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Author

  • Paul D Robbins
2012

DsAAV8-mediated gene transfer and Β-cell expression of IL-4 and Β-cell growth factors are capable of reversing early-onset diabetes in NOD mice

Gaddy, D. F., Riedel, M. J., Bertera, S., Kieffer, T. J. & Robbins, P. D., Aug 1 2012, In : Gene therapy. 19, 8, p. 791-799 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells

Yang, C., Chalasani, G., Ng, Y. H. & Robbins, P. D., Apr 27 2012, In : PloS one. 7, 4, e36138.

Research output: Contribution to journalArticle

36 Scopus citations

Immunosuppressive exosomes: A new approach for treating arthritis

Yang, C. & Robbins, P. D., Apr 18 2012, In : International Journal of Rheumatology. 2012, 573528.

Research output: Contribution to journalReview article

48 Scopus citations

ISSLS prize winner: Inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging

Nasto, L. A., Seo, H. Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., Robbins, P. D. & Vo, N. V., Oct 1 2012, In : Spine. 37, 21, p. 1819-1825 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Lim Mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through kruppel-like factor-4 downregulation and further bone-specific gene expression

Barba, M., Pirozzi, F., Saulnier, N., Vitali, T., Natale, M. T., Logroscino, G., Robbins, P. D., Gambotto, A., Neri, G., Michetti, F., Pola, E. & Lattanzi, W., 2012, In : Journal of Biomedicine and Biotechnology. 2012, 813894.

Research output: Contribution to journalArticle

17 Scopus citations

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, M., Robinson, A. R., Lu, A., Song, M., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Feb 13 2012, In : Nature communications. 3, 608.

Research output: Contribution to journalArticle

121 Scopus citations

NF-κB inhibition delays DNA damage - Induced senescence and aging in mice

Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., Huard, J., Clemens, P. R., Stolz, D. B., Guttridge, D. C., Watkins, S. C., Garinis, G. A., Wang, Y., Niedernhofer, L. J. & Robbins, P. D., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

214 Scopus citations

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells

Lu, A., Proto, J. D., Guo, L., Tang, Y., Lavasani, M., Tilstra, J. S., Niedernhofer, L. J., Wang, B., Guttridge, D. C., Robbins, P. D. & Huard, J., Mar 2012, In : Molecular Therapy. 20, 3, p. 661-668 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Orthopedic gene therapy-lost in translation?

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 2012, In : Journal of cellular physiology. 227, 2, p. 416-420 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses

Yang, C., Ruffner, M. A., Kim, S. H. & Robbins, P. D., Jul 1 2012, In : European Journal of Immunology. 42, 7, p. 1778-1784 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein transduction domains: Applications for molecular medicine

Zahid, M. & Robbins, P. D., Oct 8 2012, In : Current gene therapy. 12, 5, p. 374-380 7 p.

Research output: Contribution to journalReview article

12 Scopus citations

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease

Xun, Z., Rivera-Sánchez, S., Ayala-Peña, S., Lim, J., Budworth, H., Skoda, E. M., Robbins, P. D., Niedernhofer, L. J., Wipf, P. & McMurray, C. T., Nov 29 2012, In : Cell reports. 2, 5, p. 1137-1142 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12

Reay, J., Gambotto, A. & Robbins, P. D., Feb 1 2012, In : Cancer gene therapy. 19, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner

Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J. & Wang, Y., Aug 1 2012, In : Aging cell. 11, 4, p. 714-716 3 p.

Research output: Contribution to journalArticle

79 Scopus citations
2013

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J. & Evans, C. H., Jun 1 2013, In : Journal of Orthopaedic Research. 31, 6, p. 831-837 7 p.

Research output: Contribution to journalReview article

57 Scopus citations

Arthritis gene therapy and its tortuous path into the clinic

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Apr 2013, In : Translational Research. 161, 4, p. 205-216 12 p.

Research output: Contribution to journalReview article

58 Scopus citations

DNA damage drives accelerated bone aging via an NF- κ B-dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J. & Ouyang, H., May 1 2013, In : Journal of Bone and Mineral Research. 28, 5, p. 1214-1228 15 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs

Nasto, L. A., Wang, D., Robinson, A. R., Clauson, C. L., Ngo, K., Dong, Q., Roughley, P., Epperly, M., Huq, S. M., Pola, E., Sowa, G., Robbins, P. D., Kang, J., Niedernhofer, L. J. & Vo, N. V., Jan 1 2013, In : Mechanisms of Ageing and Development. 134, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces

Lavasani, M., Lu, A., Thompson, S. D., Robbins, P. D., Huard, J. & Niedernhofer, L. J., 2013, Stem Cells and Aging: Methods and Protocols. Humana Press Inc., p. 53-65 13 p. (Methods in Molecular Biology; vol. 976).

