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  • David D Thomas

A bifunctional spin label reports the structural topology of phospholamban in magnetically-aligned bicelles

McCaffrey, J. E., James, Z. M., Svensson, B., Binder, B. P. & Thomas, D. D., Jan 1 2016, In : Journal of Magnetic Resonance. 262, p. 50-56 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure

Guhathakurta, P., Prochniewicz, E., Roopnarine, O., Rohde, J. A. & Thomas, D. D., Jul 11 2017, In : Biophysical journal. 113, 1, p. 91-100 10 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Actin-myosin interaction: Structure, function and drug discovery

Guhathakurta, P., Prochniewicz, E. & Thomas, D. D., Sep 5 2018, In : International journal of molecular sciences. 19, 9, 2628.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

A dynamic mechanism for allosteric activation of aurora kinase a by activation loop phosphorylation

Ruff, E. F., Muretta, J. M., Thompson, A. R., Lake, E. W., Cyphers, S., Albanese, S. K., Hanson, S. M., Behr, J. M., Thomas, D. D., Chodera, J. D. & Levinson, N. M., Feb 21 2018, In : eLife. 7, e32766.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice

Phung, L. A., Karvinen, S. M., Colson, B. A., Thomas, D. D. & Lowe, D. A., Sep 2018, In : PloS one. 13, 9, e0199062.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A human β-III-spectrin spinocerebellar ataxia type 5 mutation causes high-affinity F-actin binding

Avery, A. W., Crain, J., Thomas, D. D. & Hays, T. S., Feb 17 2016, In : Scientific reports. 6, 21375.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

An Innovative High-Throughput Screening Approach for Discovery of Small Molecules That Inhibit TNF Receptors

Lo, C. H., Vunnam, N., Lewis, A. K., Chiu, T. L., Brummel, B. E., Schaaf, T. M., Grant, B. D., Bawaskar, P., Thomas, D. D. & Sachs, J. N., Sep 1 2017, In : SLAS Discovery. 22, 8, p. 950-961 12 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

A novel fluorescence resonance energy transfer-based screen in high-throughput format to identify inhibitors of malarial and human glucose transporters

Kraft, T. E., Heitmeier, M. R., Putanko, M., Edwards, R. L., Ilagan, M. X. G., Payne, M. A., Autry, J. M., Thomas, D. D., Odom, A. R. & Hruz, P. W., Dec 2016, In : Antimicrobial agents and chemotherapy. 60, 12, p. 7407-7414 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

A posttranslational modification of the mitotic kinesin Eg5 that enhances its mechanochemical coupling and alters its mitotic function

Muretta, J. M., Reddy, B. J. N., Scarabelli, G., Thompson, A. F., Jariwala, S., Major, J., Venere, M., Rich, J. N., Willard, B., Thomas, D. D., Stumpff, J., Grant, B. J., Gross, S. P. & Rosenfeld, S. S., Feb 20 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 8, p. E1779-E1788

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Atomistic Models from Orientation and Distance Constraints Using EPR of a Bifunctional Spin Label

Binder, B. P., Thompson, A. R. & Thomas, D. D., Jul 23 2019, In : Biophysical journal. 117, 2, p. 319-330 12 p.

Research output: Contribution to journalArticle

Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin

Her, C., McCaffrey, J. E., Thomas, D. D. & Karim, C. B., Dec 6 2016, In : Biophysical journal. 111, 11, p. 2387-2394 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Calcium stimulates self-assembly of protein kinase C α in vitro

Swanson, C. J., Sommese, R. F., Petersen, K. J., Ritt, M., Karslake, J., Thomas, D. D. & Sivaramakrishnan, S., Oct 2016, In : PloS one. 11, 10, e0162331.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Coding sequences of sarcoplasmic reticulum calcium ATPase regulatory peptides and expression of calcium regulatory genes in recurrent exertional rhabdomyolysis

Valberg, S. J., Soave, K., Williams, Z. J., Perumbakkam, S., Schott, M., Finno, C. J., Petersen, J. L., Fenger, C., Autry, J. M. & Thomas, D. D., Mar 1 2019, In : Journal of veterinary internal medicine. 33, 2, p. 933-941 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Converter domain mutations in myosin alter structural kinetics and motor function

Gunther, L. K., Rohde, J. A., Tang, W., Walton, S. D., Unrath, W. C., Trivedi, D. V., Muretta, J. M., Thomas, D. D. & Yengo, C. M., Feb 1 2019, In : Journal of Biological Chemistry. 294, 5, p. 1554-1567 14 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles

Bian, T., Autry, J. M., Casemore, D., Li, J., Thomas, D. D., He, G. & Xing, C., Dec 9 2016, In : Biochemical and Biophysical Research Communications. 481, 3-4, p. 206-211 6 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Dynamics of Dystrophin's Actin-Binding Domain

Fealey, M. E., Horn, B., Coffman, C., Miller, R., Lin, A. Y., Thompson, A. R., Schramel, J., Groth, E., Hinderliter, A., Cembran, A. & Thomas, D. D., Aug 7 2018, In : Biophysical journal. 115, 3, p. 445-454 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Effect of Phosphorylation on Interactions between Transmembrane Domains of SERCA and Phospholamban

Martin, P. D., James, Z. M. & Thomas, D. D., Jun 5 2018, In : Biophysical journal. 114, 11, p. 2573-2583 11 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Effects of the Arg9Cys and Arg25Cys mutations on phospholamban's conformational equilibrium in membrane bilayers

Nelson, S. E. D., Ha, K. N., Gopinath, T., Exline, M. H., Mascioni, A., Thomas, D. D. & Veglia, G., Jun 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 6, p. 1335-1341 7 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

Ceholski, D. K., Turnbull, I. C., Kong, C. W., Koplev, S., Mayourian, J., Gorski, P. A., Stillitano, F., Skodras, A. A., Nonnenmacher, M., Cohen, N., Björkegren, J. L. M., Stroik, D. R., Cornea, R. L., Thomas, D. D., Li, R. A., Costa, K. D. & Hajjar, R. J., Jun 2018, In : Journal of Molecular and Cellular Cardiology. 119, p. 147-154 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
Open Access
24 Scopus citations

High-throughput screen, using time-resolved FRET, yields actin-binding compounds that modulate actin–myosin structure and function

Guhathakurta, P., Prochniewicz, E., Grant, B. D., Peterson, K. C. & Thomas, D. D., Aug 3 2018, In : Journal of Biological Chemistry. 293, 31, p. 12288-12298 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

High-throughput screens to discover small-molecule modulators of ryanodine receptor calcium release channels

Rebbeck, R. T., Essawy, M. M., Nitu, F. R., Grant, B. D., Gillispie, G. D., Thomas, D. D., Bers, D. M. & Cornea, R. L., Jan 1 2017, In : SLAS Discovery. 22, 2, p. 176-186 11 p.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations

High-Throughput spectral and lifetime-based FRET screening in living cells to identify small-molecule effectors of SERCA

Schaaf, T. M., Peterson, K. C., Grant, B. D., Bawaskar, P., Yuen, S., Li, J., Muretta, J. M., Gillispie, G. D. & Thomas, D. D., Jan 1 2017, In : SLAS Discovery. 22, 3, p. 262-273 12 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Impaired muscle relaxation and mitochondrial fission associated with genetic ablation of cytoplasmic actin isoforms

O'Rourke, A. R., Lindsay, A., Tarpey, M. D., Yuen, S., McCourt, P., Nelson, D. M., Perrin, B. J., Thomas, D. D., Spangenburg, E. E., Lowe, D. A. & Ervasti, J. M., Feb 2018, In : FEBS Journal. 285, 3, p. 481-500 20 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Mavacamten stabilizes an autoinhibited state of two-headed cardiac myosin

Rohde, J. A., Roopnarine, O., Thomas, D. D. & Muretta, J. M., Aug 7 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 32, p. E7486-E7494

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Molecular modeling of fluorescent SERCA biosensors

Svensson, B., Autry, J. M. & Thomas, D. D., Jan 1 2016, Methods in Molecular Biology. Humana Press Inc., p. 503-522 20 p. (Methods in Molecular Biology; vol. 1377).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Myosin lever arm orientation in muscle determined with high angular resolution using bifunctional spin labels

Savich, Y., Binder, B. P., Thompson, A. R. & Thomas, D. D., Aug 5 2019, In : Journal of General Physiology. 151, 8, p. 1007-1016 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Noncompetitive inhibitors of TNFR1 probe conformational activation states

Lo, C. H., Schaaf, T. M., Grant, B. D., Lim, C. K. W., Bawaskar, P., Aldrich, C. C., Thomas, D. D. & Sachs, J. N., Jul 30 2019, In : Science signaling. 12, 592, eaav5637.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Oxidation increases the strength of the methionine-aromatic interaction

Lewis, A. K., Dunleavy, K. M., Senkow, T. L., Her, C., Horn, B. T., Jersett, M. A., Mahling, R., McCarthy, M. R., Perell, G. T., Valley, C. C., Karim, C. B., Gao, J., Pomerantz, W. C. K., Thomas, D. D., Cembran, A., Hinderliter, A. & Sachs, J. N., Oct 1 2016, In : Nature Chemical Biology. 12, 10, p. 860-866 7 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Phosphomimetic S3D cofilin binds but only weakly severs actin filaments

