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  • Bruce R Blazar
2011

A low frequency of pancreatic islet insulin-expressing cells derived from cord blood stem cell allografts in humans

Huang, C. J., Butler, A. E., Moran, A., Rao, P. N., Wagner, J. E., Blazar, B. R., Rizza, R. A., Manivel, J. C. & Butler, P. C., May 1 2011, In : Diabetologia. 54, 5, p. 1066-1074 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cardiac disease in mucopolysaccharidosis type I attributed to catecholaminergic and hemodynamic deficiencies

Palpant, N. J., Bedada, F. B., Peacock, B., Blazar, B. R., Metzger, J. M. & Tolar, J., Jan 1 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 300, 1, p. H356-H365

Research output: Contribution to journalArticle

4 Scopus citations

Clinical perspectives for regulatory T cells in transplantation tolerance

Hippen, K. L., Riley, J. L., June, C. H. & Blazar, B. R., Dec 1 2011, In : Seminars in Immunology. 23, 6, p. 462-468 7 p.

Research output: Contribution to journalReview article

87 Scopus citations

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Zhou, Q., Munger, M. E., Veenstra, R. G., Weigel, B. J., Hirashima, M., Munn, D. H., Murphy, W. J., Azuma, M., Anderson, A. C., Kuchroo, V. K. & Blazar, B. R., Apr 28 2011, In : Blood. 117, 17, p. 4501-4510 10 p.

Research output: Contribution to journalArticle

344 Scopus citations
24 Scopus citations
31 Scopus citations

Effector CD4+ T cells, the cytokines they generate, and GVHD: Something old and something new

Coghill, J. M., Sarantopoulos, S., Moran, T. P., Murphy, W. J., Blazar, B. R. & Serody, J. S., Mar 24 2011, In : Blood. 117, 12, p. 3268-3276 9 p.

Research output: Contribution to journalReview article

105 Scopus citations

Evidence for early fibrosis and increased airway resistance in bone marrow transplant recipient mice deficient in MMP12

England, K. A., Price, A. P., Tram, K. V., Shapiro, S. D., Blazar, B. R. & Panoskaltsis-Mortari, A., Oct 1 2011, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 301, 4, p. L519-L526

Research output: Contribution to journalArticle

14 Scopus citations

Ex Vivo Expanded Treg Therapy Promotes Long-Term Islet Allograft Survival in a Non-Human Primate Model

Bansal-Pakala, P., Pahuja, A., Hennessey, E., Graham, M., Hering, B. J. & Blazar, B. R., 2011, In : American Journal of Transplantation. 11, p. 209 1 p.

Research output: Contribution to journalArticle

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease

Hippen, K. L., Merkel, S. C., Schirm, D. K., Nelson, C., Tennis, N. C., Riley, J. L., June, C. H., Miller, J. S., Wagner, J. E. & Blazar, B. R., Jun 1 2011, In : American Journal of Transplantation. 11, 6, p. 1148-1157 10 p.

Research output: Contribution to journalArticle

149 Scopus citations
63 Scopus citations
112 Scopus citations

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: Safety profile and detection kinetics

Brunstein, C. G., Miller, J. S., Cao, Q., McKenna, D. H., Hippen, K. L., Curtsinger, J., DeFor, T., Levine, B. L., June, C. H., Rubinstein, P., McGlave, P. B., Blazar, B. R. & Wagner, J. E., Jan 20 2011, In : Blood. 117, 3, p. 1061-1070 10 p.

Research output: Contribution to journalArticle

660 Scopus citations

Lipid composition of whole brain and cerebellum in hurler syndrome (MPS IH) mice

Heinecke, K. A., Peacock, B. N., Blazar, B. R., Tolar, J. & Seyfried, T. N., Sep 1 2011, In : Neurochemical Research. 36, 9, p. 1669-1676 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
4 Scopus citations

Massive ex vivo expansion of human natural regulatory T cells (T regs) with minimal loss of in vivo functional activity

Hippen, K. L., Merkel, S. C., Schirm, D. K., Sieben, C. M., Sumstad, D., Kadidlo, D. M., McKenna, D. H., Bromberg, J. S., Levine, B. L., Riley, J. L., June, C. H., Scheinberg, P., Douek, D. C., Miller, J. S., Wagner, J. E. & Blazar, B. R., May 18 2011, In : Science Translational Medicine. 3, 83, 83ra41.

