Find Research Outputs

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Bruce R Blazar
2016

Adaptive NK cells with low TIGIT expression are inherently resistant to myeloid-derived suppressor cells

Sarhan, D., Cichocki, F., Zhang, B., Yingst, A., Spellman, S. R., Cooley, S., Verneris, M. R., Blazar, B. R. & Miller, J. S., Oct 1 2016, In : Cancer Research. 76, 19, p. 5696-5706 11 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations

Autophagy-dependent regulatory T cells are critical for the control of graft-versus-host disease

Le Texier, L., Lineburg, K. E., Cao, B., McDonald-Hyman, C., Leveque-El Mouttie, L., Nicholls, J., Melino, M., Nalkurthi, B. C., Alexander, K. A., Teal, B., Blake, S. J., Souza-Fonseca-Guimaraes, F., Engwerda, C. R., Kuns, R. D., Lane, S. W., Teng, M., Teh, C., Gray, D., Clouston, A. D., Nilsson, S. K. & 3 others, Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Sep 22 2016, In : JCI insight. 1, 15, p. e86850

Research output: Contribution to journalArticle

Caveolin-1 regulates TCR signal strength and regulatory T-cell differentiation into alloreactive T cells

Schönle, A., Hartl, F. A., Mentzel, J., Nöltner, T., Rauch, K. S., Prestipino, A., Wohlfeil, S. A., Apostolova, P., Hechinger, A. K., Melchinger, W., Fehrenbach, K., Guadamillas, M. C., Follo, M., Prinz, G., Ruess, A. K., Pfeifer, D., Del Pozo, M. A., Schmitt-Graeff, A., Duyster, J., Hippen, K. I. & 4 others, Blazar, B. R., Schachtrup, K., Minguet, S. & Zeiser, R., Apr 14 2016, In : Blood. 127, 15, p. 1930-1939 10 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

CD56 dim CD57+ NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT

Cichocki, F., Cooley, S., Davis, Z., DeFor, T. E., Schlums, H., Zhang, B., Brunstein, C. G., Blazar, B. R., Wagner, J., Diamond, D. J., Verneris, M. R., Bryceson, Y. T., Weisdorf, D. J. & Miller, J. S., Feb 1 2016, In : Leukemia. 30, 2, p. 456-463 8 p.

Research output: Contribution to journalArticle

94 Scopus citations

Circulating T follicular helper cells with increased function during chronic graft-versus-host disease

Forcade, E., Kim, H. T., Cutler, C., Wang, K., Alho, A. C., Nikiforow, S., Ho, V. T., Koreth, J., Armand, P., Alyea, E. P., Blazar, B. R., Soiffer, R. J., Antin, J. H. & Ritz, J., May 19 2016, In : Blood. 127, 20, p. 2489-2497 9 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Corruption of dendritic cell antigen presentation during acute GVHD leads to regulatory T-cell failure and chronic GVHD

Leveque-El Mouttie, L., Koyama, M., Le Texier, L., Markey, K. A., Cheong, M., Kuns, R. D., Lineburg, K. E., Teal, B. E., Alexander, K. A., Clouston, A. D., Blazar, B. R., Hill, G. R. & MacDonald, K. P. A., Aug 11 2016, In : Blood. 128, 6, p. 794-804 11 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations
Open Access
14 Scopus citations

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

Koreth, J., Kim, H. T., Jones, K. T., Lange, P. B., Reynolds, C. G., Chammas, M. J., Dusenbury, K., Whangbo, J., Nikiforow, S., Alyea, E. P., Armand, P., Cutler, C. S., Ho, V. T., Chen, Y. B., Avigan, D., Blazar, B. R., Antin, J. H., Ritz, J. & Soiffer, R. J., Jul 7 2016, In : Blood. 128, 1, p. 130-137 8 p.

Research output: Contribution to journalArticle

Open Access
73 Scopus citations
Open Access

Evaluation of innate and adaptive immunity contributing to the antitumor effects of PD1 blockade in an orthotopic murine model of pancreatic cancer

D'Alincourt Salazar, M., Manuel, E. R., Tsai, W., D'Apuzzo, M., Goldstein, L., Blazar, B. R. & Diamond, D. J., Jun 2 2016, In : OncoImmunology. 5, 6, e1160184.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Evaluation of TCR gene editing achieved by TALENs, CRISPR/Cas9, and megaTAL nucleases

Osborn, M. J., Webber, B. R., Knipping, F., Lonetree, C. L., Tennis, N., DeFeo, A. P., McElroy, A. N., Starker, C. G., Lee, C., Merkel, S., Lund, T. C., Kelly-Spratt, K. S., Jensen, M. C., Voytas, D. F., Von Kalle, C., Schmidt, M., Gabriel, R., Hippen, K. L., Miller, J. S., Scharenberg, A. M. & 2 others, Tolar, J. & Blazar, B. R., Mar 1 2016, In : Molecular Therapy. 24, 3, p. 570-581 12 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

Graft Versus Host Disease after Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management

Murali, A. R., Chandra, S., Stewart, Z., Blazar, B. R., Farooq, U., Ince, M. N. & Dunkelberg, J., Dec 1 2016, In : Transplantation. 100, 12, p. 2661-2670 10 p.

Research output: Contribution to journalArticle

19 Scopus citations
Open Access
88 Scopus citations

IL-7 signaling imparts polyfunctionality and stemness potential to CD4+ T cells

Ding, Z. C., Liu, C., Cao, Y., Habtetsion, T., Kuczma, M., Pi, W., Kong, H., Cacan, E., Greer, S. F., Cui, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Jun 2 2016, In : OncoImmunology. 5, 6, e1171445.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
Open Access
21 Scopus citations

Improved graft-versus-host disease-free, relapse-free survival associated with bone marrow as the stem cell source in adults

Mehta, R. S., de Latour, R. P., DeFor, T. E., Robin, M., Lazaryan, A., Xhaard, A., Bejanyan, N., de Fontbrune, F. S., Arora, M., Brunstein, C. G., Blazar, B. R., Weisdorf, D. J., MacMillan, M. L., Socie, G. & Holtan, S. G., May 31 2016, In : Haematologica. 101, 6, p. 764-772 9 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

Increasing Regulatory T Cells With Interleukin-2 and Interleukin-2 Antibody Complexes Attenuates Lung Inflammation and Heart Failure Progression

Wang, H., Hou, L., Kwak, D., Fassett, J., Xu, X., Chen, A., Chen, W., Blazar, B. R., Xu, Y., Hall, J. L., Ge, J. B., Bache, R. J. & Chen, Y., Jul 1 2016, In : Hypertension. 68, 1, p. 114-122 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Isoform-specific targeting of ROCK proteins in immune cells

Zanin-Zhorov, A., Flynn, R., Waksal, S. D. & Blazar, B. R., Jul 2 2016, In : Small GTPases. 7, 3, p. 173-177 5 p.

Research output: Contribution to journalComment/debate

Open Access
9 Scopus citations
Open Access
10 Scopus citations
Open Access
6 Scopus citations

Low-dose IL-2 selectively activates subsets of CD4+ Tregs and NK cells

Hirakawa, M., Matos, T. R., Liu, H., Koreth, J., Kim, H. T., Paul, N. E., Murase, K., Whangbo, J., Alho, A. C., Nikiforow, S., Cutler, C., Ho, V. T., Armand, P., Alyea, E. P., Antin, J. H., Blazar, B. R., Lacerda, J. F., Soiffer, R. J. & Ritz, J., Nov 3 2016, In : JCI insight. 1, 18, p. e89278

Research output: Contribution to journalArticle

MiR-146b antagomir-treated human Tregs acquire increased GVHD inhibitory potency

Lu, Y., Hippen, K. L., Lemire, A. L., Gu, J., Wang, W., Ni, X., Ranganathan, P., Levine, B. L., Riley, J. L., June, C. H., Turka, L. A., Munn, D. H., Garzon, R., Lu, L. & Blazar, B. R., Sep 8 2016, In : Blood. 128, 10, p. 1424-1435 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Modulation of immune checkpoints and graft-versus-leukemia in allogeneic transplants by antagonizing vasoactive intestinal peptide signaling

Li, J. M., Petersen, C. T., Li, J. X., Panjwani, R., Chandra, D. J., Giver, C. R., Blazar, B. R. & Waller, E. K., Dec 1 2016, In : Cancer Research. 76, 23, p. 6802-6815 14 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant

Andersen, B. M., Xia, J., Epstein, A. L., Ohlfest, J. R., Chen, W., Blazar, B. R., Pennell, C. A. & Olin, M. R., Feb 16 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 11.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Pathogenesis of acute graft-versus-host disease: from intestinal microbiota alterations to donor T cell activation

Zeiser, R., Socié, G. & Blazar, B. R., Oct 1 2016, In : British journal of haematology. 175, 2, p. 191-207 17 p.

Research output: Contribution to journalReview article

37 Scopus citations

Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD

Matta, B. M., Reichenbach, D. K., Zhang, X., Mathews, L., Koehn, B. H., Dwyer, G. K., Lott, J. M., Uhl, F. M., Pfeifer, D., Feser, C. J., Smith, M. J., Liu, Q., Zeiser, R., Blazar, B. R. & Turnquist, H. R., Jul 21 2016, In : Blood. 128, 3, p. 427-439 13 p.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations

Phase I/II Trial of StemRegenin-1 Expanded Umbilical Cord Blood Hematopoietic Stem Cells Supports Testing as a Stand-Alone Graft

Wagner, J. E., Brunstein, C. G., Boitano, A. E., Defor, T. E., McKenna, D., Sumstad, D., Blazar, B. R., Tolar, J., Le, C., Jones, J., Cooke, M. P. & Bleul, C. C., Jan 7 2016, In : Cell Stem Cell. 18, 1, p. 144-155 12 p.

Research output: Contribution to journalArticle

Open Access
131 Scopus citations

Preclinical models of acute and chronic graft-versus-host disease: How predictive are they for a successful clinical translation?

Zeiser, R. & Blazar, B. R., Jun 23 2016, In : Blood. 127, 25, p. 3117-3126 10 p.

Research output: Contribution to journalReview article

Open Access
31 Scopus citations

Preclinical Testing of Antihuman CD28 Fab′ Antibody in a Novel Nonhuman Primate Small Animal Rodent Model of Xenogenic Graft-Versus-Host Disease

Hippen, K. L., Watkins, B., Tkachev, V., Lemire, A. M., Lehnen, C., Riddle, M. J., Singh, K., Panoskaltsis-Mortari, A., Vanhove, B., Tolar, J., Kean, L. S. & Blazar, B. R., Dec 1 2016, In : Transplantation. 100, 12, p. 2630-2639 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

Saha, A., O'Connor, R. S., Thangavelu, G., Lovitch, S. B., Dandamudi, D. B., Wilson, C. B., Vincent, B. G., Tkachev, V., Pawlicki, J. M., Furlan, S. N., Kean, L. S., Aoyama, K., Taylor, P. A., Panoskaltsis-Mortari, A., Foncea, R., Ranganathan, P., Devine, S. M., Burrill, J. S., Guo, L., Sacristan, C. & 15 others, Snyder, N. W., Blair, I. A., Milone, M. C., Dustin, M. L., Riley, J. L., Bernlohr, D. A., Murphy, W. J., Fife, B. T., Munn, D. H., Miller, J. S., Serody, J. S., Freeman, G. J., Sharpe, A. H., Turka, L. A. & Blazar, B. R., Jul 1 2016, In : Journal of Clinical Investigation. 126, 7, p. 2642-2660 19 p.

Research output: Contribution to journalArticle

40 Scopus citations

Programming of donor T cells using allogeneic δ-like ligand 4-positive dendritic cells to reduce GVHD in mice

Mochizuki, K., Meng, L., Mochizuki, I., Tong, Q., He, S., Liu, Y., Purushe, J., Fung, H., Zaidi, M. R., Zhang, Y., Reshef, R., Blazar, B. R., Yagita, H., Mineishi, S. & Zhang, Y., Jun 23 2016, In : Blood. 127, 25, p. 3270-3280 11 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Proteomics analysis reveals a Th17-prone cell population in presymptomatic graft-versus-host disease

Li, W., Liu, L., Gomez, A., Zhang, J., Ramadan, A., Zhang, Q., Choi, S. W., Zhang, P., Greenson, J. K., Liu, C., Jiang, D., Virts, E., Kelich, S. L., Chu, H. W., Flynn, R., Blazar, B. R., Hanenberg, H., Hanash, S. & Paczesny, S., May 5 2016, In : JCI insight. 1, 6

Research output: Contribution to journalArticle

Open Access

Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival

Borges, C. M., Reichenbach, D. K., Kim, B. S., Misra, A., Blazar, B. R. & Turka, L. A., Aug 1 2016, In : Transplant International. 29, 8, p. 930-940 11 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Repeated PD-1/PD-L1 monoclonal antibody administration induces fatal xenogeneic hypersensitivity reactions in a murine model of breast cancer

Mall, C., Sckisel, G. D., Proia, D. A., Mirsoian, A., Grossenbacher, S. K., Pai, C. C. S., Chen, M., Monjazeb, A. M., Kelly, K., Blazar, B. R. & Murphy, W. J., Feb 1 2016, In : OncoImmunology. 5, 2

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Reply

Ince, M. N., Blazar, B. R., Edmond, M. B., Tricot, G. & Wannemuehler, M. J., May 31 2016, In : Inflammatory bowel diseases. 22, 8, p. E27-E28

Research output: Contribution to journalLetter

Open Access
Open Access
31 Scopus citations

ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Weiss, J. M., Chen, W., Nyuydzefe, M. S., Trzeciak, A., Flynn, R., Tonra, J. R., Marusic, S., Blazar, B. R., Waksal, S. D. & Alexandra, Z. Z., Jul 19 2016, In : Science signaling. 9, 437, ra73.

Research output: Contribution to journalArticle

20 Scopus citations
Open Access
6 Scopus citations

Systems analysis uncovers inflammatory Th/Tc17-driven modules during acute GVHD in monkey and human T cells

Furlan, S. N., Watkins, B., Tkachev, V., Cooley, S., Panoskaltsis-Mortari, A., Betz, K., Brown, M., Hunt, D. J., Schell, J. B., Zeleski, K., Yu, A., Giver, C. R., Waller, E. K., Miller, J. S., Blazar, B. R. & Kean, L. S., Nov 24 2016, In : Blood. 128, 21, p. 2568-2579 12 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Targeted Rho-associated kinase 2 inhibition suppresses murine and human chronic GVHD through a Stat3-dependent mechanism

Flynn, R., Paz, K., Du, J., Reichenbach, D. K., Taylor, P. A., Panoskaltsis-Mortari, A., Vulic, A., Luznik, L., MacDonald, K. K. P., Hill, G. R., Nyuydzefe, M. S., Weiss, J. M., Chen, W., Trzeciak, A., Serody, J. S., Aguilar, E. G., Murphy, W. J., Maillard, I., Munn, D., Koreth, J. & 6 others, Cutler, C. S., Antin, J. H., Ritz, J., Waksal, S. D., Zanin-Zhorov, A. & Blazar, B. R., Apr 28 2016, In : Blood. 127, 17, p. 2144-2154 11 p.

Research output: Contribution to journalArticle

Open Access
42 Scopus citations
Open Access
17 Scopus citations

Therapeutic regulatory T-cell adoptive transfer ameliorates established murine chronic GVHD in a CXCR5-dependent manner

McDonald-Hyman, C., Flynn, R., Panoskaltsis-Mortari, A., Peterson, N., MacDonald, K. P. A., Hill, G. R., Luznik, L., Serody, J. S., Murphy, W. J., Maillard, I., Munn, D. H., Turka, L. A., Koreth, J., Cutler, C. S., Soiffer, R. J., Antin, J. H., Ritz, J. & Blazar, B. R., Aug 18 2016, In : Blood. 128, 7, p. 1013-1017 5 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Brinkman, C. C., Iwami, D., Hritzo, M. K., Xiong, Y., Ahmad, S., Simon, T., Hippen, K. L., Blazar, B. R. & Bromberg, J. S., Jun 21 2016, In : Nature communications. 7, 12021.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Umbilical cord blood-derived T regulatory cells to prevent GVHD: Kinetics, toxicity profile, and clinical effect

Brunstein, C. G., Miller, J. S., McKenna, D. H., Hippen, K. L., DeFor, T. E., Sumstad, D., Curtsinger, J., Verneris, M. R., MacMillan, M. L., Levine, B. L., Riley, J. L., June, C. H., Le, C., Weisdorf, D. J., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Feb 25 2016, In : Blood. 127, 8, p. 1044-1051 8 p.

Research output: Contribution to journalArticle

Open Access
157 Scopus citations

Understanding Luminal Microorganisms and Their Potential Effectiveness in Treating Intestinal Inflammation

Ince, M. N., Blazar, B. R., Edmond, M. B., Tricot, G. & Wannemuehler, M. J., Jan 1 2016, In : Inflammatory bowel diseases. 22, 1, p. 194-201 8 p.

Research output: Contribution to journalReview article

Open Access
7 Scopus citations
2017

Acute graft-versus-host disease - Biologic process, prevention, and therapy

Zeiser, R. & Blazar, B. R., Nov 30 2017, In : New England Journal of Medicine. 377, 22, p. 2167-2179 13 p.

Research output: Contribution to journalReview article

Open Access
149 Scopus citations

Acute graft-versus-host disease is regulated by an IL-17–sensitive microbiome

Varelias, A., Ormerod, K. L., Bunting, M. D., Koyama, M., Gartlan, K. H., Kuns, R. D., Lachner, N., Locke, K. R., Lim, C. Y., Henden, A. S., Zhang, P., Clouston, A. D., Hasnain, S. Z., McGuckin, M. A., Blazar, B. R., MacDonald, K. P. A., Hugenholtz, P. & Hill, G. R., Apr 13 2017, In : Blood. 129, 15, p. 2172-2185 14 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations

Advances in targeting co-inhibitory and co-stimulatory pathways in transplantation settings: the Yin to the Yang of cancer immunotherapy

Kean, L. S., Turka, L. A. & Blazar, B. R., Mar 1 2017, In : Immunological Reviews. 276, 1, p. 192-212 21 p.

Research output: Contribution to journalReview article

Open Access
21 Scopus citations

A Functional Bioluminescent Zebrafish Screen for Enhancing Hematopoietic Cell Homing

Astuti, Y., Kramer, A. C., Blake, A. L., Blazar, B. R., Tolar, J., Taisto, M. E. & Lund, T. C., Jan 10 2017, In : Stem Cell Reports. 8, 1, p. 177-190 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations