Find Research Outputs

Search in all content

Filters for Research Output

Search concepts
Selected Filters

Publication Year

  • 2020
  • 2019
  • 2018
  • 2017
  • 2016

Author

  • Stephen S Hecht
Article
Open Access
13 Scopus citations

Acrolein exposure in hookah smokers and non-smokers exposed to hookah tobacco secondhand smoke: Implications for regulating hookah tobacco products

Kassem, N. O. F., Kassem, N. O., Liles, S., Zarth, A. T., Jackson, S. R., Daffa, R. M., Chatfield, D. A., Carmella, S. G., Hecht, S. S. & Hovell, M. F., Mar 6 2018, In : Nicotine and Tobacco Research. 20, 4, p. 492-501 10 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

A general method for detecting nitrosamide formation in the in vitro metabolism of nitrosamines by cytochrome P450s

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Sep 25 2017, In : Journal of Visualized Experiments. 2017, 127, e56312.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
8 Scopus citations
Open Access
8 Scopus citations
Open Access
2 Scopus citations
Open Access
10 Scopus citations

A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure

Meier, E., Lindgren, B. R., Anderson, A., Reisinger, S. A., Norton, K. J., Jensen, J., Strayer, L., Dick, L., Tang, M. K., Chen, M., Carmella, S. G., Hecht, S. S., Murphy, S. E., Yang, J., Stepanov, I., O'Connor, R. J., Shields, P. G. & Hatsukami, D. K., Apr 17 2020, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 22, 4, p. 473-481 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

A randomized controlled trial of progressively reduced nicotine content cigarettes on smoking behaviors, biomarkers of exposure, and subjective ratings

Mercincavage, M., Souprountchouk, V., Tang, K. Z., Dumont, R. L., Wileyto, E. P., Carmella, S. G., Hecht, S. S. & Strasser, A. A., Jul 2016, In : Cancer Epidemiology Biomarkers and Prevention. 25, 7, p. 1125-1133 9 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Association of CYP2A6 activity with lung cancer incidence in smokers: The Multiethnic Cohort Study

Park, S. L., Murphy, S. E., Wilkens, L. R., Stram, D. O., Hecht, S. S. & Le Marchand, L., May 2017, In : PloS one. 12, 5, e0178435.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Benzene uptake and glutathione S-transferase T1 status as determinants of S-phenylmercapturic acid in cigarette smokers in the multiethnic cohort

Haiman, C. A., Patel, Y. M., Stram, D. O., Carmella, S. G., Chen, M., Wilkens, L. R., Le Marchand, L. & Hecht, S. S., Mar 2016, In : PloS one. 11, 3, e0150641.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Biomarkers of exposure to new and emerging tobacco delivery products

Schick, S. F., Blount, B. C., Jacob, P., Saliba, N. A., Bernert, J. T., El Hellani, A., Jatlow, P., Pappas, R. S., Wang, L., Foulds, J., Ghosh, A., Hecht, S. S., Gomez, J. C., Martin, J. R., Mesaros, C., Srivastava, S., St. Helen, G., Tarran, R., Lorkiewicz, P. K., Blair, I. A. & 4 others, Kimmel, H. L., Doerschuk, C. M., Benowitz, N. L. & Bhatnagar, A., Sep 2017, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 313, 3, p. L425-L452

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Clinical trial of 2-phenethyl isothiocyanate as an inhibitor of metabolic activation of a tobacco-specific lung carcinogen in cigarette smokers

Yuan, J. M., Stepanov, I., Murphy, S. E., Wang, R., Allen, S., Jensen, J., Strayer, L., Adams-Haduch, J., Upadhyaya, P., Le, C., Kurzer, M. S., Nelson, H. H., Yu, M. C., Hatsukami, D. & Hecht, S. S., May 2016, In : Cancer Prevention Research. 9, 5, p. 396-405 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

Goniewicz, M. L., Smith, D. M., Edwards, K. C., Blount, B. C., Caldwell, K. L., Feng, J., Wang, L., Christensen, C., Ambrose, B., Borek, N., van Bemmel, D., Konkel, K., Erives, G., Stanton, C. A., Lambert, E., Kimmel, H. L., Hatsukami, D., Hecht, S. S., Niaura, R. S., Travers, M. & 2 others, Lawrence, C. & Hyland, A. J., Dec 7 2018, In : JAMA Network Open. 1, 8, p. e185937

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Yuan, J. M., Nelson, H. H., Carmella, S. G., Wang, R., Kuriger-Laber, J., Jin, A., Adams-Haduch, J., Hecht, S. S., Koh, W. P. & Murphy, S. E., Jan 1 2017, In : Carcinogenesis. 38, 4, p. 411-418 8 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Dietary consumption of black raspberries or their anthocyanin constituents alters innate immune cell trafficking in esophageal cancer

Peiffer, D. S., Wang, L. S., Zimmerman, N. P., Ransom, B. W. S., Carmella, S. G., Kuo, C. T., Chen, J. H., Oshima, K., Huang, Y. W., Hecht, S. S. & Stoner, G. D., Jan 2016, In : Cancer Immunology Research. 4, 1, p. 72-82 11 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations

Dietary Dihydromethysticin Increases Glucuronidation of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in A/J Mice, Potentially Enhancing Its Detoxification

Narayanapillai, S. C., Von Weymarn, L. B., Carmella, S. G., Leitzman, P., Paladino, J., Upadhyaya, P., Hecht, S. S., Murphy, S. E. & Xing, C., Mar 1 2016, In : Drug Metabolism and Disposition. 44, 3, p. 422-427 6 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers

St.Helen, G., Benowitz, N. L., Ko, J., Jacob, P., Gregorich, S. E., Pérez-Stable, E. J., Murphy, S. E., Hecht, S. S., Hatsukami, D. K. & Donny, E. C., Jan 1 2019, In : Journal of Exposure Science and Environmental Epidemiology.

Research output: Contribution to journalArticle

1 Scopus citations

DNA Adduct Formation from Metabolic 5′-Hydroxylation of the Tobacco-Specific Carcinogen N′-Nitrosonornicotine in Human Enzyme Systems and in Rats

Zarth, A. T., Upadhyaya, P., Yang, J. & Hecht, S. S., Mar 21 2016, In : Chemical research in toxicology. 29, 3, p. 380-389 10 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China

Chen, J. G., Johnson, J., Egner, P., Ng, D., Zhu, J., Wang, J. B., Xue, X. F., Sun, Y., Zhang, Y. H., Lu, L. L., Chen, Y. S., Wu, Y., Zhu, Y. R., Carmella, S., Hecht, S., Jacobson, L., Muñoz, A., Kensler, K., Rule, A., Fahey, J. & 2 others, Kensler, T. & Groopman, J., Sep 1 2019, In : American Journal of Clinical Nutrition. 110, 3, p. 675-684 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Hatsukami, D. K., Luo, X., Jensen, J. A., Al'Absi, M., Allen, S. S., Carmella, S. G., Chen, M., Cinciripini, P. M., Denlinger-Apte, R., Drobes, D. J., Koopmeiners, J. S., Lane, T., Le, C. T., Leischow, S., Luo, K., Joseph McClernon, F., Murphy, S. E., Paiano, V., Robinson, J. D., Severson, H. & 8 others, Sipe, C., Strasser, A. A., Strayer, L. G., Tang, M. K., Vandrey, R., Hecht, S. S., Benowitz, N. L. & Donny, E. C., Sep 4 2018, In : JAMA - Journal of the American Medical Association. 320, 9, p. 880-891 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Effects of 2-phenethyl isothiocyanate on metabolism of 1,3-butadiene in smokers

Boldry, E. J., Yuan, J. M., Carmella, S. G., Wang, R., Tessier, K., Hatsukami, D. K., Hecht, S. S. & Tretyakova, N. Y., Jan 1 2020, In : Cancer Prevention Research. 13, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness

Tidey, J. W., Colby, S. M., Denlinger-Apte, R. L., Goodwin, C., Cioe, P. A., Cassidy, R. N., Swift, R. M., Lindgren, B. R., Rubin, N., Murphy, S. E., Hecht, S. S., Hatsukami, D. K. & Donny, E. C., Dec 23 2019, In : Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 21, 1, p. S38-S45

Research output: Contribution to journalArticle

Open Access

Effects of cessation of cigarette smoking on eicosanoid biomarkers of inflammation and oxidative damage

McElroy, J. P., Carmella, S. G., Heskin, A. K., Tang, M. K., Murphy, S. E., Reisinger, S. A., Jensen, J. A., Hatsukami, D. K., Hecht, S. S. & Shields, P. G., Jan 1 2019, In : PloS one. 14, 6, e0218386.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects

Hatsukami, D. K., Luo, X., Heskin, A. K., Tang, M. K., Carmella, S. G., Jensen, J., Robinson, J. D., Vandrey, R., Drobes, D. J., Strasser, A. A., al'Absi, M., Leischow, S., Cinciripini, P. M., Koopmeiners, J., Ikuemonisan, J., Benowitz, N. L., Donny, E. C. & Hecht, S. S., Oct 1 2019, In : Addiction. 114, 10, p. 1824-1833 10 p.

