr 23 2015, In : Cell Death and Disease. 6, 4, e1730.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes

Dorronsoro, A. & Robbins, P. D., May 3 2013, In : Stem Cell Research and Therapy. 4, 2, 39.

Research output: Contribution to journalReview article

41 Scopus citations
2012

Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells

Yang, C., Chalasani, G., Ng, Y. H. & Robbins, P. D., Apr 27 2012, In : PloS one. 7, 4, e36138.

Research output: Contribution to journalArticle

36 Scopus citations
2017

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jul 2017, In : Journal of Orthopaedic Research. 35, 7, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2012

ISSLS prize winner: Inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging

Nasto, L. A., Seo, H. Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., Robbins, P. D. & Vo, N. V., Oct 1 2012, In : Spine. 37, 21, p. 1819-1825 7 p.

Research output: Contribution to journalArticle

44 Scopus citations
2018

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Open Access
285 Scopus citations
2011

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of duchenne muscular dystrophy

Peterson, J. M., Kline, W., Canan, B. D., Ricca, D. J., Kaspar, B., Delfín, D. A., Dirienzo, K., Clemens, P. R., Robbins, P. D., Baldwin, A. S., Flood, P., Kaumaya, P., Freitas, M., Kornegay, J. N., Mendell, J. R., Rafael-Fortney, J. A., Guttridge, D. C. & Janssen, P. M., May 1 2011, In : Molecular Medicine. 17, 5-6, p. 508-515 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2018

Senotherapeutics for healthy ageing

Niedernhofer, L. J. & Robbins, P. D., Apr 27 2018, In : Nature Reviews Drug Discovery. 17, 5, 1 p.

Research output: Contribution to journalLetter

Open Access
21 Scopus citations
2014

Regulation of immune responses by extracellular vesicles

Robbins, P. D. & Morelli, A. E., Mar 1 2014, In : Nature Reviews Immunology. 14, 3, p. 195-208 14 p.

Research output: Contribution to journalReview article

804 Scopus citations
2015

NF-κB activation with aging: Characterization and therapeutic inhibition

Zhao, J., Li, X., McGowan, S., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 543-557 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins, P. D., Dorronsoro, A. & Booker, C. N., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1173-1180 8 p.

Research output: Contribution to journalReview article

Open Access
95 Scopus citations
2017

Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype

Ngo, K., Patil, P., McGowan, S. J., Niedernhofer, L. J., Robbins, P. D., Kang, J., Sowa, G. & Vo, N., Sep 2017, In : Mechanisms of Ageing and Development. 166, p. 16-23 8 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2013

Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces

Lavasani, M., Lu, A., Thompson, S. D., Robbins, P. D., Huard, J. & Niedernhofer, L. J., 2013, Stem Cells and Aging: Methods and Protocols. Humana Press Inc., p. 53-65 13 p. (Methods in Molecular Biology; vol. 976).

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Scopus citations
2017

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

The Clinical Potential of Senolytic Drugs

Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J. & Robbins, P. D., Oct 2017, In : Journal of the American Geriatrics Society. 65, 10, p. 2297-2301 5 p.

Research output: Contribution to journalArticle

Open Access
143 Scopus citations