Austin Elam, W., Cao, W., Kang, H., Huehn, A., Hocky, G. M., Prochniewicz, E., Schramm, A. C., Negrón, K., Garcia, J., Bonello, T. T., Gunning, P. W., Thomas, D. D., Voth, G. A., Sindelar, C. V. & De La Cruz, E. M., Dec 1 2017, In : Journal of Biological Chemistry. 292, 48, p. 19565-19579 15 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

Lake, E. W., Muretta, J. M., Thompson, A. R., Rasmussen, D. M., Majumdar, A., Faber, E. B., Ruff, E. F., Thomas, D. D. & Levinson, N. M., Dec 18 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 51, p. E11894-E11903

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Red-shifted FRET biosensors for high-throughput fluorescence lifetime screening

Schaaf, T. M., Li, A., Grant, B. D., Peterson, K., Yuen, S., Bawaskar, P., Kleinboehl, E., Li, J., Thomas, D. D. & Gillispie, G. D., Oct 24 2018, In : Biosensors. 8, 4, 99.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

S100A1 protein does not compete with calmodulin for ryanodine receptor binding but structurally alters the ryanodine receptoro·calmodulin complex

Rebbeck, R. T., Nitu, F. R., Rohde, D., Most, P., Bers, D. M., Thomas, D. D. & Cornea, R. L., Jul 22 2016, In : Journal of Biological Chemistry. 291, 30, p. 15896-15907 12 p.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Sarcolipin Promotes Uncoupling of the SERCA Ca2+ Pump by Inducing a Structural Rearrangement in the Energy-Transduction Domain

Autry, J. M., Thomas, D. D. & Espinoza-Fonseca, L. M., Nov 8 2016, In : Biochemistry. 55, 44, p. 6083-6086 4 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations
Open Access
20 Scopus citations

Soluble Extracellular Domain of Death Receptor 5 Inhibits TRAIL-Induced Apoptosis by Disrupting Receptor–Receptor Interactions

Vunnam, N., Lo, C. H., Grant, B. D., Thomas, D. D. & Sachs, J. N., Sep 15 2017, In : Journal of Molecular Biology. 429, 19, p. 2943-2953 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Spectral unmixing plate reader: High-throughput, high-precision FRET Assays in living cells

Schaaf, T. M., Peterson, K. C., Grant, B. D., Thomas, D. D. & Gillispie, G. D., Jan 1 2017, In : SLAS Discovery. 22, 3, p. 250-261 12 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Structural basis for high-affinity actin binding revealed by a β-III-spectrin SCA5 missense mutation

Avery, A. W., Fealey, M. E., Wang, F., Orlova, A., Thompson, A. R., Thomas, D. D., Hays, T. S. & Egelman, E. H., Dec 1 2017, In : Nature communications. 8, 1, 1350.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Structural dynamics of calmodulin-ryanodine receptor interactions: Electron paramagnetic resonance using stereospecific spin labels

Her, C., Thompson, A. R., Karim, C. B. & Thomas, D. D., Dec 1 2018, In : Scientific reports. 8, 1, 10681.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Structural Impact of Phosphorylation and Dielectric Constant Variation on Synaptotagmin's IDR

Fealey, M. E., Binder, B. P., Uversky, V. N., Hinderliter, A. & Thomas, D. D., Feb 6 2018, In : Biophysical journal. 114, 3, p. 550-561 12 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Targeting protein-protein interactions for therapeutic discovery via FRET-based high-throughput screening in living cells

Stroik, D. R., Yuen, S. L., Janicek, K. A., Schaaf, T. M., Li, J., Ceholski, D. K., Hajjar, R. J., Cornea, R. L. & Thomas, D. D., Dec 1 2018, In : Scientific reports. 8, 1, 12560.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies

Lo, C. H., Lim, C. K. W., Ding, Z., Wickramasinghe, S. P., Braun, A. R., Ashe, K. H., Rhoades, E., Thomas, D. D. & Sachs, J. N., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1489-1502 14 p.

Research output: Contribution to journalArticle

2 Scopus citations

Trajectory-Based Simulation of EPR Spectra: Models of Rotational Motion for Spin Labels on Proteins

Martin, P. D., Svensson, B., Thomas, D. D. & Stoll, S., Dec 5 2019, In : Journal of Physical Chemistry B. 123, 48, p. 10131-10141 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
7 Scopus citations