Research output: Contribution to journalArticle

224 Scopus citations
71 Scopus citations

miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27 kip1, KPC1, and SOCS-1

Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K. I., Blazar, B. R., Zeng, Y. & Zhou, X., Apr 21 2011, In : Blood. 117, 16, p. 4293-4303 11 p.

Research output: Contribution to journalArticle

197 Scopus citations

Mouse Ly49G2+ NK cells dominate early responses during both immune reconstitution and activation independently of MHC

Barao, I., Alvarez, M., Ames, E., Orr, M. T., Stefanski, H. E., Blazar, B. R., Lanier, L. L., Anderson, S. K., Redelman, D. & Murphy, W. J., Jun 30 2011, In : Blood. 117, 26, p. 7032-7041 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Natural killer-cell differentiation by myeloid progenitors

Grzywacz, B., Kataria, N., Kataria, N., Blazar, B. R., Miller, J. S. & Verneris, M. R., Mar 31 2011, In : Blood. 117, 13, p. 3548-3558 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice

Penaloza-MacMaster, P., Rasheed, A. U., Iyer, S. S., Yagita, H., Blazar, B. R. & Ahmed, R., Jul 1 2011, In : Journal of virology. 85, 13, p. 6168-6174 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Oxygen is a master regulator of the immunogenicity of primary human glioma cells

Olin, M. R., Andersen, B. M., Litterman, A. J., Grogan, P. T., Sarver, A. L., Robertson, P. T., Liang, X., Chen, W., Parney, I. F., Hunt, M. A., Blazar, B. R. & Ohlfest, J. R., Nov 1 2011, In : Cancer Research. 71, 21, p. 6583-6589 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

PD-L1 blockade effectively restores strong graft-versus-leukemia effects without graft-versus-host disease after delayed adoptive transfer of T-cell receptor gene-engineered allogeneic CD8+ T cells

Koestner, W., Hapke, M., Herbst, J., Klein, C., Welte, K., Fruehauf, J., Flatley, A., Vignali, D. A., Hardtke-Wolenski, M., Jaeckel, E., Blazar, B. R. & Sauer, M. G., Jan 20 2011, In : Blood. 117, 3, p. 1030-1041 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Peritransplant palifermin use and lymphocyte recovery after T-cell replete, matched related allogeneic hematopoietic cell transplantation

Rizwan, R., Levine, J. E., Defor, T., Ferarra, J. L. M., Weisdorf, D. J., Blazar, B. R. & Verneris, M. R., Oct 1 2011, In : American Journal of Hematology. 86, 10, p. 879-882 4 p.

Research output: Contribution to journalLetter

12 Scopus citations

Physiologic control of IDO competence in splenic dendritic cells

Baban, B., Chandler, P. R., Johnson, B. A., Huang, L., Li, M., Sharpe, M. L., Francisco, L. M., Sharpe, A. H., Blazar, B. R., Munn, D. H. & Mellor, A. L., Sep 1 2011, In : Journal of Immunology. 187, 5, p. 2329-2335 7 p.

Research output: Contribution to journalArticle

58 Scopus citations

PKC-θ function at the immunological synapse: Prospects for therapeutic targeting

Zanin-Zhorov, A., Dustin, M. L. & Blazar, B. R., Aug 1 2011, In : Trends in Immunology. 32, 8, p. 358-363 6 p.

Research output: Contribution to journalReview article

49 Scopus citations
27 Scopus citations

Regulatory T cells in acute myelogenous leukemia: Is it time for immunomodulation?

Ustun, C., Miller, J. S., Munn, D. H., Weisdorf, D. J. & Blazar, B. R., Nov 10 2011, In : Blood. 118, 19, p. 5084-5095 12 p.

Research output: Contribution to journalReview article

105 Scopus citations

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Beyer, M., Thabet, Y., Müller, R. U., Sadlon, T., Classen, S., Lahl, K., Basu, S., Zhou, X., Bailey-Bucktrout, S. L., Krebs, W., Schönfeld, E. A., Böttcher, J., Golovina, T., Mayer, C. T., Hofmann, A., Sommer, D., Debey-Pascher, S., Endl, E., Limmer, A., Hippen, K. L. & 15 others, Blazar, B. R., Balderas, R., Quast, T., Waha, A., Mayer, G., Famulok, M., Knolle, P. A., Wickenhauser, C., Kolanus, W., Schermer, B., Bluestone, J. A., Barry, S. C., Sparwasser, T., Riley, J. L. & Schultze, J. L., Sep 1 2011, In : Nature immunology. 12, 9, p. 898-907 10 p.

Research output: Contribution to journalArticle

121 Scopus citations

Resurrecting the recalcitrant T-cell

Wagner, J. E. & Blazar, B. R., Oct 20 2011, In : Blood. 118, 16, p. 4302-4303 2 p.

Research output: Contribution to journalComment/debate

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human t regulatory cells

Golovina, T. N., Mikheeva, T., Brusko, T. M., Blazar, B. R., Bluestone, J. A. & Riley, J. L., Feb 1 2011, In : PloS one. 6, 1, e15868.

Research output: Contribution to journalArticle

90 Scopus citations

Roles of CD28, CTLA4, and inducible costimulator in acute graft-versus-host disease in mice

Li, J., Semple, K., Suh, W. K., Liu, C., Chen, F., Blazar, B. R. & Yu, X. Z., Jul 1 2011, In : Biology of Blood and Marrow Transplantation. 17, 7, p. 962-969 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sleeping Beauty-mediated correction of Fanconi anemia type C

Hyland, K. A., Olson, E. R., Clark, K. J., Aronovich, E. L., Hackett, P. B., Blazar, B. R., Tolar, J. & Scott Mcivor, R., Sep 1 2011, In : Journal of Gene Medicine. 13, 9, p. 462-469 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Stem cell gene therapy for fanconi anemia: Report from the 1st international fanconi anemia gene therapy working group meeting

Tolar, J., Adair, J. E., Antoniou, M., Bartholomae, C. C., Becker, P. S., Blazar, B. R., Bueren, J., Carroll, T., Cavazzana-Calvo, M., Clapp, D. W., Dalgleish, R., Galy, A., Gaspar, H. B., Hanenberg, H., Von Kalle, C., Kiem, H. P., Lindeman, D., Naldini, L., Navarro, S., Renella, R. & 7 others, Rio, P., Sevilla, J., Schmidt, M., Verhoeyen, E., Wagner, J. E., Williams, D. A. & Thrasher, A. J., Jul 2011, In : Molecular Therapy. 19, 7, p. 1193-1198 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

Stromal cell-derived factor-1 and hematopoietic cell homing in an adult zebrafish model of hematopoietic cell transplantation

Glass, T. J., Lund, T. C., Patrinostro, X., Tolar, J., Bowman, T. V., Zon, L. I. & Blazar, B. R., Jul 21 2011, In : Blood. 118, 3, p. 766-774 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Synthetic zinc finger nuclease design and rapid assembly

Osborn, M. J., Defeo, A. P., Blazar, B. R. & Tolar, J., Sep 1 2011, In : Human gene therapy. 22, 9, p. 1155-1165 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

Sakuishi, K., Apetoh, L., Sullivan, J. M., Blazar, B. R., Kuchroo, V. K. & Anderson, A. C., Jun 1 2011, In : Journal of Experimental Medicine. 208, 6, 1 p.

Research output: Contribution to journalComment/debate

6 Scopus citations

The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo

Yang, J., Riella, L. V., Chock, S., Liu, T., Zhao, X., Yuan, X., Paterson, A. M., Watanabe, T., Vanguri, V., Yagita, H., Azuma, M., Blazar, B. R., Freeman, G. J., Rodig, S. J., Sharpe, A. H., Chandraker, A. & Sayegh, M. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

80 Scopus citations

The programmed Death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo

Paterson, A. M., Brown, K. E., Keir, M. E., Vanguri, V. K., Riella, L. V., Chandraker, A., Sayegh, M. H., Blazar, B. R., Freeman, G. J. & Sharpe, A. H., Aug 1 2011, In : Journal of Immunology. 187, 3, p. 1097-1105 9 p.

Research output: Contribution to journalArticle

93 Scopus citations

Thymic T-cell development in allogeneic stem cell transplantation

Krenger, W., Blazar, B. R. & Holländer, G. A., Jun 23 2011, In : Blood. 117, 25, p. 6768-6776 9 p.

Research output: Contribution to journalReview article

104 Scopus citations

Vstm3 is a member of the CD28 family and an important modulator of T-cell function

Levin, S. D., Taft, D. W., Brandt, C. S., Bucher, C., Howard, E. D., Chadwick, E. M., Johnston, J., Hammond, A., Bontadelli, K., Ardourel, D., Hebb, L., Wolf, A., Bukowski, T. R., Rixon, M. W., Kuijper, J. L., Ostrander, C. D., West, J. W., Bilsborough, J., Fox, B., Gao, Z. & 4 others, Xu, W., Ramsdell, F., Blazar, B. R. & Lewis, K. E., Apr 1 2011, In : European Journal of Immunology. 41, 4, p. 902-915 14 p.

Research output: Contribution to journalArticle

132 Scopus citations

Zinc fingers hit off target.

Cheng, L., Blazar, B., High, K. & Porteus, M., Oct 1 2011, In : Nature Medicine. 17, 10, p. 1192-1193 2 p.

Research output: Contribution to journalArticle

5 Scopus citations
2012

Advances in graft-versus-host disease biology and therapy

Blazar, B. R., Murphy, W. J. & Abedi, M., Jun 1 2012, In : Nature Reviews Immunology. 12, 6, p. 443-458 16 p.

Research output: Contribution to journalReview article

484 Scopus citations

A preclinical evaluation of minnelide as a therapeutic agent against pancreatic cancer

Chugh, R., Sangwan, V., Patil, S. P., Dudeja, V., Dawra, R. K., Banerjee, S., Schumacher, R. J., Blazar, B. R., Georg, G. I., Vickers, S. M. & Saluja, A. K., Oct 17 2012, In : Science Translational Medicine. 4, 156, 156ra139.

Research output: Contribution to journalArticle

160 Scopus citations

Attenuation of acute graft-versus-host disease in the absence of the transcription factor RORγt

Fulton, L. M., Carlson, M. J., Coghill, J. M., Ott, L. E., West, M. L., Panoskaltsis-Mortari, A., Littman, D. R., Blazar, B. R. & Serody, J. S., Aug 15 2012, In : Journal of Immunology. 189, 4, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Blocking IL-21 signaling ameliorates xenogeneic GVHD induced by human lymphocytes

Hippen, K. L., Bucher, C., Schirm, D. K., Bearl, A. M., Brender, T., Mink, K. A., Waggie, K. S., De Latour, R. P., Janin, A., Curtsinger, J. M., Dillon, S. R., Miller, J. S., Socie, G. & Blazar, B. R., Jan 12 2012, In : Blood. 119, 2, p. 619-628 10 p.

Research output: Contribution to journalArticle

55 Scopus citations

Bortezomib-based graft-versus-host disease prophylaxis in HLA-mismatched unrelated donor transplantation

Koreth, J., Stevenson, K. E., Kim, H. T., McDonough, S. M., Bindra, B., Armand, P., Ho, V. T., Cutler, C., Blazar, B. R., Antin, J. H., Soiffer, R. J., Ritz, J. & Alyea, E. P., Sep 10 2012, In : Journal of Clinical Oncology. 30, 26, p. 3202-3208 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

Veenstra, R. G., Taylor, P. A., Zhou, Q., Panoskaltsis-Mortari, A., Hirashima, M., Flynn, R., Liu, D., Anderson, A. C., Strom, T. B., Kuchroo, V. K. & Blazar, B. R., Jul 19 2012, In : Blood. 120, 3, p. 682-690 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Control of acute myeloid leukemia relapse - Dance between KIRs and HLA

Miller, J. S. & Blazar, B. R., Aug 30 2012, In : New England Journal of Medicine. 367, 9, p. 866-868 3 p.

Research output: Contribution to journalEditorial

7 Scopus citations

Cooking up tolerance: Has a new recipe been created?

Kean, L. S. & Blazar, B. R., Jul 1 2012, In : American Journal of Transplantation. 12, 7, p. 1667-1669 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations