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  • Bruce R Blazar
2019

MHC Class II Antigen Presentation by the Intestinal Epithelium Initiates Graft-versus-Host Disease and Is Influenced by the Microbiota

Koyama, M., Mukhopadhyay, P., Schuster, I. S., Henden, A. S., Hülsdünker, J., Varelias, A., Vetizou, M., Kuns, R. D., Robb, R. J., Zhang, P., Blazar, B. R., Thomas, R., Begun, J., Waddell, N., Trinchieri, G., Zeiser, R., Clouston, A. D., Degli-Esposti, M. A. & Hill, G. R., Nov 19 2019, In : Immunity. 51, 5, p. 885-898.e7

Research output: Contribution to journalArticle

7 Scopus citations
2012

Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation

Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., Gobourne, A., Lipuma, L., Young, L. F., Smith, O. M., Ghosh, A., Hanash, A. M., Goldberg, J. D., Aoyama, K., Blazar, B. R., Pamer, E. G. & 1 others, van den Brink, M. R. M., May 7 2012, In : Journal of Experimental Medicine. 209, 5, p. 903-911 9 p.

Research output: Contribution to journalArticle

316 Scopus citations
2011
27 Scopus citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. & Anderson, A. C., Jun 1 2011, In : Journal of Experimental Medicine. 208, 6, 1 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

Resurrecting the recalcitrant T-cell

Wagner, J. E. & Blazar, B. R., Oct 20 2011, In : Blood. 118, 16, p. 4302-4303 2 p.

Research output: Contribution to journalComment/debate

2015

Inducible T-cell receptor expression in precursor T cells for leukemia control

Hoseini, S. S., Hapke, M., Herbst, J., Wedekind, D., Baumann, R., Heinz, N., Schiedlmeier, B., Vignali, D. A. A., Van Den Brink, M. R. M., Schambach, A., Blazar, B. R. & Sauer, M. G., Jul 13 2015, In : Leukemia. 29, 7, p. 1530-1542 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2019

Adaptive NK cell reconstitution is associated with better clinical outcomes

Cichocki, F., Taras, E., Chiuppesi, F., Wagner, J. E., Blazar, B. R., Brunstein, C., Luo, X., Diamond, D. J., Cooley, S., Weisdorf, D. J. & Miller, J. S., Jan 24 2019, In : JCI Insight. 4, 2, Y.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2016

Graft Versus Host Disease after Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management

Murali, A. R., Chandra, S., Stewart, Z., Blazar, B. R., Farooq, U., Ince, M. N. & Dunkelberg, J., Dec 1 2016, In : Transplantation. 100, 12, p. 2661-2670 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2018
Open Access
5 Scopus citations
2016

Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival

Borges, C. M., Reichenbach, D. K., Kim, B. S., Misra, A., Blazar, B. R. & Turka, L. A., Aug 1 2016, In : Transplant International. 29, 8, p. 930-940 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2020

Regulatory T Cells Condition Lymphatic Endothelia for Enhanced Transendothelial Migration

Piao, W., Xiong, Y., Li, L., Saxena, V., Smith, K. D., Hippen, K. L., Paluskievicz, C., Willsonshirkey, M., Blazar, B. R., Abdi, R. & Bromberg, J. S., Jan 28 2020, In : Cell reports. 30, 4, p. 1052-1062.e5

Research output: Contribution to journalArticle

Open Access
2014

Functional NK cell repertoires are maintained through IL-2Rα and fas ligand

Felices, M., Lenvik, T. R., Ankarlo, D. E. M., Foley, B., Curtsinger, J., Luo, X., Blazar, B. R., Anderson, S. K. & Miller, J. S., Apr 15 2014, In : Journal of Immunology. 192, 8, p. 3889-3897 9 p.

Research output: Contribution to journalArticle

15 Scopus citations
2012

Regulation of acute graft-versus-host disease by microRNA-155

Ranganathan, P., Heaphy, C. E. A., Costinean, S., Stauffer, N., Na, C., Hamadani, M., Santhanam, R., Mao, C., Taylor, P. A., Sandhu, S., He, G., Shana'ah, A., Nuovo, G. J., Lagana, A., Cascione, L., Obad, S., Broom, O., Kauppinen, S., Byrd, J. C., Caligiuri, M. & 7 others, Perrotti, D., Hadley, G. A., Marcucci, G., Devine, S. M., Blazar, B. R., Croce, C. M. & Garzon, R., May 17 2012, In : Blood. 119, 20, p. 4786-4797 12 p.

Research output: Contribution to journalArticle

96 Scopus citations
2017

T-cell expression of AhR inhibits the maintenance of pTreg cells in the gastrointestinal tract in acute GVHD

Dant, T. A., Lin, K. L., Bruce, D. W., Montgomery, S. A., Kolupaev, O. V., Bommiasamy, H., Bixby, L. M., Woosley, J. T., McKinnon, K. P., Gonzalez, F. J., Blazar, B. R., Vincent, B. G., Coghill, J. M. & Serody, J. S., Jul 20 2017, In : Blood. 130, 3, p. 348-359 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2018

Effects of MicroRNA on regulatory T Cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease

Hippen, K. L., Loschi, M., Nicholls, J., MacDonald, K. P. A. & Blazar, B. R., Jan 31 2018, In : Frontiers in immunology. 9, JAN, 57.

Research output: Contribution to journalShort survey

Open Access
11 Scopus citations
2019

Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality

Thangavelu, G., Lee, Y. C., Loschi, M., Melanie Schaechter, K., Feser, C. J., Koehn, B., Nowak, E. C., Zeiser, R., Serody, J. S., Murphy, W. J., Munn, D. H., Chambon, P., Noelle, R. J. & Blazar, B. R., May 1 2019, In : Journal of Immunology. 202, 9, p. 2795-2805 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2018
Open Access
14 Scopus citations
2012

Interleukin-22 Protects Intestinal Stem Cells from Immune-Mediated Tissue Damage and Regulates Sensitivity to Graft versus Host Disease

Hanash, A. M., Dudakov, J. A., Hua, G., O'Connor, M. H., Young, L. F., Singer, N. V., West, M. L., Jenq, R. R., Holland, A. M., Kappel, L. W., Ghosh, A., Tsai, J. J., Rao, U. K., Yim, N. L., Smith, O. M., Velardi, E., Hawryluk, E. B., Murphy, G. F., Liu, C., Fouser, L. A. & 3 others, Kolesnick, R., Blazar, B. R. & van den Brink, M. R. M., Aug 24 2012, In : Immunity. 37, 2, p. 339-350 12 p.

Research output: Contribution to journalArticle

302 Scopus citations
2014
32 Scopus citations
2017

Human in vitro-induced regulatory T cells display Dlgh1dependent and PKC-θ restrained suppressive activity

Zanin-Zhorov, A., Kumari, S., Hippen, K. L., Merkel, S. C., MacMillan, M. L., Blazar, B. R. & Dustin, M. L., Dec 1 2017, In : Scientific reports. 7, 1, 4258.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2020

Interleukin-27 Enforces Regulatory T Cell Functions to Prevent Graft-versus-Host Disease

Le, H. T., Keslar, K., Nguyen, Q. T., Blazar, B. R., Hamilton, B. K. & Min, B., Feb 12 2020, In : Frontiers in immunology. 11, 181.

Research output: Contribution to journalArticle

Open Access
2011
71 Scopus citations

Stem cell gene therapy for fanconi anemia: Report from the 1st international fanconi anemia gene therapy working group meeting

Tolar, J., Adair, J. E., Antoniou, M., Bartholomae, C. C., Becker, P. S., Blazar, B. R., Bueren, J., Carroll, T., Cavazzana-Calvo, M., Clapp, D. W., Dalgleish, R., Galy, A., Gaspar, H. B., Hanenberg, H., Von Kalle, C., Kiem, H. P., Lindeman, D., Naldini, L., Navarro, S., Renella, R. & 7 others, Rio, P., Sevilla, J., Schmidt, M., Verhoeyen, E., Wagner, J. E., Williams, D. A. & Thrasher, A. J., Jul 2011, In : Molecular Therapy. 19, 7, p. 1193-1198 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice

Li, J., Semple, K., Suh, W. K., Liu, C., Chen, F., Blazar, B. R. & Yu, X. Z., Jul 1 2011, In : Biology of Blood and Marrow Transplantation. 17, 7, p. 962-969 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
2013

An Inherently Bifunctional Subset of Foxp3+ T Helper Cells Is Controlled by the Transcription Factor Eos

Sharma, M., Huang, L., Choi, J. H., Lee, E. J., Wilson, J., Lemos, H., Pan, F., Blazar, B. R., Pardoll, D., Mellor, A., Shi, H. & Munn, D., May 23 2013, In : Immunity. 38, 5, p. 998-1012 15 p.

Research output: Contribution to journalArticle

105 Scopus citations
2011

Regulatory T cells in acute myelogenous leukemia: Is it time for immunomodulation?

Ustun, C., Miller, J. S., Munn, D. H., Weisdorf, D. J. & Blazar, B. R., Nov 10 2011, In : Blood. 118, 19, p. 5084-5095 12 p.

Research output: Contribution to journalReview article

105 Scopus citations
2017

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2015

The IL-33/ST2 axis augments effector T-cell responses during acute GVHD

Reichenbach, D. K., Schwarze, V., Matta, B. M., Tkachev, V., Lieberknecht, E., Liu, Q., Koehn, B. H., Pfeifer, D., Taylor, P. A., Prinz, G., Dierbach, H., Stickel, N., Beck, Y., Warncke, M., Junt, T., Schmitt-Graeff, A., Nakae, S., Follo, M., Wertheimer, T., Schwab, L. & 7 others, Devlin, J., Watkins, S. C., Duyster, J., Ferrara, J. L. M., Turnquist, H. R., Zeiser, R. & Blazar, B. R., Jan 1 2015, In : Blood. 125, 20, p. 3183-3192 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
2019

Publisher Correction: Absence of NKG2D ligands defines leukaemia stem cells and mediates their immune evasion (Nature, (2019), 10.1038/s41586-019-1410-1)

Paczulla, A. M., Rothfelder, K., Raffel, S., Konantz, M., Steinbacher, J., Wang, H., Tandler, C., Mbarga, M., Schaefer, T., Falcone, M., Nievergall, E., Dörfel, D., Hanns, P., Passweg, J. R., Lutz, C., Schwaller, J., Zeiser, R., Blazar, B. R., Caligiuri, M. A., Dirnhofer, S. & 7 others, Lundberg, P., Kanz, L., Quintanilla-Martinez, L., Steinle, A., Trumpp, A., Salih, H. R. & Lengerke, C., Jan 1 2019, In : Nature. 572, 7770, p. E19

Research output: Contribution to journalComment/debate

Open Access

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Qi, J., Luznik, L., Maillard, I., MacDonald, K. P., Hill, G. R., Serody, J. S., Murphy, W. J., Sage, P. T., Sharpe, A. H., Miklos, D., Cutler, C. S., Koreth, J., Antin, J. H., Soiffer, R. J., Ritz, J., Bradner, J. E., Melnick, A. M. & 1 others, Blazar, B. R., Jan 3 2019, In : Blood. 133, 1, p. 94-99 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2018

Chimeric antigen receptor T cell–mediated neurotoxicity in nonhuman primates

Taraseviciute, A., Tkachev, V., Ponce, R., Turtle, C. J., Snyder, J. M., Liggitt, H. D., Myerson, D., Gonzalez-Cuyar, L., Baldessari, A., English, C., Yu, A., Zheng, H., Furlan, S. N., Hunt, D. J., Hoglund, V., Finney, O., Brakke, H., Blazar, B. R., Berger, C., Riddell, S. R. & 3 others, Gardner, R., Kean, L. S. & Jensen, M. C., Jun 2018, In : Cancer discovery. 8, 6, p. 750-763 14 p.

Research output: Contribution to journalArticle

Open Access
57 Scopus citations
2017

Combined OX40L and mTOR blockade controls effector T cell activation while preserving Treg reconstitution after transplant

Tkachev, V., Furlan, S. N., Watkins, B., Hunt, D. J., Betty Zheng, H., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Schell, J. B., Zeleski, K., Yu, A., Kirby, I., Cooley, S., Miller, J. S., Blazar, B. R., Casson, D., Bland-Ward, P. & Kean, L. S., Sep 20 2017, In : Science Translational Medicine. 9, 408, eaan3085.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2016
Open Access
2020

Graft-versus-host disease of the CNS is mediated by TNF upregulation in microglia

Mathew, N. R., Vinnakota, J. M., Apostolova, P., Erny, D., Hamarsheh, S., Andrieux, G., Kim, J. S., Hanke, K., Goldmann, T., Chappell-Maor, L., El-Khawanky, N., Ihorst, G., Schmidt, D., Duyster, J., Finke, J., Blank, T., Boerries, M., Blazar, B. R., Jung, S., Prinz, M. & 1 others, Zeiser, R., Mar 2 2020, In : Journal of Clinical Investigation. 130, 3, p. 1315-1329 15 p.

Research output: Contribution to journalArticle

Open Access
2019

FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program

Hou, S., Clement, R. L., Diallo, A., Blazar, B. R., Rudensky, A. Y., Sharpe, A. H. & Sage, P. T., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 605-620 16 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
2018

The purinergic receptor P2RX7 directs metabolic fitness of long-lived memory CD8 + T cells

Borges Da Silva, H., Beura, L. K., Wang, H., Hanse, E. A., Gore, R., Scott, M. C., Walsh, D. A., Block, K. E., Fonseca, R., Yan, Y., Hippen, K. L., Blazar, B. R., Masopust, D., Kelekar, A., Vulchanova, L., Hogquist, K. A. & Jameson, S. C., Jul 12 2018, In : Nature. 559, 7713, p. 264-268 5 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations
2011

Effector CD4+ T cells, the cytokines they generate, and GVHD: Something old and something new

Coghill, J. M., Sarantopoulos, S., Moran, T. P., Murphy, W. J., Blazar, B. R. & Serody, J. S., Mar 24 2011, In : Blood. 117, 12, p. 3268-3276 9 p.

Research output: Contribution to journalReview article

105 Scopus citations
2019

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

Leung, W. H., Gay, J., Martin, U., Garrett, T. E., Horton, H. M., Certo, M. T., Blazar, B. R., Morgan, R. A., Gregory, P. D., Jarjour, J. & Astrakhan, A., Jun 6 2019, In : JCI insight. 4, 11, e124430.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2014

A Phase II Study of Bortezomib Plus Prednisone for Initial Therapy of Chronic Graft-versus-Host Disease

Herrera, A. F., Kim, H. T., Bindra, B., Jones, K. T., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Nikiforow, S., Blazar, B. R., Ritz, J., Antin, J. H., Soiffer, R. J. & Koreth, J., Nov 1 2014, In : Biology of Blood and Marrow Transplantation. 20, 11, p. 1737-1743 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2019

CD4 T cell sphingosine 1-phosphate receptor (S1PR)1 and S1PR4 and endothelial S1PR2 regulate afferent lymphatic migration

Xiong, Y., Piao, W., Colin Brinkman, C., Li, L., Kulinski, J. M., Olivera, A., Cartier, A., Hla, T., Hippen, K. L., Blazar, B. R., Schwab, S. R. & Bromberg, J. S., Mar 15 2019, In : Science Immunology. 4, 33, eaav1263.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2016

Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease

Li, W., Liu, L., Gomez, A., Zhang, J., Ramadan, A., Zhang, Q., Choi, S. W., Zhang, P., Greenson, J. K., Liu, C., Jiang, D., Virts, E., Kelich, S. L., Chu, H. W., Flynn, R., Blazar, B. R., Hanenberg, H., Hanash, S. & Paczesny, S., May 5 2016, In : JCI insight. 1, 6

Research output: Contribution to journalArticle

Open Access
2019

Differential effects of 2-deoxy-D-glucose on in vitro expanded human regulatory T cell subsets

Tanimine, N., Germana, S. K., Fan, M., Hippen, K., Blazar, B. R., Markmann, J. F., Turka, L. A. & Priyadharshini, B., Jun 2019, In : PloS one. 14, 6, e0217761.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
1 Scopus citations
2015
55 Scopus citations
2012

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Hippen, K. L., Bucher, C., Schirm, D. K., Bearl, A. M., Brender, T., Mink, K. A., Waggie, K. S., De Latour, R. P., Janin, A., Curtsinger, J. M., Dillon, S. R., Miller, J. S., Socie, G. & Blazar, B. R., Jan 12 2012, In : Blood. 119, 2, p. 619-628 10 p.

Research output: Contribution to journalArticle

55 Scopus citations
2013

Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation

Socie, G. & Blazar, B. R., Jan 1 2013, Elsevier Inc.

Research output: Book/ReportBook

1 Scopus citations
2019

Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease

Paz, K., Flynn, R., Du, J., Tannheimer, S., Johnson, A. J., Dong, S., Stark, A. K., Okkenhaug, K., Panoskaltsis-Mortari, A., Sage, P. T., Sharpe, A. H., Luznik, L., Ritz, J., Soiffer, R. J., Cutler, C. S., Koreth, J., Antin, J. H., Miklos, D. B., MacDonald, K. P., Hill, G. R. & 10 others, Maillard, I., Serody, J. S., Murphy, W. J., Munn, D. H., Feser, C. J., Zaiken, M., Vanhaesebroeck, B., Turka, L. A., Byrd, J. C. & Blazar, B. R., Jun 2019, In : American Journal of Transplantation. 19, 6, p. 1820-1830 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Sdf1 expression reveals a source of perivascular-derived mesenchymal stem cells in zebrafish

Lund, T. C., Patrinostro, X., Kramer, A. C., Stadem, P., Ann Higgins, L., Markowski, T. W., Wroblewski, M. S., Lidke, D. S., Tolar, J. & Blazar, B. R., Jan 1 2014, In : STEM CELLS. 32, 10, p. 2767-2779 13 p.

Research output: Contribution to journalArticle

5 Scopus citations
2015

Advances and challenges in immunotherapy for solid organ and hematopoietic stem cell transplantation

McDonald-Hyman, C., Turka, L. A. & Blazar, B. R., Mar 25 2015, In : Science Translational Medicine. 7, 280, 280rv2.

Research output: Contribution to journalReview article

54 Scopus citations
2011

Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice

Penaloza-MacMaster, P., Rasheed, A. U., Iyer, S. S., Yagita, H., Blazar, B. R. & Ahmed, R., Jul 1 2011, In : Journal of virology. 85, 13, p. 6168-6174 7 p.

Research output: Contribution to journalArticle

40 Scopus citations