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Scopus citations

LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells

Lin, Z., Rios, H. F., Park, C. H., Taut, A. D., Jin, Q., Sugai, J. V., Robbins, P. D. & Giannobile, W. V., Jan 1 2013, In : Gene therapy. 20, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Nasto, L. A., Robinson, A. R., Ngo, K., Clauson, C. L., Dong, Q., St. Croix, C., Sowa, G., Pola, E., Robbins, P. D., Kang, J., Niedernhofer, L. J., Wipf, P. & Vo, N. V., Jul 1 2013, In : Journal of Orthopaedic Research. 31, 7, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes

Dorronsoro, A. & Robbins, P. D., May 3 2013, In : Stem Cell Research and Therapy. 4, 2, 39.

Research output: Contribution to journalReview article

41 Scopus citations
2014
9 Scopus citations

Pharmacologic IKK/NF-kappa;B inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death

Tilstra, J. S., Gaddy, D. F., Zhao, J., Davé, S. H., Niedernhofer, L. J., Plevy, S. E. & Robbins, P. D., Jan 10 2014, In : Scientific reports. 4, 3631.

Research output: Contribution to journalArticle

15 Scopus citations

Regulation of immune responses by extracellular vesicles

Robbins, P. D. & Morelli, A. E., Mar 1 2014, In : Nature Reviews Immunology. 14, 3, p. 195-208 14 p.

Research output: Contribution to journalReview article

804 Scopus citations

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin

Gao, S., McMillan, R. P., Jacas, J., Zhu, Q., Li, X., Kumar, G. K., Casals, N., Hegardt, F. G., Robbins, P. D., Lopaschuk, G. D., Hulver, M. W. & Butler, A. A., Oct 1 2014, In : Diabetes. 63, 10, p. 3242-3252 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2015

Arthritis Gene Therapy: A Brief History and Perspective

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 2015, Translating Gene Therapy to the Clinic: Techniques and Approaches. Elsevier Inc., p. 85-98 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Cell-type specific penetrating peptides: Therapeutic promises and challenges

Zahid, M. & Robbins, P. D., Jul 1 2015, In : Molecules. 20, 7, p. 13055-13070 16 p.

Research output: Contribution to journalReview article

34 Scopus citations

D-amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity

Reay, D. P., Bastacky, S. I., Wack, K. E., Stolz, D. B., Robbins, P. D. & Clemens, P. R., Jan 1 2015, In : Molecular Medicine. 21, p. 442-452 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

Flores, R. R., Kim, E., Zhou, L., Yang, C., Zhao, J., Gambotto, A. & Robbins, P. D., Nov 1 2015, In : European Journal of Immunology. 45, 11, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

NF-κB activation with aging: Characterization and therapeutic inhibition

Zhao, J., Li, X., McGowan, S., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 543-557 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Proto, J. D., Tang, Y., Lu, A., Chen, W. C. W., Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. & Huard, J., Apr 23 2015, In : Cell Death and Disease. 6, 4, e1730.

Research output: Contribution to journalArticle

23 Scopus citations

The achilles’ heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B. & 13 others, McGowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., Jan 1 2015, In : Aging cell. 14, 4, p. 644-658 15 p.

Research output: Contribution to journalArticle

511 Scopus citations
2016

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : STEM CELLS. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., Jun 1 2016, In : Aging cell. 15, 3, p. 428-435 8 p.

Research output: Contribution to journalArticle

Open Access
225 Scopus citations

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins, P. D., Dorronsoro, A. & Booker, C. N., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1173-1180 8 p.

Research output: Contribution to journalReview article

Open Access
95 Scopus citations

Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Northen, T. R., Robbins, P. D., Niedernhofer, L. J., Lairson, L., Benton, H. P. & Siuzdak, G., Oct 4 2016, In : Analytical chemistry. 88, 19, p. 9753-9758 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2017

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
6 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

Open Access
300 Scopus citations

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R. W., Boccuzzi, L., Robbins, P. D. & Ricordi, C., Jun 1 2017, In : European review for medical and pharmacological sciences. 21, 12, p. 2940-2956 17 p.

Research output: Contribution to journalReview article

29 Scopus citations

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Extracellular vesicles and aging

Robbins, P. D., Dec 1 2017, In : Stem Cell Investigation. 4, 12, 98.

Research output: Contribution to journalReview article

Open Access
18 Scopus citations

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature communications. 8, 1, 422.

Research output: Contribution to journalArticle

Open Access
135 Scopus citations

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

Proto, J. D., Lu, A., Dorronsoro, A., Scibetta, A., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jun 2017, In : PloS one. 12, 6, e0179270.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jul 2017, In : Journal of Orthopaedic Research. 35, 7, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
123 Scopus citations

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Garcia-Contreras, M., Shah, S. H., Tamayo, A., Robbins, P. D., Golberg, R. B., Mendez, A. J. & Ricordi, C., Dec 1 2017, In : Scientific reports. 7, 1, 5998.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Quantitative analysis of cellular senescence in culture and in Vivo

Zhao, J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Flores, R. R., Dorronsoro, A., Stolz, D. B., St. Croix, C. M., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2017, In : Current protocols in cytometry. 2017, p. 9.51.1-9.51.25

Research output: Contribution to journalArticle

6 Scopus citations