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Author

  • Paul D Robbins
2011

Bioplasty for vertebral fractures: preliminary results of a pre-clinical study on goats using autologous modified skin fibroblasts.

Pola, E., Nasto, L. A., Tampieri, A., Lattanzi, W., Di Giacomo, G., Colangelo, D., Ciriello, V., Pagano, E., Spinelli, S., Robbins, P. D. & Logroscino, G., Jan 1 2011, In : International journal of immunopathology and pharmacology. 24, 1 Suppl 2, p. 139-142 4 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Dedifferentiation rescues senescence of progeria cells but only while pluripotent

Niedernhofer, L. J., Glorioso, J. C. & Robbins, P. D., 2011, In : Stem Cell Research and Therapy. 2, 3, 28.

Research output: Contribution to journalReview article

10 Scopus citations

Getting arthritis gene therapy into the clinic

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Apr 1 2011, In : Nature Reviews Rheumatology. 7, 4, p. 244-249 6 p.

Research output: Contribution to journalReview article

47 Scopus citations
9 Scopus citations

Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors

Gatson, N. T. N., Williams, J. L., Powell, N. D., McClain, M. A., Hennon, T. R., Robbins, P. D. & Whitacre, C. C., Jan 1 2011, In : Journal of Neuroimmunology. 230, 1-2, p. 105-113 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

NF-κB in aging and disease

Tilstra, J. S., Clauson, C. L., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2011, In : Aging and Disease. 2, 6, p. 449-465 17 p.

Research output: Contribution to journalReview article

160 Scopus citations

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of duchenne muscular dystrophy

Peterson, J. M., Kline, W., Canan, B. D., Ricca, D. J., Kaspar, B., Delfín, D. A., Dirienzo, K., Clemens, P. R., Robbins, P. D., Baldwin, A. S., Flood, P., Kaumaya, P., Freitas, M., Kornegay, J. N., Mendell, J. R., Rafael-Fortney, J. A., Guttridge, D. C. & Janssen, P. M., May 2011, In : Molecular Medicine. 17, 5-6, p. 508-515 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy

Kim, C. Y., Park, S. H., Jeong, M., Kwon, O. S., Doh, H., Kang, S. H., Robbins, P. D., Kim, B. M., Seol, D. W. & Kim, B. G., Oct 31 2011, In : Experimental and Molecular Medicine. 43, 10, p. 580-586 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Premature aging-related peripheral neuropathy in a mouse model of progeria

Goss, J. R., Stolz, D. B., Robinson, A. R., Zhang, M., Arbujas, N., Robbins, P. D., Glorioso, J. C. & Niedernhofer, L. J., Aug 1 2011, In : Mechanisms of Ageing and Development. 132, 8-9, p. 437-442 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

SIRT1 associates with eIF2-alpha and regulates the cellular stress response

Ghosh, H. S., Reizis, B. & Robbins, P. D., Dec 1 2011, In : Scientific reports. 1, 150.

Research output: Contribution to journalArticle

39 Scopus citations

Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology

Reay, D. P., Yang, M., Watchko, J. F., Daood, M., O'Day, T. L., Rehman, K. K., Guttridge, D. C., Robbins, P. D. & Clemens, P. R., Sep 2011, In : Neurobiology of Disease. 43, 3, p. 598-608 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

The roles of tumor-derived exosomes in cancer pathogenesis

Yang, C. & Robbins, P. D., Dec 1 2011, In : Clinical and Developmental Immunology. 2011, 842849.

Research output: Contribution to journalReview article

194 Scopus citations

Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model

Yang, C., Kim, S. H., Bianco, N. R. & Robbins, P. D., 2011, In : PloS one. 6, 8, e22517.

Research output: Contribution to journalArticle

71 Scopus citations
2012

DsAAV8-mediated gene transfer and Β-cell expression of IL-4 and Β-cell growth factors are capable of reversing early-onset diabetes in NOD mice

Gaddy, D. F., Riedel, M. J., Bertera, S., Kieffer, T. J. & Robbins, P. D., Aug 1 2012, In : Gene therapy. 19, 8, p. 791-799 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells

Yang, C., Chalasani, G., Ng, Y. H. & Robbins, P. D., Apr 27 2012, In : PloS one. 7, 4, e36138.

