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Author

  • John D Lipscomb
2011

Active-site structure of a β-hydroxylase in antibiotic biosynthesis

Vu, V. V., Makris, T. M., Lipscomb, J. D. & Que, L., May 11 2011, In : Journal of the American Chemical Society. 133, 18, p. 6938-6941 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

A hyperactive cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Kovaleva, E. G., Farquhar, E. R., Lipscomb, J. D. & Que, L., Feb 2011, In : Journal of Biological Inorganic Chemistry. 16, 2, p. 341-355 15 p.

Research output: Contribution to journalArticle

60 Scopus citations

Oxy intermediates of homoprotocatechuate 2,3-dioxygenase: Facile electron transfer between substrates

Mbughuni, M. M., Chakrabarti, M., Hayden, J. A., Meier, K. K., Dalluge, J. J., Hendrich, M. P., Münck, E. & Lipscomb, J. D., Nov 29 2011, In : Biochemistry. 50, 47, p. 10262-10274 13 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Characterization of an O 2 adduct of an active cobalt-substituted extradiol-cleaving catechol dioxygenase

Fielding, A. J., Lipscomb, J. D. & Que, L., Jan 18 2012, In : Journal of the American Chemical Society. 134, 2, p. 796-799 4 p.

Research output: Contribution to journalArticle

32 Scopus citations

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5)

Thompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R. & Bruick, R. K., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7357-7365 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Structural basis for the role of tyrosine 257 of homoprotocatechuate 2,3-dioxygenase in substrate and oxygen activation

Kovaleva, E. G. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8755-8763 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Substrate-mediated oxygen activation by homoprotocatechuate 2,3-dioxygenase: Intermediates formed by a tyrosine 257 variant

Mbughuni, M. M., Meier, K. K., Münck, E. & Lipscomb, J. D., Nov 6 2012, In : Biochemistry. 51, 44, p. 8743-8754 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

Cyanobacterial aldehyde deformylase oxygenation of aldehydes yields n - 1 aldehydes and alcohols in addition to alkanes

Aukema, K. G., Makris, T. M., Stoian, S. A., Richman, J. E., Münck, E., Lipscomb, J. D. & Wackett, L. P., Oct 4 2013, In : ACS Catalysis. 3, 10, p. 2228-2238 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Intermediate P* from soluble methane monooxygenase contains a diferrous cluster

Banerjee, R., Meier, K. K., Münck, E. & Lipscomb, J. D., Jun 25 2013, In : Biochemistry. 52, 25, p. 4331-4342 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

NO binding to Mn-substituted homoprotocatechuate 2,3-dioxygenase: Relationship to O2 reactivity

Hayden, J. A., Farquhar, E. R., Que, L., Lipscomb, J. D. & Hendrich, M. P., Oct 1 2013, In : Journal of Biological Inorganic Chemistry. 18, 7, p. 717-728 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Structure of a dinuclear iron cluster-containing β-hydroxylase active in antibiotic biosynthesis

Makris, T. M., Knoot, C. J., Wilmot, C. M. & Lipscomb, J. D., Sep 24 2013, In : Biochemistry. 52, 38, p. 6662-6671 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014
29 Scopus citations

Catalase (KatA) Plays a role in protection against anaerobic nitric oxide in Pseudomonas aeruginosa

Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., VanderWielen, B. D., Makris, T. M., Rogers, M., McDaniel, C., Lipscomb, J. D., Irvin, R. T., Schurr, M. J., Lancaster, J. R., Kovall, R. A. & Hassett, D. J., Mar 24 2014, In : PloS one. 9, 3, e91813.

Research output: Contribution to journalArticle

23 Scopus citations

Life in a Sea of Oxygen

Lipscomb, J. D., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15141-15153 13 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

A long-lived FeIII-(hydroperoxo) intermediate in the active H200C variant of homoprotocatechuate 2,3-dioxygenase: Characterization by mössbauer, electron paramagnetic resonance, and density functional theory methods

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Mbughuni, M. M., Bominaar, E. L., Lipscomb, J. D. & Münck, E., Nov 2 2015, In : Inorganic chemistry. 54, 21, p. 10269-10280 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

An unusual peroxo intermediate of the arylamine oxygenase of the chloramphenicol biosynthetic pathway

Makris, T. M., Vu, V. V., Meier, K. K., Komor, A. J., Rivard, B. S., Münck, E., Que, L. & Lipscomb, J. D., Feb 4 2015, In : Journal of the American Chemical Society. 137, 4, p. 1608-1617 10 p.

Research output: Contribution to journalArticle

38 Scopus citations
17 Scopus citations

Rate-Determining Attack on Substrate Precedes Rieske Cluster Oxidation during Cis-Dihydroxylation by Benzoate Dioxygenase

Rivard, B. S., Rogers, M., Marell, D. J., Neibergall, M. B., Chakrabarty, S., Cramer, C. & Lipscomb, J. D., Aug 4 2015, In : Biochemistry. 54, 30, p. 4652-4664 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Structural Basis for Substrate and Oxygen Activation in Homoprotocatechuate 2,3-Dioxygenase: Roles of Conserved Active Site Histidine 200

Kovaleva, E. G., Rogers, M. S. & Lipscomb, J. D., Sep 1 2015, In : Biochemistry. 54, 34, p. 5329-5339 11 p.

Research output: Contribution to journalArticle

16 Scopus citations

Structure of the key species in the enzymatic oxidation of methane to methanol

Banerjee, R., Proshlyakov, Y., Lipscomb, J. D. & Proshlyakov, D. A., Feb 19 2015, In : Nature. 518, 7539, p. 431-434 4 p.

Research output: Contribution to journalArticle

117 Scopus citations
2016

A Carboxylate Shift Regulates Dioxygen Activation by the Diiron Nonheme β-Hydroxylase CmlA upon Binding of a Substrate-Loaded Nonribosomal Peptide Synthetase

Jasniewski, A. J., Knoot, C., Lipscomb, J. D. & Que, L., Oct 18 2016, In : Biochemistry. 55, 41, p. 5818-5831 14 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Crystal structure of CmlI, the arylamine oxygenase from the chloramphenicol biosynthetic pathway

Knoot, C. J., Kovaleva, E. G. & Lipscomb, J. D., Sep 1 2016, In : Journal of Biological Inorganic Chemistry. 21, 5-6, p. 589-603 15 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

Enzyme Substrate Complex of the H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Mössbauer and Computational Studies

Meier, K. K., Rogers, M. S., Kovaleva, E. G., Lipscomb, J. D., Bominaar, E. L. & Münck, E., Jun 20 2016, In : Inorganic chemistry. 55, 12, p. 5862-5870 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Mechanism for Six-Electron Aryl-N-Oxygenation by the Non-Heme Diiron Enzyme CmlI

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Jun 15 2016, In : Journal of the American Chemical Society. 138, 23, p. 7411-7421 11 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2017

CmlI N-Oxygenase Catalyzes the Final Three Steps in Chloramphenicol Biosynthesis without Dissociation of Intermediates

Komor, A. J., Rivard, B. S., Fan, R., Guo, Y., Que, L. & Lipscomb, J. D., Sep 19 2017, In : Biochemistry. 56, 37, p. 4940-4950 11 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Corrigendum: Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Jun 21 2017, In : Scientific reports. 7, p. 46846 1 p., 46846.

Research output: Contribution to journalComment/debate

Open Access
2 Scopus citations

Double-flow focused liquid injector for efficient serial femtosecond crystallography

Oberthuer, D., Knoška, J., Wiedorn, M. O., Beyerlein, K. R., Bushnell, D. A., Kovaleva, E. G., Heymann, M., Gumprecht, L., Kirian, R. A., Barty, A., Mariani, V., Tolstikova, A., Adriano, L., Awel, S., Barthelmess, M., Dörner, K., Xavier, P. L., Yefanov, O., James, D. R., Nelson, G. & 25 others, Wang, D., Calvey, G., Chen, Y., Schmidt, A., Szczepek, M., Frielingsdorf, S., Lenz, O., Snell, E., Robinson, P. J., Šarler, B., Belšak, G., Maček, M., Wilde, F., Aquila, A., Boutet, S., Liang, M., Hunter, M. S., Scheerer, P., Lipscomb, J. D., Weierstall, U., Kornberg, R. D., Spence, J. C. H., Pollack, L., Chapman, H. N. & Bajt, S., Mar 16 2017, In : Scientific reports. 7, 44628.

Research output: Contribution to journalArticle

Open Access
47 Scopus citations
Open Access
24 Scopus citations

Erratum: Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria (Cell Chemical Biology (2017) 24(10) (1259–1275.e6) (S2451945617302830)(10.1016/j.chembiol.2017.08.009))

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, 1 p.

Research output: Contribution to journalComment/debate

Open Access
3 Scopus citations

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Z., Sevrioukova, I. F., Denisov, I. G., Zhang, X., Chiu, T. L., Thomas, D. G., Hanse, E. A., Cuellar, R. A. D., Grinkova, Y. V., Langenfeld, V. W., Swedien, D. S., Stamschror, J. D., Alvarez, J., Luna, F., Galván, A., Bae, Y. K., Wulfkuhle, J. D., Gallagher, R. I., Petricoin, E. F., Norris, B. & 17 others, Flory, C. M., Schumacher, R. J., O'Sullivan, M. G., Cao, Q., Chu, H., Lipscomb, J. D., Atkins, W. M., Gupta, K., Kelekar, A., Blair, I. A., Capdevila, J. H., Falck, J. R., Sligar, S. G., Poulos, T. L., Georg, G. I., Ambrose, E. & Potter, D. A., Oct 19 2017, In : Cell Chemical Biology. 24, 10, p. 1259-1275.e6

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

High-Energy-Resolution Fluorescence-Detected X-ray Absorption of the Q Intermediate of Soluble Methane Monooxygenase

Castillo, R. G., Banerjee, R., Allpress, C. J., Rohde, G. T., Bill, E., Que, L., Lipscomb, J. D. & DeBeer, S., Dec 13 2017, In : Journal of the American Chemical Society. 139, 49, p. 18024-18033 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
Open Access
4 Scopus citations

Unprecedented (μ-1,1-Peroxo)diferric Structure for the Ambiphilic Orange Peroxo Intermediate of the Nonheme N-Oxygenase CmlI

Jasniewski, A. J., Komor, A. J., Lipscomb, J. D. & Que, L., Aug 2 2017, In : Journal of the American Chemical Society. 139, 30, p. 10472-10485 14 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Use of Isotopes and Isotope Effects for Investigations of Diiron Oxygenase Mechanisms

Banerjee, R., Komor, A. J. & Lipscomb, J. D., Jan 1 2017, Methods in Enzymology. Academic Press Inc., p. 239-290 52 p. (Methods in Enzymology; vol. 596).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
2018

Diiron monooxygenases in natural product biosynthesis

Komor, A. J., Jasniewski, A. J., Que, L. & Lipscomb, J. D., Jul 2018, In : Natural Product Reports. 35, 7, p. 646-659 14 p.

Research output: Contribution to journalReview article

Open Access
10 Scopus citations
Open Access
18 Scopus citations

NRVS Studies of the Peroxide Shunt Intermediate in a Rieske Dioxygenase and Its Relation to the Native FeII O2 Reaction

Sutherlin, K. D., Rivard, B. S., Böttger, L. H., Liu, L. V., Rogers, M. S., Srnec, M., Park, K., Yoda, Y., Kitao, S., Kobayashi, Y., Saito, M., Seto, M., Hu, M., Zhao, J., Lipscomb, J. D. & Solomon, E. I., Apr 25 2018, In : Journal of the American Chemical Society. 140, 16, p. 5544-5559 16 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Nuclear Resonance Vibrational Spectroscopy Definition of O 2 Intermediates in an Extradiol Dioxygenase: Correlation to Crystallography and Reactivity

Sutherlin, K. D., Wasada-Tsutsui, Y., Mbughuni, M. M., Rogers, M. S., Park, K., Liu, L. V., Kwak, Y., Srnec, M., Böttger, L. H., Frenette, M., Yoda, Y., Kobayashi, Y., Kurokuzu, M., Saito, M., Seto, M., Hu, M., Zhao, J., Alp, E. E., Lipscomb, J. D. & Solomon, E. I., Dec 5 2018, In : Journal of the American Chemical Society. 140, 48, p. 16495-16513 19 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations