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  • Stephen S Hecht

Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

Wang, Y., Wong, L. Y., Meng, L., Pittman, E. N., Trinidad, D. A., Hubbard, K. L., Etheredge, A., Del Valle-Pinero, A. Y., Zamoiski, R., van Bemmel, D. M., Borek, N., Patel, V., Kimmel, H. L., Conway, K. P., Lawrence, C., Edwards, K. C., Hyland, A., Goniewicz, M. L., Hatsukami, D., Hecht, S. S. & 1 others, Calafat, A. M., Feb 2019, In : Environment International. 123, p. 201-208 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Davidsen, J. M., Harman, C. L. & Taylor, S. V., Mar 2018, In : Food and Chemical Toxicology. 113, p. 171-178 8 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
Open Access
18 Scopus citations

Tobacco, e-cigarettes, and child health

Peterson, L. A. & Hecht, S. S., Apr 1 2017, In : Current Opinion in Pediatrics. 29, 2, p. 225-230 6 p.

Research output: Contribution to journalReview article

Open Access
16 Scopus citations

The safety evaluation of food flavouring substances: the role of metabolic studies

Smith, R. L., Cohen, S. M., Fukushima, S., Gooderham, N. J., Hecht, S. S., Guengerich, F. P., Rietjens, I. M. C. M., Bastaki, M., Harman, C. L., McGowen, M. M. & Taylor, S. V., 2018, In : Toxicology Research. 7, 4, p. 618-646 29 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

The safety evaluation of food flavoring substances: the role of genotoxicity studies

Gooderham, N. J., Cohen, S. M., Eisenbrand, G., Fukushima, S., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Rosol, T. J., Bastaki, M., Linman, M. J. & Taylor, S. V., Jan 2 2020, In : Critical Reviews in Toxicology. 50, 1, p. 1-27 27 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

The Impact of One-week Dietary Supplementation with Kava on Biomarkers of Tobacco Use and Nitrosamine-based Carcinogenesis Risk among Active Smokers

Wang, Y., Narayanapillai, S. C., Tessier, K. M., Strayer, L. G., Upadhyaya, P., Hu, Q., Kingston, R., Salloum, R. G., Lu, J., Hecht, S. S., Hatsukami, D. K., Fujioka, N. & Xing, C., May 1 2020, In : Cancer prevention research (Philadelphia, Pa.). 13, 5, p. 483-492 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Safety evaluation of substituted thiophenes used as flavoring ingredients

Cohen, S. M., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Smith, R. L., Bastaki, M., Harman, C. L., McGowen, M. M., Valerio, L. G. & Taylor, S. V., Jan 1 2017, In : Food and Chemical Toxicology. 99, p. 40-59 20 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations

Relationships between the nicotine metabolite ratio and a panel of exposure and effect biomarkers: Findings from two studies of U.S. commercial cigarette smokers

Carroll, D. M., Murphy, S. E., Benowitz, N. L., Strasser, A. A., Kotlyar, M., Hecht, S. S., Carmella, S. G., McClernon, F. J., Pacek, L. R., Dermody, S. S., Vandrey, R. G., Donny, E. C. & Hatsukami, D. K., 2020, In : Cancer Epidemiology Biomarkers and Prevention. 29, 4, p. 871-879 9 p.

Research output: Contribution to journalArticle

Open Access

Relationship of the oxidative damage biomarker 8-epiprostaglandin F to risk of lung cancer development in the Shanghai Cohort Study

Yuan, J. M., Carmella, S. G., Wang, R., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Jul 3 2018, In : Carcinogenesis. 39, 7, p. 948-954 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

Hatsukami, D. K., Luo, X., Dick, L., Kangkum, M., Allen, S. S., Murphy, S. E., Hecht, S. S., Shields, P. G. & al'Absi, M., Jan 1 2017, In : Addiction. 112, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Recent studies on DNA adducts resulting from human exposure to tobacco smoke

Ma, B., Stepanov, I. & Hecht, S. S., Jan 1 2019, In : Toxics. 7, 1, 16.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations

Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update

Stram, D. O., Park, S. L., Haiman, C. A., Murphy, S. E., Patel, Y., Hecht, S. S. & Le Marchand, L., Aug 1 2019, In : Journal of the National Cancer Institute. 111, 8, p. 811-819 9 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
1 Scopus citations
Open Access
8 Scopus citations

Prediagnostic levels of urinary 8-epi-prostaglandin F and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma

Yuan, J. M., Grouls, M., Carmella, S. G., Wang, R., Heskin, A., Jiang, Y., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Aug 22 2019, In : Carcinogenesis. 40, 8, p. 989-997 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Polycyclic Aromatic Hydrocarbon Biomarker Levels among Smokers who Switch to Oral Nicotine

Meier, E., Vogel, R. I., Carmella, S., Paiano, V., Hecht, S. & Hatsukami, D., Apr 1 2017, In : Tobacco Regulatory Science. 3, 2, p. 204-209

Research output: Contribution to journalArticle

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., 2017, In : Journal of medicinal chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Oral Health Effects of Combusted and Smokeless Tobacco Products

Tomar, S. L., Hecht, S. S., Jaspers, I., Gregory, R. L. & Stepanov, I., Oct 1 2019, In : Advances in dental research. 30, 1, p. 4-10 7 p.

Research output: Contribution to journalReview article

4 Scopus citations

Oral Dosing of Dihydromethysticin Ahead of Tobacco Carcinogen NNK Effectively Prevents Lung Tumorigenesis in A/J Mice

Hu, Q., Corral, P., Narayanapillai, S. C., Leitzman, P., Upadhyaya, P., O'sullivan, M. G., Hecht, S. S., Lu, J. & Xing, C., Jul 20 2020, In : Chemical research in toxicology. 33, 7, p. 1980-1988 9 p.

Research output: Contribution to journalArticle

Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers

Hecht, S. S., 2017, In : Chemical research in toxicology. 30, 1, p. 367-375 9 p.

Research output: Contribution to journalReview article

Open Access
20 Scopus citations

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

on behalf of program collaborators for ECHO, May 1 2020, In : Journal of Exposure Science and Environmental Epidemiology. 30, 3, p. 397-419 23 p.

Research output: Contribution to journalReview article

2 Scopus citations

Nasal cavity carcinogens: Possible routes of metabolic activation

Hecht, S. S., Castonguay, A. & Hoffmann, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 201-232 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations
Open Access
10 Scopus citations
1 Scopus citations
Open Access
1 Scopus citations

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. & Hecht, S. S., Jan 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
Open Access
9 Scopus citations
Open Access
7 Scopus citations
Open Access
Open Access
8 Scopus citations

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 2019, In : Food and Chemical Toxicology. 124, p. 192-218 27 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients

Rietjens, I. M. C. M., Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rosol, T. J., Davidsen, J. M., Harman, C. L., Murray, I. J. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110949.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110870.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Experimental nasal cavity tumors induced by tobacco-specific nitrosamines (TSNA)

Rivenson, A., Furuya, K., Hecht, S. S. & Hoffman, D., Jan 1 2017, Nasal Tumors in Animals and Man Volume III: Experimental Nasal Carcinogenesis. CRC Press, p. 79-114 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Oct 1 2019, In : Addiction. 114, 10, p. 1824-1833 10 p.

Research output: Contribution to journalArticle

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Nov 1 2018, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness

Tidey, J. W., Colby, S. M., Denlinger-Apte, R. L., Goodwin, C., Cioe, P. A., Cassidy, R. N., Swift, R. M., Lindgren, B. R., Rubin, N., Murphy, S. E., Hecht, S. S., Hatsukami, D. K. & Donny, E. C., Dec 23 2019, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 21, 1, p. S38-S45

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effects of 2-phenethyl isothiocyanate on metabolism of 1,3-butadiene in smokers

Boldry, E. J., Yuan, J. M., Carmella, S. G., Wang, R., Tessier, K., Hatsukami, D. K., Hecht, S. S. & Tretyakova, N. Y., Jan 1 2020, In : Cancer Prevention Research. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., Al'Absi, M., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J. S., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. G., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers

St.Helen, G., Benowitz, N. L., Ko, J., Jacob, P., Gregorich, S. E., Pérez-Stable, E. J., Murphy, S. E., Hecht, S. S., Hatsukami, D. K. & Donny, E. C., Jan 1 2019, In : Journal of Exposure Science and Environmental Epidemiology.

Research output: Contribution to journalArticle

1 Scopus citations

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Goniewicz, M. L., Smith, D. M., Edwards, K. C., Blount, B. C., Caldwell, K. L., Feng, J., Wang, L., Christensen, C., Ambrose, B., Borek, N., van Bemmel, D., Konkel, K., Erives, G., Stanton, C. A., Lambert, E., Kimmel, H. L., Hatsukami, D., Hecht, S. S., Niaura, R. S., Travers, M. & 2 others, Lawrence, C. & Hyland, A. J., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185937

Research output: Contribution to journalArticle

Open Access
68 Scopus citations

Cigarette Smokers Versus Cousers of Cannabis and Cigarettes: Exposure to Toxicants

Meier, E., Vandrey, R., Rubin, N., Pacek, L. R., Jensen, J. A., Donny, E. C., Hecht, S. S., Carmella, S. G., Murphy, S. E., Luo, X., Stepanov, I., Ikuemonisan, J., Severson, H., Al'absi, M. & Hatsukami, D. K., Jul 16 2020, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22, 8, p. 1383-1389 7 p.

Research output: Contribution to journalArticle