Research output: Contribution to journalArticle

39 Scopus citations

Immunosuppressive exosomes: A new approach for treating arthritis

Yang, C. & Robbins, P. D., Apr 18 2012, In : International Journal of Rheumatology. 2012, 573528.

Research output: Contribution to journalReview article

49 Scopus citations

ISSLS prize winner: Inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging

Nasto, L. A., Seo, H. Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., Robbins, P. D. & Vo, N. V., Oct 1 2012, In : Spine. 37, 21, p. 1819-1825 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

Lim Mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through kruppel-like factor-4 downregulation and further bone-specific gene expression

Barba, M., Pirozzi, F., Saulnier, N., Vitali, T., Natale, M. T., Logroscino, G., Robbins, P. D., Gambotto, A., Neri, G., Michetti, F., Pola, E. & Lattanzi, W., 2012, In : Journal of Biomedicine and Biotechnology. 2012, 813894.

Research output: Contribution to journalArticle

17 Scopus citations

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, M., Robinson, A. R., Lu, A., Song, M., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., 2012, In : Nature communications. 3, 608.

Research output: Contribution to journalArticle

123 Scopus citations

NF-κB inhibition delays DNA damage - Induced senescence and aging in mice

Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., Huard, J., Clemens, P. R., Stolz, D. B., Guttridge, D. C., Watkins, S. C., Garinis, G. A., Wang, Y., Niedernhofer, L. J. & Robbins, P. D., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

219 Scopus citations

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells

Lu, A., Proto, J. D., Guo, L., Tang, Y., Lavasani, M., Tilstra, J. S., Niedernhofer, L. J., Wang, B., Guttridge, D. C., Robbins, P. D. & Huard, J., Mar 2012, In : Molecular Therapy. 20, 3, p. 661-668 8 p.

Research output: Contribution to journalArticle

43 Scopus citations

Orthopedic gene therapy-lost in translation?

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 2012, In : Journal of cellular physiology. 227, 2, p. 416-420 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses

Yang, C., Ruffner, M. A., Kim, S. H. & Robbins, P. D., Jul 1 2012, In : European Journal of Immunology. 42, 7, p. 1778-1784 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein transduction domains: Applications for molecular medicine

Zahid, M. & Robbins, P. D., Oct 8 2012, In : Current gene therapy. 12, 5, p. 374-380 7 p.

Research output: Contribution to journalReview article

12 Scopus citations

Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington's Disease

Xun, Z., Rivera-Sánchez, S., Ayala-Peña, S., Lim, J., Budworth, H., Skoda, E. M., Robbins, P. D., Niedernhofer, L. J., Wipf, P. & McMurray, C. T., Nov 29 2012, In : Cell reports. 2, 5, p. 1137-1142 6 p.

Research output: Contribution to journalArticle

78 Scopus citations

The antitumor effects of adenoviral-mediated, intratumoral delivery of interleukin 23 require endogenous IL-12

Reay, J., Gambotto, A. & Robbins, P. D., Feb 1 2012, In : Cancer gene therapy. 19, 2, p. 135-143 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

The oxidative DNA lesions 8,5′-cyclopurines accumulate with aging in a tissue-specific manner

Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J. & Wang, Y., Aug 2012, In : Aging cell. 11, 4, p. 714-716 3 p.

Research output: Contribution to journalArticle

79 Scopus citations
2013

An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints

Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J. & Evans, C. H., Jun 1 2013, In : Journal of Orthopaedic Research. 31, 6, p. 831-837 7 p.

Research output: Contribution to journalReview article

59 Scopus citations

Arthritis gene therapy and its tortuous path into the clinic

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Apr 2013, In : Translational Research. 161, 4, p. 205-216 12 p.

Research output: Contribution to journalReview article

59 Scopus citations

DNA damage drives accelerated bone aging via an NF- κ B-dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J. & Ouyang, H., May 2013, In : Journal of Bone and Mineral Research. 28, 5, p. 1214-1228 15 p.

Research output: Contribution to journalArticle

52 Scopus citations

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs

Nasto, L. A., Wang, D., Robinson, A. R., Clauson, C. L., Ngo, K., Dong, Q., Roughley, P., Epperly, M., Huq, S. M., Pola, E., Sowa, G., Robbins, P. D., Kang, J., Niedernhofer, L. J. & Vo, N. V., Jan 1 2013, In : Mechanisms of Ageing and Development. 134, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces

Lavasani, M., Lu, A., Thompson, S. D., Robbins, P. D., Huard, J. & Niedernhofer, L. J., 2013, Stem Cells and Aging: Methods and Protocols. Humana Press Inc., p. 53-65 13 p. (Methods in Molecular Biology; vol. 976).

Research output: Chapter in Book/Report/Conference proceedingChapter

44 Scopus citations

LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells

Lin, Z., Rios, H. F., Park, C. H., Taut, A. D., Jin, Q., Sugai, J. V., Robbins, P. D. & Giannobile, W. V., Jan 2013, In : Gene therapy. 20, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Nasto, L. A., Robinson, A. R., Ngo, K., Clauson, C. L., Dong, Q., St. Croix, C., Sowa, G., Pola, E., Robbins, P. D., Kang, J., Niedernhofer, L. J., Wipf, P. & Vo, N. V., Jul 1 2013, In : Journal of Orthopaedic Research. 31, 7, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

90 Scopus citations

Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes

Dorronsoro, A. & Robbins, P. D., May 3 2013, In : Stem Cell Research and Therapy. 4, 2, 39.

Research output: Contribution to journalReview article

44 Scopus citations
2014
9 Scopus citations

Pharmacologic IKK/NF-kappa;B inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death

Tilstra, J. S., Gaddy, D. F., Zhao, J., Davé, S. H., Niedernhofer, L. J., Plevy, S. E. & Robbins, P. D., Jan 10 2014, In : Scientific reports. 4, 3631.

Research output: Contribution to journalArticle

16 Scopus citations

Regulation of immune responses by extracellular vesicles

Robbins, P. D. & Morelli, A. E., Mar 2014, In : Nature Reviews Immunology. 14, 3, p. 195-208 14 p.

Research output: Contribution to journalReview article

837 Scopus citations

Regulation of substrate oxidation preferences in muscle by the peptide hormone adropin

Gao, S., McMillan, R. P., Jacas, J., Zhu, Q., Li, X., Kumar, G. K., Casals, N., Hegardt, F. G., Robbins, P. D., Lopaschuk, G. D., Hulver, M. W. & Butler, A. A., Oct 1 2014, In : Diabetes. 63, 10, p. 3242-3252 11 p.

Research output: Contribution to journalArticle

41 Scopus citations
2016

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : STEM CELLS. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., Jun 1 2016, In : Aging cell. 15, 3, p. 428-435 8 p.

Research output: Contribution to journalArticle

Open Access
234 Scopus citations

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins, P. D., Dorronsoro, A. & Booker, C. N., Apr 1 2016, In : Journal of Clinical Investigation. 126, 4, p. 1173-1180 8 p.

Research output: Contribution to journalReview article

Open Access
102 Scopus citations

Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses

Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., Krantz, G., Fields, M. W., Northen, T. R., Robbins, P. D., Niedernhofer, L. J., Lairson, L., Benton, H. P. & Siuzdak, G., Oct 4 2016, In : Analytical chemistry. 88, 19, p. 9753-9758 6 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2017

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
6 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

Open Access
319 Scopus citations

Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus

Garcia-Contreras, M., Brooks, R. W., Boccuzzi, L., Robbins, P. D. & Ricordi, C., Jun 1 2017, In : European review for medical and pharmacological sciences. 21, 12, p. 2940-2956 17 p.

Research output: Contribution to journalReview article

33 Scopus citations

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
22 Scopus citations

Extracellular vesicles and aging

Robbins, P. D., Dec 1 2017, In : Stem Cell Investigation. 4, 12, 98.

Research output: Contribution to journalReview article

Open Access
19 Scopus citations