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  • Paul D Robbins
Article

ADAMTS5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration

Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S. & Vo, N. V., Oct 15 2017, In : Spine. 42, 20, p. 1521-1528 8 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis–like symptoms in NOD mice

Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., Evans, C. H., Gambotto, A., Niedernhofer, L. J. & Robbins, P. D., Aug 1 2019, In : FASEB Journal. 33, 8, p. 9505-9515 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Age-dependent changes i n i ntervertebral di sc cell mi tochondri a and bi oenergeti cs

Hartman, R., Patil, P., Tisherman, R., St. Croix, C., Niedernhofer, L. J., Robbins, P. D., Ambrosio, F., Van Houten, B., Sowa, G. & Vo, N., Jan 1 2018, In : European Cells and Materials. 36, p. 171-183 13 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Arsenic promotes NF-Κb-mediated fibroblast dysfunction and matrix remodeling to impair muscle stem cell function

Zhang, C., Ferrari, R., Beezhold, K., Stearns-Reider, K., D'Amore, A., Haschak, M., Stolz, D., Robbins, P. D., Barchowsky, A. & Ambrosio, F., Mar 1 2016, In : STEM CELLS. 34, 3, p. 732-742 11 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Arthritis Gene Therapy Approved in Korea

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 15 2018, In : Journal of the American Academy of Orthopaedic Surgeons. 26, 2, p. e36-e38

Research output: Contribution to journalArticle

7 Scopus citations

ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging

Zhao, J., Zhang, L., Lu, A., Han, Y., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X., Gurkar, A. U., McGowan, S. J., Angelini, L., O'Kelly, R., Li, H., Corbo, L., Sano, T., Nick, H., Pola, E., Pilla, S. P. S., Ladiges, W. C. & 4 others, Vo, N., Huard, J., Niedernhofer, L. J. & Robbins, P. D., Mar 31 2020, In : Aging. 12, 6, p. 4688-4710 23 p.

Research output: Contribution to journalArticle

1 Scopus citations

Barriers to the Preclinical Development of Therapeutics that Target Aging Mechanisms

Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N. & Kirkland, J. L., Nov 1 2016, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 71, 11, p. 1388-1394 7 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Bioplasty for vertebral fractures: preliminary results of a pre-clinical study on goats using autologous modified skin fibroblasts.

Pola, E., Nasto, L. A., Tampieri, A., Lattanzi, W., Di Giacomo, G., Colangelo, D., Ciriello, V., Pagano, E., Spinelli, S., Robbins, P. D. & Logroscino, G., Jan 1 2011, In : International journal of immunopathology and pharmacology. 24, 1 Suppl 2, p. 139-142 4 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J. F., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature communications. 8, 14532.

Research output: Contribution to journalArticle

Open Access
300 Scopus citations

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans

Yousefzadeh, M. J., Schafer, M. J., Noren Hooten, N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K. & Niedernhofer, L. J., Apr 2018, In : Aging cell. 17, 2, e12706.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

D-amino acid substitution of peptide-mediated NF-κB suppression in mdx mice preserves therapeutic benefit in skeletal muscle, but causes kidney toxicity

Reay, D. P., Bastacky, S. I., Wack, K. E., Stolz, D. B., Robbins, P. D. & Clemens, P. R., Jan 1 2015, In : Molecular Medicine. 21, p. 442-452 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation

Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D. P., McGowan, S. J., Corbo, L., Clemens, P. R., Wilson, G. M., Watkins, S. C., Solt, L. A., Cameron, M. D., Huard, J., Niedernhofer, L. J., Kamenecka, T. M. & Robbins, P. D., Jun 2018, In : PLoS biology. 16, 6, e2004663.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

DNA damage drives accelerated bone aging via an NF- κ B-dependent mechanism

Chen, Q., Liu, K., Robinson, A. R., Clauson, C. L., Blair, H. C., Robbins, P. D., Niedernhofer, L. J. & Ouyang, H., May 1 2013, In : Journal of Bone and Mineral Research. 28, 5, p. 1214-1228 15 p.

Research output: Contribution to journalArticle

50 Scopus citations

DsAAV8-mediated gene transfer and Β-cell expression of IL-4 and Β-cell growth factors are capable of reversing early-onset diabetes in NOD mice

Gaddy, D. F., Riedel, M. J., Bertera, S., Kieffer, T. J. & Robbins, P. D., Aug 1 2012, In : Gene therapy. 19, 8, p. 791-799 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging

Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., Croix, C. M. S., Niedernhofer, L. J. & Gill, M. S., Sep 2018, In : Redox Biology. 18, p. 191-199 9 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Exosomes released from mycoplasma infected tumor cells activate inhibitory B cells

Yang, C., Chalasani, G., Ng, Y. H. & Robbins, P. D., Apr 27 2012, In : PloS one. 7, 4, e36138.

Research output: Contribution to journalArticle

36 Scopus citations

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J. & Robbins, P. D., Jun 2017, In : Aging cell. 16, 3, p. 480-487 8 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations
9 Scopus citations

Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy

Nogueira-Recalde, U., Lorenzo-Gómez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Domínguez, E. & Caramés, B., Jul 2019, In : EBioMedicine. 45, p. 588-605 18 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Fisetin is a senotherapeutic that extends health and lifespan

Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., Kato, J. I., Grassi, D., Wentworth, M., Burd, C. E., Arriaga, E. A., Ladiges, W. L., Tchkonia, T., Kirkland, J. L. & 2 others, Robbins, P. D. & Niedernhofer, L. J., Oct 2018, In : EBioMedicine. 36, p. 18-28 11 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations

Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs

Nasto, L. A., Wang, D., Robinson, A. R., Clauson, C. L., Ngo, K., Dong, Q., Roughley, P., Epperly, M., Huq, S. M., Pola, E., Sowa, G., Robbins, P. D., Kang, J., Niedernhofer, L. J. & Vo, N. V., Jan 1 2013, In : Mechanisms of Ageing and Development. 134, 1-2, p. 35-42 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues

Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M. & Robbins, P. D., Jun 1 2020, In : GeroScience. 42, 3, p. 951-961 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
9 Scopus citations

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M., Ling, Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., Robbins, P. D. & Kirkland, J. L., Jun 1 2016, In : Aging cell. 15, 3, p. 428-435 8 p.

Research output: Contribution to journalArticle

Open Access
225 Scopus citations

Identification of HSP90 inhibitors as a novel class of senolytics

Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., Bukata, C., Ring, N., Giacca, M., Li, X., Tchkonia, T., Kirkland, J. L., Niedernhofer, L. J. & Robbins, P. D., Dec 1 2017, In : Nature communications. 8, 1, 422.

Research output: Contribution to journalArticle

Open Access
135 Scopus citations

IL-Y, a synthetic member of the IL-12 cytokine family, suppresses the development of type 1 diabetes in NOD mice

Flores, R. R., Kim, E., Zhou, L., Yang, C., Zhao, J., Gambotto, A. & Robbins, P. D., Nov 1 2015, In : European Journal of Immunology. 45, 11, p. 3114-3125 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors

Gatson, N. T. N., Williams, J. L., Powell, N. D., McClain, M. A., Hennon, T. R., Robbins, P. D. & Whitacre, C. C., Jan 1 2011, In : Journal of Neuroimmunology. 230, 1-2, p. 105-113 9 p.

Research output: Contribution to journalArticle

34 Scopus citations

Inhibition of NF-κB improves the stress resistance and myogenic differentiation of MDSPCs isolated from naturally aged mice

Proto, J. D., Lu, A., Dorronsoro, A., Scibetta, A., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jun 2017, In : PloS one. 12, 6, e0179270.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

ISSLS prize winner: Inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging

Nasto, L. A., Seo, H. Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., Robbins, P. D. & Vo, N. V., Oct 1 2012, In : Spine. 37, 21, p. 1819-1825 7 p.

Research output: Contribution to journalArticle

44 Scopus citations

LIM domain protein-3 (LMP3) cooperates with BMP7 to promote tissue regeneration by ligament progenitor cells

Lin, Z., Rios, H. F., Park, C. H., Taut, A. D., Jin, Q., Sugai, J. V., Robbins, P. D. & Giannobile, W. V., Jan 1 2013, In : Gene therapy. 20, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Lim Mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through kruppel-like factor-4 downregulation and further bone-specific gene expression

Barba, M., Pirozzi, F., Saulnier, N., Vitali, T., Natale, M. T., Logroscino, G., Robbins, P. D., Gambotto, A., Neri, G., Michetti, F., Pola, E. & Lattanzi, W., 2012, In : Journal of Biomedicine and Biotechnology. 2012, 813894.

Research output: Contribution to journalArticle

17 Scopus citations

Measuring biological age in mice using differential mass spectrometry

Bell-Temin, H., Yousefzadeh, M. J., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J. & Yates, N. A., Jan 1 2019, In : Aging. 11, 3, p. 1045-1061 17 p.

Research output: Contribution to journalArticle

Open Access

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin-Smith, G. K., Ayre, D. C., Bach, J. M., Bachurski, D., Baharvand, H., Balaj, L., Baldacchino, S., Bauer, N. N., Baxter, A. A., Bebawy, M., Beckham, C. & 362 others, Bedina Zavec, A., Benmoussa, A., Berardi, A. C., Bergese, P., Bielska, E., Blenkiron, C., Bobis-Wozowicz, S., Boilard, E., Boireau, W., Bongiovanni, A., Borràs, F. E., Bosch, S., Boulanger, C. M., Breakefield, X., Breglio, A. M., Brennan, M., Brigstock, D. R., Brisson, A., Broekman, M. L. D., Bromberg, J. F., Bryl-Górecka, P., Buch, S., Buck, A. H., Burger, D., Busatto, S., Buschmann, D., Bussolati, B., Buzás, E. I., Byrd, J. B., Camussi, G., Carter, D. R. F., Caruso, S., Chamley, L. W., Chang, Y. T., Chaudhuri, A. D., Chen, C., Chen, S., Cheng, L., Chin, A. R., Clayton, A., Clerici, S. P., Cocks, A., Cocucci, E., Coffey, R. J., Cordeiro-da-Silva, A., Couch, Y., Coumans, F. A. W., Coyle, B., Crescitelli, R., Criado, M. F., D’Souza-Schorey, C., Das, S., de Candia, P., De Santana, E. F., De Wever, O., del Portillo, H. A., Demaret, T., Deville, S., Devitt, A., Dhondt, B., Di Vizio, D., Dieterich, L. C., Dolo, V., Dominguez Rubio, A. P., Dominici, M., Dourado, M. R., Driedonks, T. A. P., Duarte, F. V., Duncan, H. M., Eichenberger, R. M., Ekström, K., EL Andaloussi, S., Elie-Caille, C., Erdbrügger, U., Falcón-Pérez, J. M., Fatima, F., Fish, J. E., Flores-Bellver, M., Försönits, A., Frelet-Barrand, A., Fricke, F., Fuhrmann, G., Gabrielsson, S., Gámez-Valero, A., Gardiner, C., Gärtner, K., Gaudin, R., Gho, Y. S., Giebel, B., Gilbert, C., Gimona, M., Giusti, I., Goberdhan, D. C. I., Görgens, A., Gorski, S. M., Greening, D. W., Gross, J. C., Gualerzi, A., Gupta, G. N., Gustafson, D., Handberg, A., Haraszti, R. A., Harrison, P., Hegyesi, H., Hendrix, A., Hill, A. F., Hochberg, F. H., Hoffmann, K. F., Holder, B., Holthofer, H., Hosseinkhani, B., Hu, G., Huang, Y., Huber, V., Hunt, S., Ibrahim, A. G. E., Ikezu, T., Inal, J. M., Isin, M., Ivanova, A., Jackson, H. K., Jacobsen, S., Jay, S. M., Jayachandran, M., Jenster, G., Jiang, L., Johnson, S. M., Jones, J. C., Jong, A., Jovanovic-Talisman, T., Jung, S., Kalluri, R., Kano, S. I., Kaur, S., Kawamura, Y., Keller, E. T., Khamari, D., Khomyakova, E., Khvorova, A., Kierulf, P., Kim, K. P., Kislinger, T., Klingeborn, M., Klinke, D. J., Kornek, M., Kosanović, M. M., Kovács, Á. F., Krämer-Albers, E. M., Krasemann, S., Krause, M., Kurochkin, I. V., Kusuma, G. D., Kuypers, S., Laitinen, S., Langevin, S. M., Languino, L. R., Lannigan, J., Lässer, C., Laurent, L. C., Lavieu, G., Lázaro-Ibáñez, E., Le Lay, S., Lee, M. S., Lee, Y. X. F., Lemos, D. S., Lenassi, M., Leszczynska, A., Li, I. T. S., Liao, K., Libregts, S. F., Ligeti, E., Lim, R., Lim, S. K., Linē, A., Linnemannstöns, K., Llorente, A., Lombard, C. A., Lorenowicz, M. J., Lörincz, Á. M., Lötvall, J., Lovett, J., Lowry, M. C., Loyer, X., Lu, Q., Lukomska, B., Lunavat, T. R., Maas, S. L. N., Malhi, H., Marcilla, A., Mariani, J., Mariscal, J., Martens-Uzunova, E. S., Martin-Jaular, L., Martinez, M. C., Martins, V. R., Mathieu, M., Mathivanan, S., Maugeri, M., McGinnis, L. K., McVey, M. J., Meckes, D. G., Meehan, K. L., Mertens, I., Minciacchi, V. R., Möller, A., Møller Jørgensen, M., Morales-Kastresana, A., Morhayim, J., Mullier, F., Muraca, M., Musante, L., Mussack, V., Muth, D. C., Myburgh, K. H., Najrana, T., Nawaz, M., Nazarenko, I., Nejsum, P., Neri, C., Neri, T., Nieuwland, R., Nimrichter, L., Nolan, J. P., Nolte-’t Hoen, E. N. M., Noren Hooten, N., O’Driscoll, L., O’Grady, T., O’Loghlen, A., Ochiya, T., Olivier, M., Ortiz, A., Ortiz, L. A., Osteikoetxea, X., Ostegaard, O., Ostrowski, M., Park, J., Pegtel, D. M., Peinado, H., Perut, F., Pfaffl, M. W., Phinney, D. G., Pieters, B. C. H., Pink, R. C., Pisetsky, D. S., Pogge von Strandmann, E., Polakovicova, I., Poon, I. K. H., Powell, B. H., Prada, I., Pulliam, L., Quesenberry, P., Radeghieri, A., Raffai, R. L., Raimondo, S., Rak, J., Ramirez, M. I., Raposo, G., Rayyan, M. S., Regev-Rudzki, N., Ricklefs, F. L., Robbins, P. D., Roberts, D. D., Rodrigues, S. C., Rohde, E., Rome, S., Rouschop, K. M. A., Rughetti, A., Russell, A. E., Saá, P., Sahoo, S., Salas-Huenuleo, E., Sánchez, C., Saugstad, J. A., Saul, M. J., Schiffelers, R. M., Schneider, R., Schøyen, T. H., Scott, A., Shahaj, E., Sharma, S., Shatnyeva, O., Shekari, F., Shelke, G. V., Shetty, A. K., Shiba, K., Siljander, P. R. M., Silva, A. M., Skowronek, A., Snyder, O. L., Soares, R. P., Sódar, B. W., Soekmadji, C., Sotillo, J., Stahl, P. D., Stoorvogel, W., Stott, S. L., Strasser, E. F., Swift, S., Tahara, H., Tewari, M., Timms, K., Tiwari, S., Tixeira, R., Tkach, M., Toh, W. S., Tomasini, R., Torrecilhas, A. C., Tosar, J. P., Toxavidis, V., Urbanelli, L., Vader, P., van Balkom, B. W. M., van der Grein, S. G., Van Deun, J., van Herwijnen, M. J. C., Van Keuren-Jensen, K., van Niel, G., van Royen, M. E., van Wijnen, A. J., Vasconcelos, M. H., Vechetti, I. J., Veit, T. D., Vella, L. J., Velot, É., Verweij, F. J., Vestad, B., Viñas, J. L., Visnovitz, T., Vukman, K. V., Wahlgren, J., Watson, D. C., Wauben, M. H. M., Weaver, A., Webber, J. P., Weber, V., Wehman, A. M., Weiss, D. J., Welsh, J. A., Wendt, S., Wheelock, A. M., Wiener, Z., Witte, L., Wolfram, J., Xagorari, A., Xander, P., Xu, J., Yan, X., Yáñez-Mó, M., Yin, H., Yuana, Y., Zappulli, V., Zarubova, J., Žėkas, V., Zhang, J. Y., Zhao, Z., Zheng, L., Zheutlin, A. R., Zickler, A. M., Zimmermann, P., Zivkovic, A. M., Zocco, D. & Zuba-Surma, E. K., Jan 1 2018, In : Journal of Extracellular Vesicles. 7, 1, 1535750.

Research output: Contribution to journalArticle

Open Access
724 Scopus citations

Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration

Nasto, L. A., Robinson, A. R., Ngo, K., Clauson, C. L., Dong, Q., St. Croix, C., Sowa, G., Pola, E., Robbins, P. D., Kang, J., Niedernhofer, L. J., Wipf, P. & Vo, N. V., Jul 1 2013, In : Journal of Orthopaedic Research. 31, 7, p. 1150-1157 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging

Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Jul 2017, In : Journal of Orthopaedic Research. 35, 7, p. 1375-1382 8 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

Murine models of accelerated aging and musculoskeletal disease

Hambright, W. S., Niedernhofer, L. J., Huard, J. & Robbins, P. D., Aug 2019, In : Bone. 125, p. 122-127 6 p.

Research output: Contribution to journalArticle

Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

Lavasani, M., Robinson, A. R., Lu, A., Song, M., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J. & Huard, J., Feb 13 2012, In : Nature communications. 3, 608.

Research output: Contribution to journalArticle

121 Scopus citations

New agents that target senescent cells: The flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463

Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T. & Kirkland, J. L., 2017, In : Aging. 9, 3, p. 1-9 9 p.

Research output: Contribution to journalArticle

Open Access
123 Scopus citations

NF-κB activation with aging: Characterization and therapeutic inhibition

Zhao, J., Li, X., McGowan, S., Niedernhofer, L. J. & Robbins, P. D., Jan 1 2015, In : Methods in Molecular Biology. 1280, p. 543-557 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

NF-κB inhibition delays DNA damage - Induced senescence and aging in mice

Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., Huard, J., Clemens, P. R., Stolz, D. B., Guttridge, D. C., Watkins, S. C., Garinis, G. A., Wang, Y., Niedernhofer, L. J. & Robbins, P. D., Jul 2 2012, In : Journal of Clinical Investigation. 122, 7, p. 2601-2612 12 p.

Research output: Contribution to journalArticle

214 Scopus citations

NF-κB inhibition reveals a novel role for HGF during skeletal muscle repair

Proto, J. D., Tang, Y., Lu, A., Chen, W. C. W., Stahl, E., Poddar, M., Beckman, S. A., Robbins, P. D., Nidernhofer, L. J., Imbrogno, K., Hannigan, T., Mars, W. M., Wang, B. & Huard, J., Apr 23 2015, In : Cell Death and Disease. 6, 4, e1730.

Research output: Contribution to journalArticle

23 Scopus citations

NF-κB negatively impacts the myogenic potential of muscle-derived stem cells

Lu, A., Proto, J. D., Guo, L., Tang, Y., Lavasani, M., Tilstra, J. S., Niedernhofer, L. J., Wang, B., Guttridge, D. C., Robbins, P. D. & Huard, J., Mar 2012, In : Molecular Therapy. 20, 3, p. 661-668 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Orthopedic gene therapy-lost in translation?

Evans, C. H., Ghivizzani, S. C. & Robbins, P. D., Jan 1 2012, In : Journal of cellular physiology. 227, 2, p. 416-420 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Oxidative stress-induced senescence markedly increases disc cell bioenergetics

Patil, P., Falabella, M., Saeed, A., Lee, D., Kaufman, B., Shiva, S., Croix, C. S., Van Houten, B., Niedernhofer, L. J., Robbins, P. D., Lee, J., Gwendolyn, S. & Vo, N. V., Jun 2019, In : Mechanisms of Ageing and Development. 180, p. 97-106 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of duchenne muscular dystrophy

Peterson, J. M., Kline, W., Canan, B. D., Ricca, D. J., Kaspar, B., Delfín, D. A., Dirienzo, K., Clemens, P. R., Robbins, P. D., Baldwin, A. S., Flood, P., Kaumaya, P., Freitas, M., Kornegay, J. N., Mendell, J. R., Rafael-Fortney, J. A., Guttridge, D. C. & Janssen, P. M., May 1 2011, In : Molecular Medicine. 17, 5-6, p. 508-515 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pharmacologic IKK/NF-kappa;B inhibition causes antigen presenting cells to undergo TNFα dependent ROS-mediated programmed cell death

Tilstra, J. S., Gaddy, D. F., Zhao, J., Davé, S. H., Niedernhofer, L. J., Plevy, S. E. & Robbins, P. D., Jan 10 2014, In : Scientific reports. 4, 3631.

Research output: Contribution to journalArticle

15 Scopus citations

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Garcia-Contreras, M., Shah, S. H., Tamayo, A., Robbins, P. D., Golberg, R. B., Mendez, A. J. & Ricordi, C., Dec 1 2017, In : Scientific reports. 7, 1, 5998.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses

Yang, C., Ruffner, M. A., Kim, S. H. & Robbins, P. D., Jul 1 2012, In : European Journal of Immunology. 42, 7, p. 1778-1784 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy

Kim, C. Y., Park, S. H., Jeong, M., Kwon, O. S., Doh, H., Kang, S. H., Robbins, P. D., Kim, B. M., Seol, D. W. & Kim, B. G., Oct 31 2011, In : Experimental and Molecular Medicine. 43, 10, p. 580-586 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Premature aging-related peripheral neuropathy in a mouse model of progeria

Goss, J. R., Stolz, D. B., Robinson, A. R., Zhang, M., Arbujas, N., Robbins, P. D., Glorioso, J. C. & Niedernhofer, L. J., Aug 1 2011, In : Mechanisms of Ageing and Development. 132, 8-9, p. 437-442 6 p.

Research output: Contribution to journalArticle

27 Scopus citations