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  • David D Thomas
2016

A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles

McCaffrey, J. E., James, Z. M., Svensson, B., Binder, B. P. & Thomas, D. D., Jan 1 2016, In : Journal of Magnetic Resonance. 262, p. 50-56 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding

Avery, A. W., Crain, J., Thomas, D. D. & Hays, T. S., Feb 17 2016, In : Scientific reports. 6, 21375.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

A novel fluorescence resonance energy transfer-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters

Kraft, T. E., Heitmeier, M. R., Putanko, M., Edwards, R. L., Ilagan, M. X. G., Payne, M. A., Autry, J. M., Thomas, D. D., Odom, A. R. & Hruz, P. W., Dec 2016, In : Antimicrobial agents and chemotherapy. 60, 12, p. 7407-7414 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin

Her, C., McCaffrey, J. E., Thomas, D. D. & Karim, C. B., Dec 6 2016, In : Biophysical journal. 111, 11, p. 2387-2394 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Calcium stimulates self-assembly of protein kinase C α in vitro

Swanson, C. J., Sommese, R. F., Petersen, K. J., Ritt, M., Karslake, J., Thomas, D. D. & Sivaramakrishnan, S., Oct 2016, In : PloS one. 11, 10, e0162331.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles

Bian, T., Autry, J. M., Casemore, D., Li, J., Thomas, D. D., He, G. & Xing, C., Dec 9 2016, In : Biochemical and Biophysical Research Communications. 481, 3-4, p. 206-211 6 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Molecular modeling of fluorescent SERCA biosensors

Svensson, B., Autry, J. M. & Thomas, D. D., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 503-522 20 p. (Methods in Molecular Biology; vol. 1377).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Oxidation increases the strength of the methionine-aromatic interaction

Lewis, A. K., Dunleavy, K. M., Senkow, T. L., Her, C., Horn, B. T., Jersett, M. A., Mahling, R., McCarthy, M. R., Perell, G. T., Valley, C. C., Karim, C. B., Gao, J., Pomerantz, W. C. K., Thomas, D. D., Cembran, A., Hinderliter, A. & Sachs, J. N., Oct 1 2016, In : Nature Chemical Biology. 12, 10, p. 860-866 7 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptoro·calmodulin complex

Rebbeck, R. T., Nitu, F. R., Rohde, D., Most, P., Bers, D. M., Thomas, D. D. & Cornea, R. L., Jul 22 2016, In : Journal of Biological Chemistry. 291, 30, p. 15896-15907 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain

Autry, J. M., Thomas, D. D. & Espinoza-Fonseca, L. M., Nov 8 2016, In : Biochemistry. 55, 44, p. 6083-6086 4 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations
Open Access
20 Scopus citations
2017

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure

Guhathakurta, P., Prochniewicz, E., Roopnarine, O., Rohde, J. A. & Thomas, D. D., Jul 11 2017, In : Biophysical journal. 113, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

Lo, C. H., Vunnam, N., Lewis, A. K., Chiu, T. L., Brummel, B. E., Schaaf, T. M., Grant, B. D., Bawaskar, P., Thomas, D. D. & Sachs, J. N., Sep 1 2017, In : SLAS Discovery. 22, 8, p. 950-961 12 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
Open Access
23 Scopus citations

High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels

Rebbeck, R. T., Essawy, M. M., Nitu, F. R., Grant, B. D., Gillispie, G. D., Thomas, D. D., Bers, D. M. & Cornea, R. L., Jan 1 2017, In : SLAS Discovery. 22, 2, p. 176-186 11 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

High-Throughput spectral and lifetime-based FRET screening in living cells to identify small-molecule effectors of SERCA

Schaaf, T. M., Peterson, K. C., Grant, B. D., Bawaskar, P., Yuen, S., Li, J., Muretta, J. M., Gillispie, G. D. & Thomas, D. D., Jan 1 2017, In : SLAS Discovery. 22, 3, p. 262-273 12 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Phosphomimetic S3D cofilin binds but only weakly severs actin filaments

Austin Elam, W., Cao, W., Kang, H., Huehn, A., Hocky, G. M., Prochniewicz, E., Schramm, A. C., Negrón, K., Garcia, J., Bonello, T. T., Gunning, P. W., Thomas, D. D., Voth, G. A., Sindelar, C. V. & De La Cruz, E. M., Dec 1 2017, In : Journal of Biological Chemistry. 292, 48, p. 19565-19579 15 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor–Receptor Interactions

Vunnam, N., Lo, C. H., Grant, B. D., Thomas, D. D. & Sachs, J. N., Sep 15 2017, In : Journal of Molecular Biology. 429, 19, p. 2943-2953 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Spectral unmixing plate reader: High-throughput, high-precision FRET Assays in living cells

Schaaf, T. M., Peterson, K. C., Grant, B. D., Thomas, D. D. & Gillispie, G. D., Jan 1 2017, In : SLAS Discovery. 22, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

Avery, A. W., Fealey, M. E., Wang, F., Orlova, A., Thompson, A. R., Thomas, D. D., Hays, T. S. & Egelman, E. H., Dec 1 2017, In : Nature communications. 8, 1, 1350.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
Open Access
7 Scopus citations
2019

Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label

Binder, B. P., Thompson, A. R. & Thomas, D. D., Jul 23 2019, In : Biophysical journal. 117, 2, p. 319-330 12 p.

Research output: Contribution to journalArticle

Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis

Valberg, S. J., Soave, K., Williams, Z. J., Perumbakkam, S., Schott, M., Finno, C. J., Petersen, J. L., Fenger, C., Autry, J. M. & Thomas, D. D., Mar 1 2019, In : Journal of veterinary internal medicine. 33, 2, p. 933-941 9 p.

Research output: Contribution to journalArticle

Open Access

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C. M., Feb 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels

Savich, Y., Binder, B. P., Thompson, A. R. & Thomas, D. D., Aug 5 2019, In : Journal of General Physiology. 151, 8, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C. C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.

Research output: Contribution to journalArticle

4 Scopus citations

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Lo, C. H., Lim, C. K. W., Ding, Z., Wickramasinghe, S. P., Braun, A. R., Ashe, K. H., Rhoades, E., Thomas, D. D. & Sachs, J. N., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1489-1502 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Trajectory-Based Simulation of EPR Spectra: Models of Rotational Motion for Spin Labels on Proteins

Martin, P. D., Svensson, B., Thomas, D. D. & Stoll, S., Dec 5 2019, In : Journal of Physical Chemistry B. 123, 48, p. 10131-10141 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2020

Mechanical factors tune the sensitivity of mdx muscle to eccentric strength loss and its protection by antioxidant and calcium modulators

Lindsay, A., Baumann, C. W., Rebbeck, R. T., Yuen, S. L., Southern, W. M., Hodges, J. S., Cornea, R. L., Thomas, D. D., Ervasti, J. M. & Lowe, D. A., Feb 1 2020, In : Skeletal Muscle. 10, 1, 3.

Research output: Contribution to journalArticle

Open Access

Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A

Olivieri, C., Wang, Y., Li, G. C., Subrahmanian, M. V., Kim, J., Stultz, B. R., Neibergall, M., Porcelli, F., Muretta, J. M., Thomas, D. D., Gao, J., Blumenthal, D. K., Taylor, S. S. & Veglia, G., Apr 2020, In : eLife. 9, e55607.

Research output: Contribution to journalArticle

Open Access

Resolved Structural States of Calmodulin in Regulation of Skeletal Muscle Calcium Release

McCarthy, M. R., Savich, Y., Cornea, R. L. & Thomas, D. D., Mar 10 2020, In : Biophysical journal. 118, 5, p. 1090-1100 11 p.

Research output: Contribution to journalArticle

RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays

Rebbeck, R. T., Singh, D. P., Janicek, K. A., Bers, D. M., Thomas, D. D., Launikonis, B. S. & Cornea, R. L., Dec 1 2020, In : Scientific reports. 10, 1, 1791.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2 Scopus citations