Research output: Contribution to journalArticle

Evaluation of Nitrosamide Formation in the Cytochrome P450-Mediated Metabolism of Tobacco-Specific Nitrosamines

Carlson, E. S., Upadhyaya, P. & Hecht, S. S., Dec 19 2016, In : Chemical research in toxicology. 29, 12, p. 2194-2205 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
Open Access
50 Scopus citations

FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients

Rietjens, I. M. C. M., Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rosol, T. J., Davidsen, J. M., Harman, C. L., Murray, I. J. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110949.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. M. & Taylor, S. V., Jan 2020, In : Food and Chemical Toxicology. 135, 110870.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients

Cohen, S. M., Eisenbrand, G., Fukushima, S., Gooderham, N. J., Guengerich, F. P., Hecht, S. S., Rietjens, I. M. C. M., Bastaki, M., Davidsen, J. M., Harman, C. L., McGowen, M. & Taylor, S. V., Feb 2019, In : Food and Chemical Toxicology. 124, p. 192-218 27 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
19 Scopus citations

Harnessing the power of cruciferous vegetables: Developing a biomarker for brassica vegetable consumption using urinary 3,3'-diindolylmethane

Fujioka, N., Ransom, B. W., Carmella, S. G., Upadhyaya, P., Lindgren, B. R., Roper-Batker, A., Hatsukami, D. K., Fritz, V. A., Rohwer, C. & Hecht, S. S., Oct 2016, In : Cancer Prevention Research. 9, 10, p. 788-793 6 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
Open Access
8 Scopus citations
Open Access
Open Access
7 Scopus citations
Open Access
9 Scopus citations
Open Access

Longitudinal stability in cigarette smokers of urinary biomarkers of exposure to the toxicants acrylonitrile and acrolein

Chen, M., Carmella, S. G., Sipe, C., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. & Hecht, S. S., Jan 2019, In : PloS one. 14, 1, e0210104.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Longitudinal stability in cigarette smokers of urinary eicosanoid biomarkers of oxidative damage and inflammation

Carmella, S. G., Heskin, A. K., Tang, M. K., Jensen, J., Luo, X., Le, C. T., Murphy, S. E., Benowitz, N. L., Joseph McClernon, F., Vandrey, R., Allen, S. S., Denlinger-Apte, R., Cinciripini, P. M., Strasser, A. A., Al’Absi, M., Robinson, J. D., Donny, E. C., Hatsukami, D. K. & Hecht, S. S., Apr 2019, In : PloS one. 14, 4, e0215853.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Mass Spectrometric Quantitation of Pyridyloxobutyl DNA Phosphate Adducts in Rats Chronically Treated with N′-Nitrosonornicotine

Li, Y., Ma, B., Cao, Q., Balbo, S., Zhao, L., Upadhyaya, P. & Hecht, S. S., Apr 15 2019, In : Chemical research in toxicology. 32, 4, p. 773-783 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Metabolites of the polycyclic aromatic hydrocarbon phenanthrene in the urine of cigarette smokers from five ethnic groups with differing risks for lung cancer

Patel, Y. M., Park, S. L., Carmella, S. G., Paiano, V., Olvera, N., Stram, D. O., Haiman, C. A., Le Marchand, L. & Hecht, S. S., Jun 1 2016, In : PloS one. 11, 6, e0156203.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
Open Access
1 Scopus citations
1 Scopus citations
Open Access
10 Scopus citations

Pilot in Vivo Structure-Activity Relationship of Dihydromethysticin in Blocking 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone-Induced O6-Methylguanine and Lung Tumor in A/J Mice

Puppala, M., Narayanapillai, S. C., Leitzman, P., Sun, H., Upadhyaya, P., O'Sullivan, M. G., Hecht, S. S. & Xing, C., Jan 1 2017, In : Journal of medicinal chemistry. 60, 18, p. 7935-7940 6 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Polycyclic Aromatic Hydrocarbon Biomarker Levels among Smokers who Switch to Oral Nicotine

Meier, E., Vogel, R. I., Carmella, S., Paiano, V., Hecht, S. & Hatsukami, D., Apr 1 2017, In : Tobacco Regulatory Science. 3, 2, p. 204-209

Research output: Contribution to journalArticle

Prediagnostic levels of urinary 8-epi-prostaglandin F and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma

Yuan, J. M., Grouls, M., Carmella, S. G., Wang, R., Heskin, A., Jiang, Y., Tan, Y. T., Adams-Haduch, J., Gao, Y. T. & Hecht, S. S., Aug 22 2019, In : Carcinogenesis. 40, 8, p. 989-997 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
Open Access
8 Scopus citations